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Inhibition Of Nitric Oxide Production In Activated Macrophages Caused By Toxoplasma Gondii Infection Occurs By Distinct Mechanisms In Different Mouse Macrophage Cell Lines, Gabriel R. De Abreu Cabral, Zi T. Wang, L. D. Sibley, Renato A. Damatta Jan 2018

Inhibition Of Nitric Oxide Production In Activated Macrophages Caused By Toxoplasma Gondii Infection Occurs By Distinct Mechanisms In Different Mouse Macrophage Cell Lines, Gabriel R. De Abreu Cabral, Zi T. Wang, L. D. Sibley, Renato A. Damatta

Open Access Publications

No abstract provided.


Nitro-Fatty Acids Are Formed In Response To Virus Infection And Are Potent Inhibitors Of Sting Palmitoylation And Signaling, Cathrine A. Miner, Wei Qian, Jonathan J. Miner Jan 2018

Nitro-Fatty Acids Are Formed In Response To Virus Infection And Are Potent Inhibitors Of Sting Palmitoylation And Signaling, Cathrine A. Miner, Wei Qian, Jonathan J. Miner

Open Access Publications

No abstract provided.


Structure-Function Analysis Of The Curli Accessory Protein Csge Defines Surfaces Essential For Coordinating Amyloid Fiber Formation, Roger D. Klein, Qin Shu, Zachary T. Cusumano, Kanna Nagamatsu, Nathaniel C. Gualberto, Aaron J.L. Lynch, Chao Wu, Wenjie Wang, Neha Jain, Jerome S. Pinkner, Gaya K. Amarasinghe, Scott J. Hultgren, Carl Frieden, Matthew R. Chapman Jan 2018

Structure-Function Analysis Of The Curli Accessory Protein Csge Defines Surfaces Essential For Coordinating Amyloid Fiber Formation, Roger D. Klein, Qin Shu, Zachary T. Cusumano, Kanna Nagamatsu, Nathaniel C. Gualberto, Aaron J.L. Lynch, Chao Wu, Wenjie Wang, Neha Jain, Jerome S. Pinkner, Gaya K. Amarasinghe, Scott J. Hultgren, Carl Frieden, Matthew R. Chapman

Open Access Publications

No abstract provided.


Health Education Advanced Leadership For Zimbabwe (Healz): Developing The Infrastructure To Support Curriculum Reform, Eva M. Aagaard, Susan C. Connors, Amelia Challender, Jonathan Gandari, Kusum Nathoo, Margaret Borok, Midion Chidzonga, Michele Barry, Thomas Campbell, James Hakim Jan 2018

Health Education Advanced Leadership For Zimbabwe (Healz): Developing The Infrastructure To Support Curriculum Reform, Eva M. Aagaard, Susan C. Connors, Amelia Challender, Jonathan Gandari, Kusum Nathoo, Margaret Borok, Midion Chidzonga, Michele Barry, Thomas Campbell, James Hakim

Open Access Publications

No abstract provided.


Mechanism Of High-Level Daptomycin Resistance In Corynebacterium Striatum, Nicholas K. Goldner, Christopher Bulow, Kevin Cho, Meghan Wallace, Fong-Fu Hsu, Gary J. Patti, Carey-Ann Burnham, Paul Schlesinger, Gautam Dantas Jan 2018

Mechanism Of High-Level Daptomycin Resistance In Corynebacterium Striatum, Nicholas K. Goldner, Christopher Bulow, Kevin Cho, Meghan Wallace, Fong-Fu Hsu, Gary J. Patti, Carey-Ann Burnham, Paul Schlesinger, Gautam Dantas

Open Access Publications

No abstract provided.


Inherited P40phox Deficiency Differs From Classic Chronic Granulomatous Disease, Mary C. Dinauer, Et Al Jan 2018

Inherited P40phox Deficiency Differs From Classic Chronic Granulomatous Disease, Mary C. Dinauer, Et Al

Open Access Publications

No abstract provided.


Deficiency Of Meca In Streptococcus Mutans Causes Major Defects In Cell Envelope Biogenesis, Cell Division, And Biofilm Formation, Arpan De, Ashton N. Jorgensen, Wandy L. Beatty, Jose Lemos, Zezhang T. Wen Jan 2018

Deficiency Of Meca In Streptococcus Mutans Causes Major Defects In Cell Envelope Biogenesis, Cell Division, And Biofilm Formation, Arpan De, Ashton N. Jorgensen, Wandy L. Beatty, Jose Lemos, Zezhang T. Wen

Open Access Publications

No abstract provided.


Differences In Mortality Between Infections Due To Extended-Spectrum-Beta-Lactamase–Producing Klebsiella Pneumoniae And Escherichia Coli, Jason P. Burnham, Jennie H. Kwon, Margaret A. Olsen, Hilary M. Babcock, Marin H. Kollef Jan 2018

Differences In Mortality Between Infections Due To Extended-Spectrum-Beta-Lactamase–Producing Klebsiella Pneumoniae And Escherichia Coli, Jason P. Burnham, Jennie H. Kwon, Margaret A. Olsen, Hilary M. Babcock, Marin H. Kollef

Open Access Publications

No abstract provided.


Microneedle Interventional Therapy Combined With Cervical Spine Manipulation For Cervicogenic Dizziness, Qi Xie, Xin Duan, Yihua Shi, Xiaoyu Lv, Yuqing Wang, Yan Tao, Lijun Zhong, Jianfeng Sun, Huiyan Lei, Qingshui Yin, Junfeng Duan Jan 2018

Microneedle Interventional Therapy Combined With Cervical Spine Manipulation For Cervicogenic Dizziness, Qi Xie, Xin Duan, Yihua Shi, Xiaoyu Lv, Yuqing Wang, Yan Tao, Lijun Zhong, Jianfeng Sun, Huiyan Lei, Qingshui Yin, Junfeng Duan

Open Access Publications

No abstract provided.


A Systematic Meta-Analysis Of Oxygen-To-Glucose And Oxygen-To-Carbohydrate Ratios In The Resting Human Brain, Tyler Blazey, Abraham Z. Snyder, Manu S. Goyal, Andrei G. Vlassenko, Marcus E. Raichle Jan 2018

A Systematic Meta-Analysis Of Oxygen-To-Glucose And Oxygen-To-Carbohydrate Ratios In The Resting Human Brain, Tyler Blazey, Abraham Z. Snyder, Manu S. Goyal, Andrei G. Vlassenko, Marcus E. Raichle

Open Access Publications

No abstract provided.


Bezlotoxumab Is Associated With A Reduction In Cumulative Inpatient-Days: Analysis Of The Hospitalization Data From The Modify I And Ii Clinical Trials, Anirban Basu, Vimalanand S. Prabhu, Mary Beth Dorr, Yoav Golan, Erik R. Dubberke, Oliver A. Cornely, Sebastian M. Heimann, Alison Pedley, Ruifeng Xu, Mary E. Hanson, Stephen Marcella Jan 2018

Bezlotoxumab Is Associated With A Reduction In Cumulative Inpatient-Days: Analysis Of The Hospitalization Data From The Modify I And Ii Clinical Trials, Anirban Basu, Vimalanand S. Prabhu, Mary Beth Dorr, Yoav Golan, Erik R. Dubberke, Oliver A. Cornely, Sebastian M. Heimann, Alison Pedley, Ruifeng Xu, Mary E. Hanson, Stephen Marcella

Open Access Publications

No abstract provided.


Capillaria Ova And Diagnosis Of Trichuris Trichiura Infection In Humans By Kato-Katz Smear, Liberia, Kerstin Fischer, Abakar Gankpala, Lincoln Gankpala, Fatorma K. Bolay, Kurt C. Curtis, Gary J. Weil, Peter U. Fischer Jan 2018

Capillaria Ova And Diagnosis Of Trichuris Trichiura Infection In Humans By Kato-Katz Smear, Liberia, Kerstin Fischer, Abakar Gankpala, Lincoln Gankpala, Fatorma K. Bolay, Kurt C. Curtis, Gary J. Weil, Peter U. Fischer

Open Access Publications

No abstract provided.


Domains Within Rbpa Serve Specific Functional Roles That Regulate The Expression Of Distinct Mycobacterial Gene Subsets, Jerome Prusa, Drake Jensen, Gustavo Santiago-Collazo, Steven S Pope, Ashley L Garner, Justin J Miller, Ana Ruiz Manzano, Eric A Galburt, Christina L Stallings Jan 2018

Domains Within Rbpa Serve Specific Functional Roles That Regulate The Expression Of Distinct Mycobacterial Gene Subsets, Jerome Prusa, Drake Jensen, Gustavo Santiago-Collazo, Steven S Pope, Ashley L Garner, Justin J Miller, Ana Ruiz Manzano, Eric A Galburt, Christina L Stallings

Open Access Publications

The RNA polymerase (RNAP) binding protein A (RbpA) contributes to the formation of stable RNAP-promoter open complexes (RP


Prolonged Amenorrhea And Resumption Of Menses In Women With Hiv, Helen E. Cejtin, Charlesnika T. Evans, Ruth Greenblatt, Howard Minkoff, Kathleen M. Weber, Rodney Wright, Christine Colie, Elizabeth Golub, Stewart Massad Jan 2018

Prolonged Amenorrhea And Resumption Of Menses In Women With Hiv, Helen E. Cejtin, Charlesnika T. Evans, Ruth Greenblatt, Howard Minkoff, Kathleen M. Weber, Rodney Wright, Christine Colie, Elizabeth Golub, Stewart Massad

Open Access Publications

No abstract provided.


Pre-Operative Anti-Fungal Therapy Does Not Improve Outcomes In Perforated Peptic Ulcers, Christopher B. Horn, Adrian A. Coleoglou Centeno, Rohit K. Rasane, Jose A. Aldana, Nicholas B. Fiore, Qiao Zhang, Marlon Torres, John E. Mazuski, Obeid N. Ilahi, Laurie J. Punch, Grant V. Bochicchio Jan 2018

Pre-Operative Anti-Fungal Therapy Does Not Improve Outcomes In Perforated Peptic Ulcers, Christopher B. Horn, Adrian A. Coleoglou Centeno, Rohit K. Rasane, Jose A. Aldana, Nicholas B. Fiore, Qiao Zhang, Marlon Torres, John E. Mazuski, Obeid N. Ilahi, Laurie J. Punch, Grant V. Bochicchio

Open Access Publications

No abstract provided.


Characterization Of Cellular Immune Responses In Thai Individuals With And Without Hiv-Associated Neurocognitive Disorders, Tanate Jadwattanakul Jan 2018

Characterization Of Cellular Immune Responses In Thai Individuals With And Without Hiv-Associated Neurocognitive Disorders, Tanate Jadwattanakul

Open Access Publications

No abstract provided.


Antigen-Specific Antibody Fc Glycosylation Enhances Humoral Immunity Via The Recruitment Of Complement, Julie M. Fox, Michael S. Diamond, Et Al Jan 2018

Antigen-Specific Antibody Fc Glycosylation Enhances Humoral Immunity Via The Recruitment Of Complement, Julie M. Fox, Michael S. Diamond, Et Al

Open Access Publications

No abstract provided.


Cerebrospinal Fluid And Blood Biomarkers For Neurodegenerative Dementias: An Update Of The Consensus Of The Task Force On Biological Markers In Psychiatry Of The World Federation Of Societies Of Biological Psychiatry, Piotr Lewczuk, Anne M. Fagan, Brian A. Gordon, Et Al Oct 2017

Cerebrospinal Fluid And Blood Biomarkers For Neurodegenerative Dementias: An Update Of The Consensus Of The Task Force On Biological Markers In Psychiatry Of The World Federation Of Societies Of Biological Psychiatry, Piotr Lewczuk, Anne M. Fagan, Brian A. Gordon, Et Al

Open Access Publications

No abstract provided.


Interleukin-17 Limits Hypoxia-Inducible Factor 1Α And Development Of Hypoxic Granulomas During Tuberculosis, Racquel Domingo-Gonzalez, Shibali Das, Kristin L. Griffiths, Mushtaq Ahmed, Monika Bambouskova, Suhas Gondi, Noor Al-Hammadi, Reid Townsend, Maxim N. Artyomov, Shabaana A. Khader, Et Al. Oct 2017

Interleukin-17 Limits Hypoxia-Inducible Factor 1Α And Development Of Hypoxic Granulomas During Tuberculosis, Racquel Domingo-Gonzalez, Shibali Das, Kristin L. Griffiths, Mushtaq Ahmed, Monika Bambouskova, Suhas Gondi, Noor Al-Hammadi, Reid Townsend, Maxim N. Artyomov, Shabaana A. Khader, Et Al.

Open Access Publications

Mycobacterium tuberculosis (Mtb) is a global health threat, compounded by the emergence of drug-resistant strains. A hallmark of pulmonary tuberculosis (TB) is the formation of hypoxic necrotic granulomas, which upon disintegration, release infectious Mtb. Furthermore, hypoxic necrotic granulomas are associated with increased disease severity and provide a niche for drug-resistant Mtb. However, the host immune responses that promote the development of hypoxic TB granulomas are not well described. Using a necrotic Mtb mouse model, we show that loss of Mtb virulence factors, such as phenolic glycolipids, decreases the production of the proinflammatory cytokine IL-17 (also referred to as IL-17A). IL-17 …


N-3 Pufas Induce Inflammatory Tolerance By Formation Of Keap1-Containing Sqstm1/P62-Bodies And Activation Of Nfe2l2, Jennifer Mildenberger, Ida Johansson, Ismail Sergin, Eli Kjøbli, Jan Kristian Damås, Babak Razani, Trude Helen Flo, Geir Bjørkøy Oct 2017

N-3 Pufas Induce Inflammatory Tolerance By Formation Of Keap1-Containing Sqstm1/P62-Bodies And Activation Of Nfe2l2, Jennifer Mildenberger, Ida Johansson, Ismail Sergin, Eli Kjøbli, Jan Kristian Damås, Babak Razani, Trude Helen Flo, Geir Bjørkøy

Open Access Publications

Inflammation is crucial in the defense against infections but must be tightly controlled to limit detrimental hyperactivation. Our diet influences inflammatory processes and omega-3 polyunsaturated fatty acids (n-3 PUFAs) have known anti-inflammatory effects. The balance of pro- and anti-inflammatory processes is coordinated by macrophages and macroautophagy/autophagy has recently emerged as a cellular process that dampens inflammation. Here we report that the n-3 PUFA docosahexaenoic acid (DHA) transiently induces cytosolic speckles of the autophagic receptor SQSTM1/p62 (sequestosome 1) (described as SQSTM1/p62-bodies) in macrophages. We suggest that the formation of SQSTM1/p62-bodies represents a fast mechanism of NFE2L2/Nrf2 (nuclear factor, erythroid 2 like …


Targeting Dendritic Cells To Accelerate T-Cell Activation Overcomes A Bottleneck In Tuberculosis Vaccine Efficacy, Kristin L. Griffiths, Mushtaq Ahmed, Shibali Das, Radha Gopal, William Horne, Terry D. Connell, Kelly D. Moynihan, Jay K. Kolls, Darrell J. Irvine, Maxim N. Artyomov, Javier Rangel-Moreno, Shabaana A. Khader Jan 2017

Targeting Dendritic Cells To Accelerate T-Cell Activation Overcomes A Bottleneck In Tuberculosis Vaccine Efficacy, Kristin L. Griffiths, Mushtaq Ahmed, Shibali Das, Radha Gopal, William Horne, Terry D. Connell, Kelly D. Moynihan, Jay K. Kolls, Darrell J. Irvine, Maxim N. Artyomov, Javier Rangel-Moreno, Shabaana A. Khader

Open Access Publications

No abstract provided.


Effective Antibiotic Conservation By Emergency Antimicrobial Stewardship During A Drug Shortage, Kevin Hsueh, Maria Reyes, Tamara Krekel, Ed Casabar, David J. Ritchie, S. Reza Jafarzadeh, Amanda J. Hays, Michael A. Lane, Michael J. Durkin Jan 2017

Effective Antibiotic Conservation By Emergency Antimicrobial Stewardship During A Drug Shortage, Kevin Hsueh, Maria Reyes, Tamara Krekel, Ed Casabar, David J. Ritchie, S. Reza Jafarzadeh, Amanda J. Hays, Michael A. Lane, Michael J. Durkin

Open Access Publications

No abstract provided.


Current State Of Antimicrobial Stewardship In Children’S Hospital Emergency Departments, Rakesh D. Mistry, Jason G. Newland, Jeffrey S. Gerber, Adam L. Hersh, Larissa May, Sarah M. Perman, Nathan Kuppermann, Peter S. Dayan Jan 2017

Current State Of Antimicrobial Stewardship In Children’S Hospital Emergency Departments, Rakesh D. Mistry, Jason G. Newland, Jeffrey S. Gerber, Adam L. Hersh, Larissa May, Sarah M. Perman, Nathan Kuppermann, Peter S. Dayan

Open Access Publications

No abstract provided.


An Efficient Platform For Astrocyte Differentiation From Human Induced Pluripotent Stem Cells, Julia Tcw, Minghui Wang, Anna A. Pimenova, Kathryn R. Bowles, Brigham J. Hartley, Emre Lacin, Saima I. Machlovi, Rawan Abdelaal, Celeste M. Karch, Hemali Phatnani, Paul A. Slesinger, Bin Zhang, Alison M. Goate, Kristen J. Brennand Jan 2017

An Efficient Platform For Astrocyte Differentiation From Human Induced Pluripotent Stem Cells, Julia Tcw, Minghui Wang, Anna A. Pimenova, Kathryn R. Bowles, Brigham J. Hartley, Emre Lacin, Saima I. Machlovi, Rawan Abdelaal, Celeste M. Karch, Hemali Phatnani, Paul A. Slesinger, Bin Zhang, Alison M. Goate, Kristen J. Brennand

Open Access Publications

No abstract provided.


Icd-9-Cm Coding For Multidrug Resistant Infection Correlates Poorly With Microbiologically Confirmed Multidrug Resistant Infection, Jason P. Burnham, Jennie H. Kwon, Hilary M. Babcock, Margaret A. Olsen, Marin H. Kollef Jan 2017

Icd-9-Cm Coding For Multidrug Resistant Infection Correlates Poorly With Microbiologically Confirmed Multidrug Resistant Infection, Jason P. Burnham, Jennie H. Kwon, Hilary M. Babcock, Margaret A. Olsen, Marin H. Kollef

Open Access Publications

No abstract provided.


Realizing The Potential Of Cancer Prevention - The Role Of Implementation Science, Karen M. Emmons, Graham A. Colditz Jan 2017

Realizing The Potential Of Cancer Prevention - The Role Of Implementation Science, Karen M. Emmons, Graham A. Colditz

Open Access Publications

No abstract provided.


Topoisomerase Ii Inhibitors Induce Dna Damage-Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion, Priya Luthra, Sebastian Aguirre, Benjamin C. Yen, Colette A. Pietzsch, Maria T. Sanchez-Aparicio, Bersabeh Tigabu, Lorraine K. Morlock, Adolfo Garcia-Sastre, Daisy W. Leung, Noelle S. Williams, Ana Fernandez-Sesma, Alexander Bukreyev, Christopher F. Basler Jan 2017

Topoisomerase Ii Inhibitors Induce Dna Damage-Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion, Priya Luthra, Sebastian Aguirre, Benjamin C. Yen, Colette A. Pietzsch, Maria T. Sanchez-Aparicio, Bersabeh Tigabu, Lorraine K. Morlock, Adolfo Garcia-Sastre, Daisy W. Leung, Noelle S. Williams, Ana Fernandez-Sesma, Alexander Bukreyev, Christopher F. Basler

Open Access Publications

No abstract provided.


Esterase Mutation Is A Mechanism Of Resistance To Antimalarial Compounds, Eva S. Istvan, Jeremy P. Mallari, Victoria C. Corey, Neekesh V. Dharia, Garland R. Marshall, Elizabeth A. Winzeler, Daniel E. Goldberg Jan 2017

Esterase Mutation Is A Mechanism Of Resistance To Antimalarial Compounds, Eva S. Istvan, Jeremy P. Mallari, Victoria C. Corey, Neekesh V. Dharia, Garland R. Marshall, Elizabeth A. Winzeler, Daniel E. Goldberg

Open Access Publications

No abstract provided.


Invasive Fungal Infections Secondary To Traumatic Injury, Ryan Kronen, Stephen Y. Liang, Grant Bochicchio, Kelly Bochicchio, William G. Powderly, Andrej Spec Jan 2017

Invasive Fungal Infections Secondary To Traumatic Injury, Ryan Kronen, Stephen Y. Liang, Grant Bochicchio, Kelly Bochicchio, William G. Powderly, Andrej Spec

Open Access Publications

No abstract provided.


From The Microbiome To The Central Nervous System, An Update On The Epidemiology And Pathogenesis Of Bacterial Meningitis In Childhood [Version 1; Referees: 3 Approved], Andrew B. Janowski, Jason G. Newland Jan 2017

From The Microbiome To The Central Nervous System, An Update On The Epidemiology And Pathogenesis Of Bacterial Meningitis In Childhood [Version 1; Referees: 3 Approved], Andrew B. Janowski, Jason G. Newland

Open Access Publications

No abstract provided.