Digital Commons Network^™

Serendipity: Decitabine Monotherapy Induced Complete Molecular Response In A 77-Year-Old Patient With Acute Promyelocytic Leukemia, Ramzi Abboud, Se Young Han, Eric J. Duncavage, Amanda F. Cashen, Cara Lunn Shirai, John S. Welch, John F. Dipersio, Camille N. Abboud

Open Access Publications

No abstract provided.

Csf1r Antagonism Limits Local Restimulation Of Antiviral Cd8+ T Cells During Viral Encephalitis, Kristen E. Funk, Robyn S. Klein

Open Access Publications

No abstract provided.

Indirect Cost Of Traumatic Brachial Plexus Injuries In The United States, Thomas S. Hong, Andrea Tian, Ryan Sachar, Wilson Z. Ray, David M. Brogan, Christopher J. Dy

Open Access Publications

No abstract provided.

Risks Of Harm With Cannabinoids, Cannabis, And Cannabis-Based Medicine For Pain Management Relevant To Patients Receiving Pain Treatment: Protocol For An Overview Of Systematic Reviews, Ian Gilron, Fiona M. Blyth, Louisa Degenhardt, Marta Di Forti, Christopher Eccleston, Simon Haroutounian, Andrew Moore, Andrew S.C. Rice, Mark Wallace

Open Access Publications

No abstract provided.

Web-Based Prescription Opioid Abuse Prevention For Adolescents: Program Development And Formative Evaluation, Sarah K. Moore, Michael Grabinski, Sarah Bessen, Jacob T. Borodovsky, Lisa A. Marsch

Open Access Publications

No abstract provided.

Desmin Forms Toxic, Seeding-Competent Amyloid Aggregates That Persist In Muscle Fibers, Niraja Kedia, Khalid Arhzaouy, Sara K. Pittman, Yuanzi Sun, Mark Batchelor, Conrad C. Weihl, Jan Bieschke

Open Access Publications

No abstract provided.

Gene-Based Analysis In Hrc Imputed Genome Wide Association Data Identifies Three Novel Genes For Alzheimer’S Disease, Alison M. Goate, Carlos Cruchaga, Gerad/Perades, Charge, Adgc, Eadi, Igap, Et Al.

Open Access Publications

No abstract provided.

Two-Period Linear Mixed Effects Models To Analyze Clinical Trials With Run-In Data When The Primary Outcome Is Continuous: Applications To Alzheimer's Disease., Guoqiao Wang, Andrew J Aschenbrenner, Yan Li, Eric Mcdade, Lei Liu, Tammie L S Benzinger, Randall J Bateman, John C Morris, Jason J Hassenstab, Chengjie Xiong

Open Access Publications

Introduction: Study outcomes can be measured repeatedly based on the clinical trial protocol before randomization during what is known as the "run-in" period. However, it has not been established how best to incorporate run-in data into the primary analysis of the trial.

Methods: We proposed two-period (run-in period and randomization period) linear mixed effects models to simultaneously model the run-in data and the postrandomization data.

Results: Compared with the traditional models, the two-period linear mixed effects models can increase the power up to 15% and yield similar power for both unequal randomization and equal randomization.

Discussion: Given that analysis of …

Related And Unrelated Donor Transplantation For B-Thalassemia Major: Results Of An International Survey, Chunfu Li, Shalini Shenoy, Et Al.

Open Access Publications

No abstract provided.

Toward A Comprehensive View Of Cancer Immune Responsiveness: A Synopsis From The Sitc Workshop, Davide Bedognetti, David G. Denardo, Et Al

Open Access Publications

No abstract provided.

Influence Of Diagnostic Method On Outcomes In Phase 3 Clinical Trials Of Bezlotoxumab For The Prevention Of Recurrent Clostridioides Difficile Infection: A Post Hoc Analysis Of Modify I/Ii, Mark H. Wilcox, Galia Rahav, Erik R. Dubberke, Lori Gabryelski, Kerrie Davies, Claire Berry, Karen Eves, Misoo C. Ellison, Dalya Guris, Mary Beth Dorr

Open Access Publications

No abstract provided.

Tourette Syndrome Research Highlights From 2018 [Version 1; Peer Review: 2 Approved], Olivia Rose, Andreas Hartmann, Yulia Worbe, Jeremiah M. Scharf, Kevin J. Black

Open Access Publications

No abstract provided.

Bioresorbable Optical Sensor Systems For Monitoring Of Intracranial Pressure And Temperature, Jiho Shin, Zhonghe Liu, Wubin Bai, Yonghao Liu, Ying Yang, Yeguang Xue, Irawati Kandela, Maryam Pezhouh, Matthew R. Macewan, Yonggang Huang, Wilson Z. Ray, Weidong Zhou, John A. Rogers

Open Access Publications

No abstract provided.

A Human Memory Circuit Derived From Brain Lesions Causing Amnesia, Michael A. Ferguson, Chun Lim, Danielle Cooke, R. Ryan Darby, Ona Wu, Natalia S. Rost, Maurizio Corbetta, Jordan Grafman, Michael D. Fox

Open Access Publications

No abstract provided.

Na+-H+ Exchanger 1 Determines Atherosclerotic Lesion Acidification And Promotes Atherogenesis, Cong-Lin Liu, Xian Zhang, Jing Liu, Yunzhe Wang, Galina K. Sukhova, Gregory R. Wojtkiewicz, Tianxiao Liu, Rui Tang, Samuel Achilefu, Matthias Nahrendorf, Peter Libby, Junli Guo, Jin-Ying Zhang, Guo-Ping Shi

Open Access Publications

No abstract provided.

Fimbriae Reprogram Host Gene Expression – Divergent Effects Of P And Type 1 Fimbriae, Ines Ambite, Daniel S. C. Butler, Christoph Stork, Jenny Gronberg-Hernandez, Bela Koves, Jaroslaw Zdziarski, Jerome Pinkner, Scott J. Hultgren, Ulrich Dobrindt, Bjorn Wullt, Catharina Svanborg

Open Access Publications

No abstract provided.

Clinical Utility Of Advanced Microbiology Testing Tools, Melissa B. Miller, Carey-Ann D. Burnham, Et Al

Open Access Publications

No abstract provided.

Dosing Pole Recommendations For Lymphatic Filariasis Elimination: A Height-Weight Quantile Regression Modeling Approach, Charles W. Goss, Katiuscia O'Brian, Christine Dubray, Peter U. Fischer, Myra Hardy, Purushothaman Jambulingam, Christopher L. King, Moses Laman, Jean Frantz Lemoine, Leanne J. Robinson, Josaia Samuela, Swaminathan Subramanian, Taniawati Supali, Gary J. Weil, Kenneth B. Schechtman

Open Access Publications

BACKGROUND: The World Health Organization (WHO) currently recommends height or age-based dosing as alternatives to weight-based dosing for mass drug administration lymphatic filariasis (LF) elimination programs. The goals of our study were to compare these alternative dosing strategies to weight-based dosing and to develop and evaluate new height-based dosing pole scenarios.

METHODOLOGY/PRINCIPAL FINDINGS: Age, height and weight data were collected from >26,000 individuals in five countries during a cluster randomized LF clinical trial. Weight-based dosing for diethylcarbamazine (DEC; 6 mg/kg) and ivermectin (IVM; 200 ug/kg) with tablet numbers derived from a table of weight intervals was treated as the "gold …

Multicenter Study Demonstrates Standardization Requirements For Mold Identification By Maldi-Tof Ms, Anna F. Lau, Kaitlin F. Mitchell, Meghan A. Wallace, Carey-Ann D. Burnham, Et Al

Open Access Publications

No abstract provided.

Bogotá River Anthropogenic Contamination Alters Microbial Communities And Promotes Spread Of Antibiotic Resistance Genes, Carlos Eduardo Posada-Perlaza, Adán Ramírez-Rojas, Paola Porras, Boahemaa Adu-Oppong, Ana-María Botero-Coy, Félix Hernández, Juan M. Anzola, Lorena Díaz, Gautam Dantas, Alejandro Reyes, María Mercedes Zambrano

Open Access Publications

No abstract provided.

Therapeutic Efficacy Of Favipiravir Against Bourbon Virus In Mice, Traci L. Bricker, Md. Shafiuddin, Anshu P. Gounder, Andrew B. Janowski, Guoyan Zhao, Graham D. Williams, Brett W. Jagger, Michael S. Diamond, Thomas Bailey, Jennie H. Kwon, David Wang, Adrianus C. M. Boon

Open Access Publications

No abstract provided.

Maternal Pomegranate Juice Intake And Brain Structure And Function In Infants With Intrauterine Growth Restriction: A Randomized Controlled Pilot Study., Lillian G. Matthews, Christopher D. Smyser, Sara Cherkerzian, Dimitrios Alexopoulos, Jeanette Kenley, Methodius G. Tuuli, D. Michael Nelson, Terrie E. Inder

Open Access Publications

Polyphenol-rich pomegranate juice has been shown to have benefit as a neuroprotectant in animal models of neonatal hypoxic-ischemia. No published studies have investigated maternal polyphenol administration as a potential neuroprotectant in at-risk newborns, such as those with intrauterine growth restriction (IUGR). This was a randomized, placebo-controlled, double-blind pilot study to investigate the impact of maternal pomegranate juice intake in pregnancies with IUGR, on newborn brain structure and function at term-equivalent age (TEA). Mothers with IUGR at 24-34 weeks' gestation were recruited from Barnes-Jewish Hospital obstetrical clinic. Consented mothers were randomized to treatment (8 oz. pomegranate juice) or placebo (8 oz. …

Apobec1 Complementation Factor (A1cf) And Rbm47 Interact In Tissue-Specific Regulation Of C To U Rna Editing In Mouse Intestine And Liver, Valerie Blanc, Yan Xie, Susan Kennedy, Jesse D. Riordan, Deborah C. Rubin, Blair B. Madison, Jason C. Mills, Joseph H. Nadeau, Nicholas O. Davidson

Open Access Publications

No abstract provided.

Outcomes And Cost-Minimization Analysis Of Cement Spacers Versus Expandable Cages For Posterior-Only Reconstruction Of Metastatic Spine Corpectomies, Yusef Jordan, Jacob M. Buchowski, Mahati Mokkarala, Colleen Peters, David B. Bumpass

Open Access Publications

No abstract provided.

Oral Selinexor–Dexamethasone For Triple-Class Refractory Multiple Myeloma, Ravi Vij, Et Al.

Open Access Publications

No abstract provided.

Obesity Counseling In Obstetrics And Gynecology: Provider Perceptions And Barriers, Sarah P. Huepenbecker, Leping Wan, Andrea Leon, Diane Rosen, John Hoff, Lindsay M. Kuroki, Katherine C. Fuh, Matthew A. Powell, David G. Mutch, Graham A. Colditz, Andrea R. Hagemann

Open Access Publications

No abstract provided.

Dengue And Zika Virus Cross-Reactive Human Monoclonal Antibodies Protect Against Spondweni Virus Infection And Pathogenesis In Mice, Vanessa Salazar, Brett W. Jagger, Juthathip Mongkolsapaya, Katherine E. Burgomaster, Wanwisa Dejnirattisai, Emma S. Winkler, Estefania Fernandez, Christopher A. Nelson, Daved H. Fremont, Theodore C. Pierson, James E. Crowe Jr., Gavin R. Screaton, Michael S. Diamond

Open Access Publications

No abstract provided.

Inpatient Management Of Hypercalcemia Portends A Poor Prognosis Among Gynecologic Oncology Patients: A Trigger To Initiate Hospice Care?, James C. Cripe, Tommy R. Buchanan Jr., Leping Wan, Andrea R. Hagemann, Carolyn K. Mccourt, L. Stewart Massad, Katherine C. Fuh, David G. Mutch, Mathew A. Powell, Premal H. Thaker, Lindsay M. Kuroki

Open Access Publications

No abstract provided.

Association Between Mortality And Implantable Cardioverter-Defibrillators By Aetiology Of Heart Failure: A Propensity-Matched Analysis Of The Warcef Trial, Tetz C. Lee, Douglas L. Mann, Et Al

Open Access Publications

No abstract provided.

Parkinson's Disease And Multiple System Atrophy Have Distinct Α-Synuclein Seed Characteristics, Tritia R. Yamasaki, Brandon B. Holmes, Jennifer L. Furman, Dhruva D. Dhavale, Bryant W. Su, Eun-Suk Song, Nigel J. Cairns, Paul T. Kotzbauer, Marc I. Diamond

Open Access Publications

No abstract provided.