Digital Commons Network^™

Global Proteomics Analysis Of Circulating Extracellular Vesicles Isolated From Lung Transplant Recipients, Sandhya Bansal, Marissa Mcgilvrey, Krystine Garcia-Mansfield, Ritin Sharma, Ross M. Bremner, Michael A. Smith, Ramsey Hachem, Patrick Pirrotte, Thalachallour Mohanakumar

Open Access Publications

No abstract provided.

Depletion Interactions Modulate The Binding Between Disordered Proteins In Crowded Environments, Franziska Zosel, Andrea Soranno, Karin J. Buholzer, Daniel Nettels, Benjamin Schuler

Open Access Publications

No abstract provided.

End Of An Era Of Administering Erythropoiesis Stimulating Agents Among Veterans Administration Cancer Patients With Chemotherapy-Induced Anemia, Shamia Hoque, Brian J. Chen, Martin W. Schoen, Kenneth R. Carson, Jesse Keller, Bartlett J. Witherspoon, Kevin B. Knopf, Y Tony Yang, Benjamin Schooley, Chadi Nabhan, Oliver Sartor, Paul R. Yarnold, Paul Ray, Laura Bobolts, William J. Hrushesky, Michael Dickson, Charles L. Bennett

Open Access Publications

Erythropoisis stimulating agent (ESA) use was addressed in Food and Drug Administration (FDA) Oncology Drug Advisory Committee (ODAC) meetings between 2004 and 2008. FDA safety-focused regulatory actions occurred in 2007 and 2008. In 2007, black box warnings advised of early death and venous thromboembolism (VTE) risks with ESAs in oncology. In 2010, a Risk Evaluation Strategies (REMS) was initiated, with cancer patient consent that mortality and VTE risks were noted with ESAs. We report warnings and REMS impacts on ESA utilization among Veterans Administration (VA) cancer patients with chemotherapy-induced anemia (CIA). Data were from Veterans Affairs database (2003-2012). Epoetin and …

Single-Cell Rna-Seq Analysis Of Human Csf Microglia And Myeloid Cells In Neuroinflammation, Ekaterina Esaulova, Claudia Cantoni, Irina Shchukina, Konstantin Zaitsev, Robert C. Bucelli, Gregory F. Wu, Maxim N. Artyomov, Anne H. Cross, Brian T. Edelson

Open Access Publications

No abstract provided.

Efficacy And Safety Of Tocilizumab In The Treatment Of Acute Active Antibody-Mediated Rejection In Kidney Transplant Recipients, April A. Pottebaum, Karthikeyan Venkatachalam, Chang Liu, Daniel C. Brennan, Haris Murad, Andrew F. Malone, Tarek Alhamad

Open Access Publications

No abstract provided.

Acceptance And Commitment Therapy Delivered Via A Mobile Phone Messaging Robot To Decrease Postoperative Opioid Use In Patients With Orthopedic Trauma: Randomized Controlled Trial, Chris A Anthony, Edward Octavio Rojas, Valerie Keffala, Natalie Ann Glass, Apurva S Shah, Benjamin J Miller, Matthew Hogue, Michael C Willey, Matthew Karam, John Lawrence Marsh

Open Access Publications

BACKGROUND: Acceptance and commitment therapy (ACT) is a pragmatic approach to help individuals decrease avoidable pain.

OBJECTIVE: This study aims to evaluate the effects of ACT delivered via an automated mobile messaging robot on postoperative opioid use and patient-reported outcomes (PROs) in patients with orthopedic trauma who underwent operative intervention for their injuries.

METHODS: Adult patients presenting to a level 1 trauma center who underwent operative fixation of a traumatic upper or lower extremity fracture and who used mobile phone text messaging were eligible for the study. Patients were randomized in a 1:1 ratio to either the intervention group, who …

Atypical Cadherin Fat4 Orchestrates Lymphatic Endothelial Cell Polarity In Response To Flow, Kelly L Betterman, Drew L Sutton, Genevieve A Secker, Jan Kazenwadel, Anna Oszmiana, Lillian Lim, Naoyuki Miura, Lydia Sorokin, Benjamin M Hogan, Mark L Kahn, Helen Mcneill, Natasha L Harvey

Open Access Publications

The atypical cadherin FAT4 has established roles in the regulation of planar cell polarity and Hippo pathway signaling that are cell context dependent. The recent identification of FAT4 mutations in Hennekam syndrome, features of which include lymphedema, lymphangiectasia, and mental retardation, uncovered an important role for FAT4 in the lymphatic vasculature. Hennekam syndrome is also caused by mutations in collagen and calcium binding EGF domains 1 (CCBE1) and ADAM metallopeptidase with thrombospondin type 1 motif 3 (ADAMTS3), encoding a matrix protein and protease, respectively, that regulate activity of the key prolymphangiogenic VEGF-C/VEGFR3 signaling axis by facilitating the proteolytic cleavage and …

Influence Of Adiposity, Insulin Resistance, And Intrahepatic Triglyceride Content On Insulin Kinetics, Gordon I Smith, David C Polidori, Mihoko Yoshino, Monica L Kearney, Bruce W Patterson, Bettina Mittendorfer, Samuel Klein

Open Access Publications

BACKGROUNDInsulin is a key regulator of metabolic function. The effects of excess adiposity, insulin resistance, and hepatic steatosis on the complex integration of insulin secretion and hepatic and extrahepatic tissue extraction are not clear.METHODSA hyperinsulinemic-euglycemic clamp and a 3-hour oral glucose tolerance test were performed to evaluate insulin sensitivity and insulin kinetics after glucose ingestion in 3 groups: (a) lean subjects with normal intrahepatic triglyceride (IHTG) and glucose tolerance (lean-NL; n = 14), (b) obese subjects with normal IHTG and glucose tolerance (obese-NL; n = 24), and (c) obese subjects with nonalcoholic fatty liver disease (NAFLD) and prediabetes (obese-NAFLD; n …

Prevention And Management Of Dermatologic Adverse Events Associated With Tumor Treating Fields In Patients With Glioblastoma, Mario E Lacouture, Milan J Anadkat, Matthew T Ballo, Fabio Iwamoto, Suriya A Jeyapalan, Renato V La Rocca, Margaret Schwartz, Jennifer N Serventi, Martin Glas

Open Access Publications

No abstract provided.

Distinct Neural Networks Associated With Obsession And Delusion: A Connectome-Wide Association Study, Tae Young Lee, Wi Hoon Jung, Yoo Bin Kwak, Youngwoo B Yoon, Junhee Lee, Minah Kim, Euitae Kim, Jun Soo Kwon

Open Access Publications

BACKGROUND: Obsession and delusion are theoretically distinct from each other in terms of reality testing. Despite such phenomenological distinction, no extant studies have examined the identification of common and distinct neural correlates of obsession and delusion by employing biologically grounded methods. Here, we investigated dimensional effects of obsession and delusion spanning across the traditional diagnostic boundaries reflected upon the resting-state functional connectivity (RSFC) using connectome-wide association studies (CWAS).

METHODS: Our study sample comprised of 96 patients with obsessive-compulsive disorder, 75 patients with schizophrenia, and 65 healthy controls. A connectome-wide analysis was conducted to examine the relationship between obsession and delusion …

Neural Networks To Predict Radiographic Brain Injury In Pediatric Patients Treated With Extracorporeal Membrane Oxygenation, Neel Shah, Abdelaziz Farhat, Jefferson Tweed, Ziheng Wang, Jeon Lee, Rafe Mcbeth, Michael Skinner, Fenghua Tian, Ravi Thiagarajan, Lakshmi Raman

Open Access Publications

Brain injury is a significant source of morbidity and mortality for pediatric patients treated with Extracorporeal Membrane Oxygenation (ECMO). Our objective was to utilize neural networks to predict radiographic evidence of brain injury in pediatric ECMO-supported patients and identify specific variables that can be explored for future research. Data from 174 ECMO-supported patients were collected up to 24 h prior to, and for the duration of, the ECMO course. Thirty-five variables were collected, including physiological data, markers of end-organ perfusion, acid-base homeostasis, vasoactive infusions, markers of coagulation, and ECMO-machine factors. The primary outcome was the presence of radiologic evidence of …

Doing What We Know, Knowing What To Do: Californians Linking Action With Science For Prevention Of Breast Cancer (Clasp-Bc), Jon F Kerner, Marion H E Kavanaugh-Lynch, Lourdes Baezconde-Garbanati, Christopher Politis, Aviva Prager, Ross C Brownson

Open Access Publications

Given the lack of progress in breast cancer prevention, the California Breast Cancer Research Program (CBCRP) plans to apply current scientific knowledge about breast cancer to primary prevention at the population level. This paper describes the first phase of Californians Linking Action with Science for Prevention of Breast Cancer (CLASP-BC). The foci of Phase 1 are building coalitions and coalition capacity building through community engagement in community-based participatory research (CBPR) and dissemination and implementation (D&I) research training. Based on the successful implementation and evaluation of Phase 1, the foci of Phase 2 (presented separately in this special issue) will be …

Gene Expression In Meniscal Tears At The Time Of Arthroscopic Partial Meniscectomy Predicts The Progression Of Osteoarthritis Within 6 Years Of Surgery, Joseph D. Lamplot, Muhammad Farooq Rai, William P. Tompkins, Michael V. Friedman, Eric J. Schmidt, Linda J. Sandell, Robert H. Brophy

Open Access Publications

No abstract provided.

Survival Following Allogeneic Transplant In Patients With Myelofibrosis, Krisstina Gowin, Kierstin Luber, Et Al.

Open Access Publications

No abstract provided.

Contraception Provision In The Emergency Department: Are We Ready To Overcome The Obstacles?, Kayleigh Fischer, Lauren S. Chernick

Open Access Publications

No abstract provided.

Maternal Race/Ethnicity And Postpartum Diabetes Screening: A Systematic Review And Meta-Analysis, Cynthia J. Herrick, Ritika Puri, Rana Rahaman, Angela Hardi, Karyn Stewart, Graham A. Colditz

Open Access Publications

No abstract provided.

Lung Transplant Pulmonologists’ Views Of Specialty Palliative Care For Lung Transplant Recipients, Eric Nolley, Jessica Fleck, Dio Kavalieratos, Mary Amanda Dew, Daniel Dilling, Rebecca Colman, Maria M. Crespo, Hilary Goldberg, Steven Hays, Ramsey Hachem, Erika Lease, James Lee, John Reynolds, Matthew Morrell, Yael Schenker

Open Access Publications

No abstract provided.

Prostate Cancer Theranostics - An Overview, Diane Abou, Nadia Benabdallah, Wen Jiang, Lu Peng, Hanwen Zhang, Alexandria Villmer, Mark S Longtine, Daniel L J Thorek

Open Access Publications

Metastatic prostate cancer is incurable, and novel methods to detect the disease earlier and to direct definitive treatment are needed. Molecularly specific tools to localize diagnostic and cytotoxic radionuclide payloads to cancer cells and the surrounding microenvironment are recognized as a critical component of new approaches to combat this disease. The implementation of theranostic approaches to characterize and personalize patient management is beginning to be realized for prostate cancer patients. This review article summarized clinically translated approaches to detect, characterize, and treat disease in this rapidly expanding field.

Gata2 Regulates Constitutive Pd-L1 And Pd-L2 Expression In Brain Tumors, Yujie Fu, Connor J. Liu, Dale K. Kobayashi, Tanner M. Johanns, Jay A. Bowman-Kirigin, Maximilian O. Schaettler, Diane D. Mao, Diane Bender, Diane G. Kelley, Ravindra Uppaluri, Wenya Linda Bi, Ian F. Dunn, Yu Tao, Jingqin Luo, Albert H. Kim, Gavin P. Dunn

Open Access Publications

No abstract provided.

Residual Endotoxin Induces Primary Graft Dysfunction Through Ischemia/Reperfusion-Primed Alveolar Macrophages, Mahzad Akbarpour, Daniel Kreisel, Wenjun Li, Et Al

Open Access Publications

Despite the widespread use of antibiotics, bacterial pneumonias in donors strongly predispose to the fatal syndrome of primary graft dysfunction (PGD) following lung transplantation. We report that bacterial endotoxin persists in human donor lungs after pathogen is cleared with antibiotics and is associated with neutrophil infiltration and PGD. In mouse models, depletion of tissue-resident alveolar macrophages (TRAMs) attenuated neutrophil recruitment in response to endotoxin as shown by compartmental staining and intravital imaging. Bone marrow chimeric mice revealed that neutrophils were recruited by TRAM through activation of TLR4 in a MyD88-dependent manner. Intriguingly, low levels of endotoxin, insufficient to cause donor …

Exposure To Covid-19 Patients Increases Physician Trainee Stress And Burnout, Thomas G. Kannampallil, Charles W. Goss, Bradley A. Evanoff, Jaime R. Strickland, Rebecca P. Mcalister, Jennifer Duncan

Open Access Publications

The coronavirus disease 2019 (COVID-19) pandemic has put considerable physical and emotional strain on frontline healthcare workers. Among frontline healthcare workers, physician trainees represent a unique group-functioning simultaneously as both learners and caregivers and experiencing considerable challenges during the pandemic. However, we have a limited understanding regarding the emotional effects and vulnerability experienced by trainees during the pandemic. We investigated the effects of trainee exposure to patients being tested for COVID-19 on their depression, anxiety, stress, burnout and professional fulfillment. All physician trainees at an academic medical center (n = 1375) were invited to participate in an online survey. We …

2019 Pediatric Initiative Network: Progress, Proceedings, And Plans, Leena Nahata, Veronica Gomez-Lobo, Lillian Meacham, Leslie Appiah, Krista Childress, Holly Hoefgen, Maggie Dwiggins, Stacy Whiteside, Kari Bjornard, Julie Rios, Antoinette Anazodo, Courtney Finlayson, Olivia Frias, Teresa Woodruff, Molly Moravek

Open Access Publications

No abstract provided.

Parcel-Guided Rtms For Depression, M. Moreno Ortega, A. Kangarlu, S. Lee, T. Perera, J. Kangarlu, T. Palomo, M.F. Glasser, D.C. Javitt

Open Access Publications

No abstract provided.

Surgical Technique For Below-Knee Amputation With Concurrent Targeted Muscle Reinnervation, Timothy H.F. Daugherty, Rajiv Parikh, Brian A. Mailey, John M. Felder, Reuben A. Bueno Jr.

Open Access Publications

No abstract provided.

Reconstruction Of Severe Palm Injury With Sensate Medial Plantar Artery Flap And Nerve Grafting, William M. Padovano, Elspeth J.R. Hill, John M. Felder Iii

Open Access Publications

No abstract provided.

A Recommended "Minimum Data Set" Framework For Sd-Oct Retinal Image Acquisition And Analysis From The Atlas Of Retinal Imaging In Alzheimer's Study (Arias), Jessica Alber, Gregory Van Stavern, Et Al

Open Access Publications

Introduction: We propose a minimum data set framework for the acquisition and analysis of retinal images for the development of retinal Alzheimer's disease (AD) biomarkers. Our goal is to describe methodology that will increase concordance across laboratories, so that the broader research community is able to cross-validate findings in parallel, accumulate large databases with normative data across the cognitive aging spectrum, and progress the application of this technology from the discovery stage to the validation stage in the search for sensitive and specific retinal biomarkers in AD.

Methods: The proposed minimum data set framework is based on the Atlas of …

Challenges And Solutions For The Implementation Of Shared Decision-Making In Breast Reconstruction, Terence M. Myckatyn, Rajiv P. Parikh, Clara Lee, Mary C. Politi

Open Access Publications

No abstract provided.

Foot Salvage With Selective Arterialization Of Pedal Venosomes, Maleeh Effendi, Austin Y. Ha, John M. Felder Iii

Open Access Publications

No abstract provided.

Genetic Architecture Of Circulating Very-Long-Chain (C24:0 And C22:0) Ceramide Concentrations, Sharon Cresci, Ruibo Zhang, Qiong Yang, Meredith S Duncan, Vanessa Xanthakis, Xuntian Jiang, Ramachandran S Vasan, Jean E Schaffer, Linda R Peterson

Open Access Publications

OBJECTIVE: Total ceramide concentrations are linked with increased insulin resistance and cardiac dysfunction. However, recent studies have demonstrated that plasma concentrations of specific very-long-chain fatty ceramides (C24:0 and C22:0) are associated with a reduced incidence of coronary heart disease and all-cause mortality. We hypothesized that specific genetic loci are associated with plasma C22:0 and C24:0 concentrations.

METHODS: Heritability and genome-wide association studies of plasma C24:0 and C22:0 ceramide concentrations were performed among 2,217 participants in the Framingham Heart Study Offspring Cohort, adjusting for cardiovascular risk factor covariates and cardiovascular drug treatment.

RESULTS: The multivariable-adjusted heritability for C22:0 and C24:0 ceramides …

Practitioner Perspectives On Building Capacity For Evidence-Based Public Health In State Health Departments In The United States: A Qualitative Case Study, Stephanie Mazzucca, Cheryl A Valko, Amy A Eyler, Marti Macchi, Andrew Lau, Jeanne Alongi, John Robitscher, Ross C Brownson

Open Access Publications

BACKGROUND: Public health agencies are responsible for implementing effective, evidence-based public health programs and policies to reduce the burden of chronic diseases. Evidence-based public health can be facilitated by modifiable administrative evidence-based practices (A-EBPs) (e.g., workforce development, organizational climate), yet little is known about how practitioners view A-EBPs. Thus, the purpose of this qualitative study was to understand state health department practitioners' perceptions about how A-EBPs are implemented and what facilitators and barriers exist to using A-EBPs.

METHODS: Chronic disease prevention and health promotion program staff who were members of the National Association of Chronic Disease Directors were recruited to …