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Articles 2791 - 2820 of 5949
Full-Text Articles in Entire DC Network
Using Diffusion Tractography To Predict Cortical Connection Strength And Distance: A Quantitative Comparison With Tracers In The Monkey, Chad J. Donahue, Stamatios N. Sotiropoulos, Saad Jbabdi, Moises Hernandez-Fernandez, Timothy E. Behrens, Tim B. Dyrby, Timothy Coalson, Henry Kennedy, Kenneth Knoblauch, David C. Van Essen, Matthew F. Glasser
Using Diffusion Tractography To Predict Cortical Connection Strength And Distance: A Quantitative Comparison With Tracers In The Monkey, Chad J. Donahue, Stamatios N. Sotiropoulos, Saad Jbabdi, Moises Hernandez-Fernandez, Timothy E. Behrens, Tim B. Dyrby, Timothy Coalson, Henry Kennedy, Kenneth Knoblauch, David C. Van Essen, Matthew F. Glasser
Open Access Publications
UNLABELLED: Tractography based on diffusion MRI offers the promise of characterizing many aspects of long-distance connectivity in the brain, but requires quantitative validation to assess its strengths and limitations. Here, we evaluate tractography's ability to estimate the presence and strength of connections between areas of macaque neocortex by comparing its results with published data from retrograde tracer injections. Probabilistic tractography was performed on high-quality postmortem diffusion imaging scans from two Old World monkey brains. Tractography connection weights were estimated using a fractional scaling method based on normalized streamline density. We found a correlation between log-transformed tractography and tracer connection weights …
Tmem184b Promotes Axon Degeneration And Neuromuscular Junction Maintenance, Martha R.C. Bhattacharya, Stefanie Geisler, Sara K. Pittman, Ryan A. Doan, Conrad C. Weihl, Jeffrey Milbrandt, Aaron Diantonio
Tmem184b Promotes Axon Degeneration And Neuromuscular Junction Maintenance, Martha R.C. Bhattacharya, Stefanie Geisler, Sara K. Pittman, Ryan A. Doan, Conrad C. Weihl, Jeffrey Milbrandt, Aaron Diantonio
Open Access Publications
UNLABELLED: Complex nervous systems achieve proper connectivity during development and must maintain these connections throughout life. The processes of axon and synaptic maintenance and axon degeneration after injury are jointly controlled by a number of proteins within neurons, including ubiquitin ligases and mitogen activated protein kinases. However, our understanding of these molecular cascades is incomplete. Here we describe the phenotype resulting from mutation of TMEM184b, a protein identified in a screen for axon degeneration mediators. TMEM184b is highly expressed in the mouse nervous system and is found in recycling endosomes in neuronal cell bodies and axons. Disruption of TMEM184b expression …
Functional Significance Of The Discordance Between Transcriptional Profile And Left Ventricular Structure/Function During Reverse Remodeling, Veli K. Topkara, Kari T. Chambers, Kai-Chien Yang, Huei-Ping Tzeng, Sarah Evans, Carla Weinheimer, Attila Kovacs, Jeffrey Robbins, Philip Barger, Douglas L. Mann
Functional Significance Of The Discordance Between Transcriptional Profile And Left Ventricular Structure/Function During Reverse Remodeling, Veli K. Topkara, Kari T. Chambers, Kai-Chien Yang, Huei-Ping Tzeng, Sarah Evans, Carla Weinheimer, Attila Kovacs, Jeffrey Robbins, Philip Barger, Douglas L. Mann
Open Access Publications
To elucidate the mechanisms for reverse LV remodeling, we generated a conditional (doxycycline [dox] off) transgenic mouse tetracycline transactivating factor-TRAF2 (tTA-TRAF2) that develops a dilated heart failure (HF) phenotype upon expression of a proinflammatory transgene, TNF receptor-associated factor 2 (TRAF2), and complete normalization of LV structure and function when the transgene is suppressed. tTA-TRAF2 mice developed a significant increase in LV dimension with decreased contractile function, which was completely normalized in the tTA-TRAF2 mice fed dox for 4 weeks (tTA-TRAF2
Provisional Tic Disorder: What To Tell Parents When Their Child First Starts Ticcing, Kevin J. Black, Elizabeth Rose Black, Deanna J. Greene, Bradley L. Schlaggar
Provisional Tic Disorder: What To Tell Parents When Their Child First Starts Ticcing, Kevin J. Black, Elizabeth Rose Black, Deanna J. Greene, Bradley L. Schlaggar
Open Access Publications
No abstract provided.
Maturation Of Nav And Kv Channel Topographies In The Auditory Nerve Spike Initiator Before And After Developmental Onset Of Hearing Function, Kyunghee X. Kim, Mark A. Rutherford
Maturation Of Nav And Kv Channel Topographies In The Auditory Nerve Spike Initiator Before And After Developmental Onset Of Hearing Function, Kyunghee X. Kim, Mark A. Rutherford
Open Access Publications
No abstract provided.
Oncomodulin, An Ef-Hand Ca2+ Buffer, Is Critical For Maintaining Cochlear Function In Mice, Benton Tong, Aubrey J. Hornak, Stéphane F. Maison, Kevin K. Ohlemiller, M Charles Liberman, Dwayne D. Simmons
Oncomodulin, An Ef-Hand Ca2+ Buffer, Is Critical For Maintaining Cochlear Function In Mice, Benton Tong, Aubrey J. Hornak, Stéphane F. Maison, Kevin K. Ohlemiller, M Charles Liberman, Dwayne D. Simmons
Open Access Publications
UNLABELLED: Oncomodulin (Ocm), a member of the parvalbumin family of calcium binding proteins, is expressed predominantly by cochlear outer hair cells in subcellular regions associated with either mechanoelectric transduction or electromotility. Targeted deletion of Ocm caused progressive cochlear dysfunction. Although sound-evoked responses are normal at 1 month, by 4 months, mutants show only minimal distortion product otoacoustic emissions and 70-80 dB threshold shifts in auditory brainstem responses. Thus, Ocm is not critical for cochlear development but does play an essential role for cochlear function in the adult mouse.
SIGNIFICANCE STATEMENT: Numerous proteins act as buffers, sensors, or pumps to control …
Getting To More Effective Weight Management In Antipsychotic-Treated Youth: A Survey Of Barriers And Preferences, Ginger Nicol, Elizabeth Worsham, Debra Haire-Joshu, Alexis Duncan, Julia Schweiger, Michael Yingling, Eric Lenze
Getting To More Effective Weight Management In Antipsychotic-Treated Youth: A Survey Of Barriers And Preferences, Ginger Nicol, Elizabeth Worsham, Debra Haire-Joshu, Alexis Duncan, Julia Schweiger, Michael Yingling, Eric Lenze
Open Access Publications
No abstract provided.
Modelling Proteins’ Hidden Conformations To Predict Antibiotic Resistance, Kathryn M. Hart, Chris M. W. Ho, Supratik Dutta, Michael L. Gross, Gregory R. Bowman
Modelling Proteins’ Hidden Conformations To Predict Antibiotic Resistance, Kathryn M. Hart, Chris M. W. Ho, Supratik Dutta, Michael L. Gross, Gregory R. Bowman
Open Access Publications
No abstract provided.
Chemical Chaperone Tudca Prevents Apoptosis And Improves Survival During Polymicrobial Sepsis In Mice, Marcel Doerflinger, Jason Glab, Christina Nedeva, Irvin Jose, Ann Lin, Lorraine O’Reilly, Cody Allison, Marc Pellegrini, Richard S. Hotchkiss, Hamsa Puthalakath
Chemical Chaperone Tudca Prevents Apoptosis And Improves Survival During Polymicrobial Sepsis In Mice, Marcel Doerflinger, Jason Glab, Christina Nedeva, Irvin Jose, Ann Lin, Lorraine O’Reilly, Cody Allison, Marc Pellegrini, Richard S. Hotchkiss, Hamsa Puthalakath
Open Access Publications
No abstract provided.
Spatially- And Temporally-Controlled Postnatal P53 Knockdown Cooperates With Embryonic Schwann Cell Precursor Nf1 Gene Loss To Promote Malignant Peripheral Nerve Sheath Tumor Formation, Angela C. Hirbe, Sonika Dahiya, Dinorah Friedmann-Morvinski, Inder M. Verma, D. Wade Clapp, David H. Gutmann
Spatially- And Temporally-Controlled Postnatal P53 Knockdown Cooperates With Embryonic Schwann Cell Precursor Nf1 Gene Loss To Promote Malignant Peripheral Nerve Sheath Tumor Formation, Angela C. Hirbe, Sonika Dahiya, Dinorah Friedmann-Morvinski, Inder M. Verma, D. Wade Clapp, David H. Gutmann
Open Access Publications
No abstract provided.
Coa Protects Against The Deleterious Effects Of Caloric Overload In Drosophila, Laura Palanker Musselman, Jill L. Fink, Thomas J. Baranski
Coa Protects Against The Deleterious Effects Of Caloric Overload In Drosophila, Laura Palanker Musselman, Jill L. Fink, Thomas J. Baranski
Open Access Publications
No abstract provided.
Human Metabolome-Derived Cofactors Are Required For The Antibacterial Activity Of Siderocalin In Urine, Robin R. Shields-Cutler, Jan R. Crowley, Connelly D. Miller, Ann E. Stapleton, Weidong Cui, Jeffery P. Henderson
Human Metabolome-Derived Cofactors Are Required For The Antibacterial Activity Of Siderocalin In Urine, Robin R. Shields-Cutler, Jan R. Crowley, Connelly D. Miller, Ann E. Stapleton, Weidong Cui, Jeffery P. Henderson
Open Access Publications
No abstract provided.
A Recurrent Mosaic Mutation In Smo, Encoding The Hedgehog Signal Transducer Smoothened, Is The Major Cause Of Curry-Jones Syndrome, Dorothy K. Grange, Et Al
A Recurrent Mosaic Mutation In Smo, Encoding The Hedgehog Signal Transducer Smoothened, Is The Major Cause Of Curry-Jones Syndrome, Dorothy K. Grange, Et Al
Open Access Publications
No abstract provided.
Human Central Nervous System (Cns) Apoe Isoforms Are Increased By Age, Differentially Altered By Amyloidosis, And Relative Amounts Reversed In The Cns Compared With Plasma, Alaina T. Baker-Nigh, Kwasi G. Mawuenyega, James G. Bollinger, Vitaliy Ovod, Tom Kasten, Erin E. Franklin, Fan Liao, Hong Jiang, David Holtzman, Nigel J. Cairns, John C. Morris, Randall J. Bateman
Human Central Nervous System (Cns) Apoe Isoforms Are Increased By Age, Differentially Altered By Amyloidosis, And Relative Amounts Reversed In The Cns Compared With Plasma, Alaina T. Baker-Nigh, Kwasi G. Mawuenyega, James G. Bollinger, Vitaliy Ovod, Tom Kasten, Erin E. Franklin, Fan Liao, Hong Jiang, David Holtzman, Nigel J. Cairns, John C. Morris, Randall J. Bateman
Open Access Publications
No abstract provided.
Inhibition Of Dna Methyltransferases Blocks Mutant Huntingtin-Induced Neurotoxicity, Yanchun Pan, Takuji Daito, Yo Sasaki, Yong Hee Chung, Xiaoyun Xing, Santhi Pondugula, S. Joshua Swamidass, Ting Wang, Albert H. Kim, Hiroko Yano
Inhibition Of Dna Methyltransferases Blocks Mutant Huntingtin-Induced Neurotoxicity, Yanchun Pan, Takuji Daito, Yo Sasaki, Yong Hee Chung, Xiaoyun Xing, Santhi Pondugula, S. Joshua Swamidass, Ting Wang, Albert H. Kim, Hiroko Yano
Open Access Publications
No abstract provided.
Predicting All-Cause Mortality From Basic Physiology In The Framingham Heart Study, William B. Zhang, Zachary Pincus
Predicting All-Cause Mortality From Basic Physiology In The Framingham Heart Study, William B. Zhang, Zachary Pincus
Open Access Publications
No abstract provided.
Changes In The Relative Abundance Of Two Saccharomyces Species From Oak Forests To Wine Fermentations, Sofia Dashko, Ping Liu, Helena Volk, Lorena Butinar, Jure Piškur, Justin C. Fay
Changes In The Relative Abundance Of Two Saccharomyces Species From Oak Forests To Wine Fermentations, Sofia Dashko, Ping Liu, Helena Volk, Lorena Butinar, Jure Piškur, Justin C. Fay
Open Access Publications
No abstract provided.
Genseed-Hmm: A Tool For Progressive Assembly Using Profile Hmms As Seeds And Its Application In Alpavirinae Viral Discovery From Metagenomic Data, João M.P. Alves, Andre L. De Oliveira, Tatiana O.M. Sandberg, Jaime L. Moreno-Gallego, Marcelo A.F. De Toledo, Elisabeth M.M. De Moura, Liliane S. Oliveira, Alan M. Durham, Dolores U. Mehnert, Paolo M. De A. Zanotto, Alejandro Reyes, Arthur Gruber
Genseed-Hmm: A Tool For Progressive Assembly Using Profile Hmms As Seeds And Its Application In Alpavirinae Viral Discovery From Metagenomic Data, João M.P. Alves, Andre L. De Oliveira, Tatiana O.M. Sandberg, Jaime L. Moreno-Gallego, Marcelo A.F. De Toledo, Elisabeth M.M. De Moura, Liliane S. Oliveira, Alan M. Durham, Dolores U. Mehnert, Paolo M. De A. Zanotto, Alejandro Reyes, Arthur Gruber
Open Access Publications
No abstract provided.
Genome-Wide Association Study Of Lifetime Cannabis Use Based On A Large Meta-Analytic Sample Of 32,330 Subjects From The International Cannabis Consortium, A C. Heath, Et Al
Genome-Wide Association Study Of Lifetime Cannabis Use Based On A Large Meta-Analytic Sample Of 32,330 Subjects From The International Cannabis Consortium, A C. Heath, Et Al
Open Access Publications
No abstract provided.
Critical Evaluation Of The Expression Of Gastrin-Releasing Peptide In Dorsal Root Ganglia And Spinal Cord, Devin M. Barry, Hui Li, Xian-Yu Liu, Kai-Feng Shen, Xue-Ting Liu, Zhen-Yu Wu, Admire Munanairi, Xiao-Jun Chen, Jun Yin, Yan-Gang Sun, Yun-Qing Li, Zhou-Feng Chen
Critical Evaluation Of The Expression Of Gastrin-Releasing Peptide In Dorsal Root Ganglia And Spinal Cord, Devin M. Barry, Hui Li, Xian-Yu Liu, Kai-Feng Shen, Xue-Ting Liu, Zhen-Yu Wu, Admire Munanairi, Xiao-Jun Chen, Jun Yin, Yan-Gang Sun, Yun-Qing Li, Zhou-Feng Chen
Open Access Publications
No abstract provided.
Geographic Variation In Maternal Smoking During Pregnancy In The Missouri Adolescent Female Twin Study (Moafts), Min Lian, Pamela A. Madden, Michael T. Lynskey, Graham A. Colditz, Christina N. Lessov-Schlaggar, Mario Schootman, Andrew C. Heath
Geographic Variation In Maternal Smoking During Pregnancy In The Missouri Adolescent Female Twin Study (Moafts), Min Lian, Pamela A. Madden, Michael T. Lynskey, Graham A. Colditz, Christina N. Lessov-Schlaggar, Mario Schootman, Andrew C. Heath
Open Access Publications
No abstract provided.
Rna-Seq Of The Caribbean Reef-Building Coral Orbicella Faveolata (Scleractinia-Merulinidae) Under Bleaching And Disease Stress Expands Models Of Coral Innate Immunity, David A. Anderson, Marcus E. Walz, Ernesto Weil, Peter Tonellato, Matthew C. Smith
Rna-Seq Of The Caribbean Reef-Building Coral Orbicella Faveolata (Scleractinia-Merulinidae) Under Bleaching And Disease Stress Expands Models Of Coral Innate Immunity, David A. Anderson, Marcus E. Walz, Ernesto Weil, Peter Tonellato, Matthew C. Smith
Open Access Publications
No abstract provided.
Hyperthermic Laser Ablation Of Recurrent Glioblastoma Leads To Temporary Disruption Of The Peritumoral Blood Brain Barrier, Eric C. Leuthardt, Chong Duan, Michael J. Kim, Jian L. Campian, Albert H. Kim, Michelle M. Miller-Thomas, Joshua S. Shimony, David D. Tran
Hyperthermic Laser Ablation Of Recurrent Glioblastoma Leads To Temporary Disruption Of The Peritumoral Blood Brain Barrier, Eric C. Leuthardt, Chong Duan, Michael J. Kim, Jian L. Campian, Albert H. Kim, Michelle M. Miller-Thomas, Joshua S. Shimony, David D. Tran
Open Access Publications
No abstract provided.
The Z-Cad Dual Fluorescent Sensor Detects Dynamic Changes Between The Epithelial And Mesenchymal Cellular States, M. J. Toneff, A. Sreekumar, A. Tinnirello, P. Den Hollander, S. Habib, Shunqiang Li, M. J. Ellis, L. Xin, S. A. Mani, J. M. Rosen
The Z-Cad Dual Fluorescent Sensor Detects Dynamic Changes Between The Epithelial And Mesenchymal Cellular States, M. J. Toneff, A. Sreekumar, A. Tinnirello, P. Den Hollander, S. Habib, Shunqiang Li, M. J. Ellis, L. Xin, S. A. Mani, J. M. Rosen
Open Access Publications
No abstract provided.
Small Molecule Dual-Inhibitors Of Trpv4 And Trpa1 For Attenuation Of Inflammation And Pain, Patrick Kanju, Yong Chen, Whasil Lee, Michele Yeo, Suk Hee Lee, Joelle Romac, Rafiq Shahid, Ping Fan, David M. Gooden, Sidney A. Simon, Ivan Spasojevic, Robert A. Mook, Rodger A. Liddle, Farshid Guilack, Wolfgang B. Liedtke
Small Molecule Dual-Inhibitors Of Trpv4 And Trpa1 For Attenuation Of Inflammation And Pain, Patrick Kanju, Yong Chen, Whasil Lee, Michele Yeo, Suk Hee Lee, Joelle Romac, Rafiq Shahid, Ping Fan, David M. Gooden, Sidney A. Simon, Ivan Spasojevic, Robert A. Mook, Rodger A. Liddle, Farshid Guilack, Wolfgang B. Liedtke
Open Access Publications
No abstract provided.
The Fallacy Of Univariate Solutions To Complex Systems Problems, Christina N. Lessov-Schlaggar, Joshua B. Rubin, Bradley L. Schlaggar
The Fallacy Of Univariate Solutions To Complex Systems Problems, Christina N. Lessov-Schlaggar, Joshua B. Rubin, Bradley L. Schlaggar
Open Access Publications
No abstract provided.
Evolutionary Inactivation Of A Sialidase In Group B Streptococcus, Masaya Yamaguchi, Yujiro Hirose, Masanobu Nakata, Satoshi Uchiyama, Yuka Yamaguchi, Kana Goto, Tomoko Sumitomo, Amanda L. Lewis, Shigetada Kawabata, Victor Nizet
Evolutionary Inactivation Of A Sialidase In Group B Streptococcus, Masaya Yamaguchi, Yujiro Hirose, Masanobu Nakata, Satoshi Uchiyama, Yuka Yamaguchi, Kana Goto, Tomoko Sumitomo, Amanda L. Lewis, Shigetada Kawabata, Victor Nizet
Open Access Publications
No abstract provided.
Endothelial To Mesenchymal Transition Is Common In Atherosclerotic Lesions And Is Associated With Plaque Instability, Gwendalyn J. Randolph, Et Al
Endothelial To Mesenchymal Transition Is Common In Atherosclerotic Lesions And Is Associated With Plaque Instability, Gwendalyn J. Randolph, Et Al
Open Access Publications
No abstract provided.
A Disintegrin And Metalloproteinase10 (Adam10) Regulates Notch Signaling During Early Retinal Development, Joseph A. Toonen, Adam Ronchetti, D. J. Sidjanin
A Disintegrin And Metalloproteinase10 (Adam10) Regulates Notch Signaling During Early Retinal Development, Joseph A. Toonen, Adam Ronchetti, D. J. Sidjanin
Open Access Publications
No abstract provided.
A Critical Evaluation Of The Down Syndrome Diagnosis For Lb1, Type Specimen Of Homo Floresiensis, Karen L. Baab, Peter Brown, Dean Falk, Joan T. Richtsmeier, Charles F. Hildebolt, Kirk Smith, William Jungers
A Critical Evaluation Of The Down Syndrome Diagnosis For Lb1, Type Specimen Of Homo Floresiensis, Karen L. Baab, Peter Brown, Dean Falk, Joan T. Richtsmeier, Charles F. Hildebolt, Kirk Smith, William Jungers
Open Access Publications
No abstract provided.