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Protection Of Bone In Premenopausal Women With Breast Cancer: Focus On Zoledronic Acid, Rebecca Aft Oct 2012

Protection Of Bone In Premenopausal Women With Breast Cancer: Focus On Zoledronic Acid, Rebecca Aft

Open Access Publications

No abstract provided.


Off-Clamp Robot-Assisted Partial Nephrectomy: Initial Washington University Experience, Youssef S. Tanagho, Sam B. Bhayani, Eric H. Kim, Gurdarshan S. Sandhu, Nicolas P. Vaughn, R. Sherburne Figenshau Oct 2012

Off-Clamp Robot-Assisted Partial Nephrectomy: Initial Washington University Experience, Youssef S. Tanagho, Sam B. Bhayani, Eric H. Kim, Gurdarshan S. Sandhu, Nicolas P. Vaughn, R. Sherburne Figenshau

Open Access Publications

No abstract provided.


The Use Of Live Attenuated Influenza Vaccine (Laiv) In Healthcare Personnel (Hcp): Guidance From The Society For Healthcare Epidemiology Of America (Shea), Thomas R. Talbot, Hilary Babcock, Deborah Cotton, Lisa L. Maragakis, Gregory A. Poland, Edward J. Septimus, Michael L. Tapper, David J. Weber Oct 2012

The Use Of Live Attenuated Influenza Vaccine (Laiv) In Healthcare Personnel (Hcp): Guidance From The Society For Healthcare Epidemiology Of America (Shea), Thomas R. Talbot, Hilary Babcock, Deborah Cotton, Lisa L. Maragakis, Gregory A. Poland, Edward J. Septimus, Michael L. Tapper, David J. Weber

Open Access Publications

No abstract provided.


Rehabilitation After Anterior Cruciate Ligament Reconstruction: A Systematic Review, L. M. Kruse, B. Gray, R. W. Wright Oct 2012

Rehabilitation After Anterior Cruciate Ligament Reconstruction: A Systematic Review, L. M. Kruse, B. Gray, R. W. Wright

Open Access Publications

No abstract provided.


“Genomics And Translational Medicine For Information Professionals”: An Innovative Course To Educate The Next Generation Of Librarians, Ana D. Cleveland, Kristi L. Holmes, Jodi L. Philbrick Oct 2012

“Genomics And Translational Medicine For Information Professionals”: An Innovative Course To Educate The Next Generation Of Librarians, Ana D. Cleveland, Kristi L. Holmes, Jodi L. Philbrick

Open Access Publications

No abstract provided.


Metabolic Effects Of Darunavir/Ritonavir Versus Atazanavir/Ritonavir In Treatment-Naive, Hiv Type 1-Infected Subjects Over 48 Weeks, Judith A. Aberg, Pablo Tebas, Edgar Turner Overton, Samir K. Gupta, Paul E. Sax, Alan Landay, Ron Falcon, Robert Ryan, Guy De La Rosa Sep 2012

Metabolic Effects Of Darunavir/Ritonavir Versus Atazanavir/Ritonavir In Treatment-Naive, Hiv Type 1-Infected Subjects Over 48 Weeks, Judith A. Aberg, Pablo Tebas, Edgar Turner Overton, Samir K. Gupta, Paul E. Sax, Alan Landay, Ron Falcon, Robert Ryan, Guy De La Rosa

Open Access Publications

No abstract provided.


Off-Clamp Robot-Assisted Partial Nephrectomy For Complex Renal Tumors, Eric H. Kim, Youssef S. Tanagho, Gurdarshan Sandhu, Sam B. Bhayani, R. Sherburne Figenshau Aug 2012

Off-Clamp Robot-Assisted Partial Nephrectomy For Complex Renal Tumors, Eric H. Kim, Youssef S. Tanagho, Gurdarshan Sandhu, Sam B. Bhayani, R. Sherburne Figenshau

Open Access Publications

No abstract provided.


Polygenic Threshold Model With Sex Dimorphism In Adolescent Idiopathic Scoliosis: The Carter Effect, Lisa M. Kruse, Jillian G. Buchan, Christina A. Gurnett, Matthew B. Dobbs Aug 2012

Polygenic Threshold Model With Sex Dimorphism In Adolescent Idiopathic Scoliosis: The Carter Effect, Lisa M. Kruse, Jillian G. Buchan, Christina A. Gurnett, Matthew B. Dobbs

Open Access Publications

No abstract provided.


Antegrade Endoscopic Removal Of Retained Urethral Sling Mesh In The Bladder, Michael H. Johnson, Genoa G. Ferguson, Carl G. Klutke Aug 2012

Antegrade Endoscopic Removal Of Retained Urethral Sling Mesh In The Bladder, Michael H. Johnson, Genoa G. Ferguson, Carl G. Klutke

Open Access Publications

No abstract provided.


Loss Of Atm Kinase Activity Leads To Embryonic Lethality In Mice, Jeremy A. Daniel, Manuela Pellegrini, Baeck-Seung Lee, Zhi Guo, Darius Filsuf, Natalya V. Belkina, Zhongsheng You, Tanya T. Paull, Barry P. Sleckman, Lionel Feigenbaum, André Nussenzweig Aug 2012

Loss Of Atm Kinase Activity Leads To Embryonic Lethality In Mice, Jeremy A. Daniel, Manuela Pellegrini, Baeck-Seung Lee, Zhi Guo, Darius Filsuf, Natalya V. Belkina, Zhongsheng You, Tanya T. Paull, Barry P. Sleckman, Lionel Feigenbaum, André Nussenzweig

Open Access Publications

No abstract provided.


I(A) Channels Encoded By Kv1.4 And Kv4.2 Regulate Neuronal Firing In The Suprachiasmatic Nucleus And Circadian Rhythms In Locomotor Activity, Daniel Granados-Fuentes, Aaron J. Norris, Yarimar Carrasquillo, Jeanne M. Nerbonne, Erik D. Herzog Jul 2012

I(A) Channels Encoded By Kv1.4 And Kv4.2 Regulate Neuronal Firing In The Suprachiasmatic Nucleus And Circadian Rhythms In Locomotor Activity, Daniel Granados-Fuentes, Aaron J. Norris, Yarimar Carrasquillo, Jeanne M. Nerbonne, Erik D. Herzog

Open Access Publications

Neurons in the suprachiasmatic nucleus (SCN) display coordinated circadian changes in electrical activity that are critical for daily rhythms in physiology, metabolism, and behavior. SCN neurons depolarize spontaneously and fire repetitively during the day and hyperpolarize, drastically reducing firing rates, at night. To explore the hypothesis that rapidly activating and inactivating A-type (I(A)) voltage-gated K(+) (Kv) channels, which are also active at subthreshold membrane potentials, are critical regulators of the excitability of SCN neurons, we examined locomotor activity and SCN firing in mice lacking Kv1.4 (Kv1.4(-/-)), Kv4.2 (Kv4.2(-/-)), or Kv4.3 (Kv4.3(-/-)), the pore-forming (α) subunits of I(A) channels. Mice lacking …


Intermediate Outcomes Following Percutaneous Fixation Of Proximal Humeral Fractures, Alicia K. Harrison, Konrad I. Gruson, Benjamin Zmistowski, Jay Keener, Leesa Galatz, Gerald Williams, Bradford O. Parsons, Evan L. Flatgow Jul 2012

Intermediate Outcomes Following Percutaneous Fixation Of Proximal Humeral Fractures, Alicia K. Harrison, Konrad I. Gruson, Benjamin Zmistowski, Jay Keener, Leesa Galatz, Gerald Williams, Bradford O. Parsons, Evan L. Flatgow

Open Access Publications

No abstract provided.


Hunter-Gatherer Energetics And Human Obesity, Herman Pontzer, David A. Raichlen, Brian M. Wood, Audax Z. P. Mabulla, Susan B. Racette, Frank W. Marlowe Jul 2012

Hunter-Gatherer Energetics And Human Obesity, Herman Pontzer, David A. Raichlen, Brian M. Wood, Audax Z. P. Mabulla, Susan B. Racette, Frank W. Marlowe

Open Access Publications

No abstract provided.


Loss Of Intranetwork And Internetwork Resting State Functional Connections With Alzheimer's Disease Progression, Mathew R. Brier, Jewell B. Thomas, Abraham Z. Snyder, Tammie L. Benzinger, Dongyang Zhang, Marcus E. Raichle, David M. Holtzman, John C. Morris, Beau M. Ances Jun 2012

Loss Of Intranetwork And Internetwork Resting State Functional Connections With Alzheimer's Disease Progression, Mathew R. Brier, Jewell B. Thomas, Abraham Z. Snyder, Tammie L. Benzinger, Dongyang Zhang, Marcus E. Raichle, David M. Holtzman, John C. Morris, Beau M. Ances

Open Access Publications

Alzheimer's disease (AD) is the most common cause of dementia. Much is known concerning AD pathophysiology but our understanding of the disease at the systems level remains incomplete. Previous AD research has used resting-state functional connectivity magnetic resonance imaging (rs-fcMRI) to assess the integrity of functional networks within the brain. Most studies have focused on the default-mode network (DMN), a primary locus of AD pathology. However, other brain regions are inevitably affected with disease progression. We studied rs-fcMRI in five functionally defined brain networks within a large cohort of human participants of either gender (n = 510) that ranged in …


Diagnostic Performance And Reliability Of Ultrasonography For Fatty Degeneration Of The Rotator Cuff Muscles, Lindley B. Wall, Sharlene A. Teefey, William D. Middleton, Nirvikar Dahiya, Karen Steger-May, H. Mike Kim, Daniel Wessell, Ken Yamaguchi Jun 2012

Diagnostic Performance And Reliability Of Ultrasonography For Fatty Degeneration Of The Rotator Cuff Muscles, Lindley B. Wall, Sharlene A. Teefey, William D. Middleton, Nirvikar Dahiya, Karen Steger-May, H. Mike Kim, Daniel Wessell, Ken Yamaguchi

Open Access Publications

No abstract provided.


What's New In Spine Surgery, Keith H. Bridwell, Paul A. Anderson, Scott D. Boden, Alexander R. Vaccaro, Jeffrey C. Wang Jun 2012

What's New In Spine Surgery, Keith H. Bridwell, Paul A. Anderson, Scott D. Boden, Alexander R. Vaccaro, Jeffrey C. Wang

Open Access Publications

No abstract provided.


Detection Thresholds Of Macaque Otolith Afferents, Xiong-Jie Yu, J David Dickman, Dora E. Angelaki Jun 2012

Detection Thresholds Of Macaque Otolith Afferents, Xiong-Jie Yu, J David Dickman, Dora E. Angelaki

Open Access Publications

The vestibular system is our sixth sense and is important for spatial perception functions, yet the sensory detection and discrimination properties of vestibular neurons remain relatively unexplored. Here we have used signal detection theory to measure detection thresholds of otolith afferents using 1 Hz linear accelerations delivered along three cardinal axes. Direction detection thresholds were measured by comparing mean firing rates centered on response peak and trough (full-cycle thresholds) or by comparing peak/trough firing rates with spontaneous activity (half-cycle thresholds). Thresholds were similar for utricular and saccular afferents, as well as for lateral, fore/aft, and vertical motion directions. When computed …


Multi-Institutional Analysis Of Robot-Assisted Partial Nephrectomy For Renal Tumors >4 Cm Versus ≤4 Cm In 445 Consecutive Patients, Firas Petros, Shyam Sukumar, Georges-Pascal Haber, Lori Dulabon, Sam Bhayani, Michael Stifelman, Jihad Kaouk, Craig Rogers Jun 2012

Multi-Institutional Analysis Of Robot-Assisted Partial Nephrectomy For Renal Tumors >4 Cm Versus ≤4 Cm In 445 Consecutive Patients, Firas Petros, Shyam Sukumar, Georges-Pascal Haber, Lori Dulabon, Sam Bhayani, Michael Stifelman, Jihad Kaouk, Craig Rogers

Open Access Publications

No abstract provided.


Vascular Anatomy Of The Tibiofibular Syndesmosis, Kathleen E. Mckeon, Rick W. Wright, Jeffrey E. Johnson, Jeremy J. Mccormick, Sandra E. Klein May 2012

Vascular Anatomy Of The Tibiofibular Syndesmosis, Kathleen E. Mckeon, Rick W. Wright, Jeffrey E. Johnson, Jeremy J. Mccormick, Sandra E. Klein

Open Access Publications

No abstract provided.


Synaptic Nmda Receptors Mediate Hypoxic Excitotoxic Death, Christine M. Wroge, Joshua Hogins, Larry Eisenman, Steven Mennerick May 2012

Synaptic Nmda Receptors Mediate Hypoxic Excitotoxic Death, Christine M. Wroge, Joshua Hogins, Larry Eisenman, Steven Mennerick

Open Access Publications

Excessive NMDA receptor activation and excitotoxicity underlies pathology in many neuropsychiatric and neurological disorders, including hypoxia/ischemia. Thus, the development of effective therapeutics for these disorders demands a complete understanding of NMDA receptor (NMDAR) activation during excitotoxic insults. The extrasynaptic NMDAR hypothesis posits that synaptic NMDARs are neurotrophic/neuroprotective and extrasynaptic NMDARs are neurotoxic. The extrasynaptic hypothesis is built in part on observed selectivity for extrasynaptic receptors of a neuroprotective use-dependent NMDAR channel blocker, memantine. In rat hippocampal neurons, we found that a neuroprotective concentration of memantine shows little selectivity for extrasynaptic NMDARs when all receptors are tonically activated by exogenous glutamate. …


Alix Binds A Ypx3l Motif Of The Gpcr Par1 And Mediates Ubiquitin-Independent Escrt-Iii/Mvb Sorting, Michael R. Dores, Buxin Chen, Huilan Lin, May M. Paing, William A. Montagne, Timo Meerlo, Joann Trejo Apr 2012

Alix Binds A Ypx3l Motif Of The Gpcr Par1 And Mediates Ubiquitin-Independent Escrt-Iii/Mvb Sorting, Michael R. Dores, Buxin Chen, Huilan Lin, May M. Paing, William A. Montagne, Timo Meerlo, Joann Trejo

Open Access Publications

No abstract provided.


A Model Of Toxic Neuropathy In Drosophila Reveals A Role For Morn4 In Promoting Axonal Degeneration, Martha R.C. Bhattacharya, Josiah Gerdts, Sarah A. Naylor, Emily X. Royse, Sarah Y. Ebstein, Yo Sasaki, Jeffrey Milbrandt, Aaron Diantonio Apr 2012

A Model Of Toxic Neuropathy In Drosophila Reveals A Role For Morn4 In Promoting Axonal Degeneration, Martha R.C. Bhattacharya, Josiah Gerdts, Sarah A. Naylor, Emily X. Royse, Sarah Y. Ebstein, Yo Sasaki, Jeffrey Milbrandt, Aaron Diantonio

Open Access Publications

Axonal degeneration is a molecular self-destruction cascade initiated following traumatic, toxic, and metabolic insults. Its mechanism underlies a number of disorders including hereditary and diabetic neuropathies and the neurotoxic side effects of chemotherapy drugs. Molecules that promote axonal degeneration could represent potential targets for therapy. To identify such molecules, we designed a screening platform based on intoxication of Drosophila larvae with paclitaxel (taxol), a chemotherapeutic agent that causes neuropathy in cancer patients. In Drosophila, taxol treatment causes swelling, fragmentation, and loss of axons in larval peripheral nerves. This axonal loss is not due to apoptosis of neurons. Taxol-induced axonal degeneration …


Outcome Of Revision Anterior Cruciate Ligament Reconstruction: A Systematic Review, Rick W. Wright, Corey S. Gill, Ling Chen, Robert H. Brophy, Matthew J. Matava, Matthew V. Smith, Nathan A. Mall Mar 2012

Outcome Of Revision Anterior Cruciate Ligament Reconstruction: A Systematic Review, Rick W. Wright, Corey S. Gill, Ling Chen, Robert H. Brophy, Matthew J. Matava, Matthew V. Smith, Nathan A. Mall

Open Access Publications

No abstract provided.


Neuronal Encoding Of Subjective Value In Dorsal And Ventral Anterior Cingulate Cortex, Xinying Cai, Camillo Padoa-Schioppa Mar 2012

Neuronal Encoding Of Subjective Value In Dorsal And Ventral Anterior Cingulate Cortex, Xinying Cai, Camillo Padoa-Schioppa

Open Access Publications

We examined the activity of individual cells in the primate anterior cingulate cortex during an economic choice task. In the experiments, monkeys chose between different juices offered in variables amounts and subjective values were inferred from the animals' choices. We analyzed neuronal firing rates in relation to a large number of behaviorally relevant variables. We report three main results. First, there were robust differences between the dorsal bank (ACCd) and the ventral bank (ACCv) of the cingulate sulcus. Specifically, neurons in ACCd but not in ACCv were modulated by the movement direction. Furthermore, neurons in ACCd were most active before …


Molecular Analysis Of Age And Sex-Related Gene Expression In Meniscal Tears With And Without A Concomitant Anterior Cruciate Ligament Tear, Robert H. Brophy, Muhammad Farooq Rai, Zhiqi Zhang, Adelina Torgomyan, Linda J. Sandell Mar 2012

Molecular Analysis Of Age And Sex-Related Gene Expression In Meniscal Tears With And Without A Concomitant Anterior Cruciate Ligament Tear, Robert H. Brophy, Muhammad Farooq Rai, Zhiqi Zhang, Adelina Torgomyan, Linda J. Sandell

Open Access Publications

No abstract provided.


Lower Extremity-Specific Measures Of Disability And Outcomes In Orthopaedic Surgery, Matthew V. Smith, Sandra E. Klein, John C. Clohisy, Geneva R. Baca, Robert H. Brophy, Rick W. Wright Mar 2012

Lower Extremity-Specific Measures Of Disability And Outcomes In Orthopaedic Surgery, Matthew V. Smith, Sandra E. Klein, John C. Clohisy, Geneva R. Baca, Robert H. Brophy, Rick W. Wright

Open Access Publications

No abstract provided.


Transmitted Drug-Resistant Hiv Type 1 Remains Prevalent And Impacts Virologic Outcomes Despite Genotype-Guided Antiretroviral Therapy, Toshibumi Taniguchi, Diana Nurutdinova, Jessica R. Grubb, Nur F. Önen, Enbal Sacham, Michael Donovan, Edgar Turner Overton Mar 2012

Transmitted Drug-Resistant Hiv Type 1 Remains Prevalent And Impacts Virologic Outcomes Despite Genotype-Guided Antiretroviral Therapy, Toshibumi Taniguchi, Diana Nurutdinova, Jessica R. Grubb, Nur F. Önen, Enbal Sacham, Michael Donovan, Edgar Turner Overton

Open Access Publications

No abstract provided.


Cystatin C And Baseline Renal Function Among Hiv-Infected Persons In The Sun Study, Edgar Turner Overton, Pragna Patel, Kristin Mondy, Tim Bush, Lois Conley, Frank Rhame, Erna Milunka Kojic, John Hammer, Keith Henry, John T. Brooks Feb 2012

Cystatin C And Baseline Renal Function Among Hiv-Infected Persons In The Sun Study, Edgar Turner Overton, Pragna Patel, Kristin Mondy, Tim Bush, Lois Conley, Frank Rhame, Erna Milunka Kojic, John Hammer, Keith Henry, John T. Brooks

Open Access Publications

No abstract provided.


Upper Extremity-Specific Measures Of Disability And Outcomes In Orthopaedic Surgery, Matthew V. Smith, Ryan P. Calfee, Keith M. Baumgarten, Robert H. Brophy, Rick W. Wright Feb 2012

Upper Extremity-Specific Measures Of Disability And Outcomes In Orthopaedic Surgery, Matthew V. Smith, Ryan P. Calfee, Keith M. Baumgarten, Robert H. Brophy, Rick W. Wright

Open Access Publications

No abstract provided.


Effect Of Inhaled Glucocorticoids In Childhood On Adult Height, H. William Kelly, Alice L. Sternberg, Rachel Lescher, Anne L. Fuhlbrigge, Paul Williams, Robert S. Zeiger, Hengameh H. Raissy, Mark L. Van Natta, James Tonascia, Robert C. Strunk Jan 2012

Effect Of Inhaled Glucocorticoids In Childhood On Adult Height, H. William Kelly, Alice L. Sternberg, Rachel Lescher, Anne L. Fuhlbrigge, Paul Williams, Robert S. Zeiger, Hengameh H. Raissy, Mark L. Van Natta, James Tonascia, Robert C. Strunk

Open Access Publications

No abstract provided.