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Articles 1231 - 1260 of 6228
Full-Text Articles in Entire DC Network
Discovery Of A Novel Simian Pegivirus In Common Marmosets (Callithrix Jacchus) With Lymphocytic Enterocolitis, Anna S. Heffron, Michael Lauck, Elizabeth D. Somsen, Elizabeth C. Townsend, Adam L. Bailey, Megan Sosa, Jens Eickhoff, Saverio Capuano Iii, Christina M. Newman, Jens H. Kuhn, Andres Mejia, Heather A. Simmons, David H. O'Connor
Discovery Of A Novel Simian Pegivirus In Common Marmosets (Callithrix Jacchus) With Lymphocytic Enterocolitis, Anna S. Heffron, Michael Lauck, Elizabeth D. Somsen, Elizabeth C. Townsend, Adam L. Bailey, Megan Sosa, Jens Eickhoff, Saverio Capuano Iii, Christina M. Newman, Jens H. Kuhn, Andres Mejia, Heather A. Simmons, David H. O'Connor
Open Access Publications
No abstract provided.
Impact Of Functional Status On Outcomes Of Simultaneous Pancreas-Kidney Transplantation: Risks And Opportunities For Patient Benefit, Krista L. Lentine, Tarek Alhamad, Wisit Cheungpasitporn, Jane C. Tan, Su-Hsin Chang, Matthew Cooper, Darshana M. Dadhania, David A. Axelrod, Mark A. Schnitzler, Rosemary Ouseph, Franco H. Cabeza Rivera, Bertram L. Kasiske, Kenneth J. Woodside, Ronald F. Parsons
Impact Of Functional Status On Outcomes Of Simultaneous Pancreas-Kidney Transplantation: Risks And Opportunities For Patient Benefit, Krista L. Lentine, Tarek Alhamad, Wisit Cheungpasitporn, Jane C. Tan, Su-Hsin Chang, Matthew Cooper, Darshana M. Dadhania, David A. Axelrod, Mark A. Schnitzler, Rosemary Ouseph, Franco H. Cabeza Rivera, Bertram L. Kasiske, Kenneth J. Woodside, Ronald F. Parsons
Open Access Publications
No abstract provided.
Six-Year Follow-Up Of A Trial Of Antenatal Vitamin D For Asthma Reduction, Augusto A. Litonjua, Vincent J. Carey, Nancy Laranjo, Benjamin J. Stubbs, Hooman Mirzakhani, George T. O'Connor, Megan Sandel, Avraham Beigelman, Leonard B. Bacharier, Robert S. Zeiger, Michael Schatz, Bruce W. Hollis, Scott T. Weiss
Six-Year Follow-Up Of A Trial Of Antenatal Vitamin D For Asthma Reduction, Augusto A. Litonjua, Vincent J. Carey, Nancy Laranjo, Benjamin J. Stubbs, Hooman Mirzakhani, George T. O'Connor, Megan Sandel, Avraham Beigelman, Leonard B. Bacharier, Robert S. Zeiger, Michael Schatz, Bruce W. Hollis, Scott T. Weiss
Open Access Publications
No abstract provided.
Lack Of Neurosteroid Selectivity At Δ Vs. Γ2-Containing Gabaa Receptors In Dentate Granule Neurons, Xinguo Lu, Charles F Zorumski, Steven Mennerick
Lack Of Neurosteroid Selectivity At Δ Vs. Γ2-Containing Gabaa Receptors In Dentate Granule Neurons, Xinguo Lu, Charles F Zorumski, Steven Mennerick
Open Access Publications
GABA
Improved Small Blob Detection In 3d Images Using Jointly Constrained Deep Learning And Hessian Analysis, Yanzhe Xu, Teresa Wu, Fei Gao, Jennifer R. Charlton, Kevin M. Bennett
Improved Small Blob Detection In 3d Images Using Jointly Constrained Deep Learning And Hessian Analysis, Yanzhe Xu, Teresa Wu, Fei Gao, Jennifer R. Charlton, Kevin M. Bennett
Open Access Publications
No abstract provided.
Two-Stage Electro–Mechanical Coupling Of A Kv Channel In Voltage-Dependent Activation, Panpan Hou, Po Wei Kang, Audrey Deyawe Kongmeneck, Nien-Du Yang, Yongfeng Liu, Jingyi Shi, Xianjin Xu, Kelli Mcfarland White, Mark A. Zaydman, Marina A. Kasimova, Guiscard Seebohm, Ling Zhong, Xiaoqin Zou, Mounir Tarek, Jianmin Cui
Two-Stage Electro–Mechanical Coupling Of A Kv Channel In Voltage-Dependent Activation, Panpan Hou, Po Wei Kang, Audrey Deyawe Kongmeneck, Nien-Du Yang, Yongfeng Liu, Jingyi Shi, Xianjin Xu, Kelli Mcfarland White, Mark A. Zaydman, Marina A. Kasimova, Guiscard Seebohm, Ling Zhong, Xiaoqin Zou, Mounir Tarek, Jianmin Cui
Open Access Publications
No abstract provided.
Live Neuron High-Content Screening Reveals Synaptotoxic Activity In Alzheimer Mouse Model Homogenates, Hao Jiang, Thomas J. Esparza, Terrance T. Kummer, Haining Zhong, Jens Rettig, David L. Brody
Live Neuron High-Content Screening Reveals Synaptotoxic Activity In Alzheimer Mouse Model Homogenates, Hao Jiang, Thomas J. Esparza, Terrance T. Kummer, Haining Zhong, Jens Rettig, David L. Brody
Open Access Publications
No abstract provided.
Comparison Of Three Magnetization Transfer Ratio Parameters For Assessment Of Intestinal Fibrosis In Patients With Crohn’S Disease, Jixin Meng, Siyun Huang, Canhui Sun, Zhong-Wei Zhang, Ren Mao, Yan-Hong Yang, Shi-Ting Feng, Zi-Ping Li, Xuehua Li
Comparison Of Three Magnetization Transfer Ratio Parameters For Assessment Of Intestinal Fibrosis In Patients With Crohn’S Disease, Jixin Meng, Siyun Huang, Canhui Sun, Zhong-Wei Zhang, Ren Mao, Yan-Hong Yang, Shi-Ting Feng, Zi-Ping Li, Xuehua Li
Open Access Publications
No abstract provided.
Remethylation Of Dnmt3a−/− Hematopoietic Cells Is Associated With Partial Correction Of Gene Dysregulation And Reduced Myeloid Skewing, Shamika Ketkar, Angela M. Verdoni, Amanda M. Smith, Celia V. Bangert, Elizabeth R. Leight, David Y. Chen, Meryl K. Brune, Nichole M. Helton, Mieke Hoock, Daniel R. George, Catrina Fronick, Robert S. Fulton, Sai Mukund Ramakrishnan, Gue Su Chang, Allegra A. Petti, David H. Spencer, Christopher A. Miller, Timothy J. Ley
Remethylation Of Dnmt3a−/− Hematopoietic Cells Is Associated With Partial Correction Of Gene Dysregulation And Reduced Myeloid Skewing, Shamika Ketkar, Angela M. Verdoni, Amanda M. Smith, Celia V. Bangert, Elizabeth R. Leight, David Y. Chen, Meryl K. Brune, Nichole M. Helton, Mieke Hoock, Daniel R. George, Catrina Fronick, Robert S. Fulton, Sai Mukund Ramakrishnan, Gue Su Chang, Allegra A. Petti, David H. Spencer, Christopher A. Miller, Timothy J. Ley
Open Access Publications
No abstract provided.
Nutrition In Necrotizing Enterocolitis And Following Intestinal Resection, Jocelyn Ou, Cathleen M Courtney, Allie E Steinberger, Maria E Tecos, Brad W Warner
Nutrition In Necrotizing Enterocolitis And Following Intestinal Resection, Jocelyn Ou, Cathleen M Courtney, Allie E Steinberger, Maria E Tecos, Brad W Warner
Open Access Publications
This review aims to discuss the role of nutrition and feeding practices in necrotizing enterocolitis (NEC), NEC prevention, and its complications, including surgical treatment. A thorough PubMed search was performed with a focus on meta-analyses and randomized controlled trials when available. There are several variables in nutrition and the feeding of preterm infants with the intention of preventing necrotizing enterocolitis (NEC). Starting feeds later rather than earlier, advancing feeds slowly and continuous feeds have not been shown to prevent NEC and breast milk remains the only effective prevention strategy. The lack of medical treatment options for NEC often leads to …
Radiation And Checkpoint Inhibitor Immunotherapy Lead To Long Term Disease Control In A Metastatic Rcc Patient With Brain Metastases, Maria Levitin, Joel Ofori, Woo Jae Shin, Jiayi Huang, Mackenzie Daly, Dengfeng Cao, Russell Pachynski
Radiation And Checkpoint Inhibitor Immunotherapy Lead To Long Term Disease Control In A Metastatic Rcc Patient With Brain Metastases, Maria Levitin, Joel Ofori, Woo Jae Shin, Jiayi Huang, Mackenzie Daly, Dengfeng Cao, Russell Pachynski
Open Access Publications
Renal cell carcinoma (RCC) comprises 4.2% of all new cancer cases in the United States and 30% of cases are metastatic (mRCC) at diagnosis. Brain metastatic RCC historically has poor prognosis, but the development of immune checkpoint inhibitors has revolutionized their care and may be successfully combined with SBRT to improve prognosis. Here, we present a case of a patient with mRCC who had brain metastases treated with concurrent immune checkpoint inhibitors and SBRT. He continues to survive with good functional status years following his initial diagnosis. We discuss the relevant history regarding treatment approach in patients with brain metastatic …
Solvent/Detergent-Treated Plasma In The Management Of Pediatric Patients Who Require Replacement Of Multiple Coagulation Factors: An Open-Label, Multicenter, Post-Marketing Study, Philip C Spinella, Santiago Borasino, Jeffrey Alten
Solvent/Detergent-Treated Plasma In The Management Of Pediatric Patients Who Require Replacement Of Multiple Coagulation Factors: An Open-Label, Multicenter, Post-Marketing Study, Philip C Spinella, Santiago Borasino, Jeffrey Alten
Open Access Publications
No abstract provided.
When Sting Meets Viruses: Sensing, Trafficking And Response, Zhaohe Li, Siqi Cai, Yutong Sun, Li Li, Siyuan Ding, Xin Wang
When Sting Meets Viruses: Sensing, Trafficking And Response, Zhaohe Li, Siqi Cai, Yutong Sun, Li Li, Siyuan Ding, Xin Wang
Open Access Publications
To effectively defend against microbial pathogens, the host cells mount antiviral innate immune responses by producing interferons (IFNs), and hundreds of IFN-stimulated genes (ISGs). Upon recognition of cytoplasmic viral or bacterial DNAs and abnormal endogenous DNAs, the DNA sensor cGAS synthesizes 2',3'-cGAMP that induces STING (stimulator of interferon genes) undergoing conformational changes, cellular trafficking, and the activation of downstream factors. Therefore, STING plays a pivotal role in preventing microbial pathogen infection by sensing DNAs during pathogen invasion. This review is dedicated to the recent advances in the dynamic regulations of STING activation, intracellular trafficking, and post-translational modifications (PTMs) by the …
Altered Outer Hair Cell Mitochondrial And Subsurface Cisternae Connectomics Are Candidate Mechanisms For Hearing Loss In Mice, Guy Perkins, Jeong Han Lee, Seojin Park, Mincheol Kang, Maria C. Perez-Flores, Saeyeon Ju, Grady Phillips, Anna Lysakowski, Michael Anne Gratton, Ebenezer N. Yamoah
Altered Outer Hair Cell Mitochondrial And Subsurface Cisternae Connectomics Are Candidate Mechanisms For Hearing Loss In Mice, Guy Perkins, Jeong Han Lee, Seojin Park, Mincheol Kang, Maria C. Perez-Flores, Saeyeon Ju, Grady Phillips, Anna Lysakowski, Michael Anne Gratton, Ebenezer N. Yamoah
Open Access Publications
Organelle crosstalk is vital for cellular functions. The propinquity of mitochondria, ER, and plasma membrane promote regulation of multiple functions, which include intracellular Ca
Large-Scale Targeted Sequencing Identifies Risk Genes For Neurodevelopmental Disorders, Tianyun Wang, Tychele N. Turner, Et Al.
Large-Scale Targeted Sequencing Identifies Risk Genes For Neurodevelopmental Disorders, Tianyun Wang, Tychele N. Turner, Et Al.
Open Access Publications
No abstract provided.
Apoptotic Stress Induces Bax-Dependent, Caspase-Independent Redistribution Of Linc Complex Nesprins, Liora Lindenboim, Dan Grozki, Ayelet R. Amsalem-Zafran, Aida Peña-Blanco, Gregg G. Gundersen, Christoph Borner, Didier Hodzic, Ana J. Garcia-Sáez, Howard J. Worman, Reuven Stein
Apoptotic Stress Induces Bax-Dependent, Caspase-Independent Redistribution Of Linc Complex Nesprins, Liora Lindenboim, Dan Grozki, Ayelet R. Amsalem-Zafran, Aida Peña-Blanco, Gregg G. Gundersen, Christoph Borner, Didier Hodzic, Ana J. Garcia-Sáez, Howard J. Worman, Reuven Stein
Open Access Publications
No abstract provided.
Braf Alteration In Central And Peripheral Nervous System Tumors, Komal Srinivasa, Kevin A Cross, Sonika Dahiya
Braf Alteration In Central And Peripheral Nervous System Tumors, Komal Srinivasa, Kevin A Cross, Sonika Dahiya
Open Access Publications
No abstract provided.
Targeted Muscle Reinnervation For The Management Of Pain In The Setting Of Major Limb Amputation, Blair R Peters, Stephanie A Russo, Julie M West, Amy M Moore, Steven A Schulz
Targeted Muscle Reinnervation For The Management Of Pain In The Setting Of Major Limb Amputation, Blair R Peters, Stephanie A Russo, Julie M West, Amy M Moore, Steven A Schulz
Open Access Publications
The life altering nature of major limb amputations may be further complicated by neuroma formation in up to 60% of the estimated 2 million major limb amputees in the United States. This can be a source of pain and functional limitation of the residual limb. Pain associated with neuromas may limit prosthetic limb use, require reoperation, lead to opioid dependence, and dramatically reduce quality of life. A number of management options have been described including excision alone, excision with repair, excision with transposition, and targeted muscle reinnervation. Targeted muscle reinnervation has been shown to reduce phantom limb and neuroma pain …
Lung Secretoglobin Scgb1a1 Influences Alveolar Macrophage-Mediated Inflammation And Immunity, Min Xu, Wei Yang, Xuanchuan Wang, Deepak Kumar Nayak
Lung Secretoglobin Scgb1a1 Influences Alveolar Macrophage-Mediated Inflammation And Immunity, Min Xu, Wei Yang, Xuanchuan Wang, Deepak Kumar Nayak
Open Access Publications
Alveolar macrophage (AM) is a mononuclear phagocyte key to the defense against respiratory infections. To understand AM's role in airway disease development, we examined the influence of Secretoglobin family 1a member 1 (SCGB1A1), a pulmonary surfactant protein, on AM development and function. In a murine model, high-throughput RNA-sequencing and gene expression analyses were performed on purified AMs isolated from mice lacking in
A Novel Method For High-Dimensional Anatomical Mapping Of Extra-Axial Cerebrospinal Fluid: Application To The Infant Brain, Mahmoud Mostapha, Sun Hyung Kim, Alan C Evans, Stephen R Dager, Annette M Estes, Robert C Mckinstry, Kelly N Botteron, Guido Gerig, Stephen M Pizer, Robert T Schultz, Heather C Hazlett, Joseph Piven, Jessica B Girault, Mark D Shen, Martin A Styner
A Novel Method For High-Dimensional Anatomical Mapping Of Extra-Axial Cerebrospinal Fluid: Application To The Infant Brain, Mahmoud Mostapha, Sun Hyung Kim, Alan C Evans, Stephen R Dager, Annette M Estes, Robert C Mckinstry, Kelly N Botteron, Guido Gerig, Stephen M Pizer, Robert T Schultz, Heather C Hazlett, Joseph Piven, Jessica B Girault, Mark D Shen, Martin A Styner
Open Access Publications
Cerebrospinal fluid (CSF) plays an essential role in early postnatal brain development. Extra-axial CSF (EA-CSF) volume, which is characterized by CSF in the subarachnoid space surrounding the brain, is a promising marker in the early detection of young children at risk for neurodevelopmental disorders. Previous studies have focused on global EA-CSF volume across the entire dorsal extent of the brain, and not regionally-specific EA-CSF measurements, because no tools were previously available for extracting local EA-CSF measures suitable for localized cortical surface analysis. In this paper, we propose a novel framework for the localized, cortical surface-based analysis of EA-CSF. The proposed …
Orsay Virus Cp-Δ Adopts A Novel Β-Bracelet Structural Fold And Incorporates Into Virions As A Head Fiber, Yusong R. Guo, Yanlin Fan, Ying Zhou, Miao Jin, Jim L. Zhang, Hongbing Jiang, Matthew V. Holt, Tao Wang, Nicolas L. Young, David Wang, Weiwei Zhong, Yizhi J. Tao
Orsay Virus Cp-Δ Adopts A Novel Β-Bracelet Structural Fold And Incorporates Into Virions As A Head Fiber, Yusong R. Guo, Yanlin Fan, Ying Zhou, Miao Jin, Jim L. Zhang, Hongbing Jiang, Matthew V. Holt, Tao Wang, Nicolas L. Young, David Wang, Weiwei Zhong, Yizhi J. Tao
Open Access Publications
Fiber proteins are commonly found in eukaryotic and prokaryotic viruses, where they play important roles in mediating viral attachment and host cell entry. They typically form trimeric structures and are incorporated into virions via noncovalent interactions. Orsay virus, a small RNA virus which specifically infects the laboratory model nematode
Isg15 Fast-Tracks Dna Replication, Alice Meroni, Alessandro Vindigni
Isg15 Fast-Tracks Dna Replication, Alice Meroni, Alessandro Vindigni
Open Access Publications
In this issue, Raso et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.202002175) uncover a novel replication fork speed regulatory network controlled by the ubiquitin-like modifier interferon-stimulated gene 15 (ISG15), which plays a central role in the innate immune response and regulates tumorigenesis as well as chemotherapy response.
Atacgraph: Profiling Genome-Wide Chromatin Accessibility From Atac-Seq, Rita Jui-Hsien Lu, Yen-Ting Liu, Chih Wei Huang, Ming-Ren Yen, Chung-Yen Lin, Pao-Yang Chen
Atacgraph: Profiling Genome-Wide Chromatin Accessibility From Atac-Seq, Rita Jui-Hsien Lu, Yen-Ting Liu, Chih Wei Huang, Ming-Ren Yen, Chung-Yen Lin, Pao-Yang Chen
Open Access Publications
Assay for transposase-accessible chromatin using sequencing data (ATAC-seq) is an efficient and precise method for revealing chromatin accessibility across the genome. Most of the current ATAC-seq tools follow chromatin immunoprecipitation sequencing (ChIP-seq) strategies that do not consider ATAC-seq-specific properties. To incorporate specific ATAC-seq quality control and the underlying biology of chromatin accessibility, we developed a bioinformatics software named ATACgraph for analyzing and visualizing ATAC-seq data. ATACgraph profiles accessible chromatin regions and provides ATAC-seq-specific information including definitions of nucleosome-free regions (NFRs) and nucleosome-occupied regions. ATACgraph also allows identification of differentially accessible regions between two ATAC-seq datasets. ATACgraph incorporates the docker image …
Campylobacter Colonization, Environmental Enteric Dysfunction, Stunting, And Associated Risk Factors Among Young Children In Rural Ethiopia: A Cross-Sectional Study From The Campylobacter Genomics And Environmental Enteric Dysfunction (Caged) Project, Dehao Chen, Mark J Manary, Et Al
Campylobacter Colonization, Environmental Enteric Dysfunction, Stunting, And Associated Risk Factors Among Young Children In Rural Ethiopia: A Cross-Sectional Study From The Campylobacter Genomics And Environmental Enteric Dysfunction (Caged) Project, Dehao Chen, Mark J Manary, Et Al
Open Access Publications
Livestock farming provides a possible mechanism by which smallholder farmers can meet their household need for animal source foods (ASF), which may reduce the risk of stunting. However, direct/indirect contacts with domestic animals may increase colonization by
Cd4 Inhibits Helper T Cell Activation At Lower Affinity Threshold For Full-Length T Cell Receptors Than Single Chain Signaling Constructs, Deborah K Johnson, Wyatt Magoffin, Sheldon J Myers, Jordan G Finnell, John C Hancock, Taylor S Orton, Stephen P Persaud, Kenneth A Christensen, K Scott Weber
Cd4 Inhibits Helper T Cell Activation At Lower Affinity Threshold For Full-Length T Cell Receptors Than Single Chain Signaling Constructs, Deborah K Johnson, Wyatt Magoffin, Sheldon J Myers, Jordan G Finnell, John C Hancock, Taylor S Orton, Stephen P Persaud, Kenneth A Christensen, K Scott Weber
Open Access Publications
CD4
Insights From Genetic Studies Of Cerebral Palsy, Sara A Lewis, Sheetal Shetty, Bryce A Wilson, Aris J Huang, Sheng Chih Jin, Hayley Smithers-Sheedy, Michael C Fahey, Michael C Kruer
Insights From Genetic Studies Of Cerebral Palsy, Sara A Lewis, Sheetal Shetty, Bryce A Wilson, Aris J Huang, Sheng Chih Jin, Hayley Smithers-Sheedy, Michael C Fahey, Michael C Kruer
Open Access Publications
Cohort-based whole exome and whole genome sequencing and copy number variant (CNV) studies have identified genetic etiologies for a sizable proportion of patients with cerebral palsy (CP). These findings indicate that genetic mutations collectively comprise an important cause of CP. We review findings in CP genomics and propose criteria for CP-associated genes at the level of gene discovery, research study, and clinical application. We review the published literature and report 18 genes and 5 CNVs from genomics studies with strong evidence of for the pathophysiology of CP. CP-associated genes often disrupt early brain developmental programming or predispose individuals to known …
Assessment Of Potential Risk Factors For The Development Of Persistent Postural-Perceptual Dizziness: A Case-Control Pilot Study, Aaron Trinidade, Paula Harman, Jon Stone, Jeffrey P Staab, Joel A Goebel
Assessment Of Potential Risk Factors For The Development Of Persistent Postural-Perceptual Dizziness: A Case-Control Pilot Study, Aaron Trinidade, Paula Harman, Jon Stone, Jeffrey P Staab, Joel A Goebel
Open Access Publications
No abstract provided.
Nonmicrobial Activation Of Tlrs Controls Intestinal Growth, Wound Repair, And Radioprotection, William F Stenson, Matthew A Ciorba
Nonmicrobial Activation Of Tlrs Controls Intestinal Growth, Wound Repair, And Radioprotection, William F Stenson, Matthew A Ciorba
Open Access Publications
TLRs, key components of the innate immune system, recognize microbial molecules. However, TLRs also recognize some nonmicrobial molecules. In particular, TLR2 and TLR4 recognize hyaluronic acid, a glycosaminoglycan in the extracellular matrix. In neonatal mice endogenous hyaluronic acid binding to TLR4 drives normal intestinal growth. Hyaluronic acid binding to TLR4 in pericryptal macrophages results in cyclooxygenase2- dependent PGE
Mental Distress And Human Rights Violations During Covid-19: A Rapid Review Of The Evidence Informing Rights, Mental Health Needs, And Public Policy Around Vulnerable Populations, Muhammad Rahman, Rabab Ahmed, Ross Brownson, Mary Mckay, Et Al
Mental Distress And Human Rights Violations During Covid-19: A Rapid Review Of The Evidence Informing Rights, Mental Health Needs, And Public Policy Around Vulnerable Populations, Muhammad Rahman, Rabab Ahmed, Ross Brownson, Mary Mckay, Et Al
Open Access Publications
No abstract provided.
Anti-Cd20 B Cell Treatment For Relapsing Multiple Sclerosis, Charles A Roach, Anne H Cross
Anti-Cd20 B Cell Treatment For Relapsing Multiple Sclerosis, Charles A Roach, Anne H Cross
Open Access Publications
Several clinical trials have demonstrated the efficacy of lytic therapies targeting B cells in the treatment of relapsing multiple sclerosis (MS). More modest efficacy has been noted in the primary progressive subtype of MS. Clinical success has increased interest in the role of B cells in the pathogenesis of MS and in ways to potentially improve upon current B cell therapies. In this mini review, we will critically review previous and ongoing clinical trials of anti-CD20 monoclonal antibodies in MS, including rituximab, ocrelizumab, ofatumumab, and ublituximab. Side effects and adverse event profiles will be discussed. Studies examining the proposed mechanisms …