Digital Commons Network^™

Comorbid Conditions Explain The Association Between Posttraumatic Stress Disorder And Incident Cardiovascular Disease, Jeffrey F. Scherrer, Joanne Salas, Beth E. Cohen, Paula P. Schnurr, F. David Schneider, Kathleen M. Chard, Peter Tuerk, Matthew J. Friedman, Sonya B. Norman, Carissa Van Den Berk-Clark, Patrick J. Lustman

Open Access Publications

No abstract provided.

First International Descriptive And Interventional Survey For Cholesterol And Non-Cholesterol Sterol Determination By Gas- And Liquid-Chromatography-Urgent Need For Harmonisation Of Analytical Methods, Dieter Lütjohann, Richard E. Ostlund, Et Al

Open Access Publications

No abstract provided.

Toward A Comprehensive View Of Cancer Immune Responsiveness: A Synopsis From The Sitc Workshop, Davide Bedognetti, David G. Denardo, Et Al

Open Access Publications

No abstract provided.

Multiplatform Urinary Metabolomics Profiling To Discriminate Cachectic From Non-Cachectic Colorectal Cancer Patients: Pilot Results From The Colocare Study, Jennifer Ose, Adetunji T Toriola, Et Al

Open Access Publications

Cachexia is a multifactorial syndrome that is characterized by loss of skeletal muscle mass in cancer patients. The biological pathways involved remain poorly characterized. Here, we compare urinary metabolic profiles in newly diagnosed colorectal cancer patients (stage I-IV) from the ColoCare Study in Heidelberg, Germany. Patients were classified as cachectic (

Regulation Of Rep Helicase Unwinding By An Auto-Inhibitory Subdomain, Monika A. Makuratha, Kevin D. Whitley, Binh Nguyen, Timothy M. Lohman, Yann R. Chemla

Open Access Publications

No abstract provided.

Sedentary Behaviors, Tv Viewing Time, And Risk Of Young-Onset Colorectal Cancer, Long H. Nguyen, Po-Hong Liu, Xiaobin Zheng, Nana Keum, Xiaoyu Zong, Xiao Li, Kana Wu, Charles S. Fuchs, Shuji Ogino, Kimmie Ng, Walter C. Willett, Andrew T. Chan, Edward L. Giovannucci, Yin Cao

Open Access Publications

No abstract provided.

N-Acyl-O-Phosphocholineserines: Structures Of A Novel Class Of Lipids That Are Biomarkers For Niemann-Pick C1 Disease, Rohini Sidhu, Yawo Mondjinou, Mingxing Qian, Fong-Fu Hsu, Dennis J. Dietzen, Jean E. Schaffer, Daniel S. Ory, Xuntian Jiang, Et Al.

Open Access Publications

No abstract provided.

Transcriptomic Analysis Of Enteropathy In Zambian Children With Severe Acute Malnutrition, Mubanga Chama, Beatrice C. Amadi, Kanta Chandwe, Kanekwa Zyambo, Ellen Besa, Nurmohammad Shaikh, I. Malick Ndao, Phillip I. Tarr, Chad Storer, Richard Head, Paul Kelly

Open Access Publications

No abstract provided.

The Role Of Membrane Excitability In Pancreatic Β-Cell Glucotoxicity, Zeenat A. Shyr, Zhiyu Wang, Nathaniel W. York, Colin G. Nichols, Maria S. Remedi

Open Access Publications

No abstract provided.

A Mixture Of U.S. Food And Drug Administration–Approved Monoaminergic Drugs Protects The Retina From Light Damage In Diverse Models Of Night Blindness, Henri Leinonen, Elliot H. Choi, Anthony Gardella, Vladimir J. Kefalov, Krzysztof Palczewski

Open Access Publications

No abstract provided.

Comparative Evaluation Of Enteric Bacterial Culture And A Molecular Multiplex Syndromic Panel In Children With Acute Gastroenteritis, Thomas Kellner, Brandon Parsons, Linda Chui, Byron M. Berenger, Jianling Xie, Carey-Ann D. Burnham, Phillip I. Tarr, Bonita E. Lee, Alberto Nettel-Aguirre, Jonas Szelewicki, Otto G. Vanderkooi, Xiao-Li Pang, Nathan Zelyas, Stephen B. Freedman, Alberta Provincial Pediatric Enteric Infection Team (Appetite)

Open Access Publications

No abstract provided.

Hif-Transcribed P53 Chaperones Hif-1Α, Esha Madan, Christopher J. Pelham, Et Al

Open Access Publications

No abstract provided.

Comparative Analysis Of Roseoloviruses In Humans, Pigs, Mice, And Other Species, Joachim Denner, Tarin M Bigley, Tuan L Phan, Cosima Zimmermann, Xiaofeng Zhou, Benedikt B Kaufer

Open Access Publications

Viruses of the genus

Viral Mhci Inhibition Evades Tissue-Resident Memory T Cell Formation And Responses, Elvin J. Lauron, Liping Yang, Ian B. Harvey, Dorothy K. Sojka, Graham D. Williams, Michael A. Paley, Michael D. Bern, Eugene Park, Francisco Victorino, Adrianus C.M. Boon, Wayne M. Yokoyama

Open Access Publications

Tissue-resident memory CD8

Regional Gene Repression By Dna Double-Strand Breaks In G1 Phase Cells, Caitlin E. Purman, Patrick L. Collins, Sofia I. Porter, Ankita Saini, Harshath Gupta, Barry P. Sleckman, Eugene M. Oltz

Open Access Publications

DNA damage responses (DDR) to double-strand breaks (DSBs) alter cellular transcription programs at the genome-wide level. Through processes that are less well understood, DSBs also alter transcriptional responses locally, which may be important for efficient DSB repair. Here, we developed an approach to elucidate the

Potential Role Of Gut Microbiota In Induction And Regulation Of Innate Immune Memory, Shikha Negi, Deepjyoti Kumar Das, Susanta Pahari, Sajid Nadeem, Javed N Agrewala

Open Access Publications

The gut microbiota significantly regulates the development and function of the innate and adaptive immune system. The attribute of immunological memory has long been linked only with adaptive immunity. Recent evidence indicates that memory is also present in the innate immune cells such as monocytes/macrophages and natural killer cells. These cells exhibit pattern recognition receptors (PRRs) that recognize microbe- or pathogen-associated molecular patterns (MAMPs or PAMPs) expressed by the microbes. Interaction between PRRs and MAMPs is quite crucial since it triggers the sequence of signaling events and epigenetic rewiring that not only play a cardinal role in modulating the activation …

Computational Search For Uv Radiation Resistance Strategies In Deinococcus Swuensis Isolated From Paramo Ecosystems, Jorge Díaz-Riaño, Leonardo Posada, Iván Camilo Acosta, Carlos Ruíz-Pérez, Catalina García-Castillo, Alejandro Reyes, María Mercedes Zambrano

Open Access Publications

Ultraviolet radiation (UVR) is widely known as deleterious for many organisms since it can cause damage to biomolecules either directly or indirectly via the formation of reactive oxygen species. The goal of this study was to analyze the capacity of high-mountain Espeletia hartwegiana plant phyllosphere microorganisms to survive UVR and to identify genes related to resistance strategies. A strain of Deinococcus swuensis showed a high survival rate of up to 60% after UVR treatment at 800J/m2 and was used for differential expression analysis using RNA-seq after exposing cells to 400J/m2 of UVR (with >95% survival rate). Differentially expressed genes were …

Mechanism Of Action Of Vp1-001 In Cryab(R120g)-Associated And Age-Related Cataracts, Kathleen S. Molnar, Bryan M. Dunyak, Bonnie Su, Yevgeniy Izrayelit, Brittney Mcglasson-Naumann, Paul D. Hamilton, Mingxing Qian, Douglas F. Covey, Jason E. Gestwicki, Leah N. Makley, Usha P. Andley

Open Access Publications

No abstract provided.

Epigenetic Dysregulation Of Enhancers In Neurons Is Associated With Alzheimer’S Disease Pathology And Cognitive Symptoms, Peipei Li, Lee Marshall, Gabriel Oh, Jennifer L. Jakubowski, Daniel Groot, Yu He, Ting Wang, Arturas Petronis, Viviane Labrie

Open Access Publications

No abstract provided.

Clinical Outcomes With Neoadjuvant Versus Adjuvant Chemotherapy For Triple Negative Breast Cancer: A Report From The National Cancer Database, Nusayba A Bagegni, Yu Tao, Foluso O Ademuyiwa

Open Access Publications

PURPOSE: Triple negative breast cancer (TNBC) patients frequently receive neoadjuvant chemotherapy (NAC). Only 50% will achieve pathological complete response (pCR). In this retrospective study, we evaluated TNBC outcomes with NAC vs. AC.

METHODS: Patients with stages II and III TNBC treated with NAC or AC between 2010 and 2013 were identified from the National Cancer Database. Baseline characteristics were compared with χ2 and two sample t tests. Kaplan-Meier survival analyses were computed in patients treated with NAC or AC, and log-rank tests used to examine differences. Unadjusted analyses of trends in proportions over time were performed using Cochran-Armitage tests. Log-binomial …

Lncrna Malat1 Gene Polymorphisms In Coronary Artery Disease: A Case-Control Study In A Chinese Population, Weina Hu, Hanxi Ding, An Ouyang, Xiaohong Zhang, Qian Xu, Yunan Han, Xueying Zhang, Yuanzhe Jin

Open Access Publications

No abstract provided.

The Peptide Hormone Adropin Regulates Signal Transduction Pathways Controlling Hepatic Glucose Metabolism In A Mouse Model Of Diet-Induced Obesity, Su Gao, Sarbani Ghoshal, Liyan Zhang, Joseph R. Stevens, Kyle S. Mccommis, Brian N. Finck, Gary D. Lopaschuk, Andrew A. Butler

Open Access Publications

No abstract provided.

Mapping Brain Function During Naturalistic Viewing Using High-Density Diffuse Optical Tomography, Andrew K. Fishell, Tracy M. Burns-Yocum, Karla M. Bergonzi, Adam T. Eggebrecht, Joseph P. Culver

Open Access Publications

No abstract provided.

Serendipity: Decitabine Monotherapy Induced Complete Molecular Response In A 77-Year-Old Patient With Acute Promyelocytic Leukemia, Ramzi Abboud, Se Young Han, Eric J. Duncavage, Amanda F. Cashen, Cara Lunn Shirai, John S. Welch, John F. Dipersio, Camille N. Abboud

Open Access Publications

No abstract provided.

Pain Inhibits Grpr Neurons Via Gabaergic Signaling In The Spinal Cord, Rita Bardoni, Kai-Feng Shen, Hui Li, Joseph Jeffry, Devin M. Barry, Antonella Comitato, Yun-Qing Li, Zhou-Feng Chen

Open Access Publications

No abstract provided.

Adaptation Of Translational Machinery In Malaria Parasites To Accommodate Translation Of Poly-Adenosine Stretches Throughout Its Life Cycle, Jessey Erath, Sergej Djuranovic, Slavica Pavlovic Djuranovic

Open Access Publications

Malaria is caused by unicellular apicomplexan parasites of the genus

Neuroinflammation And White Matter Alterations In Obesity Assessed By Diffusion Basis Spectrum Imaging, Amjad Samara, Tatianna Murphy, Jeremy Strain, Jerrel Rutlin, Peng Sun, Olga Neyman, Nitya Sreevalsan, Joshua S Shimony, Beau M Ances, Sheng-Kwei Song, Tamara Hershey, Sarah A Eisenstein

Open Access Publications

Human obesity is associated with low-grade chronic systemic inflammation, alterations in brain structure and function, and cognitive impairment. Rodent models of obesity show that high-calorie diets cause brain inflammation (neuroinflammation) in multiple regions, including the hippocampus, and impairments in hippocampal-dependent memory tasks. To determine if similar effects exist in humans with obesity, we applied Diffusion Basis Spectrum Imaging (DBSI) to evaluate neuroinflammation and axonal integrity. We examined diffusion-weighted magnetic resonance imaging (MRI) data in two independent cohorts of obese and non-obese individuals (Cohort 1: 25 obese/21 non-obese; Cohort 2: 18 obese/41 non-obese). We applied Tract-based Spatial Statistics (TBSS) to allow …

Quantitative 18f-Av1451 Brain Tau Pet Imaging In Cognitively Normal Older Adults, Mild Cognitive Impairment, And Alzheimer's Disease Patients, Qian Zhao, Min Liu, Lingxia Ha, Yun Zhou, Alzheimer's Disease Neuroimaging Initiative

Open Access Publications

No abstract provided.

The Spectrum Of Bladder Health: The Relationship Between Lower Urinary Tract Symptoms And Interference With Activities, Siobhan Sutcliffe, Tamara Bavendam, Charles Cain, Neill Epperson, Colleen M. Fitzgerald, Sheila Gahagan, Alayne D. Markland, David A. Shoham, Ariana L. Smith, Mary K. Townsend, Kyle Rudser, Prevention Of Lower Urinary Tract Symptoms Research Consortium

Open Access Publications

No abstract provided.

Clostridium Difficile Infection Increases Acute And Chronic Morbidity And Mortality, Margaret A. Olsen, Dustin Stwalley, Clarisse Demont, Erik R. Dubberke

Open Access Publications

No abstract provided.