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Transcriptional Remodeling Patterns In Murine Dendritic Cells Infected With Paracoccidioides Brasiliensis: More Is Not Necessarily Better, Calliandra M De-Souza-Silva, Fabián Andrés Hurtado, Aldo Henrique Tavares, Getúlio P De Oliveira, Taina Raiol, Christiane Nishibe, Daniel Paiva Agustinho, Nalvo Franco Almeida, Maria Emília Machado Telles Walter, André Moraes Nicola, Anamélia Lorenzetti Bocca, Patrícia Albuquerque, Ildinete Silva-Pereira

Open Access Publications

Most people infected with the fungus

Dnmt3a Haploinsufficiency Results In Behavioral Deficits And Global Epigenomic Dysregulation Shared Across Neurodevelopmental Disorders, Diana L Christian, Dennis Y Wu, Jenna R Martin, J Russell Moore, Yiran R Liu, Adam W Clemens, Sabin A Nettles, Nicole M Kirkland, Thomas Papouin, Cheryl A Hill, David F Wozniak, Joseph D Dougherty, Harrison W Gabel

Open Access Publications

Mutations in DNA methyltransferase 3A (DNMT3A) have been detected in autism and related disorders, but how these mutations disrupt nervous system function is unknown. Here, we define the effects of DNMT3A mutations associated with neurodevelopmental disease. We show that diverse mutations affect different aspects of protein activity but lead to shared deficiencies in neuronal DNA methylation. Heterozygous DNMT3A knockout mice mimicking DNMT3A disruption in disease display growth and behavioral alterations consistent with human phenotypes. Strikingly, in these mice, we detect global disruption of neuron-enriched non-CG DNA methylation, a binding site for the Rett syndrome protein MeCP2. Loss of this methylation …

Mild Traumatic Brain Injury Is Associated With Effect Of Inflammation On Structural Changes Of Default Mode Network In Those Developing Chronic Pain, Xuan Niu, Lijun Bai, Yingxiang Sun, Yuan Wang, Guanghui Bai, Bo Yin, Shan Wang, Shuoqiu Gan, Xiaoyan Jia, Hongjuan Liu

Open Access Publications

BACKGROUND: Mild traumatic brain injury (mTBI) has a higher prevalence (more than 50%) of developing chronic posttraumatic headache (CPTH) compared with moderate or severe TBI. However, the underlying neural mechanism for CPTH remains unclear. This study aimed to investigate the inflammation level and cortical volume changes in patients with acute PTH (APTH) and further examine their potential in identifying patients who finally developed CPTH at follow-up.

METHODS: Seventy-seven mTBI patients initially underwent neuropsychological measurements, 9-plex panel of serum cytokines and MRI scans within 7 days post-injury (T-1) and 54 (70.1%) of patients completed the same protocol at a 3-month follow-up …

Design And Development Of The Pediatric Urology Recovery After Surgery Endeavor (Pursue) Multicentre Pilot And Exploratory Study, Kyle O Rove, Andrew C Strine, Duncan T Wilcox, Gino J Vricella, Timothy P Welch, Brian Vanderbrink, David I Chu, Rajeev Chaudhry, Rebecca S Zee, Megan A Brockel, Pursue Study Group

Open Access Publications

INTRODUCTION: Lower urinary tract reconstruction in paediatric urology represents a physiologically stressful event that is associated with high complication rates, including readmissions and emergency room visits. Enhanced recovery after surgery (ERAS) protocol is a set of multidisciplinary, perioperative strategies designed to expedite surgical recovery without adversely impacting readmission or reoperation rates. Early paediatric urology data demonstrated ERAS reduced complications in this population.

METHODS AND ANALYSIS: In 2016, a working group of paediatric urologists and anaesthesiologists convened to develop an ERAS protocol suitable for patients undergoing lower urinary tract reconstruction and define study process measures, patient-reported outcomes and clinically relevant outcomes …

High-Resolution Transcriptional And Morphogenetic Profiling Of Cells From Micropatterned Human Esc Gastruloid Cultures, Kyaw Thu Minn, Yuheng C. Fu, Shenghua He, Sabine Dietmann, Steven C. George, Mark A. Anastasio, Samantha A. Morris, Lilianna Solnica-Krezel

Open Access Publications

During mammalian gastrulation, germ layers arise and are shaped into the body plan while extraembryonic layers sustain the embryo. Human embryonic stem cells, cultured with BMP4 on extracellular matrix micro-discs, reproducibly differentiate into gastruloids, expressing markers of germ layers and extraembryonic cells in radial arrangement. Using single-cell RNA sequencing and cross-species comparisons with mouse, cynomolgus monkey gastrulae, and post-implantation human embryos, we reveal that gastruloids contain cells transcriptionally similar to epiblast, ectoderm, mesoderm, endoderm, primordial germ cells, trophectoderm, and amnion. Upon gastruloid dissociation, single cells reseeded onto micro-discs were motile and aggregated with the same but segregated from distinct cell …

Full-Length Trkb Variant In Nsclc Is Associated With Brain Metastasis, Mariangela Lombardi, Michela D'Ascanio, Stefania Scarpino, Davide Scozzi, Marco Giordano, Leopoldo Costarelli, Enrico Rathina Raj, Rita Mancini, Giuseppe Cardillo, Vittorio Cardaci, Marta Innammorato, Andrea Vecchione, Alberto Ricci

Open Access Publications

Despite remarkable therapeutic advances have been made in the last few decades, non-small cell lung cancer (NSCLC) is still one of the leading causes of death worldwide. Brain metastases are a common complication of a wide range of human malignancies and in particular NSCLC. Brain-derived neurotrophic factor (BDNF), binding its high-affinity tyrosine kinase B receptor, has been shown to promote cancer progression and metastasis. We hereby investigated the expression of the BDNF and its TrkB receptor in its full-length and truncated isoform T1, in samples from primary adenocarcinomas (ADKs) of the lung and in their metastasis to evaluate if their …

Requisite Chromatin Remodeling For Myeloid And Erythroid Lineage Differentiation From Erythromyeloid Progenitors, Jun Wu, Karen Krchma, Hyung Joo Lee, Sairam Prabhakar, Xiaoli Wang, Haiyong Zhao, Xiaoyun Xing, Rho H Seong, Daved H Fremont, Maxim N Artyomov, Ting Wang, Kyunghee Choi

Open Access Publications

The mammalian SWitch/Sucrose Non-Fermentable (SWI/SNF) chromatin-remodeling BAF (BRG1/BRM-associated factor) complex plays an essential role in developmental and pathological processes. We show that the deletion of Baf155, which encodes a subunit of the BAF complex, in the Tie2(+) lineage (Baf155 (CKO) leads to defects in yolk sac myeloid and definitive erythroid (EryD) lineage differentiation from erythromyeloid progenitors (EMPs). The chromatin of myeloid gene loci in Baf155 CKO EMPs is mostly inaccessible and enriched mainly by the ETS binding motif. BAF155 interacts with PU.1 and is recruited to PU.1 target gene loci together with p300 and KDM6a. Treatment of Baf155 CKO embryos …

Structure Of The Receptor Binding Domain Of Envp(B)1, An Endogenous Retroviral Envelope Protein Expressed In Human Tissues, Kevin R Mccarthy, Joseph L Timpona, Simon Jenni, Louis-Marie Bloyet, Vesna Brusic, Welkin E Johnson, Sean P J Whelan, Lindsey R Robinson-Mccarthy

Open Access Publications

EnvP(b)1 is an endogenous retroviral envelope gene found in human and other primate genomes. We report EnvP(b)1 sequences in primate genomes consistent with an integration event between 40 and 71 million years ago. Using a highly specific polyclonal antiserum raised against the putative receptor binding domain (RBD) of human EnvP(b)1, we detected expression in human placenta, ovaries, and thymus. We found that EnvP(b)1 is proteolytically processed, and using cell-cell fusion assays in multiple primate cell lines, we demonstrated that extant EnvP(b)1 proteins from a variety of primate genomes are fusogenic. This work supports the idea that EnvP(b)1 is under purifying …

Inflammasomes Within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-Tumor Immunity, Dania Zhivaki, Francesco Borriello, Ohn A Chow, Benjamin Doran, Ira Fleming, Derek J Theisen, Paris Pallis, Alex K Shalek, Caroline L Sokol, Ivan Zanoni, Jonathan C Kagan

Open Access Publications

Central to anti-tumor immunity are dendritic cells (DCs), which stimulate long-lived protective T cell responses. Recent studies have demonstrated that DCs can achieve a state of hyperactivation, which is associated with inflammasome activities within living cells. Herein, we report that hyperactive DCs have an enhanced ability to migrate to draining lymph nodes and stimulate potent cytotoxic T lymphocyte (CTL) responses. This enhanced migratory activity is dependent on the chemokine receptor CCR7 and is associated with a unique transcriptional program that is not observed in conventionally activated or pyroptotic DCs. We show that hyperactivating stimuli are uniquely capable of inducing durable …

Metachronous Cutaneous Squamous Cell Carcinoma In A Young Patient As The Only Presenting Symptom To Uncover Lynch Syndrome With Mlh1 Germline Mutation, Karam Khaddour, Ryan C Fields, Michael Ansstas, Ilana S Rosman, George Ansstas

Open Access Publications

BACKGROUND: Cutaneous malignancies are rare complications of Lynch syndrome and can include Muir-Torre and Turcot syndromes that are associated with sebaceous gland tumors and keratoacanthomas. The incidence and clinical course of cutaneous squamous cell carcinoma have not been well documented in Lynch syndrome due to its rarity.

CASE PRESENTATION: A 49-year male presented with an enlarging groin skin lesion that was biopsed and demonstrated cutaneous squamous cell carcinoma for which he underwent a surgical resection. The patient experienced later a recurrence of cutaneous squamous cell carcinoma around the resected margins. Next generation sequencing of tumor tissue revealed mutations in MSH6 …

Multivariate Lesion-Behavior Mapping Of General Cognitive Ability And Its Psychometric Constituents, Mark Bowren, Ralph Adolphs, Joel Bruss, Kenneth Manzel, Maurizio Corbetta, Daniel Tranel, Aaron D. Boes

Open Access Publications

General cognitive ability, or general intelligence (g), is central to cognitive science, yet the processes that constitute it remain unknown, in good part because most prior work has relied on correlational methods. Large-scale behavioral and neuroanatomical data from neurologic patients with focal brain lesions can be leveraged to advance our understanding of the key mechanisms of g, as this approach allows inference on the independence of cognitive processes along with elucidation of their respective neuroanatomical substrates. We analyzed behavioral and neuroanatomical data from 402 humans (212 males; 190 females) with chronic, focal brain lesions. Structural equation models (SEMs) demonstrated a …

Tfeb Transcriptional Responses Reveal Negative Feedback By Bhlhe40 And Bhlhe41, Kimberly L Carey, Geraldine L C Paulus, Lingfei Wang, Dale R Balce, Jessica W Luo, Phil Bergman, Ianina C Ferder, Lingjia Kong, Nicole Renaud, Shantanu Singh, Maria Kost-Alimova, Beat Nyfeler, Kara G Lassen, Herbert W Virgin, Ramnik J Xavier

Open Access Publications

Transcription factor EB (TFEB) activates lysosomal biogenesis genes in response to environmental cues. Given implications of impaired TFEB signaling and lysosomal dysfunction in metabolic, neurological, and infectious diseases, we aim to systematically identify TFEB-directed circuits by examining transcriptional responses to TFEB subcellular localization and stimulation. We reveal that steady-state nuclear TFEB is sufficient to activate transcription of lysosomal, autophagy, and innate immunity genes, whereas other targets require higher thresholds of stimulation. Furthermore, we identify shared and distinct transcriptional signatures between mTOR inhibition and bacterial autophagy. Using a genome-wide CRISPR library, we find TFEB targets that protect cells from or sensitize …

Prepronociceptin-Expressing Neurons In The Extended Amygdala Encode And Promote Rapid Arousal Responses To Motivationally Salient Stimuli, Jose Rodriguez-Romaguera, Michael R Bruchas, Et Al

Open Access Publications

Motivational states consist of cognitive, emotional, and physiological components controlled by multiple brain regions. An integral component of this neural circuitry is the bed nucleus of the stria terminalis (BNST). Here, we identify that neurons within BNST that express the gene prepronociceptin (Pnoc

Increased Mtor Activity And Metabolic Efficiency In Mouse And Human Cells Containing The African-Centric Tumor-Predisposing P53 Variant Pro47ser, Keerthana Gnanapradeepan, Julia I-Ju Leu, Subhasree Basu, Thibaut Barnoud, Madeline Good, Joyce V. Lee, William J. Quinn, Che-Pei Kung, Rexford Ahima, Joseph A. Baur, Kathryn E. Wellen, Qin Liu, Zachary T. Schug, Donna L. George, Maureen E. Murphy

Open Access Publications

The Pro47Ser variant of p53 (S47) exists in African-descent populations and is associated with increased cancer risk in humans and mice. Due to impaired repression of the cystine importer

Kir6.1- And Sur2-Dependent Katp Over-Activity Disrupts Intestinal Motility In Murine Models Of Cantu Syndrome, Nathaniel W York, Helen Parker, Zili Xie, David Tyus, Maham A Waheed, Zihan Yan, Dorothy K Grange, Maria S Remedi, Sarah K England, Hongzhen Hu, Colin G Nichols

Open Access Publications

Cantύ Syndrome (CS), caused by gain-of-function (GOF) mutations in pore-forming (Kir6.1, KCNJ8) and accessory (SUR2, ABCC9) ATP-sensitive potassium (KATP) channel subunit genes, is frequently accompanied by gastrointestinal (GI) dysmotility, and we describe one CS patient who required an implanted intestinal irrigation system for successful stooling. We used gene-modified mice to assess the underlying KATP channel subunits in gut smooth muscle, and to model the consequences of altered KATP channels in CS gut. We show that Kir6.1/SUR2 subunits underlie smooth muscle KATP channels throughout the small intestine and colon. Knock-in mice, carrying human KCNJ8 and ABCC9 CS mutations in the endogenous …

Treatment Of Epithelial Ovarian Cancer, Lindsay Kuroki, Saketh R Guntupalli

Open Access Publications

Ovarian cancer is the third most common gynecologic malignancy worldwide but accounts for the highest mortality rate among these cancers. A stepwise approach to assessment, diagnosis, and treatment is vital to appropriate management of this disease process. An integrated approach with gynecologic oncologists as well as medical oncologists, pathologists, and radiologists is of paramount importance to improving outcomes. Surgical cytoreduction to R0 is the mainstay of treatment, followed by adjuvant chemotherapy. Genetic testing for gene mutations that affect treatment is the standard of care for all women with epithelial ovarian cancer. Nearly all women will have a recurrence, and the …

Myh3-Associated Distal Arthrogryposis Zebrafish Model Is Normalized With Para-Aminoblebbistatin, Julia Whittle, Lilian Antunes, Mya Harris, Zachary Upshaw, Diane S Sepich, Aaron N Johnson, Mayssa Mokalled, Lilianna Solnica-Krezel, Matthew B Dobbs, Christina A Gurnett

Open Access Publications

Distal arthrogryposis (DA) is group of syndromes characterized by congenital joint contractures. Treatment development is hindered by the lack of vertebrate models. Here, we describe a zebrafish model in which a common MYH3 missense mutation (R672H) was introduced into the orthologous zebrafish gene smyhc1 (slow myosin heavy chain 1) (R673H). We simultaneously created a smyhc1 null allele (smyhc1

Ante- And Postmortem Tau In Autosomal Dominant And Late-Onset Alzheimer's Disease, Charles D Chen, Timothy R Holden, Brian A Gordon, Erin E Franklin, Yan Li, Dean W Coble, Hongbo Luo, Randall J Bateman, Dominantly Inherited Alzheimer Network (Dian) And For The Dominantly Inherited Alzheimer Network Trials Unit (Dian-Tu), Beau M Ances, Richard J Perrin, Tammie L S Benzinger, Nigel J Cairns, John C Morris

Open Access Publications

Antemortem tau positron emission tomography imaging suggests elevated tau pathology in autosomal dominant versus late-onset Alzheimer's disease at equivalent clinical stages, but does not implicate the specific tau pathologies responsible. Here we made stereological measurements of tau neurofibrillary tangles, neuritic plaques, and neuropil threads and found compared to late-onset Alzheimer's disease, autosomal dominant Alzheimer's disease showed even greater tangle and thread burdens. Regional tau burden resembled that observed in tau imaging of a separate cohort at earlier clinical stages. Finally, our results suggest tau imaging measures total tau burden in Alzheimer's disease, composed predominantly of tangle and thread pathology.

Urban-Rural Disparities In Access To Low-Dose Computed Tomography Lung Cancer Screening In Missouri And Illinois, Karthik W Rohatgi, Christine M Marx, Marquita W Lewis-Thames, Jingxia Liu, Graham A Colditz, Aimee S James

Open Access Publications

INTRODUCTION: Low-dose computed tomography (LDCT) lung cancer screening is recommended for current and former smokers who meet eligibility criteria. Few studies have quantitatively examined disparities in access to LDCT screening. The objective of this study was to examine relationships between 1) rurality, sociodemographic characteristics, and access to LDCT lung cancer screening and 2) screening access and lung cancer mortality.

METHODS: We used census block group and county-level data from Missouri and Illinois. We defined access to screening as presence of an accredited screening center within 30 miles of residence as of May 2019. We used mixed-effects logistic models for screening …

Airway Microbiota-Host Interactions Regulate Secretory Leukocyte Protease Inhibitor Levels And Influence Allergic Airway Inflammation, Natalia Jaeger, Ryan T Mcdonough, Anne L Rosen, Ariel Hernandez-Leyva, Naomi G Wilson, Michael A Lint, Emilie V Russler-Germain, Jiani N Chai, Leonard B Bacharier, Chyi-Song Hsieh, Andrew L Kau

Open Access Publications

Homeostatic mucosal immune responses are fine-tuned by naturally evolved interactions with native microbes, and integrating these relationships into experimental models can provide new insights into human diseases. Here, we leverage a murine-adapted airway microbe, Bordetella pseudohinzii (Bph), to investigate how chronic colonization impacts mucosal immunity and the development of allergic airway inflammation (AAI). Colonization with Bph induces the differentiation of interleukin-17A (IL-17A)-secreting T-helper cells that aid in controlling bacterial abundance. Bph colonization protects from AAI and is associated with increased production of secretory leukocyte protease inhibitor (SLPI), an antimicrobial peptide with anti-inflammatory properties. These findings are additionally supported by clinical …

Hsv-1 And Zika Virus But Not Sars-Cov-2 Replicate In The Human Cornea And Are Restricted By Corneal Type Iii Interferon, Jonathan J Miner, Derek J Platt, Cyrus M Ghaznavi, Pallavi Chandra, Andrea Santeford, Amber M Menos, Zhenyu Dong, Erin R Wang, Wei Qian, Elysse S Karozichian, Jennifer A Philips, Rajendra S Apte

Open Access Publications

Here, we report our studies of immune-mediated regulation of Zika virus (ZIKV), herpes simplex virus 1 (HSV-1), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the human cornea. We find that ZIKV can be transmitted via corneal transplantation in mice. However, in human corneal explants, we report that ZIKV does not replicate efficiently and that SARS-CoV-2 does not replicate at all. Additionally, we demonstrate that type III interferon (IFN-λ) and its receptor (IFNλR1) are expressed in the corneal epithelium. Treatment of human corneal explants with IFN-λ, and treatment of mice with IFN-λ eye drops, upregulates antiviral interferon-stimulated genes. …

Moonshots For Aging, Sandeep Kumar, Timothy R Peterson

Open Access Publications

As the global population ages, there is increased interest in living longer and improving one's quality of life in later years. However, studying aging - the decline in body function - is expensive and time-consuming. And despite research success to make model organisms live longer, there still aren't really any feasible solutions for delaying aging in humans. With space travel, scientists and engineers couldn't know what it would take to get to the moon. They had to extrapolate from theory and shorter-range tests. Perhaps with aging, we need a similar moonshot philosophy. And though "shot" might imply medicine, perhaps we …

Assessment Of Neighborhood Poverty, Cognitive Function, And Prefrontal And Hippocampal Volumes In Children, Rita L. Taylor, Shelly R. Cooper, Joshua J. Jackson, Deanna M. Barch

Open Access Publications

Importance: The association between poverty and unfavorable cognitive outcomes is robust, but most research has focused on individual household socioeconomic status (SES). There is increasing evidence that neighborhood context explains unique variance not accounted for by household SES.

Objective: To evaluate whether neighborhood poverty (NP) is associated with cognitive function and prefrontal and hippocampal brain structure in ways that are dissociable from household SES.

Design, Setting, and Participants: This cross-sectional study used a baseline sample of the ongoing longitudinal Adolescent Brain Cognitive Development (ABCD) Study. The ABCD Study will follow participants for assessments each year for 10 years. Data were …

Blood Plasma Phosphorylated-Tau Isoforms Track Cns Change In Alzheimer's Disease, Nicolas R. Barthélemy, Kanta Horie, Chihiro Sato, Randall J. Bateman

Open Access Publications

Highly sensitive and specific plasma biomarkers for Alzheimer's disease (AD) have the potential to improve diagnostic accuracy in the clinic and facilitate research studies including enrollment in prevention and treatment trials. We recently reported CSF tau hyperphosphorylation, especially on T217, is an accurate predictor of β-amyloidosis at asymptomatic and symptomatic stages. In the current study, we determine by mass spectrometry the potential utility of plasma p-tau isoforms to detect AD pathology and investigate CSF and plasma tau isoforms' profile relationships. Plasma tau was truncated as previously described in CSF. CSF and plasma measures of p-tau-217 and p-tau-181 were correlated. No …

Implications Of Pneumonitis After Chemoradiation And Durvalumab For Locally Advanced Non-Small Cell Lung Cancer, Comron Hassanzadeh, Timothy Sita, Rohan Savoor, Pamela P Samson, Jeffrey Bradley, Michelle Gentile, Michael Roach, Nisha Mohindra, Saiama Waqar, Timothy J Kruser, Clifford Robinson

Open Access Publications

Background: Consolidation durvalumab improved overall survival (OS) in locally advanced non-small cell lung cancer (LA-NSCLC) treated with chemoradiotherapy (CRT) in the PACIFIC trial; however, pneumonitis was increased with durvalumab. We sought to examine real-world outcomes with the PACIFIC paradigm, especially factors associated with pneumonitis, using a multi-institutional review.

Methods: Patients with LA-NSCLC treated with CRT followed by durvalumab from January 2017-February 2019 were identified at 2 institutions. We characterized demographics, tumor factors, radiotherapy, and duration of durvalumab. We examined pneumonitis outcomes including re-challenge success, with secondary endpoints of progression-free survival (PFS) and OS.

Results: Thirty-four patients were included with median …

Detection Of A Somatic Greb1-Ncoa1 Gene Fusion In A Uterine Tumor Resembling Ovarian Sex Cord Tumor (Utrosct), Whitney R Grither, Brendan C Dickson, Katherine C Fuh, Ian S Hagemann

Open Access Publications

Uterine tumor resembling ovarian sex cord tumor (UTROSCT) is a rare uterine neoplasm of uncertain malignant potential. We present the case of a 69-year-old woman who underwent hysterectomy for postmenopausal bleeding and was found to have a myometrial UTROSCT. RNA-sequencing identified a somatic

Prospective, Randomized, Double-Blind, Placebo-Controlled Evaluation Of The Pharmacokinetics, Safety And Efficacy Of Recombinant Antithrombin Versus Placebo In Preterm Preeclampsia, Michael J Paidas, George A Macones, Et Al

Open Access Publications

BACKGROUND: Despite expectant management, preeclampsia remote from term usually results in preterm delivery. Antithrombin, which displays antiinflammatory and anticoagulant properties, may have a therapeutic role in treating preterm preeclampsia, a disorder characterized by endothelial dysfunction, inflammation, and activation of the coagulation system.

OBJECTIVE: This randomized, placebo-controlled clinical trial aimed to evaluate whether intravenous recombinant human antithrombin could prolong gestation and therefore improve maternal and fetal outcomes.

STUDY DESIGN: We performed a double-blind, placebo-controlled trial at 23 hospitals. Women were eligible if they had a singleton pregnancy, early-onset or superimposed preeclampsia at 23 0/7 to 30 0/7 weeks' gestation, and planned …

The Impact Of Direct-To-Consumer Wearables In Pediatric Electrophysiology Telehealth Clinics: A Real-World Case Series, Lisa Roelle, Aarti S Dalal, Nathan Miller, William B Orr, George Van Hare, Jennifer N Avari Silva

Open Access Publications

No abstract provided.

The Perceived Challenge Of Everyday Technologies In Sweden, The United States And England: Exploring Differential Item Functioning In The Everyday Technology Use Questionnaire, Sarah Wallcook, Camilla Malinowsky, Louise Nygård, Georgina Charlesworth, Jenica Lee, Ryan Walsh, Sophie Gaber, Anders Kottorp

Open Access Publications

No abstract provided.

Short-Term Clinical Outcomes Of Hip Arthroscopy Versus Physical Therapy In Patients With Femoroacetabular Impingement: A Systematic Review And Meta-Analysis Of Randomized Controlled Trials, Maria T Schwabe, John C Clohisy, Abby L Cheng, Cecilia Pascual-Garrido, Marcie Harris-Hayes, Devyani M Hunt, Michael D. Harris, Heidi Prather, Jeffrey J Nepple

Open Access Publications

Background: Both physical therapy (PT) and surgery are effective in treating femoroacetabular impingement (FAI), but their relative efficacy has not been well established until recently. Several randomized controlled trials (RCTs) comparing the early clinical outcomes of these treatments have been published, with contradictory results.

Purpose/Hypothesis: The purpose of this study was to perform a meta-analysis of RCTs that compared early patient-reported outcomes (PROs) of hip arthroscopy versus PT in patients with symptomatic FAI. The hypothesis was that surgical treatment of FAI leads to better short-term outcomes than PT.

Study Design: Systematic review; Level of evidence, 1.

Methods: In March 2019, …