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Exome Sequencing Identifies A Rare Hspg2 Variant Associated With Familial Idiopathic Scoliosis, Erin E. Baschal, Cambria I. Wethey, Kandice Swindle, Robin M. Baschal, Katherine Gowan, Nelson L.S. Tang, David M. Alvarado, Gabe E. Haller, Matthew B. Dobbs, Matthew R.G. Taylor, Christina A. Gurnett, Kenneth L. Jones, Nancy H. Miller Jan 2015

Exome Sequencing Identifies A Rare Hspg2 Variant Associated With Familial Idiopathic Scoliosis, Erin E. Baschal, Cambria I. Wethey, Kandice Swindle, Robin M. Baschal, Katherine Gowan, Nelson L.S. Tang, David M. Alvarado, Gabe E. Haller, Matthew B. Dobbs, Matthew R.G. Taylor, Christina A. Gurnett, Kenneth L. Jones, Nancy H. Miller

Open Access Publications

No abstract provided.


End-Stage Liver Disease Is A Strong Predictor Of Early Mortality In Cryptococcosis, Andrej Spec, Krunal Raval, William G. Powderly Jan 2015

End-Stage Liver Disease Is A Strong Predictor Of Early Mortality In Cryptococcosis, Andrej Spec, Krunal Raval, William G. Powderly

Open Access Publications

No abstract provided.


Surgery For Lymph Node Metastases Of Medullary Thyroid Carcinoma, Linda X. Jin, Jeffrey F. Moley Jan 2015

Surgery For Lymph Node Metastases Of Medullary Thyroid Carcinoma, Linda X. Jin, Jeffrey F. Moley

Open Access Publications

No abstract provided.


A Review Of Gene Therapy In Canine And Feline Models Of Lysosomal Storage Disorders, Allison M. Bradbury, Brittney L. Gurda, Margret L. Casal, Katherine P. Ponder, Charles H. Vite, Mark E. Haskins Jan 2015

A Review Of Gene Therapy In Canine And Feline Models Of Lysosomal Storage Disorders, Allison M. Bradbury, Brittney L. Gurda, Margret L. Casal, Katherine P. Ponder, Charles H. Vite, Mark E. Haskins

Open Access Publications

No abstract provided.


The Role Of Hypoxia In Cancer Progression, Angiogenesis, Metastasis, And Resistance To Therapy, Barbara Muz, Pilar De La Puente, Feda Azab, Abdel K. Azab Jan 2015

The Role Of Hypoxia In Cancer Progression, Angiogenesis, Metastasis, And Resistance To Therapy, Barbara Muz, Pilar De La Puente, Feda Azab, Abdel K. Azab

Open Access Publications

No abstract provided.


A Critical Review Of The Role Of Local Excision In The Treatment Of Early (T1 And T2) Rectal Tumors, Thomas A. Heafner, Sean C. Glasgow Oct 2014

A Critical Review Of The Role Of Local Excision In The Treatment Of Early (T1 And T2) Rectal Tumors, Thomas A. Heafner, Sean C. Glasgow

Open Access Publications

The optimal treatment of early (T1 and T2) rectal adenocarcinomas remains controversial. Local excision and radical resection with total mesorectal excision are the two surgical techniques for excising early rectal cancer. Each has their respective benefits, with local excision allowing for decreased operative morbidity and mortality while radical resection provides an oncologically complete treatment through lymphadenectomy. Local excision can be accomplished via transanal endoscopic microsurgery or transanal excision. There is no significant difference in the recurrence rates (21% vs. 33%) or overall survival (80% vs. 66%) between the two local excision modalities; however, transanal endoscopic microsurgery does allow for a …


Skpa Restrains Synaptic Terminal Growth During Development And Promotes Axonal Degeneration Following Injury, E. J. Brace, Chunlai Wu, Vera Valakh, Aaron Diantonio Jun 2014

Skpa Restrains Synaptic Terminal Growth During Development And Promotes Axonal Degeneration Following Injury, E. J. Brace, Chunlai Wu, Vera Valakh, Aaron Diantonio

Open Access Publications

The Wallenda (Wnd)/dual leucine zipper kinase (DLK)-Jnk pathway is an evolutionarily conserved MAPK signaling pathway that functions during neuronal development and following axonal injury. Improper pathway activation causes defects in axonal guidance and synaptic growth, whereas loss-of-function mutations in pathway components impairs axonal regeneration and degeneration after injury. Regulation of this pathway is in part through the E3 ubiquitin ligase Highwire (Hiw), which targets Wnd/DLK for degradation to limit MAPK signaling. To explore mechanisms controlling Wnd/DLK signaling, we performed a large-scale genetic screen in Drosophila to identify negative regulators of the pathway. Here we describe the identification and characterization of …


Comparison Of Antibodies That Mediate Hiv Type 1 Gp120 Antibody-Dependent Cell-Mediated Cytotoxicity In Asymptomatic Hiv Type 1-Positive Men And Women, Mariana M. Mata, Joyce R. Iwema, Shanna Dell, Leslie Neems, Beth D. Jamieson, John Phair, Mardge H. Cohen, Kathryn Anastos, Linda L. Baum Jan 2014

Comparison Of Antibodies That Mediate Hiv Type 1 Gp120 Antibody-Dependent Cell-Mediated Cytotoxicity In Asymptomatic Hiv Type 1-Positive Men And Women, Mariana M. Mata, Joyce R. Iwema, Shanna Dell, Leslie Neems, Beth D. Jamieson, John Phair, Mardge H. Cohen, Kathryn Anastos, Linda L. Baum

Open Access Publications

No abstract provided.


Circadian Rhythm Reprogramming During Lung Inflammation, Jeffrey A. Haspel, Et Al Jan 2014

Circadian Rhythm Reprogramming During Lung Inflammation, Jeffrey A. Haspel, Et Al

Open Access Publications

No abstract provided.


Helminth.Net: Expansions To Nematode.Net And An Introduction To Trematode.Net., John Martin, Bruce A. Rosa, Philip Ozersky, Kymberlie Hallsworth-Pepin, Xu Zhang, Veena Bhonagiri-Palsikar, Rahul Tyagi, Qi Wang, Young-Jun Choi, Xin Gao, Samantha N. Mcnulty, Paul J. Brindley, Makedonka Mitreva Jan 2014

Helminth.Net: Expansions To Nematode.Net And An Introduction To Trematode.Net., John Martin, Bruce A. Rosa, Philip Ozersky, Kymberlie Hallsworth-Pepin, Xu Zhang, Veena Bhonagiri-Palsikar, Rahul Tyagi, Qi Wang, Young-Jun Choi, Xin Gao, Samantha N. Mcnulty, Paul J. Brindley, Makedonka Mitreva

Open Access Publications

No abstract provided.


The Transcription Factor Gtf2ird1 Regulates The Topology And Function Of Photoreceptors By Modulating Photoreceptor Gene Expression Across The Retina, Tomohiro Masuda, Xiaodong Zhang, Cindy Berlinicke, Jun Wan, Anitha Yerrabelli, Elizabeth A. Conner, Sten Kjellstrom, Ronald Bush, Snorri S. Thorgeirsson, Anand Swaroop, Shiming Chen, Donald J. Zack Jan 2014

The Transcription Factor Gtf2ird1 Regulates The Topology And Function Of Photoreceptors By Modulating Photoreceptor Gene Expression Across The Retina, Tomohiro Masuda, Xiaodong Zhang, Cindy Berlinicke, Jun Wan, Anitha Yerrabelli, Elizabeth A. Conner, Sten Kjellstrom, Ronald Bush, Snorri S. Thorgeirsson, Anand Swaroop, Shiming Chen, Donald J. Zack

Open Access Publications

No abstract provided.


Targeting Hepatic Glycerolipid Synthesis And Turnover To Treat Fatty Liver Disease, George G. Schweitzer, Brian N. Finck Jan 2014

Targeting Hepatic Glycerolipid Synthesis And Turnover To Treat Fatty Liver Disease, George G. Schweitzer, Brian N. Finck

Open Access Publications

No abstract provided.


Natural Antisense Transcripts Regulate The Neuronal Stress Response And Excitability, Xingguo Zheng, Vera Valakh, Aaron Diantonio, Yehuda Ben-Shahar Jan 2014

Natural Antisense Transcripts Regulate The Neuronal Stress Response And Excitability, Xingguo Zheng, Vera Valakh, Aaron Diantonio, Yehuda Ben-Shahar

Open Access Publications

No abstract provided.


Studies Of Inactivation Mechanism Of Non-Enveloped Icosahedral Virus By A Visible Ultrashort Pulsed Laser, Shaw-Wei D. Tsen, David H. Kingsley, Christian Poweleit, Samuel Achilefu, Douglas S. Soroka, T. C. Wu, Kong-Thon Tsen Jan 2014

Studies Of Inactivation Mechanism Of Non-Enveloped Icosahedral Virus By A Visible Ultrashort Pulsed Laser, Shaw-Wei D. Tsen, David H. Kingsley, Christian Poweleit, Samuel Achilefu, Douglas S. Soroka, T. C. Wu, Kong-Thon Tsen

Open Access Publications

No abstract provided.


Expanding The Direct Hetr Regulon In Anabaena Sp. Strain Pcc 7120, Patrick Videau, Shuisong Ni, Orion S. Rivers, Blake Ushijima, Erik A. Feldmann, Loralyn M. Cozy, Michael A. Kennedy, Sean M. Callahan Jan 2014

Expanding The Direct Hetr Regulon In Anabaena Sp. Strain Pcc 7120, Patrick Videau, Shuisong Ni, Orion S. Rivers, Blake Ushijima, Erik A. Feldmann, Loralyn M. Cozy, Michael A. Kennedy, Sean M. Callahan

Open Access Publications

No abstract provided.


Clonal Analysis Of Kit Ligand A Functional Expression Reveals Lineage-Specific Competence To Promote Melanocyte Rescue In The Mutant Regenerating Caudal Fin, Robert C. Tyron, Stephen L. Johnson Jan 2014

Clonal Analysis Of Kit Ligand A Functional Expression Reveals Lineage-Specific Competence To Promote Melanocyte Rescue In The Mutant Regenerating Caudal Fin, Robert C. Tyron, Stephen L. Johnson

Open Access Publications

No abstract provided.


Management Of Anticoagulant-Related Intracranial Hemorrhage: An Evidence-Based Review, Bappaditya Ray, Salah G. Keyrouz Jan 2014

Management Of Anticoagulant-Related Intracranial Hemorrhage: An Evidence-Based Review, Bappaditya Ray, Salah G. Keyrouz

Open Access Publications

No abstract provided.


Actin Scaffolding By Clathrin Heavy Chain Is Required For Skeletal Muscle Sarcomere Organization, Stéphane Vassilopoulos, Christel Gentil, Jeanne Lainé, Pierre-Olivier Buclez, Agathe Franck, Arnaud Ferry, Guillaume Précigout, Robyn Roth, John E. Heuser, Frances M. Brodsky, Luis Garcia, Gisèle Bonne, Thomas Voit, France Piétri-Rouxel, Marc Bitoun Jan 2014

Actin Scaffolding By Clathrin Heavy Chain Is Required For Skeletal Muscle Sarcomere Organization, Stéphane Vassilopoulos, Christel Gentil, Jeanne Lainé, Pierre-Olivier Buclez, Agathe Franck, Arnaud Ferry, Guillaume Précigout, Robyn Roth, John E. Heuser, Frances M. Brodsky, Luis Garcia, Gisèle Bonne, Thomas Voit, France Piétri-Rouxel, Marc Bitoun

Open Access Publications

No abstract provided.


Cortical–Subcortical Interactions In Hypersomnia Disorders: Mechanisms Underlying Cognitive And Behavioral Aspects Of The Sleep–Wake Cycle, Linda J. Larson-Prior, Yo-El Ju, James E. Galvin Jan 2014

Cortical–Subcortical Interactions In Hypersomnia Disorders: Mechanisms Underlying Cognitive And Behavioral Aspects Of The Sleep–Wake Cycle, Linda J. Larson-Prior, Yo-El Ju, James E. Galvin

Open Access Publications

No abstract provided.


Cross Talk Between The Cell Wall Integrity And Cyclic Amp/Protein Kinase A Pathways In Cryptococcus Neoformans, Maureen J. Donlin, Rajendra Upadhya, Kimberly J. Gerik, Woei Lam, Laura G. Vanarendonk, Charles A. Specht, Neil K. Sharma, Jennifer K. Lodge Jan 2014

Cross Talk Between The Cell Wall Integrity And Cyclic Amp/Protein Kinase A Pathways In Cryptococcus Neoformans, Maureen J. Donlin, Rajendra Upadhya, Kimberly J. Gerik, Woei Lam, Laura G. Vanarendonk, Charles A. Specht, Neil K. Sharma, Jennifer K. Lodge

Open Access Publications

No abstract provided.


Single Nucleotide Variants In Transcription Factors Associate More Tightly With Phenotype Than With Gene Expression, Priya Sudarsanam, Barak A. Cohen Jan 2014

Single Nucleotide Variants In Transcription Factors Associate More Tightly With Phenotype Than With Gene Expression, Priya Sudarsanam, Barak A. Cohen

Open Access Publications

No abstract provided.


Bacterial Nucleoid-Associated Protein Uncouples Transcription Levels From Transcription Timing, Igor Zwir, Won-Sik Yeo, Dongwoo Shin, Tammy Latifi, Henry Huang, Eduardo A. Groisman Jan 2014

Bacterial Nucleoid-Associated Protein Uncouples Transcription Levels From Transcription Timing, Igor Zwir, Won-Sik Yeo, Dongwoo Shin, Tammy Latifi, Henry Huang, Eduardo A. Groisman

Open Access Publications

No abstract provided.


A Statin-Loaded Reconstituted High-Density Lipoprotein Nanoparticle Inhibits Atherosclerotic Plaque Inflammation, Catherine Martel, Gwendalyn J. Randolph, Et Al Jan 2014

A Statin-Loaded Reconstituted High-Density Lipoprotein Nanoparticle Inhibits Atherosclerotic Plaque Inflammation, Catherine Martel, Gwendalyn J. Randolph, Et Al

Open Access Publications

No abstract provided.


Feasibility Of Isotope Harvesting At A Projectile Fragmentation Facility: ⁶⁷Cu, Tara Mastren, Aranh Pen, Graham F. Peaslee, Nick Wozniak, Shaun Loveless, Scott Essenmacher, Lee G. Sobotka, David J. Morrissey, Suzanne E. Lapi Jan 2014

Feasibility Of Isotope Harvesting At A Projectile Fragmentation Facility: ⁶⁷Cu, Tara Mastren, Aranh Pen, Graham F. Peaslee, Nick Wozniak, Shaun Loveless, Scott Essenmacher, Lee G. Sobotka, David J. Morrissey, Suzanne E. Lapi

Open Access Publications

No abstract provided.


Construction And Radiolabeling Of Adenovirus Variants That Incorporate Human Metallothionein Into Protein Ix For Analysis Of Biodistribution, David T. Curiel, Et Al Jan 2014

Construction And Radiolabeling Of Adenovirus Variants That Incorporate Human Metallothionein Into Protein Ix For Analysis Of Biodistribution, David T. Curiel, Et Al

Open Access Publications

No abstract provided.


Network Inefficiencies In Autism Spectrum Disorder At 24 Months, J R. Pruett, K Botteron, R Mckinstry, Et Al Jan 2014

Network Inefficiencies In Autism Spectrum Disorder At 24 Months, J R. Pruett, K Botteron, R Mckinstry, Et Al

Open Access Publications

No abstract provided.


Systems Biology Studies Of Adult Paragonimus Lung Flukes Facilitate The Identification Of Immunodominant Parasite Antigens, Samantha N. Mcnulty, Peter U. Fischer, R Reid Townsend, Kurt C. Curtis, Gary J. Weil, Makedonka Mitreva Jan 2014

Systems Biology Studies Of Adult Paragonimus Lung Flukes Facilitate The Identification Of Immunodominant Parasite Antigens, Samantha N. Mcnulty, Peter U. Fischer, R Reid Townsend, Kurt C. Curtis, Gary J. Weil, Makedonka Mitreva

Open Access Publications

No abstract provided.


Comparative Dna Methylome Analysis Of Endometrial Carcinoma Reveals Complex And Distinct Deregulation Of Cancer Promoters And Enhancers, Bo Zhang, Xiao Yun Xing, Jing Li, Rebecca F. Lowdon, Yan Zhou, Nan Lin, Baoxue Zhang, Vasavi Sundaram, Katherine B. Chiappinelli, Ian S. Hagemann, David G. Mutch, Paul J. Goodfellow, Ting Wang Jan 2014

Comparative Dna Methylome Analysis Of Endometrial Carcinoma Reveals Complex And Distinct Deregulation Of Cancer Promoters And Enhancers, Bo Zhang, Xiao Yun Xing, Jing Li, Rebecca F. Lowdon, Yan Zhou, Nan Lin, Baoxue Zhang, Vasavi Sundaram, Katherine B. Chiappinelli, Ian S. Hagemann, David G. Mutch, Paul J. Goodfellow, Ting Wang

Open Access Publications

No abstract provided.


The Taxonomy Of Brain Cancer Stem Cells: What's In A Name?, David H. Gutmann Jan 2014

The Taxonomy Of Brain Cancer Stem Cells: What's In A Name?, David H. Gutmann

Open Access Publications

With the increasing recognition that stem cells play vital roles in the formation, maintenance, and potential targeted treatment of brain tumors, there has been an exponential increase in basic laboratory and translational research on these cell types. However, there are several different classes of stem cells germane to brain cancer, each with distinct capabilities and functions. In this perspective, we discuss the types of stem cells relevant to brain tumor pathogenesis, and suggest a nomenclature for future preclinical and clinical investigation.


Overview Of Gene Structure In C. Elegans, John Spieth, Daniel Lawson, Paul Davis, Gary Williams, Kevin Howe Jan 2014

Overview Of Gene Structure In C. Elegans, John Spieth, Daniel Lawson, Paul Davis, Gary Williams, Kevin Howe

Open Access Publications

No abstract provided.