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Structure Of A Bacterial Voltage-Gated Sodium Channel Pore Reveals Mechanisms Of Opening And Closing, Emily C. Mccusker, Claire Bagnéris, Claire E. Naylor, Ambrose R. Cole, Nazzareno D'Avanzo, Colin G. Nichols, B A. Wallace Jan 2012

Structure Of A Bacterial Voltage-Gated Sodium Channel Pore Reveals Mechanisms Of Opening And Closing, Emily C. Mccusker, Claire Bagnéris, Claire E. Naylor, Ambrose R. Cole, Nazzareno D'Avanzo, Colin G. Nichols, B A. Wallace

Open Access Publications

No abstract provided.


Plasmodium Falciparum  Heat Shock Protein 110 Stabilizes The Asparagine Repeat-Rich Parasite Proteome During Malarial Fevers, Vasant Muralidharan, Anna Oksman, Priya Pal, Susan Lindquist, Daniel E. Goldberg Jan 2012

Plasmodium Falciparum  Heat Shock Protein 110 Stabilizes The Asparagine Repeat-Rich Parasite Proteome During Malarial Fevers, Vasant Muralidharan, Anna Oksman, Priya Pal, Susan Lindquist, Daniel E. Goldberg

Open Access Publications

No abstract provided.


Quantitative Trait Loci Affecting Liver Fat Content In Mice, Olga Minkina, James M. Cheverud, Gloria Fawcett, Clay F. Semenkovich, Jane P. Kenney-Hunt Jan 2012

Quantitative Trait Loci Affecting Liver Fat Content In Mice, Olga Minkina, James M. Cheverud, Gloria Fawcett, Clay F. Semenkovich, Jane P. Kenney-Hunt

Open Access Publications

No abstract provided.


A Window Into Domain Amplification Through Piccolo In Teleost Fish, Michael L. Nonet Jan 2012

A Window Into Domain Amplification Through Piccolo In Teleost Fish, Michael L. Nonet

Open Access Publications

No abstract provided.


Administration Of Cog1410 Reduces Axonal Amyloid Precursor Protein Immunoreactivity And Microglial Activation After Controlled Cortical Impact In Mice, Yong Jiang, David L. Brody Jan 2012

Administration Of Cog1410 Reduces Axonal Amyloid Precursor Protein Immunoreactivity And Microglial Activation After Controlled Cortical Impact In Mice, Yong Jiang, David L. Brody

Open Access Publications

No abstract provided.


Imaging Of Poly(Α-Hydroxy-Ester) Scaffolds With X-Ray Phase-Contrast Microcomputed Tomography, Alyssa A. Appel, Jeffery C. Larson, Sami Somo, Zhong Zhong, Patrick P. Spicer, Kurtis Kasper, Alfred B. Garson Iii, Adam M. Zysk, Antonios G. Mikos, Mark A. Anastasio, Eric M. Brey Jan 2012

Imaging Of Poly(Α-Hydroxy-Ester) Scaffolds With X-Ray Phase-Contrast Microcomputed Tomography, Alyssa A. Appel, Jeffery C. Larson, Sami Somo, Zhong Zhong, Patrick P. Spicer, Kurtis Kasper, Alfred B. Garson Iii, Adam M. Zysk, Antonios G. Mikos, Mark A. Anastasio, Eric M. Brey

Open Access Publications

No abstract provided.


Sadness In The Sun: Using Computerized Screening To Analyze Correlates Of Depression And Adherence In Hiv-Infected Adults In The United States, Ellen M. Tedaldi, Mary Van Den Berg-Wolf, James Richardson, Pragna Patel, Marcus Durham, John Hammer, Keith Henry, Sara Metzler, Nur Onen, Lois Conley, Kathy Wood, John T. Brooks, Kate Buchacz Jan 2012

Sadness In The Sun: Using Computerized Screening To Analyze Correlates Of Depression And Adherence In Hiv-Infected Adults In The United States, Ellen M. Tedaldi, Mary Van Den Berg-Wolf, James Richardson, Pragna Patel, Marcus Durham, John Hammer, Keith Henry, Sara Metzler, Nur Onen, Lois Conley, Kathy Wood, John T. Brooks, Kate Buchacz

Open Access Publications

No abstract provided.


Snail Promotes The Cell-Autonomous Generation Of Flk1 + Endothelial Cells Through The Repression Of The Microrna-200 Family, Jennider G. Gill, Ellen M. Langer, R Coleman Lindsley, Mi Cai, Theresa L. Murphy, Kenneth M. Murphy Jan 2012

Snail Promotes The Cell-Autonomous Generation Of Flk1 + Endothelial Cells Through The Repression Of The Microrna-200 Family, Jennider G. Gill, Ellen M. Langer, R Coleman Lindsley, Mi Cai, Theresa L. Murphy, Kenneth M. Murphy

Open Access Publications

No abstract provided.


Micrornas Are Exported From Malignant Cells In Customized Particles, Jaime Palma, Scree C. Yaddanapudi, Lucy Pigati, Mallory A. Havens, Sarah Jeong, Geoffrey A. Weiner, Kristina Mary Ellen Weimer, Brittany Stern, Michelle L. Hastings, Dominik M. Duelli Jan 2012

Micrornas Are Exported From Malignant Cells In Customized Particles, Jaime Palma, Scree C. Yaddanapudi, Lucy Pigati, Mallory A. Havens, Sarah Jeong, Geoffrey A. Weiner, Kristina Mary Ellen Weimer, Brittany Stern, Michelle L. Hastings, Dominik M. Duelli

Open Access Publications

No abstract provided.


Primerbank: A Pcr Primer Database For Quantitative Gene Expression Analysis, 2012 Update, Xiaowei Wang, Athanasia Spandidos, Huajun Wang, Brian Seed Jan 2012

Primerbank: A Pcr Primer Database For Quantitative Gene Expression Analysis, 2012 Update, Xiaowei Wang, Athanasia Spandidos, Huajun Wang, Brian Seed

Open Access Publications

No abstract provided.


Structural Insight Into Mr1-Mediated Recognition Of The Mucosal Associated Invariant T Cell Receptor, Rangsima Reantragoon, Lars Kjer-Nielsen, Onisha Patel, Zhenjun Chen, Patricia T. Illing, Mugdha Bhati, Lyudmila Kostenko, Mandvi Bharadwaj, Bronwyn Meehan, Ted H. Hansen, Dale I. Godfrey, Jamie Rossjohn, James Mccluskey Jan 2012

Structural Insight Into Mr1-Mediated Recognition Of The Mucosal Associated Invariant T Cell Receptor, Rangsima Reantragoon, Lars Kjer-Nielsen, Onisha Patel, Zhenjun Chen, Patricia T. Illing, Mugdha Bhati, Lyudmila Kostenko, Mandvi Bharadwaj, Bronwyn Meehan, Ted H. Hansen, Dale I. Godfrey, Jamie Rossjohn, James Mccluskey

Open Access Publications

Mucosal-associated invariant T (MAIT) cells express a semiinvariant αβ T cell receptor (TCR) that binds MHC class I-like molecule (MR1). However, the molecular basis for MAIT TCR recognition by MR1 is unknown. In this study, we present the crystal structure of a human Vα7.2Jα33-Vβ2 MAIT TCR. Mutagenesis revealed highly conserved requirements for the MAIT TCR-MR1 interaction across different human MAIT TCRs stimulated by distinct microbial sources. Individual residues within the MAIT TCR β chain were dispensable for the interaction with MR1, whereas the invariant MAIT TCR α chain controlled specificity through a small number of residues, which are conserved across …


Retrotransposon Profiling Of Rna Polymerase Iii Initiation Sites, Xiaojie Qi, Kenneth Daily, Kim Nguyen, Haoyi Wang, David Mayhew, Paul Rigor, Sholeh Forouzan, Mark Johnston, Robi David Mitra, Pierre Baldi, Suzanne Sandmeyer Jan 2012

Retrotransposon Profiling Of Rna Polymerase Iii Initiation Sites, Xiaojie Qi, Kenneth Daily, Kim Nguyen, Haoyi Wang, David Mayhew, Paul Rigor, Sholeh Forouzan, Mark Johnston, Robi David Mitra, Pierre Baldi, Suzanne Sandmeyer

Open Access Publications

No abstract provided.


Reclamation Of Ampicillin Sensitivity For The Genetic Manipulation Of Legionella Pneumophila, Molly C. Sutherland, Joseph P. Vogel Jan 2012

Reclamation Of Ampicillin Sensitivity For The Genetic Manipulation Of Legionella Pneumophila, Molly C. Sutherland, Joseph P. Vogel

Open Access Publications

No abstract provided.


Β-Cell Metabolic Alterations Under Chronic Nutrient Overload In Rat And Human Islets, Stephanie Vernier, Angela Chiu, Joseph Schober, Theresa Weber, Phuong Nguyen, Mark Luer, Timothy Mcpherson, Paul E. Wanda, Connie A. Marshall, Nidhi Rohatgi, Michael L. Mcdaniel, Andrew S. Greenberg, Guim Kwon Jan 2012

Β-Cell Metabolic Alterations Under Chronic Nutrient Overload In Rat And Human Islets, Stephanie Vernier, Angela Chiu, Joseph Schober, Theresa Weber, Phuong Nguyen, Mark Luer, Timothy Mcpherson, Paul E. Wanda, Connie A. Marshall, Nidhi Rohatgi, Michael L. Mcdaniel, Andrew S. Greenberg, Guim Kwon

Open Access Publications

No abstract provided.


Cross-Priming For Antitumor Ctl Induced By Soluble Ag + Polyi:C Depends On The Ticam-1 Pathway In Mouse Cd11c+ /Cd8Α+ Dendritic Cells, Masahiro Azuma, Takashi Ebihara, Hiroyuki Oshiumi, Misako Matsumoto, Tsukasa Seya Jan 2012

Cross-Priming For Antitumor Ctl Induced By Soluble Ag + Polyi:C Depends On The Ticam-1 Pathway In Mouse Cd11c+ /Cd8Α+ Dendritic Cells, Masahiro Azuma, Takashi Ebihara, Hiroyuki Oshiumi, Misako Matsumoto, Tsukasa Seya

Open Access Publications

No abstract provided.


Lecture: New Light On The Role Of Claudins In The Kidney, Jianghui Hou Jan 2012

Lecture: New Light On The Role Of Claudins In The Kidney, Jianghui Hou

Open Access Publications

No abstract provided.


Development Of A Novel Xenotransplantation Strategy For Treatment Of Diabetes Mellitus In Rat Hosts And Translation To Non-Human Primates, Marc R. Hammerman Jan 2012

Development Of A Novel Xenotransplantation Strategy For Treatment Of Diabetes Mellitus In Rat Hosts And Translation To Non-Human Primates, Marc R. Hammerman

Open Access Publications

No abstract provided.


Expression Of Stm4467-Encoded Arginine Deiminase Controlled By The Stm4463 Regulator Contributes To Salmonella Enterica Serovar Typhimurium Virulence, Younho Choi, Jeongjoon Choi, Eduardo A. Groisman, Dong-Hyun Kang, Dongwoo Shin, Sangryeol Ryu Jan 2012

Expression Of Stm4467-Encoded Arginine Deiminase Controlled By The Stm4463 Regulator Contributes To Salmonella Enterica Serovar Typhimurium Virulence, Younho Choi, Jeongjoon Choi, Eduardo A. Groisman, Dong-Hyun Kang, Dongwoo Shin, Sangryeol Ryu

Open Access Publications

No abstract provided.


Immune Modulation By Group B Streptococcus Influences Host Susceptibility To Urinary Tract Infection By Uropathogenic Escherichia Coli, Kimberly A. Kline, Drew J. Schwartz, Nicole M. Gilbert, Scott J. Hultgren, Amanda L. Lewis Jan 2012

Immune Modulation By Group B Streptococcus Influences Host Susceptibility To Urinary Tract Infection By Uropathogenic Escherichia Coli, Kimberly A. Kline, Drew J. Schwartz, Nicole M. Gilbert, Scott J. Hultgren, Amanda L. Lewis

Open Access Publications

No abstract provided.


Schistosome-Derived Omega-1 Drives Th2 Polarization By Suppressing Protein Synthesis Following Internalization By The Mannose Receptor, Bart Everts, Leonie Hussaarts, Nicole N. Driessen, Moniek H.J. Meevissen, Gabriele Schramm, Alwin J. Van Der Ham, Barbara Van Der Hoeven, Thomas Scholzen, Sven Burgdorf, Markus Mohrs, Edward J. Pearce, Cornelis H. Hokke, Helmut Haas, Hermelijn H. Smits, Maria Yazdanbakhsh Jan 2012

Schistosome-Derived Omega-1 Drives Th2 Polarization By Suppressing Protein Synthesis Following Internalization By The Mannose Receptor, Bart Everts, Leonie Hussaarts, Nicole N. Driessen, Moniek H.J. Meevissen, Gabriele Schramm, Alwin J. Van Der Ham, Barbara Van Der Hoeven, Thomas Scholzen, Sven Burgdorf, Markus Mohrs, Edward J. Pearce, Cornelis H. Hokke, Helmut Haas, Hermelijn H. Smits, Maria Yazdanbakhsh

Open Access Publications

Omega-1, a glycosylated T2 ribonuclease (RNase) secreted by Schistosoma mansoni eggs and abundantly present in soluble egg antigen, has recently been shown to condition dendritic cells (DCs) to prime Th2 responses. However, the molecular mechanisms underlying this effect remain unknown. We show in this study by site-directed mutagenesis of omega-1 that both the glycosylation and the RNase activity are essential to condition DCs for Th2 polarization. Mechanistically, we demonstrate that omega-1 is bound and internalized via its glycans by the mannose receptor (MR) and subsequently impairs protein synthesis by degrading both ribosomal and messenger RNA. These experiments reveal an unrecognized …


The New Nucleoporin: Regulator Of Transcriptional Repression And Beyond, Nayan J. Sarma, Kristine Willis Jan 2012

The New Nucleoporin: Regulator Of Transcriptional Repression And Beyond, Nayan J. Sarma, Kristine Willis

Open Access Publications

No abstract provided.


No Evidence Of Xenotropic Murine Leukemia Virus-Related Virus Transmission By Blood Transfusion From Infected Rhesus Macaques, Dhanya K. Williams, Teresa A. Galvin, Yamei Gao, Christina O'Neill, Dustin Glasner, Arifa S. Khan Jan 2012

No Evidence Of Xenotropic Murine Leukemia Virus-Related Virus Transmission By Blood Transfusion From Infected Rhesus Macaques, Dhanya K. Williams, Teresa A. Galvin, Yamei Gao, Christina O'Neill, Dustin Glasner, Arifa S. Khan

Open Access Publications

No abstract provided.


Induction Of Alternatively Activated Macrophages Enhances Pathogenesis During Severe Acute Respiratory Syndrome Coronavirus Infection, Carly Page, Lindsay Golcohea, Krystal Matthews, Yong Zhang, Peter Klover, Michael J. Holtzman, Lothar Hennighausen, Matthew Frieman Jan 2012

Induction Of Alternatively Activated Macrophages Enhances Pathogenesis During Severe Acute Respiratory Syndrome Coronavirus Infection, Carly Page, Lindsay Golcohea, Krystal Matthews, Yong Zhang, Peter Klover, Michael J. Holtzman, Lothar Hennighausen, Matthew Frieman

Open Access Publications

No abstract provided.


Exploring Metazoan Evolution Through Dynamic And Holistic Changes In Protein Families And Domains, Zhengyuan Wang, Dante Zarlenga, John Martin, Sahar Abubucker, Makedonka Mitreva Jan 2012

Exploring Metazoan Evolution Through Dynamic And Holistic Changes In Protein Families And Domains, Zhengyuan Wang, Dante Zarlenga, John Martin, Sahar Abubucker, Makedonka Mitreva

Open Access Publications

No abstract provided.


High Throughput Screening For Small Molecule Enhancers Of The Interferon Signaling Pathway To Drive Next-Generation Antiviral Drug Discovery, Dhara A. Patel, Anand C. Patel, William C. Nolan, Yong Zhang, Michael J. Holtzman Jan 2012

High Throughput Screening For Small Molecule Enhancers Of The Interferon Signaling Pathway To Drive Next-Generation Antiviral Drug Discovery, Dhara A. Patel, Anand C. Patel, William C. Nolan, Yong Zhang, Michael J. Holtzman

Open Access Publications

No abstract provided.


Expression Of Novel Alzheimer’S Disease Risk Genes In Control And Alzheimer’S Disease Brains, Celeste M. Karch, Amanda T. Jeng, Petra Nowotny, Janet Cady, Carlos Cruchaga, Alison M. Goate Jan 2012

Expression Of Novel Alzheimer’S Disease Risk Genes In Control And Alzheimer’S Disease Brains, Celeste M. Karch, Amanda T. Jeng, Petra Nowotny, Janet Cady, Carlos Cruchaga, Alison M. Goate

Open Access Publications

No abstract provided.


Dendritic Cell Based Psma Immunotherapy For Prostate Cancer Using A Cd40-Targeted Adenovirus Vector, Briana Jill Williams, Shilpa Bhatia, Lisa K. Adams, Susan Boling, Jennifer L. Carroll, Xiao-Lin Li, Donna L. Rogers, Nikolay Korokhov, Imre Kovesdi, Alexander V. Pereboev, David T. Curiel, Michael Mathis Jan 2012

Dendritic Cell Based Psma Immunotherapy For Prostate Cancer Using A Cd40-Targeted Adenovirus Vector, Briana Jill Williams, Shilpa Bhatia, Lisa K. Adams, Susan Boling, Jennifer L. Carroll, Xiao-Lin Li, Donna L. Rogers, Nikolay Korokhov, Imre Kovesdi, Alexander V. Pereboev, David T. Curiel, Michael Mathis

Open Access Publications

No abstract provided.


Estimating The Heritability Of Reporting Stressful Life Events Captured By Common Genetic Variants, J. P. Rice, Et Al Jan 2012

Estimating The Heritability Of Reporting Stressful Life Events Captured By Common Genetic Variants, J. P. Rice, Et Al

Open Access Publications

No abstract provided.


Ligand-Induced Movements Of Inner Transmembrane Helices Of Glut1 Revealed By Chemical Cross-Linking Of Di-Cysteine Mutants, Mike Mueckler, Carol Makepeace Jan 2012

Ligand-Induced Movements Of Inner Transmembrane Helices Of Glut1 Revealed By Chemical Cross-Linking Of Di-Cysteine Mutants, Mike Mueckler, Carol Makepeace

Open Access Publications

No abstract provided.


Effects Of Doxycycline On Gene Expression In Wolbachia And Brugia Malayi Adult Female Worms In Vivo, Ramakrishna U. Rao, Yuefang Huang, Sahar Abubucker, Michael Heinz, Seth D. Crosby, Makedonka Mitreva, Gary J. Weil Jan 2012

Effects Of Doxycycline On Gene Expression In Wolbachia And Brugia Malayi Adult Female Worms In Vivo, Ramakrishna U. Rao, Yuefang Huang, Sahar Abubucker, Michael Heinz, Seth D. Crosby, Makedonka Mitreva, Gary J. Weil

Open Access Publications

No abstract provided.