Digital Commons Network^™

Interscalene Brachial Plexus Block For Arthroscopic Shoulder Surgery: A Systematic Review, Michael S. Hughes, Matthew J. Matava, Rick W. Wright, Robert H. Brophy, Matthew V. Smith

Open Access Publications

No abstract provided.

What's New In Orthopaedic Trauma, William M. Ricci, Andre Spiguel, Christopher Mcandrew, Michael Gardner

Open Access Publications

No abstract provided.

Progression Of Foot Deformity In Charcot Neuropathic Osteoarthropathy, Mary K. Hastings, Jeffrey E. Johnson, Michael J. Strube, Charles F. Hildebolt, Kathryn L. Bohnert, Fred W. Prior, David R. Sinacore

Open Access Publications

No abstract provided.

Counting Unstained, Confluent Cells By Modified Bright-Field Microscopy, L. Louis Drey, Michael Graber, Jan Bieschke

Open Access Publications

We present a very simple procedure yielding high-contrast images of adherent, confluent cells such as human neuroblastoma (SH-EP) cells by ordinary bright-field microscopy. Cells are illuminated through a color filter and a pinhole aperture placed between the condenser and the cell culture surface. Refraction by each cell body generates a sharp, bright spot when the image is defocused. The technique allows robust, automatic cell counting from a single bright-field image in a wide range of focal positions using free, readily available image-analysis tools. Contrast may be enhanced by swelling cell bodies with a brief incubation in PBS. The procedure was …

What's New In Spine Surgery, Keith H. Bridwell, Paul A. Anderson, Scott D. Boden, Alexander R. Vaccaro, Jeffrey C. Wang

Open Access Publications

No abstract provided.

Camera-Port Site Metastasis Of A Renal-Cell Carcinoma After Robot-Assisted Partial Nephrectomy, Joseph B. Song, Youssef S. Tanagho, Eric H. Kim, Phillip H. Abbosh, Phillip H. Abbosh, Goutham Vemana, R. Sherburne Figenshau

Open Access Publications

No abstract provided.

Differential Lymph Node Retrieval In Rectal Cancer: Associated Factors And Effect On Survival, Cedrek Mcfadden, Brian Mckinley, Brian Greenwell, Kaylee Knuckolls, Patrick Culumovic, David Schammel, Christine Schammel, Steven D. Trocha

Open Access Publications

BACKGROUND: Recent publications have identified positive associations between numbers of lymph nodes pathologically examined and five-year overall survival (5-yr OS) in colon cancer. However, focused examinations of relationships between survival of rectal cancer and lymph node counts are less common. We conducted a single institution, retrospective review of rectal cancer resections to determine whether lymph node counts correlated with 5-yr OS and to explore the relationship between lymph node counts and various clinical and pathologic factors.

METHODS: A retrospective review of our institutional tumor registry identified 159 patients with AJCC Stage 1, 2, or 3 rectal cancers that underwent surgical …

Global Analysis Of Drosophila Cys2-His2 Zinc Finger Proteins Reveals A Multitude Of Novel Recognition Motifs And Binding Determinants, Ryan G. Christensen, Gary D. Stormo, Et Al

Open Access Publications

No abstract provided.

Obesity Is Associated With Poor Surgical Outcome In Crohn's Disease, Talha Malik, Ashish Manne, Robert Oster, Austin Eckhoff, Seidu Inusah, Alexandra M Gutierrez

Open Access Publications

BACKGROUND: Published data suggest a link between obesity and adverse outcomes in Crohn's disease (CD). We aimed to test the hypothesis that obese CD patients would be more likely than non-obese CD patients to have poor surgical outcome when undergoing surgery for a complication of CD.

METHODS: We designed a retrospective cohort study to test our hypothesis. The population comprised of adult CD patients who underwent CD related surgery at a tertiary referral center. The exposed and unexposed cohorts were represented by patients who were obese vs. non-obese at the pre-op visit respectively. Outcome was represented by successful vs. unsuccessful …

Ulnar Collateral Ligament Injuries Of The Thumb: Phalangeal Translation During Valgus Stress In Human Cadavera, Kathleen E. Mckeon, Richard H. Gelberman, Ryan P. Calfee

Open Access Publications

No abstract provided.

Clinical And Radiographic Outcomes Of Failed Repairs Of Large Or Massive Rotator Cuff Tears: Minimum Ten-Year Follow-Up, E. Scott Paxton, Sharlene A. Teefey, Nirvikar Dahiya, Jay D. Keener, Ken Yamaguchi, Leesa M. Galatz

Open Access Publications

No abstract provided.

Protective Effect Of Surfactant Protein D In Pulmonary Vaccinia Virus Infection: Implication Of A27 Viral Protein, Julien Perino, Nicole M. Thielens, Erika Crouch, Danièle Spehner, Jean-Marc Crance, Anne-Laure Favier

Open Access Publications

No abstract provided.

Somatic Neurofibromatosis Type 1 (Nf1) Inactivation Characterizes Nf1-Associated Pilocytic Astrocytoma, David H. Gutmann, Michael D. Mclellan, Ibrahim Hussain, John W. Wallis, Lucinda L. Fulton, Robert S. Fulton, Vincent Magrini, Ryan Demeter, Todd Wylie, Cyriac Kandoth, Jeffrey R. Leonard, Abhijit Guha, Christopher A. Miller, Li Ding, Elaine R. Mardis

Open Access Publications

No abstract provided.

Evolutionarily Novel Functional Networks In The Human Brain?, Dante Mantini, Maurizio Corbetta, Gian Luca Romani, Guy A. Orban, Wim Vanduffel

Open Access Publications

Primate evolution has been accompanied by complex reorganizations in brain anatomy and function. Little is known, however, about the relationship between anatomical and functional changes induced through primate evolution. Using functional magnetic resonance imaging, we assessed spatial and temporal correspondences of cortical networks in humans and monkeys. We provided evidence for topologically and functionally correspondent networks in sensory-motor and attention regions. More specifically, we revealed a possible monkey equivalent of the human ventral attention network. For other human networks, such as the language and the default-mode networks, we detected topological correspondent networks in the monkey, but with different functional signatures. …

The Disruption Of Celf6, A Gene Identified By Translational Profiling Of Serotonergic Neurons, Results In Autism-Related Behaviors, Joseph D. Dougherty, Susan E. Maloney, David F. Wozniak, Michael A. Rieger, Lisa Sonnenblick, Giovanni Coppola, Nathaniel G. Mahieu, Juliet Zhang, Jinlu Cai, Gary J. Patti, Brett S. Abrahams, Daniel H. Geschwind, Nathaniel Heintz

Open Access Publications

The immense molecular diversity of neurons challenges our ability to understand the genetic and cellular etiology of neuropsychiatric disorders. Leveraging knowledge from neurobiology may help parse the genetic complexity: identifying genes important for a circuit that mediates a particular symptom of a disease may help identify polymorphisms that contribute to risk for the disease as a whole. The serotonergic system has long been suspected in disorders that have symptoms of repetitive behaviors and resistance to change, including autism. We generated a bacTRAP mouse line to permit translational profiling of serotonergic neurons. From this, we identified several thousand serotonergic-cell expressed transcripts, …

Fatty Acid Transport Protein 4 (Fatp4) Prevents Light-Induced Degeneration Of Cone And Rod Photoreceptors By Inhibiting Rpe65 Isomerase, Songhua Li, Jungsoo Lee, Yongdong Zhou, William C. Gordon, James M. Hill, Nicolas G. Bazan, Jeffrey H. Miner, Minghao Jin

Open Access Publications

Although rhodopsin is essential for sensing light for vision, it also mediates light-induced apoptosis of photoreceptors in mouse. RPE65, which catalyzes isomerization of all-trans retinyl fatty acid esters to 11-cis-retinol (11cROL) in the visual cycle, controls the rhodopsin regeneration rate and photoreceptor susceptibility to light-induced degeneration. Mutations in RPE65 have been linked to blindness in affected children. Despite such importance, the mechanism that regulates RPE65 function remains unclear. Through unbiased expression screening of a bovine retinal pigment epithelium (RPE) cDNA library, we have identified elongation of very long-chain fatty acids-like 1 (ELOVL1) and fatty acid transport protein 4 (FATP4), which …

Spatiotemporal Clustering Of The Epigenome Reveals Rules Of Dynamic Gene Regulation, Pengfei Yu, Shu Xiao, Xiaoyun Xin, Chun-Xiao Song, Wei Huang, Darina Mcdee, Tetsuya Tanaka, Ting Wang, Chuan He, Sheng Zhong

Open Access Publications

No abstract provided.

Brca1 Loss Activates Cathepsin L–Mediated Degradation Of 53bp1 In Breast Cancer Cells, David A. Grotsky, Ignacio Gonzalez-Suarez, Anna Novell, Martin A. Neumann, Sree C. Yaddanapudi, Monica Croke, Montserrat Martinez-Alonso, Abena B. Redwood, Sylvia Ortega-Martinez, Zhihui Feng, Enrique Lerma, Teresa Ramon Y Cajal, Junran Zhang, Xavier Matias-Guiu, Adriana Dusso, Susana Gonzalo

Open Access Publications

No abstract provided.

Management Of Chronic Pain In Elderly Frail Patients Finding A Suitable Personalized Method Of Control, Rahul Rastogi, Brian D. Meek

Open Access Publications

No abstract provided.

Robot-Assisted Partial Nephrectomy: Off-Clamp Technique, Gurdarshan S. Sandhu, Eric H. Kim, Youssef S. Tanagho, Sam B. Bhayani, R. Sherburne Figenshau

Open Access Publications

No abstract provided.

Impulsivity And Self-Control During Intertemporal Decision Making Linked To The Neural Dynamics Of Reward Value Representation, Koji Jimura, Maria S. Chushak, Todd S. Braver

Open Access Publications

A characteristic marker of impulsive decision making is the discounting of delayed rewards, demonstrated via choice preferences and choice-related brain activity. However, delay discounting may also arise from how subjective reward value is dynamically represented in the brain when anticipating an upcoming chosen reward. In the current study, brain activity was continuously monitored as human participants freely selected an immediate or delayed primary liquid reward and then waited for the specified delay before consuming it. The ventromedial prefrontal cortex (vmPFC) exhibited a characteristic pattern of activity dynamics during the delay period, as well as modulation during choice, that is consistent …

Identification Of A Pan-Cancer Oncogenic Microrna Superfamily Anchored By A Central Core Seed Motif, Mark P. Hamilton, Kimal Rajapakshe, Sean M. Hartig, Boris Reva, Michael D. Mclellan, Cyriac Kandoth, Li Ding, Travis I. Zack, Preethi H. Gunaratne, David A. Wheeler, Cristian Coarfa, Sean E. Mcguire

Open Access Publications

No abstract provided.

Rapid-Selex For Rna Aptamers, Kylan Szeto, David R. Latulippe, Abdullah Ozer, John M. Pagano, Brian S. White, David Shalloway, John T. Lis, Harold G. Craighead

Open Access Publications

No abstract provided.

Enhanced Hemangioblast Generation And Improved Vascular Repair And Regeneration From Embryonic Stem Cells By Defined Transcription Factors, Fang Liu, Suk Ho Bhang, Elizabeth Arentson, Atsushi Sawada, Chan Kyu Kim, Inyoung Kang, Jinsheng Yu, Nagisa Sakurai, Suk Hyung Kim, Judy Ji Woon Yoo, Paul Kim, Seong Ho Pahng, Younan Xia, Lilianna Solnica-Krezel, Kyunghee Choi

Open Access Publications

No abstract provided.

Observer Ratings Of Neighborhoods: Comparison Of Two Methods, Elena M. Andresen, Theodore K. Malmstrom, Mario Schootman, Fredric D. Wolinsky, J. Philip Miller, Douglas K. Miller

Open Access Publications

No abstract provided.

Prolonged Systemic Inflammation Persistently Modifies Synaptic Plasticity In The Hippocampus: Modulation By The Stress Hormones, Nicola Maggio, Efrat Shavit-Stein, Amir Dori, Ilan Blatt, Joab Chapman

Open Access Publications

No abstract provided.

Infection Of Myofibers Contributes To Increased Pathogenicity During Infection With An Epidemic Strain Of Chikungunya Virus, Anjali Rohatgi, Joseph C. Corbo, Kristen Monte, Stephen Higgs, Dana L. Vanlandingham, Gabrielle Kardon, Deborah J. Lenschow

Open Access Publications

No abstract provided.

Short Report: Semi-Quantitative Scoring Of An Immunochromatographic Test For Circulating Filarial Antigen, Cedric B. Chesnais, Francois Missamou, Sebastien D.S. Pion, Jean Bopda, Frederic Louya, Andrew C. Majewski, Gary J. Weil, Michel Boussinesq

Open Access Publications

No abstract provided.

Interactive Effects Of Dehydroepiandrosterone And Testosterone On Cortical Thickness During Early Brain Development, Tuong Vi Nguyen, James T. Mccracken, Simon Ducharme, Brett F. Cropp, Kelly N. Botteron, Alan C. Evans, Sherif Karama

Open Access Publications

No abstract provided.

Genomic And Metabolic Disposition Of Non-Obese Type 2 Diabetic Rats To Increased Myocardial Fatty Acid Metabolism, Sriram Devanathan, Samuel T. Nemanich, Attila Kovacs, Nicole Fettig, Robert J. Gropler, Kooresh I. Shoghi

Open Access Publications

No abstract provided.