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The Circadian Neuropeptide Pdf Signals Preferentially Through A Specific Adenylate Cyclase Isoform Ac3 In M Pacemakers Of Drosophila, Laura B. Duvall, Paul H. Taghert Jan 2012

The Circadian Neuropeptide Pdf Signals Preferentially Through A Specific Adenylate Cyclase Isoform Ac3 In M Pacemakers Of Drosophila, Laura B. Duvall, Paul H. Taghert

Open Access Publications

No abstract provided.


Proteasome-Dependent Disruption Of The E3 Ubiquitin Ligase Anaphase-Promoting Complex By Hcmv Protein Pul21a, Anthony R. Fehr, Nathaniel C. Gualberto, John Paul Savaryn, Scott S. Terhune, Dong Yu Jan 2012

Proteasome-Dependent Disruption Of The E3 Ubiquitin Ligase Anaphase-Promoting Complex By Hcmv Protein Pul21a, Anthony R. Fehr, Nathaniel C. Gualberto, John Paul Savaryn, Scott S. Terhune, Dong Yu

Open Access Publications

No abstract provided.


Chemokine Gpcr Signaling Inhibits Beta-Catenin During Zebrafish Axis Formation, Shu-Yu Wu, Jimann Shin, Diane S. Sepich, Lilianna Solnica-Krezel Jan 2012

Chemokine Gpcr Signaling Inhibits Beta-Catenin During Zebrafish Axis Formation, Shu-Yu Wu, Jimann Shin, Diane S. Sepich, Lilianna Solnica-Krezel

Open Access Publications

No abstract provided.


Fatty Acid Oxidation Is Essential For Egg Production By The Parasitic Flatworm Schistosoma Mansoni, Stanley Ching-Cheng Huang, Tori C. Freitas, Eyal Amiel, Bart Everts, Erika L. Pearce, James B. Lok, Edward J. Pearce Jan 2012

Fatty Acid Oxidation Is Essential For Egg Production By The Parasitic Flatworm Schistosoma Mansoni, Stanley Ching-Cheng Huang, Tori C. Freitas, Eyal Amiel, Bart Everts, Erika L. Pearce, James B. Lok, Edward J. Pearce

Open Access Publications

No abstract provided.


Structural Basis Of Differential Neutralization Of Denv-1 Genotypes By An Antibody That Recognizes A Cryptic Epitope, S. Kyle Austin, Kimberly A. Dowd, Bimmi Shrestha, Christopher A. Nelson, Melissa A. Edeling, Syd Johnson, Theodore C. Pierson, Michael S. Diamond, Daved H. Fremont Jan 2012

Structural Basis Of Differential Neutralization Of Denv-1 Genotypes By An Antibody That Recognizes A Cryptic Epitope, S. Kyle Austin, Kimberly A. Dowd, Bimmi Shrestha, Christopher A. Nelson, Melissa A. Edeling, Syd Johnson, Theodore C. Pierson, Michael S. Diamond, Daved H. Fremont

Open Access Publications

No abstract provided.


Chfr Is Important For The First Wave Of Ubiquitination At Dna Damage Sites, Chao Liu, Jiaxue Wu, Sharad C. Paudyal, Zhongsheng You, Xiaochun Yu Jan 2012

Chfr Is Important For The First Wave Of Ubiquitination At Dna Damage Sites, Chao Liu, Jiaxue Wu, Sharad C. Paudyal, Zhongsheng You, Xiaochun Yu

Open Access Publications

No abstract provided.


Whole Genome Sequence Of Treponema Pallidum Ssp. Pallidum, Strain Mexico A, Suggests Recombination Between Yaws And Syphilis Strains, Helena Petrosova, Maria Zobanikova, Darina Cejkova, Lenka Mikalova, Petra Pospisilova, Michal Strouhal, Lei Chen, Xiang Qin, Donna M. Muzny, George M. Weinstock, David Smajs Jan 2012

Whole Genome Sequence Of Treponema Pallidum Ssp. Pallidum, Strain Mexico A, Suggests Recombination Between Yaws And Syphilis Strains, Helena Petrosova, Maria Zobanikova, Darina Cejkova, Lenka Mikalova, Petra Pospisilova, Michal Strouhal, Lei Chen, Xiang Qin, Donna M. Muzny, George M. Weinstock, David Smajs

Open Access Publications

No abstract provided.


Novel Modeling Of Combinatorial Mirna Targeting Identifies Snp With Potential Role In Bone Density, Claudia Coronnello, Ryan Hartmaier, Arshi Arora, Luai Huleihel, Kusum V. Padit, Abha S. Bais, Michael Butterworth, Naftali Kaminski, Gary D. Stormo, Steffi Oesterreich, Panayiotis V. Benos Jan 2012

Novel Modeling Of Combinatorial Mirna Targeting Identifies Snp With Potential Role In Bone Density, Claudia Coronnello, Ryan Hartmaier, Arshi Arora, Luai Huleihel, Kusum V. Padit, Abha S. Bais, Michael Butterworth, Naftali Kaminski, Gary D. Stormo, Steffi Oesterreich, Panayiotis V. Benos

Open Access Publications

No abstract provided.


Actin Cap Associated Focal Adhesions And Their Distinct Role In Cellular Mechanosensing, Dong-Hwee Kim, Shyam B. Khatau, Yunfeng Feng, Sam Walcott, Sean X. Sun, Gregory D. Longmore, Denis Wirtz Jan 2012

Actin Cap Associated Focal Adhesions And Their Distinct Role In Cellular Mechanosensing, Dong-Hwee Kim, Shyam B. Khatau, Yunfeng Feng, Sam Walcott, Sean X. Sun, Gregory D. Longmore, Denis Wirtz

Open Access Publications

No abstract provided.


Unraveling The Genetic Etiology Of Adult Antisocial Behavior: A Genome-Wide Association Study, Jorim J. Tielbeek, Sarah E. Medland, Beben Benyamin, Enda M. Byrne, Andrew C. Heath, Pamela A. F. Madden, Nicholas G. Martin, Naomi R. Wray, Karin J. H. Verweij Jan 2012

Unraveling The Genetic Etiology Of Adult Antisocial Behavior: A Genome-Wide Association Study, Jorim J. Tielbeek, Sarah E. Medland, Beben Benyamin, Enda M. Byrne, Andrew C. Heath, Pamela A. F. Madden, Nicholas G. Martin, Naomi R. Wray, Karin J. H. Verweij

Open Access Publications

No abstract provided.


Absence Of Ca2+-Stimulated Adenylyl Cyclases Leads To Reduced Synaptic Plasticity And Impaired Experience-Dependent Fear Memory, L. Wieczorek, D. Majumdar, T. A. Wills, L. Hu, D. G. Winder, D. J. Webb, L. J. Muglia Jan 2012

Absence Of Ca2+-Stimulated Adenylyl Cyclases Leads To Reduced Synaptic Plasticity And Impaired Experience-Dependent Fear Memory, L. Wieczorek, D. Majumdar, T. A. Wills, L. Hu, D. G. Winder, D. J. Webb, L. J. Muglia

Open Access Publications

No abstract provided.


Deciphering A Global Network Of Functionally Associated Post-Translational Modifications, Pablo Minguez, Luca Parca, Francesca Diella, Daniel R. Mende, Runjun Kumar, Manuela Helmer-Citterich, Anne-Claude Gavin, Vera Van Noort, Peer Bork Jan 2012

Deciphering A Global Network Of Functionally Associated Post-Translational Modifications, Pablo Minguez, Luca Parca, Francesca Diella, Daniel R. Mende, Runjun Kumar, Manuela Helmer-Citterich, Anne-Claude Gavin, Vera Van Noort, Peer Bork

Open Access Publications

No abstract provided.


The Distinct Roles Of The Nucleus And Nucleus-Cytoskeleton Connections In Three-Dimensional Cell Migration, Shyam B. Khatau, Ryan J. Bloom, Saumendra Bajpai, David Razafsky, Shu Zhang, Anjil Giri, Pei-Hsun Wu, Jorge Marchand, Alfredo Celedon, Christopher M. Hale, Sean X. Sun, Didier Hodzic, Denis Wirtz Jan 2012

The Distinct Roles Of The Nucleus And Nucleus-Cytoskeleton Connections In Three-Dimensional Cell Migration, Shyam B. Khatau, Ryan J. Bloom, Saumendra Bajpai, David Razafsky, Shu Zhang, Anjil Giri, Pei-Hsun Wu, Jorge Marchand, Alfredo Celedon, Christopher M. Hale, Sean X. Sun, Didier Hodzic, Denis Wirtz

Open Access Publications

No abstract provided.


Ubiquitination And Degradation Of The Hominoid- Specific Oncoprotein Tbc1d3 Is Mediated By Cul7 E3 Ligase, Chen Kong, Dmitri Samovski, Priya Srikanth, Marisa J. Wainszelbaum, Audra J. Charron, Jialiu Liu, Jeffrey J. Lange, Pin-I Chen, Zhen-Qiang Pan, Xiong Su, Philip D. Stahl Jan 2012

Ubiquitination And Degradation Of The Hominoid- Specific Oncoprotein Tbc1d3 Is Mediated By Cul7 E3 Ligase, Chen Kong, Dmitri Samovski, Priya Srikanth, Marisa J. Wainszelbaum, Audra J. Charron, Jialiu Liu, Jeffrey J. Lange, Pin-I Chen, Zhen-Qiang Pan, Xiong Su, Philip D. Stahl

Open Access Publications

No abstract provided.


Mouse Transgenesis In A Single Locus With Independent Regulation For Multiple Fluorophores, Joseph D. Dougherty, Juliet Zhang, Huifen Feng, Shiaoching Gong, Nathaniel Heintz Jan 2012

Mouse Transgenesis In A Single Locus With Independent Regulation For Multiple Fluorophores, Joseph D. Dougherty, Juliet Zhang, Huifen Feng, Shiaoching Gong, Nathaniel Heintz

Open Access Publications

No abstract provided.


Expression And Function Of Pml-Rara In The Hematopoietic Progenitor Cells Of Ctsg-Pml-Rara Mice, Lukas D. Wartman, John S. Welch, Geoffrey L. Uy, Jeffery M. Klco, Tamara Lamprecht, Nobish Varhese, Rakesh Nagarajan, Timothy J. Ley Jan 2012

Expression And Function Of Pml-Rara In The Hematopoietic Progenitor Cells Of Ctsg-Pml-Rara Mice, Lukas D. Wartman, John S. Welch, Geoffrey L. Uy, Jeffery M. Klco, Tamara Lamprecht, Nobish Varhese, Rakesh Nagarajan, Timothy J. Ley

Open Access Publications

No abstract provided.


Functional Assessment Of Human Coding Mutations Affecting Skin Pigmentation Using Zebrafish, Zurab R. Tsetskhladze, Victor A. Canfield, Khai C. Ang, Steven M. Wentzel, Katherine P. Reid, Arthur S. Berg, Stephen L. Johnson, Koichi Kawakami, Keith C. Cheng Jan 2012

Functional Assessment Of Human Coding Mutations Affecting Skin Pigmentation Using Zebrafish, Zurab R. Tsetskhladze, Victor A. Canfield, Khai C. Ang, Steven M. Wentzel, Katherine P. Reid, Arthur S. Berg, Stephen L. Johnson, Koichi Kawakami, Keith C. Cheng

Open Access Publications

No abstract provided.


Genome-Wide Association Studies Of Asthma In Population-Based Cohorts Confirm Known And Suggested Loci And Identify An Additional Association Near Hla, Andrew C. Heath, Pamela A. F. Madden, Et Al Jan 2012

Genome-Wide Association Studies Of Asthma In Population-Based Cohorts Confirm Known And Suggested Loci And Identify An Additional Association Near Hla, Andrew C. Heath, Pamela A. F. Madden, Et Al

Open Access Publications

No abstract provided.


Simultaneous Necrotizing Soft Tissue Infection And Colonic Necrosis Caused By Clostridium Septicum, Jennifer L. Gnerlich, Jon H. Ritter, John P. Kirby, John E. Mazuski Dec 2011

Simultaneous Necrotizing Soft Tissue Infection And Colonic Necrosis Caused By Clostridium Septicum, Jennifer L. Gnerlich, Jon H. Ritter, John P. Kirby, John E. Mazuski

Open Access Publications

No abstract provided.


Ajuba Is Required For Rac Activation And Maintenance Of E-Cadherin Adhesion, Sébastien Nola, Reiko Daigaku, Kasia Smolarczyk, Maryke Carstens, Belen Martin-Martin, Gregory Longmore, Maryse Bailly, Vania M.M. Braga Nov 2011

Ajuba Is Required For Rac Activation And Maintenance Of E-Cadherin Adhesion, Sébastien Nola, Reiko Daigaku, Kasia Smolarczyk, Maryke Carstens, Belen Martin-Martin, Gregory Longmore, Maryse Bailly, Vania M.M. Braga

Open Access Publications

No abstract provided.


Mycoplasma Pneumoniae Periprosthetic Joint Infection Identified By 16s Ribosomal Rna Gene Amplification And Sequencing: A Case Report, Zhuolin Han, Carey-Ann D. Burnham, John Clohisy, Hilary Babcock Sep 2011

Mycoplasma Pneumoniae Periprosthetic Joint Infection Identified By 16s Ribosomal Rna Gene Amplification And Sequencing: A Case Report, Zhuolin Han, Carey-Ann D. Burnham, John Clohisy, Hilary Babcock

Open Access Publications

No abstract provided.


What's New In Orthopaedic Trauma, William M. Ricci, Christopher Mcandrew, David Merriman, Michael J. Gardner Sep 2011

What's New In Orthopaedic Trauma, William M. Ricci, Christopher Mcandrew, David Merriman, Michael J. Gardner

Open Access Publications

No abstract provided.


In Vivo Microdialysis Reveals Age-Dependent Decrease Of Brain Interstitial Fluid Tau Levels In P301s Human Tau Transgenic Mice, Kaoru Yamada, John R. Cirrito, Floy R. Stewart, Hong Jiang, Mary Beth Finn, Brandon B. Holmes, Lester I. Binder, Eva-Maria Mandelkow, Marc I. Diamond, Virginia M.-Y. Lee, David M. Holtzman Sep 2011

In Vivo Microdialysis Reveals Age-Dependent Decrease Of Brain Interstitial Fluid Tau Levels In P301s Human Tau Transgenic Mice, Kaoru Yamada, John R. Cirrito, Floy R. Stewart, Hong Jiang, Mary Beth Finn, Brandon B. Holmes, Lester I. Binder, Eva-Maria Mandelkow, Marc I. Diamond, Virginia M.-Y. Lee, David M. Holtzman

Open Access Publications

Although tau is a cytoplasmic protein, it is also found in brain extracellular fluids, e.g., CSF. Recent findings suggest that aggregated tau can be transferred between cells and extracellular tau aggregates might mediate spread of tau pathology. Despite these data, details of whether tau is normally released into the brain interstitial fluid (ISF), its concentration in ISF in relation to CSF, and whether ISF tau is influenced by its aggregation are unknown. To address these issues, we developed a microdialysis technique to analyze monomeric ISF tau levels within the hippocampus of awake, freely moving mice. We detected tau in ISF …


Neural Correlates Of Visual–Spatial Attention In Electrocorticographic Signals In Humans, Aysegul Gunduz, Peter Brunner, Amy Daitch, Eric C. Leuthardt, Anthony L. Ritaccio, Bijan Pesaran, Gerwin Schalk Sep 2011

Neural Correlates Of Visual–Spatial Attention In Electrocorticographic Signals In Humans, Aysegul Gunduz, Peter Brunner, Amy Daitch, Eric C. Leuthardt, Anthony L. Ritaccio, Bijan Pesaran, Gerwin Schalk

Open Access Publications

No abstract provided.


Spinal Reconstruction With Pedicle Screw-Based Instrumentation And Rhbmp-2 In Patients With Neurofibromatosis And Severe Dural Ectasia And Spinal Deformity: Report Of Two Cases And A Review Of The Literature, Samuel K. Cho, Geoffrey E. Stoker, Keith H. Bridwell Aug 2011

Spinal Reconstruction With Pedicle Screw-Based Instrumentation And Rhbmp-2 In Patients With Neurofibromatosis And Severe Dural Ectasia And Spinal Deformity: Report Of Two Cases And A Review Of The Literature, Samuel K. Cho, Geoffrey E. Stoker, Keith H. Bridwell

Open Access Publications

No abstract provided.


Neural Representation Of Temporal Duration: Coherent Findings Obtained With The “Lossy Integration” Model, Olga V. Sysoeva, Marc Wittmann, Jiri Wackermann Aug 2011

Neural Representation Of Temporal Duration: Coherent Findings Obtained With The “Lossy Integration” Model, Olga V. Sysoeva, Marc Wittmann, Jiri Wackermann

Open Access Publications

No abstract provided.


Ethanol Enhances Neurosteroidogenesis In Hippocampal Pyramidal Neurons By Paradoxical Nmda Receptor Activation, Kazuhiro Tokuda, Yukitoshi Izumi, Charles F. Zorumski Jul 2011

Ethanol Enhances Neurosteroidogenesis In Hippocampal Pyramidal Neurons By Paradoxical Nmda Receptor Activation, Kazuhiro Tokuda, Yukitoshi Izumi, Charles F. Zorumski

Open Access Publications

Using an antibody against 5α-reduced neurosteroids, predominantly allopregnanolone, we found that immunostaining in the CA1 region of rat hippocampal slices was confined to pyramidal neurons. This neurosteroid staining was increased following 15 min administration of 60 mm but not 20 mm ethanol, and the enhancement was blocked by finasteride and dutasteride, selective inhibitors of 5α-reductase, a key enzyme required for allopregnanolone synthesis. Consistent with a prior report indicating that N-methyl-D-aspartate (NMDA) receptor (NMDAR) activation can promote steroid production, we observed that D-2-amino-5-phosphonovalerate (APV), a competitive NMDAR antagonist, blocked the effects of 60 mm ethanol on staining. We previously reported that …


Controlled Cortical Impact Traumatic Brain Injury In 3xtg-Ad Mice Causes Acute Intra-Axonal Amyloid-Β Accumulation And Independently Accelerates The Development Of Tau Abnormalities, Hien T. Tran, Frank M. Laferla, David M. Holtzman, David L. Brody Jun 2011

Controlled Cortical Impact Traumatic Brain Injury In 3xtg-Ad Mice Causes Acute Intra-Axonal Amyloid-Β Accumulation And Independently Accelerates The Development Of Tau Abnormalities, Hien T. Tran, Frank M. Laferla, David M. Holtzman, David L. Brody

Open Access Publications

Alzheimer's disease (AD) is a neurodegenerative disorder characterized pathologically by progressive neuronal loss, extracellular plaques containing the amyloid-β (Aβ) peptides, and neurofibrillary tangles composed of hyperphosphorylated tau proteins. Aβ is thought to act upstream of tau, affecting its phosphorylation and therefore aggregation state. One of the major risk factors for AD is traumatic brain injury (TBI). Acute intra-axonal Aβ and diffuse extracellular plaques occur in ∼30% of human subjects after severe TBI. Intra-axonal accumulations of tau but not tangle-like pathologies have also been found in these patients. Whether and how these acute accumulations contribute to subsequent AD development is not …


Exome Sequencing Identifies An Myh3 Mutation In A Family With Distal Arthrogryposis Type 1, David M. Alvarado, Jillian G. Buchan, Christina A. Gurnett, Matthew B. Dobbs Jun 2011

Exome Sequencing Identifies An Myh3 Mutation In A Family With Distal Arthrogryposis Type 1, David M. Alvarado, Jillian G. Buchan, Christina A. Gurnett, Matthew B. Dobbs

Open Access Publications

No abstract provided.


Role Of Guanylyl Cyclase Modulation In Mouse Cone Phototransduction, Keisuke Sakurai, Jeannie Chen, Vladimir J. Kefalov Jun 2011

Role Of Guanylyl Cyclase Modulation In Mouse Cone Phototransduction, Keisuke Sakurai, Jeannie Chen, Vladimir J. Kefalov

Open Access Publications

A negative phototransduction feedback in rods and cones is critical for the timely termination of their light responses and for extending their function to a wide range of light intensities. The calcium feedback mechanisms that modulate phototransduction in rods have been studied extensively. However, the corresponding modulation mechanisms that enable cones to terminate rapidly their light responses and to adapt in bright light, properties critical for our daytime vision, are still not understood. In cones, calcium feedback to guanylyl cyclase is potentially a key step in phototransduction modulation. The guanylyl cyclase activity is modulated by the calcium-binding guanylyl cyclase activating …