Digital Commons Network^™

Urinary Tract Colonization Is Enhanced By A Plasmid That Regulates Uropathogenic Acinetobacter Baumannii Chromosomal Genes, Gisela Di Venanzio, Ana L. Flores-Mireles, Juan J. Calix, Maria Florencia Haurat, Nichollas E. Scott, Lauren D. Palmer, Robert F. Potter, Michael E. Hibbing, Laura Friedman, Bin Wang, Gautam Dantas, Eric P. Skaar, Scott J. Hultgren, Mario F. Feldman

Open Access Publications

No abstract provided.

A Comparison Of Shallow And Deep Learning Methods For Predicting Cognitive Performance Of Stroke Patients From Mri Lesion Images, Sucheta Chauhan, Lovekesh Vig, Michele De Filippo De Grazia, Maurizio Corbetta, Shandar Ahmad, Marco Zorzi

Open Access Publications

No abstract provided.

Dermal And Muscle Fibroblasts And Skeletal Myofibers Survive Chikungunya Virus Infection And Harbor Persistent Rna, Alissa R. Young, Marissa C. Locke, Lindsey E. Cook, Bradley E. Hiller, Rong Zhang, Matthew L. Hedberg, Kristen J. Monte, Deborah J. Veis, Michael J. Diamond, Deborah J. Lenschow

Open Access Publications

No abstract provided.

Spatiotemporal Dynamics Of Multidrug Resistant Bacteria On Intensive Care Unit Surfaces, Alaric W. D'Souza, Robert F. Potter, Meghan Wallace, Angela Shupe, Sanket Patel, Xiaoqing Sun, Danish Gul, Jennie H. Kwon, Saadia Andleeb, Carey-Ann D. Burnham, Gautam Dantas

Open Access Publications

No abstract provided.

Phase 1 Dose Escalation Study Of The Allosteric Akt Inhibitor Bay 1125976 In Advanced Solid Cancer-Lack Of Association Between Activating Akt Mutation And Akt Inhibition-Derived Efficacy, Andreas Schneeweiss, Dagmar Hess, Markus Joerger, Andrea Varga, Stacy Moulder, Apostolia M Tsimberidou, Cynthia Ma, Sara A Hurvitz, Christine Rentzsch, Marion Rudolph, Silke Thiele, Oliver Boix, Gary Wilkinson, Eleni Lagkadinou, Matthias Ocker

Open Access Publications

This open-label, phase I first-in-human study (NCT01915576) of BAY 1125976, a highly specific and potent allosteric inhibitor of AKT1/2, aimed to evaluate the safety, pharmacokinetics, and maximum tolerated dose of BAY 1125976 in patients with advanced solid tumors. Oral dose escalation was investigated with a continuous once daily (QD) treatment (21 days/cycle) and a twice daily (BID) schedule. A dose expansion in 28 patients with hormone receptor-positive metastatic breast cancer, including nine patients harboring the

Cisplatin Exposure Causes C-Myc-Dependent Resistance To Cdk4/6 Inhibition In Hpv-Negative Head And Neck Squamous Cell Carcinoma, Anthony M. Robinson, Richa Rathore, Nathan J. Redlich, Douglas R. Adkins, Todd Vanarsdale, Brian A. Van Tine, Loren S. Michel

Open Access Publications

No abstract provided.

Thromboelastography Variables, Immune Markers, And Endothelial Factors Associated With Shock And Npmods In Children With Severe Sepsis, Arun Saini, Philip C Spinella, Steven P Ignell, John C Lin

Open Access Publications

No abstract provided.

The Abcs Of Wheeze: Asthma And Bacterial Communities, Naomi G. Wilson, Ariel Hernandez-Leyva, Andrew L. Kau

Open Access Publications

No abstract provided.

Simple Nutrients Bypass The Requirement For Hlh-30 In Coupling Lysosomal Nutrient Sensing To Survival, John T. Murphy, Haiyan Liu, Xiucui Ma, Alex Shaver, Brian M. Egan, Clara Oh, Alexander Boyko, Travis Mazer, Samuel Ang, Rohan Khopkar, Ali Javaheri, Sandeep Kumar, Xuntian Jiang, Daniel Ory, Kartik Mani, Scot J. Matkovich, Kerry Kornfeld, Abhinav Diwan

Open Access Publications

No abstract provided.

Mr Diffusion Changes In The Perimeter Of The Lateral Ventricles Demonstrate Periventricular Injury In Post-Hemorrhagic Hydrocephalus Of Prematurity, Albert M Isaacs, Christopher D Smyser, Rachel E Lean, Dimitrios Alexopoulos, Rowland H Han, Jeffrey J Neil, Sophia A Zimbalist, Cynthia E Rogers, Yan Yan, Joshua S Shimony, David D Limbrick

Open Access Publications

OBJECTIVES: Injury to the preterm lateral ventricular perimeter (LVP), which contains the neural stem cells responsible for brain development, may contribute to the neurological sequelae of intraventricular hemorrhage (IVH) and post-hemorrhagic hydrocephalus of prematurity (PHH). This study utilizes diffusion MRI (dMRI) to characterize the microstructural effects of IVH/PHH on the LVP and segmented frontal-occipital horn perimeters (FOHP).

STUDY DESIGN: Prospective study of 56 full-term infants, 72 very preterm infants without brain injury (VPT), 17 VPT infants with high-grade IVH without hydrocephalus (HG-IVH), and 13 VPT infants with PHH who underwent dMRI at term equivalent. LVP and FOHP dMRI measures and …

Bone Marrow Adipose Tissue Does Not Express Ucp1 During Development Or Adrenergic-Induced Remodeling, Clarissa S. Craft, Hero Robles, Madelyn R. Lorenz, Eric D. Hilker, Kristann L. Magee, Thomas L. Andersen, William P. Cawthorn, Ormond A. Macdougald, Charles A. Harris, Erica L. Scheller

Open Access Publications

No abstract provided.

De Novo Assembly Of The Brugia Malayi Genome Using Long Reads From A Single Minion Flowcell, Joseph R. Fauver, John Martin, Gary J. Weil, Makedonka Mitreva, Peter U. Fischer

Open Access Publications

No abstract provided.

Mutant P53 Drives Clonal Hematopoiesis Through Modulating Epigenetic Pathway, Sisi Chen, Terrence N. Wong, Daniel C. Link, Et Al.

Open Access Publications

No abstract provided.

Vaccine-Induced Skewing Of T Cell Responses Protects Against Chikungunya Virus Disease, Rebecca M Broeckel, Nicole Haese, Takeshi Ando, Igor Dmitriev, Craig N Kreklywich, John Powers, Michael Denton, Patricia Smith, Thomas E Morrison, Mark Heise, Victor Defilippis, Ilhem Messaoudi, David T Curiel, Daniel N Streblow

Open Access Publications

Chikungunya virus (CHIKV) infections can cause severe and debilitating joint and muscular pain that can be long lasting. Current CHIKV vaccines under development rely on the generation of neutralizing antibodies for protection; however, the role of T cells in controlling CHIKV infection and disease is still unclear. Using an overlapping peptide library, we identified the CHIKV-specific T cell receptor epitopes recognized in C57BL/6 infected mice at 7 and 14 days post-infection. A fusion protein containing peptides 451, 416, a small region of nsP4, peptide 47, and an HA tag (CHKVf5) was expressed using adenovirus and cytomegalovirus-vectored vaccines. Mice vaccinated with …

Natural History Of The Dysplastic Hip Following Modern Periacetabular Osteotomy, Cody C. Wyles, Juan S. Vargas, Mark J. Heidenreich, Kristin C. Mara, Christopher L. Peters, John C. Clohisy, Robert T. Trousdale, Rafael J. Sierra

Open Access Publications

No abstract provided.

22q11.2 Duplication: A Review Of Neuropsychiatric Correlates And A Newly Observed Case Of Prototypic Sociopathy, Sonam Vyas, John N Constantino, Dustin Baldridge

Open Access Publications

Callous-unemotional (CU) traits are highly disabling behavioral characteristics, common predictors of delinquency and criminality, and pathognomonic for antisocial personality disorder. They are highly heritable, but their specific molecular genetic causes are unknown. Here, we briefly review the literature on neuropsychiatric correlates of 22q11.2 duplication and describe a newly identified case of a 737-kb microduplication within the low copy repeat (LCR) B-D region, involving a 13-yr-old early adoptee with mild developmental delay and severe, chronic antisocial behavior of early childhood onset. When psychiatric symptoms have been reported in relation to duplications in this specific region, 19% of the reports feature aggression-but …

Neural Processes Of Proactive And Reactive Controls Modulated By Motor-Skill Experiences, Qiuhua Yu, Bolton K H Chau, Bess Y H Lam, Alex W K Wong, Jiaxin Peng, Chetwyn C H Chan

Open Access Publications

This study investigated the experience of open and closed motor skills on modulating proactive and reactive control processes in task switching. Fifty-four participants who were open-skilled (

The Human Milk Protein-Lipid Complex Hamlet Disrupts Glycolysis And Induces Death In Streptococcus Pneumoniae, Hazeline Roche-Hakansson, Goutham Vansarla, Laura R. Marks, Anders P. Hakansson

Open Access Publications

No abstract provided.

Shared And Specific Genetic Risk Factors For Lifetime Major Depression, Depressive Symptoms And Neuroticism In Three Population-Based Twin Samples, Kenneth S Kendler, Charles O Gardner, Michael C Neale, Steve Aggen, Andrew Heath, Lucía Colodro-Conde, Baptiste Couvyduchesne, Enda M Byrne, Nicholas G Martin, Nathan A Gillespie

Open Access Publications

BACKGROUND: Vulnerability to depression can be measured in different ways. We here examine how genetic risk factors are inter-related for lifetime major depression (MD), self-report current depressive symptoms and the personality trait Neuroticism.

METHOD: We obtained data from three population-based adult twin samples (Virginia n = 4672, Australia #1 n = 3598 and Australia #2 n = 1878) to which we fitted a common factor model where risk for 'broadly defined depression' was indexed by (i) lifetime MD assessed at personal interview, (ii) depressive symptoms, and (iii) neuroticism. We examined the proportion of genetic risk for MD deriving from the …

Reported Variability In Healthcare Facility Policies Regarding Healthcare Personnel Working While Experiencing Influenza-Like Illnesses: An Emerging Infections Network Survey, Hilary M Babcock, Susan E Beekmann, Satish K Pillai, Scott Santibanez, Leslie Lee, David T Kuhar, Angela P Campbell, Anita Patel, Philip M Polgreen

Open Access Publications

BACKGROUND: Presenteeism, or working while ill, by healthcare personnel (HCP) experiencing influenza-like illness (ILI) puts patients and coworkers at risk. However, hospital policies and practices may not consistently facilitate HCP staying home when ill.

OBJECTIVE AND METHODS: We conducted a mixed-methods survey in March 2018 of Emerging Infections Network infectious diseases physicians, describing institutional experiences with and policies for HCP working with ILI.

RESULTS: Of 715 physicians, 367 (51%) responded. Of 367, 135 (37%) were unaware of institutional policies. Of the remaining 232 respondents, 206 (89%) reported institutional policies regarding work restrictions for HCP with influenza or ILI, but only …

Teg Platelet Mapping And Impedance Aggregometry To Predict Platelet Transfusion During Cardiopulmonary Bypass In Pediatric Patients, Erin E Barker, Arun Saini, Avihu Z Gazit, Susan M Shea, Sirine Baltagi, Brian F Gage, Philip C Spinella

Open Access Publications

No abstract provided.

Local Health Department Accreditation Is Associated With Organizational Supports For Evidence-Based Decision Making, Peg Allen, Stephanie Mazzucca, Renee G Parks, Mackenzie Robinson, Rachel G Tabak, Ross Brownson

Open Access Publications

No abstract provided.

Dramatic Changes In Gene Expression In Different Forms Of Crithidia Fasciculata Reveal Potential Mechanisms For Insect-Specific Adhesion In Kinetoplastid Parasites, John N. Filosa, Corbett T. Berry, Gordon Ruthel, Stephen M. Beverley, Wesley C. Warren, Chad Tomlinson, Peter J. Myler, Elizabeth A. Dudkin, Megan L. Povelones, Michael Povelones

Open Access Publications

Kinetoplastids are a group of parasites that includes several medically-important species. These human-infective species are transmitted by insect vectors in which the parasites undergo specific developmental transformations. For each species, this includes a stage in which parasites adhere to insect tissue via a hemidesmosome-like structure. Although this structure has been described morphologically, it has never been molecularly characterized. We are using Crithidia fasciculata, an insect parasite that produces large numbers of adherent parasites inside its mosquito host, as a model kinetoplastid to investigate both the mechanism of adherence and the signals required for differentiation to an adherent form. An advantage …

Regional Differences In The Expression Of Tetrodotoxin-Sensitive Inward Ca2+ And Outward Cs+ /K+ Currents In Mouse And Human Ventricles, Wei Wang, Rebecca L. Mellor, Jeanne M. Nerbonne, C. William Blake

Open Access Publications

No abstract provided.

High Myc Mrna Expression Is More Clinically Relevant Than Myc Dna Amplification In Triple-Negative Breast Cancer, Eriko Katsuta, Li Yan, Takashi Takeshita, Kerry-Ann Mcdonald, Subhamoy Dasgupta, Mateusz Opyrchal, Kazuaki Takabe

Open Access Publications

DNA abnormalities are used in inclusion criteria of clinical trials for treatments with specific targeted molecules. MYC is one of the most powerful oncogenes and is known to be associated with triple-negative breast cancer (TNBC). Its DNA amplification is often part of the targeted DNA-sequencing panels under the assumption of reflecting upregulated signaling. However, it remains unclear if MYC DNA amplification is a surrogate of its upregulated signaling. Thus, we investigated the difference between MYC DNA amplification and mRNA high expression in TNBCs utilizing publicly available cohorts. MYC DNA amplified tumors were found to have various mRNA expression levels, suggesting …

Embracing Differences To Improve Success: American Orthopaedic Association Presidential Address, Boston, Massachusetts, June 23, 2017: Aoa Critical Issues, Regis J O'Keefe

Open Access Publications

No abstract provided.

Melanoma In Individuals With Neurofibromatosis Type 1: A Retrospective Study, May Zhang, Trisha Bhat, David H. Gutmann, Kimberly J. Johnson

Open Access Publications

No abstract provided.

Detection Of Neoantigen-Specific T Cells Following A Personalized Vaccine In A Patient With Glioblastoma, Tanner M. Johanns, Christopher A. Miller, Connor J. Liu, Richard J. Perrin, Diane Bender, Dale K. Kobayashi, Jian L. Campian, Michael R. Chicoine, Ralph G. Dacey, Jiayi Huang, Edward F. Fritsch, William E. Gillanders, Maxim N. Artyomov, Elaine R. Mardis, Robert D. Schreiber, Gavin P. Dunn

Open Access Publications

No abstract provided.

The Impact Of The Geometric Correction Scheme On Meg Functional Topology At Rest, Stefania Della Penna, Maurizio Corbetta, Vincent Wens, Francesco De Pasquale

Open Access Publications

Spontaneous activity is correlated across brain regions in large scale networks (RSN) closely resembling those recruited during several behavioral tasks and characterized by functional specialization and dynamic integration. Specifically, MEG studies revealed a set of central regions (dynamic core) possibly facilitating communication among differently specialized brain systems. However, source projected MEG signals, due to the fundamentally ill-posed inverse problem, are affected by spatial leakage, leading to the estimation of spurious, blurred connections that may affect the topological properties of brain networks and their integration. To reduce leakage effects, several correction schemes have been proposed including the Geometric Correction Scheme (GCS) …

68ga-Galmydar: A Pet Imaging Tracer For Noninvasive Detection Of Doxorubicin-Induced Cardiotoxicity, Jothilingam Sivapackiam, Shivesh Kabra, Sylvia Speidel, Monica Sharma, Richard Laforest, Amber Salter, Michael P. Rettig, Vijay Sharma

Open Access Publications

No abstract provided.