Digital Commons Network^™

Two-Year Evaluation Of Mandatory Bundled Payments For Joint Replacement, Michael L. Barnett, Andrew Wilcock, J. Michael Mcwilliams, Arnold M. Epstein, Karen E. Joynt Maddox, E. John Orav, David C. Grabowski, Ateev Mehrotra

Open Access Publications

No abstract provided.

Multi-Platform Discovery Of Haplotype-Resolved Structural Variation In Human Genomes, Li Ding

Open Access Publications

No abstract provided.

Repetitive Concussive And Subconcussive Injury In A Human Tau Mouse Model Results In Chronic Cognitive Dysfunction And Disruption Of White Matter Tracts, But Not Tau Pathology, Mihika Gangolli, Joseph Benetatos, Thomas J. Esparza, Emeka M. Fountain, Shamilka Seneviratne, David L. Brody

Open Access Publications

No abstract provided.

Pd-L1 Expression And Its Clinicopathological Correlation In Advanced Esophageal Squamous Cell Carcinoma In A Chinese Population, Lulu Rong, Yong Liu, Zhouguang Hui, Zitong Zhao, Yueming Zhang, Bingzhi Wang, Yanling Yuan, Wenbin Li, Lei Guo, Jianming Ying, Yongmei Song, Luhua Wang, Zhongren Zhou, Liyan Xue, Ning Lu

Open Access Publications

No abstract provided.

Comparison Of Two Models Of Family-Based Treatment For Childhood Obesity: A Pilot Study, Kristie Bergmann, Zoe Mestre, David Strong, Dawn M. Eichen, Kyung Rhee, Scott Crow, Denise Wilfley, Kerri N. Boutelle

Open Access Publications

No abstract provided.

The Macaque Cerebellar Flocculus Outputs A Forward Model Of Eye Movement, Gyutae Kim, Jean Laurens, Tatyana A. Yakusheva, Pablo M. Blazquez

Open Access Publications

No abstract provided.

Repeatability Of Brown Adipose Tissue Measurements On Fdg Pet/Ct Following A Simple Cooling Procedure For Bat Activation, John P. Crandall, Prateek Gajwani, Joo H. O., Daniel D. Mawhinney, Fred Sterzer, Richard L. Wahl

Open Access Publications

No abstract provided.

Systems Analysis-Based Assessment Of Post-Treatment Adverse Events In Lymphatic Filariasis, Britt J. Andersen, Bruce A. Rosa, Jonah Kupritz, Aboulaye Meite, Traye Serge, Marla I. Hertz, Kurt Curtis, Christopher L. King, Makedonka Mitreva, Peter U. Fischer, Gary J. Weil

Open Access Publications

No abstract provided.

Functional Analysis Of Bard1 Missense Variants In Homology-Directed Repair And Damage Sensitivity, Aleksandra I. Adamovich, Tapahsama Banerjee, Margaret Wingo, Kathryn Duncan, Jie Ning, Fernanda Martins Rodrigues, Kuan-Lin Huang, Cindy Lee, Feng Chen, Li Ding, Jeffrey D. Parvin

Open Access Publications

No abstract provided.

Steady-State Activation Of The High-Affinity Isoform Of The Α4Β2Δ Gabaa Receptor, Spencer R. Pierce, Thomas C. Senneff, Allison L. Germann, Gustav Akk

Open Access Publications

No abstract provided.

A Pilot Study On The Kinetics Of Metabolites And Microvascular Cutaneous Effects Of Nitric Oxide Inhalation In Healthy Volunteers, Adriano R Tonelli, Kulwant S Aulak, Mostafa K Ahmed, Alfred Hausladen, Batool Abuhalimeh, Charlie J Casa, Stephen C Rogers, David Timm, Allan Doctor, Benjamin Gaston, Raed A Dweik

Open Access Publications

RATIONALE: Inhaled nitric oxide (NO) exerts a variety of effects through metabolites and these play an important role in regulation of hemodynamics in the body. A detailed investigation into the generation of these metabolites has been overlooked.

OBJECTIVES: We investigated the kinetics of nitrite and S-nitrosothiol-hemoglobin (SNO-Hb) in plasma derived from inhaled NO subjects and how this modifies the cutaneous microvascular response.

FINDINGS: We enrolled 15 healthy volunteers. Plasma nitrite levels at baseline and during NO inhalation (15 minutes at 40 ppm) were 102 (86-118) and 114 (87-129) nM, respectively. The nitrite peak occurred at 5 minutes of discontinuing NO …

Association Of Polygenic Liability For Alcohol Dependence And Eeg Connectivity In Adolescence And Young Adulthood, Jacquelyn L. Meyers, Emma C Johnson, Arpana Agrawal, Et Al

Open Access Publications

Differences in the connectivity of large-scale functional brain networks among individuals with alcohol use disorders (AUD), as well as those at risk for AUD, point to dysfunctional neural communication and related cognitive impairments. In this study, we examined how polygenic risk scores (PRS), derived from a recent GWAS of DSM-IV Alcohol Dependence (AD) conducted by the Psychiatric Genomics Consortium, relate to longitudinal measures of interhemispheric and intrahemispheric EEG connectivity (alpha, theta, and beta frequencies) in adolescent and young adult offspring from the Collaborative Study on the Genetics of Alcoholism (COGA) assessed between ages 12 and 31. Our findings indicate that …

Myeloid Acat1/Soat1 Ko Attenuates Pro-Inflammatory Responses In Macrophages And Protects Against Atherosclerosis In A Model Of Advanced Lesions, Elaina M. Melton, Haibo Li, Jalen Benson, Paul Sohn, Li-Hao Huang, Bao-Liang Song, Bo-Liang Li, Catherine C.Y. Chang, Ta-Yuan Chang

Open Access Publications

No abstract provided.

Duraseal Exact Is A Safe Adjunctive Treatment For Durotomy In Spine: Postapproval Study, Kee D. Kim, Dinesh Ramanathan, Jason Highsmith, William Lavelle, Peter Gerszten, Fernando Vale, Neill Wright

Open Access Publications

No abstract provided.

Safety And Efficacy Of Digital Single-Operator Pancreatoscopy For Obstructing Pancreatic Ductal Stones, Olaya I. Brewer Gutierrez, Daniel K. Mullady, Natalie Cosgrove, Et Al.

Open Access Publications

No abstract provided.

Respiratory Viral Surveillance Of Healthcare Personnel And Patients At An Adult Long-Term Care Facility, Caroline A O'Neil, Lindsay Kim, Mila M Prill, H Keipp Talbot, Brett Whitaker, Senthilkumar K Sakthivel, Yange Zhang, Jing Zhang, Suxiang Tong, Nimalie Stone, Shikha Garg, Susan I Gerber, Hilary M Babcock

Open Access Publications

We conducted active surveillance of acute respiratory viral infections (ARIs) among residents and healthcare personnel (HCP) at a long-term care facility during the 2015-2016 respiratory illness season. ARIs were observed among both HCP and patients, highlighting the importance of including HCP in surveillance programs.

Association Between Rotator Cuff Muscle Size And Glenoid Deformity In Primary Glenohumeral Osteoarthritis, Alexander W Aleem, Peter N Chalmers, Daniel Bechtold, Adam Z Khan, Robert Z Tashjian, Jay D Keener

Open Access Publications

BACKGROUND: Although glenoid morphology has been associated with fatty infiltration of the rotator cuff in arthritic shoulders, the association of rotator cuff muscle area with specific patterns of glenoid wear has not been studied. The purpose of our study was to assess the associations of glenoid deformity in primary glenohumeral osteoarthritis and rotator cuff muscle area.

METHODS: A retrospective study of 370 computed tomographic (CT) scans of osteoarthritic shoulders was performed. Glenoid deformity according to the modified Walch classification was determined, and retroversion, inclination, and humeral-head subluxation were calculated using automated 3-dimensional software. Rotator cuff muscle area was measured on …

Pathogen-Negative Sepsis—An Opportunity For Antimicrobial Stewardship, Gabriel C. Lockhart, Jacob Hanin, Scott T. Micek, Marin H. Kollef

Open Access Publications

No abstract provided.

Understanding The Experience Of Psychopathology After Intimate Partner Violence: The Role Of Personality, Paulo A S Moreira, Márcia Pinto, C. Robert Cloninger, Daniela Rodrigues, Carlos Fernandes Da Silva

Open Access Publications

Objectives: To fully understand the dynamics of Intimate Partner Violence (IPV) it is necessary to understand the role of personality. The current understanding of which personality characteristics are associated with IPV victimization is, however, far from comprehensive. Given this gap in the literature, our objective was to examine the associations between the dimensions of the psychobiological model of personality and psychopathological symptoms in women who had experienced IPV.

Methods: Using a case-control design, a group of women who had experienced IPV and who were living in shelters (

Results: Victims of IPV showed significantly higher levels of Harm Avoidance and …

Imaging Biomarkers Of Adiposity And Sarcopenia As Potential Predictors For Overall Survival Among Patients With Endometrial Cancer Treated With Bevacizumab, J. Gillen, K. A. Mills, J. Dvorak, B. Zheng, T. Thai, R. Salani, C. M. Cosgrove, B. Davidson, P. H. Thaker, K. N. Moore

Open Access Publications

No abstract provided.

Nfat5 Up-Regulates Expression Of The Kidney-Specific Ubiquitin Ligase Gene Rnf183 Under Hypertonic Conditions In Inner-Medullary Collecting Duct Cells, Yujiro Maeoka, Yan Wu, Takumi Okamoto, Soshi Kanemoto, Xiao Peng Guo, Atsushi Saito, Rie Asada, Koji Matsuhisa, Takao Masaki, Kazunori Imaizumi, Masayuki Kaneko

Open Access Publications

No abstract provided.

Field-In-Field Breast Planning For A Jawless, Double-Stack Mlc Linac Using Flattening-Filter-Free Beams, Robert Morris, Eric Laugeman, Jessica Hilliard, Imran Zoberi, Ana Heerman, Geoffrey Hugo, Sasa Mutic, Bin Cai

Open Access Publications

BACKGROUND: This study intends to develop an efficient field-in-field (FiF) planning technique with the Eclipse treatment planning system (TPS) to determine the feasibility of using the Halcyon treatment delivery system for 3D treatment of breast cancer.

METHODS: Ten treatment plans were prepared on the Halcyon treatment planning system and compared to the same patients' clinically delivered TrueBeam plans which used flattened 6 MV and 10 MV beams. Patients selected for this study were treated via simple, tangential breast irradiation and did not receive radiotherapy of the supraclavicular or internal mammary lymph nodes. Planning target volumes (PTV) volumes ranged from 519 …

Operative Vaginal Delivery Is A Safe Option In Women Undergoing A Trial Of Labor After Cesarean, Erin Krizman, Patricia Grzebielski, Kathleen M Antony, Emmanuel Sampene, Matthew Shanahan, J Igor Iruretagoyena, Justin Bohrer

Open Access Publications

No abstract provided.

Co-Registered Photoacoustic And Ultrasound Imaging Of Human Colorectal Cancer, Guang Yang, Eghbal Amidi, William C. Chapman Jr., Sreyankar Nandy, Atahar Mostafa, Heba Abdelal, Zahra Alipour, Deyali Chatterjee, Matthew Mutch, Quing Zhu

Open Access Publications

No abstract provided.

High-Density Speckle Contrast Optical Tomography Of Cerebral Blood Flow Response To Functional Stimuli In The Rodent Brain, Tanja Dragojević, Ernesto E. Vidal Rosas, Joseph L. Hollmann, Joseph P. Culver, Carles Justicia, Turgut Durduran

Open Access Publications

No abstract provided.

Qsofa Score And Lqsofa Score As Predictors Of Outcome In An Elderly Population With Chest Infection Treated In The Emergency Department. A Case Series, Dimitrios Velissaris, Vasileios Karamouzos, Nikolaos Dimitrios Pantzaris, Loukas Kakoullis, Charalampos Pierrakos, Menelaos Karanikolas, Charalampos Gogos

Open Access Publications

No abstract provided.

Neutrophils Promote Vla-4–Dependent B Cell Antigen Presentation And Accumulation Within The Meninges During Neuroinflammation, Chelsea R. Parker Harp, Angela S. Archambault, Matthew Cheung, Jesse W. Williams, Rafael S. Czepielewski, Patrick C. Duncker, Aaron J. Kilgore, Aidan T. Miller, Benjamin M. Segal, Alfred H. J. Kim, Gwendalyn J. Randolph, Gregory F. Wu

Open Access Publications

No abstract provided.

Categorical Encoding Of Decision Variables In Orbitofrontal Cortex, Arno Onken, Jue Xie, Stefano Panzeri, Camillo Padoa-Schioppa

Open Access Publications

No abstract provided.

Application Of An Antibiotic Spectrum Index In The Neonatal Intensive Care Unit, Alexandra C Lahart, Christopher C Mcpherson, Jeffrey S Gerber, Barbara B Warner, Brian R Lee, Jason G Newland

Open Access Publications

Antimicrobial stewardship programs typically use days of therapy to assess antimicrobial use. However, this metric does not account for the antimicrobial spectrum of activity. We applied an antibiotic spectrum index to a population of very-low-birth-weight infants to assess its utility to evaluate the impact of antimicrobial stewardship interventions.

Glutathione Synthesis Contributes To Virulence Of Streptococcus Agalactiae In A Murine Model Of Sepsis, Elizabeth A Walker, Gary C Port, Michael G Caparon, Blythe E Janowiak

Open Access Publications

No abstract provided.