Digital Commons Network^™

Concentration Of 2c-Methyladenosine Triphosphate By Leishmania Guyanensis Enables Specific Inhibition Of Leishmania Rna Virus 1 Via Its Rna Polymerase, John I. Robinson, Stephen M. Beverley

Open Access Publications

No abstract provided.

Ybtt Is A Low-Specificity Type Ii Thioesterase That Maintains Production Of The Metallophore Yersiniabactin In Pathogenic Enterobacteria, Shannon I. Ohlemacher, Yiquan Xu, Daniel L. Kober, Mahnoor Malik, Jay C. Nix, Tom J. Brett, Jeffrey P. Henderson

Open Access Publications

No abstract provided.

Trisomy Of Human Chromosome 21 Enhances Amyloid-Β Deposition Independently Of An Extra Copy Of App, Frances K. Wiseman, Fan Liao, Floy Stewart, David M. Holtzman, Et Al

Open Access Publications

No abstract provided.

Structural And Functional Differences Between Porcine Brain And Budding Yeast Microtubules, Stuart C. Howes, Elisabeth A. Geyer, Benjamin Lafrance, Rui Zhang, Elizabeth H. Kellogg, Stefan Westermann, Luke M. Rice, Eva Nogales

Open Access Publications

No abstract provided.

Molecular Mechanisms Of Cell Death: Recommendations Of The Nomenclature Committee On Cell Death 2018, Lorenzo Galluzzi, Herbert W. Virgin, Et Al.

Open Access Publications

No abstract provided.

The Role Of Twist1 In Mutant Huntingtin–Induced Transcriptional Alterations And Neurotoxicity, Yanchun Pan, Ying Zhu, Wei Yang, Eric Tycksen, Shaopeng Liu, John Palucki, Linjian Zhu, Yo Sasaki, Mukesh K. Sharma, Albert H. Kim, Bo Zhang, Hiroko Yano

Open Access Publications

No abstract provided.

Changes In Cytokine, Filarial Antigen, And Dna Levels Associated With Adverse Events Following Treatment Of Lymphatic Filariasis, Britt J. Andersen, Jessica Kumar, Kurt Curtis, Nelly Sanuku, Samson Satofan, Christopher L. King, Peter U. Fischer, Gary J. Weil

Open Access Publications

No abstract provided.

Walking, Gross Motor Development, And Brain Functional Connectivity In Infants And Toddlers, Natasha Marrus, Adam T. Eggebrecht, Alexandre Todorov, Lyndsey Cole, Cheryl L. Klohr, Chloe M. Adams, Kelly N. Botteron, Robert C. Mckinstry, John N. Constantino, The Ibis Network, Bradley L. Schlaggar, John R. Pruett Jr, Et Al

Open Access Publications

No abstract provided.

Regulation Of Amyloid-Β Dynamics And Pathology By The Circadian Clock, Geraldine J. Kress, Fan Liao, Julie Dimitry, Michelle R. Cedeno, Garret A Fitzgerald, David M. Holtzman, Erik S. Musiek

Open Access Publications

Nighttime restlessness and daytime drowsiness are common and early symptoms of Alzheimer's Disease (AD). This symptomology implicates dysfunctional biological timing, yet the role of the circadian system in AD pathogenesis is unknown. To evaluate the role of the circadian clock in amyloid-β (Aβ) dynamics and pathology, we used a mouse model of β-amyloidosis and disrupted circadian clock function either globally or locally in the brain via targeted deletion of the core clock gene

Longo: An R Package For Interactive Gene Length Dependent Analysis For Neuronal Identity, Matthew J. Mccoy, Alexander J. Paul, Matheus B. Victor, Michelle Richner, Harrison W. Gabel, Haijun Gong, Andrew S. Yoo, Tae-Hyuk Ahn

Open Access Publications

Motivation: Reprogramming somatic cells into neurons holds great promise to model neuronal development and disease. The efficiency and success rate of neuronal reprogramming, however, may vary between different conversion platforms and cell types, thereby necessitating an unbiased, systematic approach to estimate neuronal identity of converted cells. Recent studies have demonstrated that long genes (>100 kb from transcription start to end) are highly enriched in neurons, which provides an opportunity to identify neurons based on the expression of these long genes.

Results: We have developed a versatile R package, LONGO, to analyze gene expression based on gene length. We propose …

Selective Inhibition Of The P38Α Mapk-Mk2 Axis Inhibits Inflammatory Cues Including Inflammasome Priming Signals, Chun Wang, Yael Alippe, Yousef Abu-Amer, Gabriel Mbalaviele, Et Al

Open Access Publications

p38α activation of multiple effectors may underlie the failure of global p38α inhibitors in clinical trials. A unique inhibitor (CDD-450) was developed that selectively blocked p38α activation of the proinflammatory kinase MK2 while sparing p38α activation of PRAK and ATF2. Next, the hypothesis that the p38α-MK2 complex mediates inflammasome priming cues was tested. CDD-450 had no effect on NLRP3 expression, but it decreased IL-1β expression by promoting IL-1β mRNA degradation. Thus, IL-1β is regulated not only transcriptionally by NF-κB and posttranslationally by the inflammasomes but also posttranscriptionally by p38α-MK2. CDD-450 also accelerated TNF-α and IL-6 mRNA decay, inhibited inflammation in …

Combination Anti-Aβ Treatment Maximizes Cognitive Recovery And Rebalances Mtor Signaling In App Mice, Angie C.A. Chiang, Stephanie W. Fowler, Ricky R. Savjani, Susan G. Hilsenbeck, Clare E. Wallace, John R. Cirrito, Pritam Das, Joanna L. Jankowsky

Open Access Publications

Drug development for Alzheimer's disease has endeavored to lower amyloid β (Aβ) by either blocking production or promoting clearance. The benefit of combining these approaches has been examined in mouse models and shown to improve pathological measures of disease over single treatment; however, the impact on cellular and cognitive functions affected by Aβ has not been tested. We used a controllable APP transgenic mouse model to test whether combining genetic suppression of Aβ production with passive anti-Aβ immunization improved functional outcomes over either treatment alone. Compared with behavior before treatment, arresting further Aβ production (but not passive immunization) was sufficient …

Altered Compensatory Cytokine Signaling Underlies The Discrepancy Between Flt3–/– And Flt3l–/– Mice, Vivek Durai, Prachi Bagadia, Carlos G. Briseño, Derek J. Theisen, Arifumi Iwata, Jesse T. Davidson, Marco Gargaro, Daved H. Fremont, Theresa L. Murphy, Kenneth M. Murphy

Open Access Publications

The receptor Flt3 and its ligand Flt3L are both critical for dendritic cell (DC) development, but DC deficiency is more severe in

Hypothalamic Sirt1 Protects Terminal Schwann Cells And Neuromuscular Junctions From Age‐Related Morphological Changes, Alison K. Snyder-Warwick, Akiko Satoh, Katherine B. Santosa, Shin-Ichiro Imai, Albina Jablonka-Shariff

Open Access Publications

No abstract provided.

Lifelong Reduction In Complex Iv Induces Tissue‐Specific Metabolic Effects But Does Not Reduce Lifespan Or Healthspan In Mice, Sathyaseelan S. Deepa, Gavin Pharaoh, Michael Kinter, Vivian Diaz, Wilson C. Fok, Kaitlyn Riddle, Daniel Pulliam, Shauna Hill, Kathleen E. Fischer, Vanessa Soto, Constantin Georgescu, Jonathan D. Wren, Carlo Viscomi, Arlan Richardson, Holly Van Remmen

Open Access Publications

No abstract provided.

Examining The Reversibility Of Long-Term Behavioral Disruptions In Progeny Of Maternal Ssri Exposure, Susan E. Maloney, Shyam Akula, Michael A. Rieger, Katherine B. Mccullough, Krystal Chandler, Adrian M. Corbett, Audrey E. Mcgowin, Joseph D. Dougherty

Open Access Publications

No abstract provided.

Inhibition Of Nitric Oxide Production In Activated Macrophages Caused By Toxoplasma Gondii Infection Occurs By Distinct Mechanisms In Different Mouse Macrophage Cell Lines, Gabriel R. De Abreu Cabral, Zi T. Wang, L. D. Sibley, Renato A. Damatta

Open Access Publications

No abstract provided.

Nitro-Fatty Acids Are Formed In Response To Virus Infection And Are Potent Inhibitors Of Sting Palmitoylation And Signaling, Cathrine A. Miner, Wei Qian, Jonathan J. Miner

Open Access Publications

No abstract provided.

Metabolic Importance Of Adipose Tissue Monoacylglycerol Acyltransferase 1 In Mice And Humans, Kim H. H. Liss, Andrew J. Lutkewitte, Terri Pietka, Brian N. Finck, Michael Franczyk, Jun Yoshino, Samuel Klein, Angela M. Hall

Open Access Publications

No abstract provided.

Autophagy Regulates Duox1 Localization And Superoxide Production In Airway Epithelial Cells During Chronic Il-13 Stimulation, John D. Dickinson, Jenea M. Sweeter, Kristi J. Warren, Iman M. Ahmad, Xavier De Deken, Matthew C. Zimmerman, Steven L. Brody

Open Access Publications

No abstract provided.

Genome Sequence Of Acetomicrobium Hydrogeniformans Os1, Lauren E. Cook, Spencer S. Gang, Alicia Ihlan, Matthew Maune, Ralph S. Tanner, Michael J. Mcinerney, George Weinstock, Elizabeth A. Lobos, Robert P. Gunsalus

Open Access Publications

No abstract provided.

Draft Genome Sequence Of A White Spot Syndrome Virus Isolate Obtained In Ecuador, Leda Restrepo, Alejandro Reyes, Leandro Bajaña, Irma Betancourt, Bonny Bayot

Open Access Publications

No abstract provided.

Structure-Function Analysis Of The Curli Accessory Protein Csge Defines Surfaces Essential For Coordinating Amyloid Fiber Formation, Roger D. Klein, Qin Shu, Zachary T. Cusumano, Kanna Nagamatsu, Nathaniel C. Gualberto, Aaron J.L. Lynch, Chao Wu, Wenjie Wang, Neha Jain, Jerome S. Pinkner, Gaya K. Amarasinghe, Scott J. Hultgren, Carl Frieden, Matthew R. Chapman

Open Access Publications

No abstract provided.

Immunosuppressants And Risk Of Parkinson Disease, Brad A. Racette, Anat Gross, Scott Martin Vouri, Alejandra Camacho-Soto, Allison W. Willis, Susan Searles Nielsen

Open Access Publications

No abstract provided.

The Acyl-Coa Synthetase, Pudgy, Promotes Sleep And Is Required For The Homeostatic Response To Sleep Deprivation, Matthew S. Thimgan, Natalie Kress, Josh Lisse, Courtney Fiebelman, Thomas Hilderbrand

Open Access Publications

No abstract provided.

The Endocannabinoid/Cannabinoid Receptor 2 System Protects Against Cisplatin-Induced Hearing Loss, Sumana Ghosh, Sandeep Sheth, Kelly Sheehan, Debashree Mukherjea, Asmita Dhukhwa, Vikrant Borse, Leonard P. Rybak, Vickram Ramkumar

Open Access Publications

No abstract provided.

Hepatocyte Aloxe3 Is Induced During Adaptive Fasting And Enhances Insulin Sensitivity By Activating Hepatic Pparγ, Cassandra B. Higgins, Yiming Zhang, Allyson L. Mayer, Hideji Fujiwara, Alicyn I. Stothard, Mark J. Graham, Benjamin M. Swarts, Brian J. Debosch

Open Access Publications

No abstract provided.

Mechanism Of High-Level Daptomycin Resistance In Corynebacterium Striatum, Nicholas K. Goldner, Christopher Bulow, Kevin Cho, Meghan Wallace, Fong-Fu Hsu, Gary J. Patti, Carey-Ann Burnham, Paul Schlesinger, Gautam Dantas

Open Access Publications

No abstract provided.

Application Of Machine Learning To Automated Analysis Of Cerebral Edema In Large Cohorts Of Ischemic Stroke Patients, Rajat Dhar, Yasheng Chen, Hongyu An, Jin-Moo Lee

Open Access Publications

No abstract provided.

Relationships Between Estimated Autozygosity And Complex Traits In The Uk Biobank, Emma C. Johnson, Luke M. Evans, Matthew C. Keller

Open Access Publications

No abstract provided.