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Articles 9841 - 9870 of 11655
Full-Text Articles in Entire DC Network
Early Toxicity Predicts Long-Term Survival In High-Grade Glioma, Yaacov R. Lawrence, Meihua Wang, Adam Paul Dicker, David W. Andrews, Walter John Curran, Jeff Michael Michalski, Luis Souhami, Alfred K. Yung, Minesh Mehta
Early Toxicity Predicts Long-Term Survival In High-Grade Glioma, Yaacov R. Lawrence, Meihua Wang, Adam Paul Dicker, David W. Andrews, Walter John Curran, Jeff Michael Michalski, Luis Souhami, Alfred K. Yung, Minesh Mehta
Open Access Publications
No abstract provided.
Long-Term Effects Of Multiple Glucocorticoid Exposures In Neonatal Mice, Susan E. Maloney, Kevin K. Noguchi, David F. Wozniak, Stephen C. Fowler, Nuri B. Farber
Long-Term Effects Of Multiple Glucocorticoid Exposures In Neonatal Mice, Susan E. Maloney, Kevin K. Noguchi, David F. Wozniak, Stephen C. Fowler, Nuri B. Farber
Open Access Publications
No abstract provided.
Genomic And Metabolic Profiling Of Nonulosonic Acids In Vibrionaceae Reveal Biochemical Phenotypes Of Allelic Divergence In Vibrio Vulnificus, Amanda L. Lewis, Jean-Bernard Lubin, Shilpa Argade, Natasha Naidu, Biswa Choudhury, E. Fidelma Boyd
Genomic And Metabolic Profiling Of Nonulosonic Acids In Vibrionaceae Reveal Biochemical Phenotypes Of Allelic Divergence In Vibrio Vulnificus, Amanda L. Lewis, Jean-Bernard Lubin, Shilpa Argade, Natasha Naidu, Biswa Choudhury, E. Fidelma Boyd
Open Access Publications
No abstract provided.
Card: A New Rna Polymerase Modulator In Mycobacteria, Christina L. Stallings, Michael S. Glickman
Card: A New Rna Polymerase Modulator In Mycobacteria, Christina L. Stallings, Michael S. Glickman
Open Access Publications
No abstract provided.
Calling Cards Enable Multiplexed Identification Of The Genomic Targets Of Dna-Binding Proteins, Haoyi Wang, David Mayhew, Xuhua Chen, Mark Johnston, Robi David Mitra
Calling Cards Enable Multiplexed Identification Of The Genomic Targets Of Dna-Binding Proteins, Haoyi Wang, David Mayhew, Xuhua Chen, Mark Johnston, Robi David Mitra
Open Access Publications
No abstract provided.
Plasticity In Patterns Of Histone Modifications And Chromosomal Proteins In Drosophila Heterochromatin, Nicole C. Riddle, Sarah C.R. Elgin, Et Al
Plasticity In Patterns Of Histone Modifications And Chromosomal Proteins In Drosophila Heterochromatin, Nicole C. Riddle, Sarah C.R. Elgin, Et Al
Open Access Publications
No abstract provided.
Cd103+ Pulmonary Dendritic Cells Preferentially Acquire And Present Apoptotic Cell-Associated Antigen, A Nicole Desch, Gwendalyn J. Randolph, Kenneth Murphy, Emmanuel L. Gautier, Ross M. Kedl, Mireille H. Lahoud, Irina Caminschi, Ken Shortman, Peter M. Henson, Claudia V. Jakubzick
Cd103+ Pulmonary Dendritic Cells Preferentially Acquire And Present Apoptotic Cell-Associated Antigen, A Nicole Desch, Gwendalyn J. Randolph, Kenneth Murphy, Emmanuel L. Gautier, Ross M. Kedl, Mireille H. Lahoud, Irina Caminschi, Ken Shortman, Peter M. Henson, Claudia V. Jakubzick
Open Access Publications
Cells undergoing programmed cell death (apoptosis) are removed in situ by macrophages and dendritic cells (DCs) through a specialized form of phagocytosis (efferocytosis). In the lung, there are two primary DC subsets with the potential to migrate to the local lymph nodes (LNs) and initiate adaptive immune responses. In this study, we show that only CD103(+) DCs were able to acquire and transport apoptotic cells to the draining LNs and cross present apoptotic cell-associated antigen to CD8 T cells. In contrast, both the CD11b(hi) and the CD103(+) DCs were able to ingest and traffic latex beads or soluble antigen. CD103(+) …
Type I Interferon Is Selectively Required By Dendritic Cells For Immune Rejection Of Tumors, Mark S. Diamond, Michelle Kinder, Hirokazu Matsushita, Mona Mashayekhi, Gavin P. Dunn, Jessica M. Archambault, Hsiaoju Lee, Cora D. Arthur, J Michael White, Ulrich Kalinke, Kenneth M. Murphy, Robert D. Schreiber
Type I Interferon Is Selectively Required By Dendritic Cells For Immune Rejection Of Tumors, Mark S. Diamond, Michelle Kinder, Hirokazu Matsushita, Mona Mashayekhi, Gavin P. Dunn, Jessica M. Archambault, Hsiaoju Lee, Cora D. Arthur, J Michael White, Ulrich Kalinke, Kenneth M. Murphy, Robert D. Schreiber
Open Access Publications
Cancer immunoediting is the process whereby the immune system suppresses neoplastic growth and shapes tumor immunogenicity. We previously reported that type I interferon (IFN-α/β) plays a central role in this process and that hematopoietic cells represent critical targets of type I IFN's actions. However, the specific cells affected by IFN-α/β and the functional processes that type I IFN induces remain undefined. Herein, we show that type I IFN is required to initiate the antitumor response and that its actions are temporally distinct from IFN-γ during cancer immunoediting. Using mixed bone marrow chimeric mice, we demonstrate that type I IFN sensitivity …
Bop5 Mutations Reveal New Roles For The Ic138 Phosphoprotein In The Regulation Of Flagellar Motility And Asymmetric Waveforms, Kristyn E. Vanderwaal, Ryosuke Yamamoto, Ken-Ichi Wakabayashi, Laura Fox, Ritsu Kamiya, Susan K. Dutcher, Phillip V. Bayly, Winfield S. Sale, Mary E. Porter
Bop5 Mutations Reveal New Roles For The Ic138 Phosphoprotein In The Regulation Of Flagellar Motility And Asymmetric Waveforms, Kristyn E. Vanderwaal, Ryosuke Yamamoto, Ken-Ichi Wakabayashi, Laura Fox, Ritsu Kamiya, Susan K. Dutcher, Phillip V. Bayly, Winfield S. Sale, Mary E. Porter
Open Access Publications
No abstract provided.
Procurement Of Human Tissues For Research Banking In The Surgical Pathology Laboratory: Prioritization Practices At Washington University Medical Center, Sandra A. Mcdonald, Rebecca D. Chernock, Tracey A. Leach, Ajaz A. Kahn, James H. Yip, Joan Rossi, John D. Pfeifer
Procurement Of Human Tissues For Research Banking In The Surgical Pathology Laboratory: Prioritization Practices At Washington University Medical Center, Sandra A. Mcdonald, Rebecca D. Chernock, Tracey A. Leach, Ajaz A. Kahn, James H. Yip, Joan Rossi, John D. Pfeifer
Open Access Publications
No abstract provided.
Cell Wall Chitosan Is Necessary For Virulence In The Opportunistic Pathogen Cryptococcus Neoformans, Lorina G. Baker, Charles A. Specht, Jennifer K. Lodge
Cell Wall Chitosan Is Necessary For Virulence In The Opportunistic Pathogen Cryptococcus Neoformans, Lorina G. Baker, Charles A. Specht, Jennifer K. Lodge
Open Access Publications
No abstract provided.
Do Shared Etiological Factors Contribute To The Relationship Between Sexual Orientation And Depression?, B. P. Zietsch, K. J H Verweij, A. C. Heath, P. A F Madden, N. G. Martin, E. C. Nelson, M. T. Lynskey
Do Shared Etiological Factors Contribute To The Relationship Between Sexual Orientation And Depression?, B. P. Zietsch, K. J H Verweij, A. C. Heath, P. A F Madden, N. G. Martin, E. C. Nelson, M. T. Lynskey
Open Access Publications
No abstract provided.
An Evolutionary Genomic Approach To Identify Genes Involved In Human Birth Timing, Jevon Plunkett, Scott Doniger, Guilherme Orabona, Thomas Morgan, Ritva Haataja, Mikko Hallman, Hilkka Puttonen, Ramkumar Menon, Edward Kuczynski, Errol Norwitz, Victoria Snegovskikh, Aarno Palotie, Leena Peltonen, Vineta Fellman, Emily A. Defranco, Bimal P. Chaudhari, Tracy L. Mcgregor, Jude J. Mcelroy, Matthew T. Oetjens, Kari Teramo, Ingrid Borecki, Justin Fay, Louis Muglia
An Evolutionary Genomic Approach To Identify Genes Involved In Human Birth Timing, Jevon Plunkett, Scott Doniger, Guilherme Orabona, Thomas Morgan, Ritva Haataja, Mikko Hallman, Hilkka Puttonen, Ramkumar Menon, Edward Kuczynski, Errol Norwitz, Victoria Snegovskikh, Aarno Palotie, Leena Peltonen, Vineta Fellman, Emily A. Defranco, Bimal P. Chaudhari, Tracy L. Mcgregor, Jude J. Mcelroy, Matthew T. Oetjens, Kari Teramo, Ingrid Borecki, Justin Fay, Louis Muglia
Open Access Publications
No abstract provided.
Dynamic Analysis Of Amyloid Β-Protein In Behaving Mice Reveals Opposing Changes In Isf Versus Parenchymal Aβ During Age-Related Plaque Formation, Soyon Hong, Omar Quintero-Monzon, Beth L. Ostaszewski, Daniel R. Podlisny, William T. Cavanaugh, Ting Yang, David M. Holtzman, John R. Cirrito, Dennis J. Selkoe
Dynamic Analysis Of Amyloid Β-Protein In Behaving Mice Reveals Opposing Changes In Isf Versus Parenchymal Aβ During Age-Related Plaque Formation, Soyon Hong, Omar Quintero-Monzon, Beth L. Ostaszewski, Daniel R. Podlisny, William T. Cavanaugh, Ting Yang, David M. Holtzman, John R. Cirrito, Dennis J. Selkoe
Open Access Publications
No abstract provided.
Micrornas Modulate Schwann Cell Response To Nerve Injury By Reinforcing Transcriptional Silencing Of Dedifferentiation-Related Genes, Andreu Viader, Li-Wei Chang, Timothy Fahrner, Rakesh Nagarajan, Jeffrey Milbrandt
Micrornas Modulate Schwann Cell Response To Nerve Injury By Reinforcing Transcriptional Silencing Of Dedifferentiation-Related Genes, Andreu Viader, Li-Wei Chang, Timothy Fahrner, Rakesh Nagarajan, Jeffrey Milbrandt
Open Access Publications
No abstract provided.
Behavioral State Modulates The Activity Of Brainstem Sensorimotor Neurons, Kimberly L. Mcarthur, J. David Dickman
Behavioral State Modulates The Activity Of Brainstem Sensorimotor Neurons, Kimberly L. Mcarthur, J. David Dickman
Open Access Publications
No abstract provided.
A Clustering Analysis Of Lipoprotein Diameters In The Metabolic Syndrome, Alexis C. Frazier-Wood, Stephen Glasser, W Timothy Garvey, Edmond K. Kabagambe, Ingrid B. Borecki, Hemant K. Tiwari, Michael Y. Tsai, Paul N. Hopkins, Jose M. Ordovas, Donna K. Arnett
A Clustering Analysis Of Lipoprotein Diameters In The Metabolic Syndrome, Alexis C. Frazier-Wood, Stephen Glasser, W Timothy Garvey, Edmond K. Kabagambe, Ingrid B. Borecki, Hemant K. Tiwari, Michael Y. Tsai, Paul N. Hopkins, Jose M. Ordovas, Donna K. Arnett
Open Access Publications
No abstract provided.
Resorufin Analogs Preferentially Bind Cerebrovascular Amyloid: Potential Use As Imaging Ligands For Cerebral Amyloid Angiopathy, Byung Hee Han, Meng-Liang Zhou, Ananth K. Vellimana, Eric Milner, David H. Kim, Jacob K. Greenberg, Wenhua Chu, Robert H. Mach, Gregory J. Zipfel
Resorufin Analogs Preferentially Bind Cerebrovascular Amyloid: Potential Use As Imaging Ligands For Cerebral Amyloid Angiopathy, Byung Hee Han, Meng-Liang Zhou, Ananth K. Vellimana, Eric Milner, David H. Kim, Jacob K. Greenberg, Wenhua Chu, Robert H. Mach, Gregory J. Zipfel
Open Access Publications
No abstract provided.
Type I Interferon Negatively Controls Plasmacytoid Dendritic Cell Numbers In Vivo, Melissa Swiecki, Yaming Wang, William Vermi, Susan Gilfillan, Robert D. Schreiber, Marco Colonna
Type I Interferon Negatively Controls Plasmacytoid Dendritic Cell Numbers In Vivo, Melissa Swiecki, Yaming Wang, William Vermi, Susan Gilfillan, Robert D. Schreiber, Marco Colonna
Open Access Publications
No abstract provided.
Memory B Cells, But Not Long-Lived Plasma Cells, Possess Antigen Specificities For Viral Escape Mutants, Whitney E. Purtha, Thomas F. Tedder, Syd Johnson, Deepta Bhattacharya, Michael S. Diamond
Memory B Cells, But Not Long-Lived Plasma Cells, Possess Antigen Specificities For Viral Escape Mutants, Whitney E. Purtha, Thomas F. Tedder, Syd Johnson, Deepta Bhattacharya, Michael S. Diamond
Open Access Publications
No abstract provided.
Midazolam Inhibits Hippocampal Long-Term Potentiation And Learning Through Dual Central And Peripheral Benzodiazepine Receptor Activation And Neurosteroidogenesis, Kazuhiro Tokuda, Kazuko A. O'Dell, Yukitoshi Izumi, Charles F. Zorumski
Midazolam Inhibits Hippocampal Long-Term Potentiation And Learning Through Dual Central And Peripheral Benzodiazepine Receptor Activation And Neurosteroidogenesis, Kazuhiro Tokuda, Kazuko A. O'Dell, Yukitoshi Izumi, Charles F. Zorumski
Open Access Publications
Benzodiazepines (BDZs) enhance GABA(A) receptor inhibition by direct actions on central BDZ receptors (CBRs). Although some BDZs also bind mitochondrial receptors [translocator protein (18 kDa) (TSPO)] and promote the synthesis of GABA-enhancing neurosteroids, the role of neurosteroids in the clinical effects of BDZs is unknown. In rat hippocampal slices, we compared midazolam, an anesthetic BDZ, with clonazepam, an anticonvulsant/anxiolytic BDZ that activates CBRs selectively. Midazolam, but not clonazepam, increased neurosteroid levels in CA1 pyramidal neurons without changing TSPO immunostaining. Midazolam, but not clonazepam, also augmented a form of spike inhibition after stimulation adjacent to the pyramidal cell layer and inhibited …
Golgi Cells Operate As State-Specific Temporal Filters At The Input Stage Of The Cerebellar Cortex, Shane A. Heine, Stephen M. Highstein, Pablo M. Blazquez
Golgi Cells Operate As State-Specific Temporal Filters At The Input Stage Of The Cerebellar Cortex, Shane A. Heine, Stephen M. Highstein, Pablo M. Blazquez
Open Access Publications
Cerebellar processing of incoming information begins at the synapse between mossy fibers and granule cells, a synapse that is strongly controlled through Golgi cell inhibition. Thus, Golgi cells are uniquely positioned to control the flow of information into the cerebellar cortex and understanding their responses during behavior is essential to understanding cerebellar function. Here we show, for the first time, that Golgi cells express a unique oculomotor-related signal that can be used to provide state- and time-specific filtering of granule cell activity. We used newly established criteria to identify the unique electrophysiological signature of Golgi cells and recorded these neurons …
The Contraceptive Choice Project: Recruiting Women At Highest Risk For Unintended Pregnancy And Sexually Transmitted Infection, Janine E. Spain, Jeffrey F. Peipert, Tessa Madden, Jenifer E. Allsworth, Gina M. Secura
The Contraceptive Choice Project: Recruiting Women At Highest Risk For Unintended Pregnancy And Sexually Transmitted Infection, Janine E. Spain, Jeffrey F. Peipert, Tessa Madden, Jenifer E. Allsworth, Gina M. Secura
Open Access Publications
No abstract provided.
Symptomatic Progression Of Asymptomatic Rotator Cuff Tears A Prospective Study Of Clinical And Sonographic Variables, Nathan A. Mall, H. Mike Kim, Jay D. Keener, Karen Steger-May, Sharlene A. Teefey, William D. Middleton, Georgia Stobbs, Ken Yamaguchi
Symptomatic Progression Of Asymptomatic Rotator Cuff Tears A Prospective Study Of Clinical And Sonographic Variables, Nathan A. Mall, H. Mike Kim, Jay D. Keener, Karen Steger-May, Sharlene A. Teefey, William D. Middleton, Georgia Stobbs, Ken Yamaguchi
Open Access Publications
No abstract provided.
Membrane Anchoring Subunits Specify Selective Regulation Of Rgs9·Gbeta5 Gap Complex In Photoreceptor Neurons, Yan Cao, Alexander V. Kolesnikov, Ikuo Masuho, Vladimir J. Kefalov, Kirill A. Martemyanov
Membrane Anchoring Subunits Specify Selective Regulation Of Rgs9·Gbeta5 Gap Complex In Photoreceptor Neurons, Yan Cao, Alexander V. Kolesnikov, Ikuo Masuho, Vladimir J. Kefalov, Kirill A. Martemyanov
Open Access Publications
The RGS9·Gβ5 complex is the key regulator of neuronal G-protein signaling and shows remarkable selectivity of subunit composition. In retinal photoreceptors, RGS9·Gβ5 is bound to the membrane anchor R9AP and the complex regulates visual signaling. In the basal ganglia neurons, RGS9·Gβ5 is instead associated with a homologous protein, R7BP, and regulates reward circuit. Switching this selective subunit composition of the complex in rod photoreceptors allowed us to study the molecular underpinning of signaling specificity in diverse G-protein pathways. We have found that both membrane anchoring subunits play a conserved role in regulating protein levels of RGS9·Gβ5 and enhancing the ability …
Report From The 2009 Aoa North American Traveling Fellowship, Ryan T. Bicknell, Gregory J. Della Rocca, Wellington K. Hsu, Amanda D. Marshall, Robert H. Brophy
Report From The 2009 Aoa North American Traveling Fellowship, Ryan T. Bicknell, Gregory J. Della Rocca, Wellington K. Hsu, Amanda D. Marshall, Robert H. Brophy
Open Access Publications
No abstract provided.
Protein Turnover Of The Wallenda/Dlk Kinase Regulates A Retrograde Response To Axonal Injury, Xin Xiong, Xin Wang, Ronny Ewanek, Pavan Bhat, Aaron Diantonio, Catherine A. Collins
Protein Turnover Of The Wallenda/Dlk Kinase Regulates A Retrograde Response To Axonal Injury, Xin Xiong, Xin Wang, Ronny Ewanek, Pavan Bhat, Aaron Diantonio, Catherine A. Collins
Open Access Publications
No abstract provided.
What's New In Spine Surgery, Keith H. Bridwell, Paul A. Anderson, Scott D. Boden, Alexander R. Vaccaro, Jeffrey C. Wang
What's New In Spine Surgery, Keith H. Bridwell, Paul A. Anderson, Scott D. Boden, Alexander R. Vaccaro, Jeffrey C. Wang
Open Access Publications
No abstract provided.
Age-Related Deterioration Of Rod Vision In Mice, Alexander V. Kolesnikov, Jie Fan, Rosalie K. Crouch, Vladimir J. Kefalov
Age-Related Deterioration Of Rod Vision In Mice, Alexander V. Kolesnikov, Jie Fan, Rosalie K. Crouch, Vladimir J. Kefalov
Open Access Publications
Even in healthy individuals, aging leads to deterioration in visual acuity, contrast sensitivity, visual field, and dark adaptation. Little is known about the neural mechanisms that drive the age-related changes of the retina and, more specifically, photoreceptors. According to one hypothesis, the age-related deterioration in rod function is due to the limited availability of 11-cis-retinal for rod pigment formation. To determine how aging affects rod photoreceptors and to test the retinoid-deficiency hypothesis, we compared the morphological and functional properties of rods of adult and aged B6D2F1/J mice. We found that the number of rods and the length of their outer …
Combined Hip Arthroscopy And Limited Open Osteochondroplasty For Anterior Femoroacetabular Impingement, John C. Clohisy, Lukas P. Zebala, Jeffrey J. Nepple, Gail Pashos
Combined Hip Arthroscopy And Limited Open Osteochondroplasty For Anterior Femoroacetabular Impingement, John C. Clohisy, Lukas P. Zebala, Jeffrey J. Nepple, Gail Pashos
Open Access Publications
No abstract provided.