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Lysis Of Arterial Thrombi By Perfusion Of N,N'-Diacetyl-L-Cystine (Dinac), Dongjune Kim, Susan M. Shea, David N. Ku
Lysis Of Arterial Thrombi By Perfusion Of N,N'-Diacetyl-L-Cystine (Dinac), Dongjune Kim, Susan M. Shea, David N. Ku
Open Access Publications
The search persists for a safe and effective agent to lyse arterial thrombi in the event of acute heart attacks or strokes due to thrombotic occlusion. The culpable thrombi are composed either primarily of platelets and von Willebrand Factor (VWF), or polymerized fibrin, depending on the mechanism of formation. Current thrombolytics were designed to target red fibrin-rich clots, but may be not be efficacious on white VWF-platelet-rich arterial thrombi. We have developed an in vitro system to study the efficacy of known and proposed thrombolytic agents on white clots formed from whole blood in a stenosis with arterial conditions. The …
Cortical Regions Activated By Spectrally Degraded Speech In Adults With Single Sided Deafness Or Bilateral Normal Hearing, Harold Burton, Ruth M Reeder, Tim Holden, Alvin Agato, Jill B Firszt
Cortical Regions Activated By Spectrally Degraded Speech In Adults With Single Sided Deafness Or Bilateral Normal Hearing, Harold Burton, Ruth M Reeder, Tim Holden, Alvin Agato, Jill B Firszt
Open Access Publications
Those with profound sensorineural hearing loss from single sided deafness (SSD) generally experience greater cognitive effort and fatigue in adverse sound environments. We studied cases with right ear, SSD compared to normal hearing (NH) individuals. SSD cases were significantly less correct in naming last words in spectrally degraded 8- and 16-band vocoded sentences, despite high semantic predictability. Group differences were not significant for less intelligible 4-band sentences, irrespective of predictability. SSD also had diminished BOLD percent signal changes to these same sentences in left hemisphere (LH) cortical regions of early auditory, association auditory, inferior frontal, premotor, inferior parietal, dorsolateral prefrontal, …
Guidelines For Conducting Virtual Cognitive Interviews During A Pandemic, James A Shepperd, Gabrielle Pogge, Jean M Hunleth, Sienna Ruiz, Erika A Waters
Guidelines For Conducting Virtual Cognitive Interviews During A Pandemic, James A Shepperd, Gabrielle Pogge, Jean M Hunleth, Sienna Ruiz, Erika A Waters
Open Access Publications
The COVID-19 pandemic has challenged researchers working in physical contact with research participants. Cognitive interviews examine whether study components (most often questionnaire items) are worded or structured in a manner that allows study participants to interpret the items in a way intended by the researcher. We developed guidelines to conduct cognitive interviews virtually to accommodate interviewees who have limited access to the internet. The guidelines describe the essential communication and safety equipment requirements and outline a procedure for collecting responses while maintaining the safety of the participants and researchers. Furthermore, the guidelines provide suggestions regarding training of participants to use …
Sars-Cov-2 Variants And Convalescent Plasma: Reality, Fallacies, And Opportunities, Arturo Casadevall, Jeffrey P Henderson, Michael J Joyner, Liise-Anne Pirofski
Sars-Cov-2 Variants And Convalescent Plasma: Reality, Fallacies, And Opportunities, Arturo Casadevall, Jeffrey P Henderson, Michael J Joyner, Liise-Anne Pirofski
Open Access Publications
No abstract provided.
Initial Clinical Experience Of Mr-Guided Radiotherapy For Non-Small Cell Lung Cancer, Cathryn B Crockett, Pamela Samson, Robert Chuter, Michael Dubec, Corinne Faivre-Finn, Olga L Green, Sara L Hackett, Fiona Mcdonald, Clifford Robinson, Anna-Maria Shiarli, Michael W Straza, Joost J C Verhoeff, Maria Werner-Wasik, Gregory Vlacich, David Cobben
Initial Clinical Experience Of Mr-Guided Radiotherapy For Non-Small Cell Lung Cancer, Cathryn B Crockett, Pamela Samson, Robert Chuter, Michael Dubec, Corinne Faivre-Finn, Olga L Green, Sara L Hackett, Fiona Mcdonald, Clifford Robinson, Anna-Maria Shiarli, Michael W Straza, Joost J C Verhoeff, Maria Werner-Wasik, Gregory Vlacich, David Cobben
Open Access Publications
Curative-intent radiotherapy plays an integral role in the treatment of lung cancer and therefore improving its therapeutic index is vital. MR guided radiotherapy (MRgRT) systems are the latest technological advance which may help with achieving this aim. The majority of MRgRT treatments delivered to date have been stereotactic body radiation therapy (SBRT) based and include the treatment of (ultra-) central tumors. However, there is a move to also implement MRgRT as curative-intent treatment for patients with inoperable locally advanced NSCLC. This paper presents the initial clinical experience of using the two commercially available systems to date: the ViewRay MRIdian and …
De Novo Synthesis Of Phosphatidylcholine Is Essential For The Promastigote But Not Amastigote Stage In Leishmania Major, Samrat Moitra, Somrita Basu, Mattie Pawlowic, Fong-Fu Hsu, Kai Zhang
De Novo Synthesis Of Phosphatidylcholine Is Essential For The Promastigote But Not Amastigote Stage In Leishmania Major, Samrat Moitra, Somrita Basu, Mattie Pawlowic, Fong-Fu Hsu, Kai Zhang
Open Access Publications
Phosphatidylcholine (PC) is the most abundant type of phospholipids in eukaryotes constituting ~30% of total lipids in
Neuroscience Of Object Relations In Health And Disorder: A Proposal For An Integrative Model, Dragan M Svrakic, Charles F Zorumski
Neuroscience Of Object Relations In Health And Disorder: A Proposal For An Integrative Model, Dragan M Svrakic, Charles F Zorumski
Open Access Publications
Recent advances in the neuroscience of episodic memory provide a framework to integrate object relations theory, a psychoanalytic model of mind development, with potential neural mechanisms. Object relations are primordial cognitive-affective units of the mind derived from survival- and safety-level experiences with caretakers during phase-sensitive periods of infancy and toddlerhood. Because these are learning experiences, their neural substrate likely involves memory, here affect-enhanced episodic memory. Inaugural object relations are encoded by the hippocampus-amygdala synaptic plasticity, and systems-consolidated by medial prefrontal cortex (mPFC). Self- and object-mental representations, extracted from these early experiences, are at first dichotomized by contradictory affects evoked by …
The Context-Dependent Influence Of Promoter Sequence Motifs On Transcription Initiation Kinetics And Regulation, Drake Jensen, Eric A Galburt
The Context-Dependent Influence Of Promoter Sequence Motifs On Transcription Initiation Kinetics And Regulation, Drake Jensen, Eric A Galburt
Open Access Publications
The fitness of an individual bacterial cell is highly dependent upon the temporal tuning of gene expression levels when subjected to different environmental cues. Kinetic regulation of transcription initiation is a key step in modulating the levels of transcribed genes to promote bacterial survival. The initiation phase encompasses the binding of RNA polymerase (RNAP) to promoter DNA and a series of coupled protein-DNA conformational changes prior to entry into processive elongation. The time required to complete the initiation phase can vary by orders of magnitude and is ultimately dictated by the DNA sequence of the promoter. In this review, we …
Therapeutic Ultrasound-Enhanced Immune Checkpoint Inhibitor Therapy, Jinyun Yuan, Dezhuang Ye, Si Chen, Hong Chen
Therapeutic Ultrasound-Enhanced Immune Checkpoint Inhibitor Therapy, Jinyun Yuan, Dezhuang Ye, Si Chen, Hong Chen
Open Access Publications
No abstract provided.
Cognitive Gain Or Handicap: Magical Ideation And Self-Absorption In Clinical And Non-Clinical Participants, János Kállai, Gábor Vincze, Imre András Török, Rita Hargitai, Sándor Rózsa, István Hartung, István Tamás, András Láng, Róbert Herold
Cognitive Gain Or Handicap: Magical Ideation And Self-Absorption In Clinical And Non-Clinical Participants, János Kállai, Gábor Vincze, Imre András Török, Rita Hargitai, Sándor Rózsa, István Hartung, István Tamás, András Láng, Róbert Herold
Open Access Publications
No abstract provided.
Correspondence Between Perceived Pubertal Development And Hormone Levels In 9-10 Year-Olds From The Adolescent Brain Cognitive Development Study, Megan M. Herting, Andrey P. Anokhin, Deanna M. Barch, Nico Dosenbach, Paul E.A. Glaser, Andrew C. Heath, Nicole R. Karcher, Et Al
Correspondence Between Perceived Pubertal Development And Hormone Levels In 9-10 Year-Olds From The Adolescent Brain Cognitive Development Study, Megan M. Herting, Andrey P. Anokhin, Deanna M. Barch, Nico Dosenbach, Paul E.A. Glaser, Andrew C. Heath, Nicole R. Karcher, Et Al
Open Access Publications
No abstract provided.
Cxcl17 Is A Specific Diagnostic Biomarker For Severe Pandemic Influenza A(H1n1) That Predicts Poor Clinical Outcome, Jose Alberto Choreño-Parra, Shabaana A Khader, Et Al
Cxcl17 Is A Specific Diagnostic Biomarker For Severe Pandemic Influenza A(H1n1) That Predicts Poor Clinical Outcome, Jose Alberto Choreño-Parra, Shabaana A Khader, Et Al
Open Access Publications
The C-X-C motif chemokine ligand 17 (CXCL17) is chemotactic for myeloid cells, exhibits bactericidal activity, and exerts anti-viral functions. This chemokine is constitutively expressed in the respiratory tract, suggesting a role in lung defenses. However, little is known about the participation of CXCL17 against relevant respiratory pathogens in humans. Here, we evaluated the serum levels and lung tissue expression pattern of CXCL17 in a cohort of patients with severe pandemic influenza A(H1N1) from Mexico City. Peripheral blood samples obtained on admission and seven days after hospitalization were processed for determinations of serum CXCL17 levels by enzyme-linked immunosorbent assay (ELISA). The …
Transcriptome Analysis Of Dnmt3l Knock-Out Mice Derived Multipotent Mesenchymal Stem/Stromal Cells During Osteogenic Differentiation, Chih-Yi Yang, Rita Jui-Hsien Lu, Ming-Kang Lee, Felix Shih-Hsian Hsiao, Ya-Ping Yen, Chun-Chun Cheng, Pu-Sheng Hsu, Yi-Tzang Tsai, Shih-Kuo Chen, I-Hsuan Liu, Pao-Yang Chen, Shau-Ping Lin
Transcriptome Analysis Of Dnmt3l Knock-Out Mice Derived Multipotent Mesenchymal Stem/Stromal Cells During Osteogenic Differentiation, Chih-Yi Yang, Rita Jui-Hsien Lu, Ming-Kang Lee, Felix Shih-Hsian Hsiao, Ya-Ping Yen, Chun-Chun Cheng, Pu-Sheng Hsu, Yi-Tzang Tsai, Shih-Kuo Chen, I-Hsuan Liu, Pao-Yang Chen, Shau-Ping Lin
Open Access Publications
Multipotent mesenchymal stem/stromal cells (MSCs) exhibit great potential for cell-based therapy. Proper epigenomic signatures in MSCs are important for the maintenance and the subsequent differentiation potential. The DNA methyltransferase 3-like (DNMT3L) that was mainly expressed in the embryonic stem (ES) cells and the developing germ cells plays an important role in shaping the epigenetic landscape. Here, we report the reduced colony forming ability and impaired
Gestational Age-Specific Complete Blood Count Signatures In Necrotizing Enterocolitis, Julia M Pantalone, Silvia Liu, Oluwabunmi O Olaloye, Erica C Prochaska, Toby Yanowitz, Melissa M Riley, Justin R Buland, Beverly S Brozanski, Misty Good, Liza Konnikova
Gestational Age-Specific Complete Blood Count Signatures In Necrotizing Enterocolitis, Julia M Pantalone, Silvia Liu, Oluwabunmi O Olaloye, Erica C Prochaska, Toby Yanowitz, Melissa M Riley, Justin R Buland, Beverly S Brozanski, Misty Good, Liza Konnikova
Open Access Publications
No abstract provided.
Machine Learning Analytics Of Resting-State Functional Connectivity Predicts Survival Outcomes Of Glioblastoma Multiforme Patients, Bidhan Lamichhane, Andy G S Daniel, John J Lee, Daniel S Marcus, Joshua S Shimony, Eric C Leuthardt
Machine Learning Analytics Of Resting-State Functional Connectivity Predicts Survival Outcomes Of Glioblastoma Multiforme Patients, Bidhan Lamichhane, Andy G S Daniel, John J Lee, Daniel S Marcus, Joshua S Shimony, Eric C Leuthardt
Open Access Publications
Glioblastoma multiforme (GBM) is the most frequently occurring brain malignancy. Due to its poor prognosis with currently available treatments, there is a pressing need for easily accessible, non-invasive techniques to help inform pre-treatment planning, patient counseling, and improve outcomes. In this study we determined the feasibility of resting-state functional connectivity (rsFC) to classify GBM patients into short-term and long-term survival groups with respect to reported median survival (14.6 months). We used a support vector machine with rsFC between regions of interest as predictive features. We employed a novel hybrid feature selection method whereby features were first filtered using correlations between …
Mitofusin Activation Enhances Mitochondrial Motility And Promotes Neuroregeneration In Cmt2a, Gerald W. Dorn Ii
Mitofusin Activation Enhances Mitochondrial Motility And Promotes Neuroregeneration In Cmt2a, Gerald W. Dorn Ii
Open Access Publications
No abstract provided.
Defining Intermediates And Redundancies In Coenzyme Q Precursor Biosynthesis, Kyle P. Robinson, Adam Jochem, Sheila E. Johnson, Thiruchelvi R. Reddy, Jason D. Russell, Joshua J. Coon, David J. Pagliarini
Defining Intermediates And Redundancies In Coenzyme Q Precursor Biosynthesis, Kyle P. Robinson, Adam Jochem, Sheila E. Johnson, Thiruchelvi R. Reddy, Jason D. Russell, Joshua J. Coon, David J. Pagliarini
Open Access Publications
No abstract provided.
Proportion And Number Of Upper-Extremity Musculoskeletal Disorders Attributable To The Combined Effect Of Biomechanical And Psychosocial Risk Factors In A Working Population, Aboubakari Nambiema, Julie Bodin, Susan Stock, Agnès Aublet-Cuvelier, Alexis Descatha, Bradley Evanoff, Yves Roquelaure
Proportion And Number Of Upper-Extremity Musculoskeletal Disorders Attributable To The Combined Effect Of Biomechanical And Psychosocial Risk Factors In A Working Population, Aboubakari Nambiema, Julie Bodin, Susan Stock, Agnès Aublet-Cuvelier, Alexis Descatha, Bradley Evanoff, Yves Roquelaure
Open Access Publications
The objective of this paper is to assess the combined effect of occupational biomechanical and psychosocial risk factors on the incidence of work-related upper-extremity musculoskeletal disorders (UEMSDs) and estimate the proportion and number of incident cases attributable to these risk factors in a working population. Using data from the French COSALI (COhorte des SAlariés LIgériens) cohort (enrolment phase: 2002-2005; follow-up phase: 2007-2010), a complete case analysis including 1246 workers (59% men, mean age: 38 years ± 8.6 at baseline) was performed. All participants underwent a standardized clinical examination at enrolment and 1611 workers were re-examined at follow-up. Population attributable fractions …
The Position Of Single-Base Deletions In The Vntr Sequence Of The Carboxyl Ester Lipase (Cel) Gene Determines Proteotoxicity, Anny Gravdal, Xunjun Xiao, Miriam Cnop, Khadija El Jellas, Stefan Johansson, Pål R. Njølstad, Mark E. Lowe, Bente B. Johansson, Anders Molven, Karianne Fjeld
The Position Of Single-Base Deletions In The Vntr Sequence Of The Carboxyl Ester Lipase (Cel) Gene Determines Proteotoxicity, Anny Gravdal, Xunjun Xiao, Miriam Cnop, Khadija El Jellas, Stefan Johansson, Pål R. Njølstad, Mark E. Lowe, Bente B. Johansson, Anders Molven, Karianne Fjeld
Open Access Publications
No abstract provided.
High-Fat Diet Activates Liver Ipla2Γ Generating Eicosanoids That Mediate Metabolic Stress, Sung Ho Moon, Beverly Gibson Dilthey, Xinping Liu, Shaoping Guan, Harold F. Sims, Richard W. Gross
High-Fat Diet Activates Liver Ipla2Γ Generating Eicosanoids That Mediate Metabolic Stress, Sung Ho Moon, Beverly Gibson Dilthey, Xinping Liu, Shaoping Guan, Harold F. Sims, Richard W. Gross
Open Access Publications
No abstract provided.
Generation Of A Gene-Corrected Human Isogenic Ipsc Line From An Alzheimer’S Disease Ipsc Line Carrying The London Mutation In App (V717i), Damian Hernandez, Stephanie Morgan Schlicht, Maciej Daniszewski, Celeste M. Karch, Dominantly Inherited Network (Dian), Alison M. Goate, Alice Pebay
Generation Of A Gene-Corrected Human Isogenic Ipsc Line From An Alzheimer’S Disease Ipsc Line Carrying The London Mutation In App (V717i), Damian Hernandez, Stephanie Morgan Schlicht, Maciej Daniszewski, Celeste M. Karch, Dominantly Inherited Network (Dian), Alison M. Goate, Alice Pebay
Open Access Publications
No abstract provided.
Familial Lipomas Without Classic Neurofibromatosis-1 Caused By A Missense Germline Nf1 Mutation, Erika Ramirez, Stephanie M. Morris, Tychele N. Turner, David H. Gutmann
Familial Lipomas Without Classic Neurofibromatosis-1 Caused By A Missense Germline Nf1 Mutation, Erika Ramirez, Stephanie M. Morris, Tychele N. Turner, David H. Gutmann
Open Access Publications
No abstract provided.
Cytokine Profiling In Plasma From Patients With Brain Tumors Versus Healthy Individuals Using 2 Different Multiplex Immunoassay Platforms, Diane Elizabeth Bender, Maximilian O. Schaettler, Kathleen C.F. Sheehan, Tanner M. Johanns, Gavin P. Dunn
Cytokine Profiling In Plasma From Patients With Brain Tumors Versus Healthy Individuals Using 2 Different Multiplex Immunoassay Platforms, Diane Elizabeth Bender, Maximilian O. Schaettler, Kathleen C.F. Sheehan, Tanner M. Johanns, Gavin P. Dunn
Open Access Publications
No abstract provided.
Toward A More Comprehensive Assessment Of School Age Children With Hemiplegic Cerebral Palsy, Catherine R. Hoyt, Sarah K. Sherman, Shelby K. Brown, Dillan J. Newbold, Ryland L. Miller, Andrew N. Van, Joshua S. Shimony, Mario Ortega, Annie L. Nguyen, Bradley L. Schlaggar, Nico U.F. Dosenbach
Toward A More Comprehensive Assessment Of School Age Children With Hemiplegic Cerebral Palsy, Catherine R. Hoyt, Sarah K. Sherman, Shelby K. Brown, Dillan J. Newbold, Ryland L. Miller, Andrew N. Van, Joshua S. Shimony, Mario Ortega, Annie L. Nguyen, Bradley L. Schlaggar, Nico U.F. Dosenbach
Open Access Publications
No abstract provided.
Monocyte Progenitors Give Rise To Multinucleated Giant Cells, Anne Kathrin Lösslein, Micah D. Dunlap, Shabaana A. Khader, Et Al.
Monocyte Progenitors Give Rise To Multinucleated Giant Cells, Anne Kathrin Lösslein, Micah D. Dunlap, Shabaana A. Khader, Et Al.
Open Access Publications
No abstract provided.
Paroxysmal Kinesigenic Dyskinesia In Twins With Chromosome 16p11.2 Duplication Syndrome, Keisuke Ueda, Marwan Shinawi, Toni S. Pearson
Paroxysmal Kinesigenic Dyskinesia In Twins With Chromosome 16p11.2 Duplication Syndrome, Keisuke Ueda, Marwan Shinawi, Toni S. Pearson
Open Access Publications
No abstract provided.
Pushing The Needle Of Entrepreneurship And Innovation: Where Do Plastic And Reconstructive Surgeons Stand?, Sumun Khetpal, Alvaro Reátegui, Joseph Lopez, Justin M. Sacks, Adnan Prsic
Pushing The Needle Of Entrepreneurship And Innovation: Where Do Plastic And Reconstructive Surgeons Stand?, Sumun Khetpal, Alvaro Reátegui, Joseph Lopez, Justin M. Sacks, Adnan Prsic
Open Access Publications
No abstract provided.
Role Of Sirt1 In Isoflurane Conditioning-Induced Neurovascular Protection Against Delayed Cerebral Ischemia Secondary To Subarachnoid Hemorrhage, Meizi Liu, Keshav Jayaraman, Tusar Giri, Gregory J Zipfel, Umeshkumar Athiraman
Role Of Sirt1 In Isoflurane Conditioning-Induced Neurovascular Protection Against Delayed Cerebral Ischemia Secondary To Subarachnoid Hemorrhage, Meizi Liu, Keshav Jayaraman, Tusar Giri, Gregory J Zipfel, Umeshkumar Athiraman
Open Access Publications
We recently reported that isoflurane conditioning provided multifaceted protection against subarachnoid hemorrhage (SAH)-induced delayed cerebral ischemia (DCI), and this protection was through the upregulation of endothelial nitric oxide synthase (eNOS). SIRT1, an NAD-dependent deacetylase, was shown to be one of the critical regulators of eNOS. The aim of our current study is to examine the role of SIRT1 in isoflurane conditioning-induced neurovascular protection against SAH-induced DCI. Mice were divided into four groups: sham, SAH, or SAH with isoflurane conditioning (with and without EX-527). Experimental SAH via endovascular perforation was performed. Anesthetic conditioning was performed with isoflurane 2% for 1 h, …
African Americans Have Differences In Csf Soluble Trem2 And Associated Genetic Variants, Suzanne E. Schindler, Carlos Cruchaga, Amulya Jospeh, Lena Mccue, Fabiana H.G. Farias, Consuelo H. Wilkins, Yuetiva Deming, Rachel L. Henson, Robert J. Mikesell, Laura Piccio, Jorge J. Llibre-Guerra, Krista L. Moulder, Anne M. Fagan, Beau M. Ances, Tammie L.S. Benzinger, Chengjie Xiong, David M. Holtzman, John C. Morris
African Americans Have Differences In Csf Soluble Trem2 And Associated Genetic Variants, Suzanne E. Schindler, Carlos Cruchaga, Amulya Jospeh, Lena Mccue, Fabiana H.G. Farias, Consuelo H. Wilkins, Yuetiva Deming, Rachel L. Henson, Robert J. Mikesell, Laura Piccio, Jorge J. Llibre-Guerra, Krista L. Moulder, Anne M. Fagan, Beau M. Ances, Tammie L.S. Benzinger, Chengjie Xiong, David M. Holtzman, John C. Morris
Open Access Publications
No abstract provided.
Kcnk3 Mutation Causes Altered Immune Function In Pulmonary Arterial Hypertension Patients And Mouse Models, James D West, Eric D Austin, Elise M Rizzi, Ling Yan, Harikrishna Tanjore, Amber L Crabtree, Christy S Moore, Gladson Muthian, Erica J Carrier, David A Jacobson, Rizwan Hamid, Peggy L Kendall, Susan Majka, Anandharajan Rathinasabapathy
Kcnk3 Mutation Causes Altered Immune Function In Pulmonary Arterial Hypertension Patients And Mouse Models, James D West, Eric D Austin, Elise M Rizzi, Ling Yan, Harikrishna Tanjore, Amber L Crabtree, Christy S Moore, Gladson Muthian, Erica J Carrier, David A Jacobson, Rizwan Hamid, Peggy L Kendall, Susan Majka, Anandharajan Rathinasabapathy
Open Access Publications
Loss of function KCNK3 mutation is one of the gene variants driving hereditary pulmonary arterial hypertension (PAH). KCNK3 is expressed in several cell and tissue types on both membrane and endoplasmic reticulum and potentially plays a role in multiple pathological process associated with PAH. However, the role of various stressors driving the susceptibility of KCNK3 mutation to PAH is unknown. Hence, we exposed