Digital Commons Network^™

In Vitro Growth Environment Produces Lipidomic And Electron Transport Chain Abnormalities In Mitochondria From Nontumorigenic Astrocytes And Brain Tumours, Michael A. Kiebish, Xianlin Han, Hua Cheng, Thomas N. Seyfried

Open Access Publications

No abstract provided.

Bringing Kash Under The Sun: The Many Faces Of Nucleo-Cytoskeletal Connections, David Razafsky, Didier Hodzic

Open Access Publications

No abstract provided.

Physical Activity And Colon Cancer Prevention: A Meta-Analysis, Kathleen Yaus Wolin, Yan Yan, Graham A. Colditz, I. M. Lee

Open Access Publications

No abstract provided.

Phase Ii Study Of Continuous Daily Sunitinib Dosing In Patients With Previously Treated Advanced Non-Small Cell Lung Cancer, Silvia Novello, Giorgio V. Scagliotti, Rafael C. Rosell, Mark A. Socinski, Julie R. Brahmer, James N. Atkins, Cinta Palleres, Russell E. Burgess, Lesley Tye, Paulina Selaru, Erjian Wang, Richard Chao, Ramaswamy Govindan

Open Access Publications

No abstract provided.

Oncogenic Hpv Infection Interrupts The Expression Of Tumor-Suppressive Mir-34a Through Viral Oncoprotein E6, Xiaohong Wang, Hsukun Wang, John P. Mccoy, Nilam Sanjib Banerjee, Janet S. Rader, Thomas R. Broker, Craig A. Meyers, Louise Chow, Zhiming Zheng

Open Access Publications

No abstract provided.

A Phase 2 Study Of Vorinostat In Acute Myeloid Leukemia, Eric W. Schaefer, Arturo Loaiza-Bonilla, Mark Juckett, John F. Dipersio, Vivek Roy, James Slack, Wenting Wu, Kristina Laumann, Igor Espinoza-Delgado, Steven D. Gore

Open Access Publications

No abstract provided.

Nematode.Net Update 2008: Improvements Enabling More Efficient Data Mining And Comparative Nematode Genomics, John Martin, Sahar Abubucker, Todd Wylie, Yong Yin, Zhengyuan Wang, Makedonka Mitreva

Open Access Publications

No abstract provided.

Dorsal Root Ganglion Neurons React To Semaphorin 3a Application Through A Biphasic Response That Requires Multiple Myosin Ii Isoforms, Jacquelyn A. Brown, Robert B. Wysolmerski, Paul C. Bridgman

Open Access Publications

No abstract provided.

Systematic Review Of The Role Of Sedation In Diagnostic Spinal Interventional Techniques, Howard S. Smith, Pradeep Chopra, Vikram B. Patel, Michael E. Frey, Rahul Rastogi

Open Access Publications

No abstract provided.

Key Role Of T Cell Defects In Age-Related Vulnerability To West Nile Virus, James D. Brien, Jennifer L. Uhrlaub, Alec Hirsch, Clayton A. Wiley, Janko Nikolich-Zugich

Open Access Publications

West Nile virus (WNV) infection causes a life-threatening meningoencephalitis that becomes increasingly more prevalent over the age of 50 and is 40-50x more prevalent in people over the age of 70, compared with adults under the age of 40. In a mouse model of age-related vulnerability to WNV, we demonstrate that death correlates with increased viral titers in the brain and that this loss of virus control with age was the result of defects in the CD4 and CD8 T cell response against WNV. Specific age-related defects in T cell responses against dominant WNV epitopes were detected at the level …

Trem-2 (Triggering Receptor Expressed On Myeloid Cells 2) Is A Phagocytic Receptor For Bacteria, Elsa-Noah N'Diaye, Catherine S. Branda, Steven S. Branda, Lisette Nevarez, Marco Colonna, Clifford Lowell, Jessica A. Hamerman, William E. Seaman

Open Access Publications

Phagocytosis, which is essential for the immune response to pathogens, is initiated by specific interactions between pathogens and cell surface receptors expressed by phagocytes. This study identifies triggering receptor expressed on myeloid cells 2 (TREM-2) and its signaling counterpart DAP12 as a molecular complex that promotes phagocytosis of bacteria. Expression of TREM-2-DAP12 enables nonphagocytic Chinese hamster ovary cells to internalize bacteria. This function depends on actin cytoskeleton dynamics and the activity of the small guanosine triphosphatases Rac and Cdc42. Internalization also requires src kinase activity and tyrosine phosphorylation. In bone marrow-derived macrophages, phagocytosis is decreased in the absence of DAP12 …

Cdc42 Antagonizes Rho1 Activity At Adherens Junctions To Limit Epithelial Cell Apical Tension, Stephen J. Warner, Gregory D. Longmore

Open Access Publications

In epithelia, cells are arranged in an orderly pattern with a defined orientation and shape. Cadherin containing apical adherens junctions (AJs) and the associated actomyosin cytoskeleton likely contribute to epithelial cell shape by providing apical tension. The Rho guanosine triphosphatases are well known regulators of cell junction formation, maintenance, and function. Specifically, Rho promotes actomyosin activity and cell contractility; however, what controls and localizes this Rho activity as epithelia remodel is unresolved. Using mosaic clonal analysis in the Drosophila melanogaster pupal eye, we find that Cdc42 is critical for limiting apical cell tension by antagonizing Rho activity at AJs. Cdc42 …

Environment-Specific Combinatorial Cis-Regulation In Synthetic Promoters, Jason Gertz, Barak A. Cohen

Open Access Publications

No abstract provided.

Detailed Analysis Of A Contiguous 22-Mb Region Of The Maize Genome, Robert S. Fulton, Laura Courtney, Scott Kruchowski, Tina A. Graves, Susan M. Rock, Stephanie Adams, Lucinda A. Fulton, Catrina Fronick, William Courtney, Sandra W. Clifton, Richard K. Wilson, Et Al.

Open Access Publications

No abstract provided.

A Proposal For A Coordinated Effort For The Determination Of Brainwide Neuroanatomical Connectivity In Model Organisms At A Mesoscopic Scale, Joseph L. Price, David C. Van Essen, Et Al.

Open Access Publications

No abstract provided.

The Mus81 Endonuclease Is Essential For Telomerase Negative Cell Proliferation, Sicong Zeng, Qin Yang

Open Access Publications

No abstract provided.

Identification Of Atg5-Dependent Transcriptional Changes And Increases In Mitochondrial Mass In Atg5-Deficient T Lymphocytes, Linda M. Stephenson, Brian C. Miller, Aylwin Ng, Jason Eisenberg, Zijiang Zhao, Ken Cadwell, Daniel B. Graham, Noboru N. Mizushima, Ramnik Xavier, Herbert W. Virgin, Wojciech Swat

Open Access Publications

No abstract provided.

A Common Role For Atg16l1, Atg5 And Atg7 In Small Intestinal Paneth Cells And Crohn Disease, Ken Cadwell, Khushbu K. Patel, Masaaki Komatsu, Herbert W. Virgin Iv, Thaddeus S. Stappenbeck

Open Access Publications

No abstract provided.

Skin-Derived Tslp Triggers Progression From Epidermal- Barrier Defects To Asthma, Shadmehr Demehri, Mitsuru Morimoto, Michael J. Holtzman, Raphael Kopan

Open Access Publications

No abstract provided.

Diagnosing Cervical Fusion: A Comprehensive Literature Review, Nanin Sethi, James Devney, Holly L. Steiner, K. Daniel Riew

Open Access Publications

STUDY DESIGN: Comprehensive literature review.

PURPOSE: To document the criteria for fusion utilized in these studies to determine if a consensus on the definition of a solid fusion exists.

OVERVIEW OF LITERATURE: Numerous studies have reported on fusion rates following anterior cervical arthrodesis. There is a wide discrepancy in the fusion rates in these studies. While factors such as graft type, Instrumentation, and technique play a factor in fusion rate, another reason for the difference may be a result of differences in the definition of fusion following anterior cervical spine surgery.

METHODS: A comprehensive English Medline literature review from 1966 …

What's New In Spine Surgery, Keith H. Bridwell, Paul A. Anderson, Scott D. Boden, Alexander R. Vaccaro, Jeffrey C. Wang

Open Access Publications

No abstract provided.

Myt1 Protein Kinase Is Essential For Golgi And Er Assembly During Mitotic Exit, Hiroyuki Nakajima, Shigenobu Yonemura, Masayuki Murata, Nobuhiro Nakamura, Helen Piwnica-Worms, Eisuke Nishida

Open Access Publications

No abstract provided.

The Drosophila Cd2ap/Cin85 Orthologue Cindr Regulates Junctions And Cytoskeleton Dynamics During Tissue Patterning, Ruth I. Johnson, Midori J. Seppa, Ross L. Cagan

Open Access Publications

No abstract provided.

Binding Of Cargo Sorting Signals To Ap-1 Enhances Its Association With Adp Ribosylation Factor 1-Gtp, Intaek Lee, Balraj Doray, Jennifer Govero, Stuart Kornfeld

Open Access Publications

No abstract provided.

Plasma Membrane Deformation By Circular Arrays Of Escrt-Iii Protein Filaments, Phyllis I. Hanson, Robyn Roth, Yuan Lin, John E. Heuser

Open Access Publications

No abstract provided.

Roles Of Trypanothione S-Transferase And Tryparedoxin Peroxidase In Resistance To Antimonials, Susan Wyllie, Tim J. Vickers, Alan H. Fairlamb

Open Access Publications

No abstract provided.

The Mammalian Ortholog Of Drosophila Mof That Acetylates Histone H4 Lysine 16 Is Essential For Embryogenesis And Oncogenesis, Arun Gupta, T. Geraldine Guerin-Peyrou, Girdhar G. Sharma, Changwon Park, Manjula Agarwal, Ramesh K. Ganju, Shruti Pandita, Kyunghee Choi, Saraswati Sukumar, Raj K. Pandita, Thomas Ludwig, Tej K. Pandita

Open Access Publications

No abstract provided.

The Lim Protein Ajuba Recruits Protein Arginine Methyltransferase 5 To Mediate Snail-Dependent Transcriptional Repression, Zhaoyuan Hou, Hongahuamg Peng, Kasirajan Ayyanathan, Kai-Ping Yan, Ellen M. Langer, Gregory D. Longmore, Frank J. Rauscher Iii

Open Access Publications

No abstract provided.

The Absence Of Cutaneous Lymph Nodes Results In A Th2 Response And Increased Susceptibility To Leishmania Major Infection In Mice, Jan M. Ehrchen, Joannes Roth, Kirsten Roebrock, Georg Varga, Wolfram Domschke, Rodney Newberry, Clemens Sorg, Carsten Muller-Tidow, Cord Sunderkotter, Torsten Kucharzik, Thomas W. Spahn

Open Access Publications

No abstract provided.

Dissociating Early And Late Error Signals In Perceptual Recognition, Mark E. Wheeler, Steven E. Petersen, Steven M. Nelson, Elisabeth J. Ploran, Katerina Velanova

Open Access Publications

No abstract provided.