Digital Commons Network^™

Therapeutic Ultrasound-Enhanced Immune Checkpoint Inhibitor Therapy, Jinyun Yuan, Dezhuang Ye, Si Chen, Hong Chen

Open Access Publications

No abstract provided.

Cerebrospinal Fluid Ncam-1 Concentration Is Associated With Neurodevelopmental Outcome In Post-Hemorrhagic Hydrocephalus Of Prematurity, David D. Limbrick, Diego M. Morales, Et Al.

Open Access Publications

OBJECTIVE: Efforts directed at mitigating neurological disability in preterm infants with intraventricular hemorrhage (IVH) and post hemorrhagic hydrocephalus (PHH) are limited by a dearth of quantifiable metrics capable of predicting long-term outcome. The objective of this study was to examine the relationships between candidate cerebrospinal fluid (CSF) biomarkers of PHH and neurodevelopmental outcomes in infants undergoing neurosurgical treatment for PHH.

STUDY DESIGN: Preterm infants with PHH were enrolled across the Hydrocephalus Clinical Research Network. CSF samples were collected at the time of temporizing neurosurgical procedure (n = 98). Amyloid precursor protein (APP), L1CAM, NCAM-1, and total protein (TP) were compared …

Get Privacy Trending: Best Practices For The Social Media Educator, Sara W. Dong, Nathanial S. Nolan, Miguel A. Chavez, Yijia Li, Gerome V. Escota, Wendy Stead

Open Access Publications

Social media is an increasingly popular forum for medical education. Many educators, including those in infectious diseases, are now creating and sharing unique and educational patient cases online. Unfortunately, some educators unknowingly threaten patient privacy and open themselves to legal liability. Further, the use of published figures or tables creates risk of copyright infringement. As more and more infectious diseases physicians engage in social media, it is imperative to create best practices to protect both patients and physicians. This summary will define the legal requirements of patient de-identification as well as other practical recommendations as they relate to use of …

Clinical Prediction Rule For Sars-Cov-2 Infection From 116 U.S. Emergency Departments 2-22-2021, Jeffrey A. Kline, Stacey House, Et Al.

Open Access Publications

OBJECTIVES: Accurate and reliable criteria to rapidly estimate the probability of infection with the novel coronavirus-2 that causes the severe acute respiratory syndrome (SARS-CoV-2) and associated disease (COVID-19) remain an urgent unmet need, especially in emergency care. The objective was to derive and validate a clinical prediction score for SARS-CoV-2 infection that uses simple criteria widely available at the point of care.

METHODS: Data came from the registry data from the national REgistry of suspected COVID-19 in EmeRgency care (RECOVER network) comprising 116 hospitals from 25 states in the US. Clinical variables and 30-day outcomes were abstracted from medical records …

Genetic Association Analysis Of The Cardiovascular Biomarker: N-Terminal Fragment Of Pro-B-Type Natriuretic Peptide (Nt-Probnp), Yuan Yang, Joseph M. Zmuda, Mary K. Wojczynski, Bharat Thyagarajan, Kaare Christensen, Ryan K. Cvejkus, Allison L. Kuipers

Open Access Publications

BACKGROUND: NT-proBNP is a biomarker of cardiovascular disease (CVD). Little is known about the heritability and genetic variants associated with NT-proBNP. Therefore, we estimated the heritability of and examined genetic associations of SNPs in the BNP gene region with circulating NT-proBNP and prevalent CVD in 4,331 participants from the Long Life Family Study (LLFS).

METHODS AND RESULTS: Genotypes of 10 SNPs from the NPPB and NPPA regions that encode BNP and A-type natriuretic peptide, respectively, were tested for association with NT-proBNP and prevalent cardiovascular disease and risk factors. We performed analyses using the Sequential Oligogenic Linkage Analysis (SOLAR) program to …

Acute Symptoms Of Mild To Moderate Covid-19 Are Highly Heterogeneous Across Individuals And Over Time, Thomas L. Rodebaugh, Madelyn R. Frumkin, Angela M. Reiersen, Eric J. Lenze, Michael S. Avidan, J. Philip Miller, Jay F. Piccirillo, Charles F. Zorumski, Caline Mattar

Open Access Publications

Background: The symptoms of coronavirus disease 2019 (COVID-19) appear to be heterogenous, and the typical course of these symptoms is unknown. Our objectives were to characterize the common trajectories of COVID-19 symptoms and to assess how symptom course predicts other symptom changes as well as clinical deterioration.

Methods: One hundred sixty-two participants with acute COVID-19 responded to surveys up to 31 times for up to 17 days. Several statistical methods were used to characterize the temporal dynamics of these symptoms. Because 9 participants showed clinical deterioration, we explored whether these participants showed any differences in symptom profiles.

Results: Trajectories varied …

Cognitive Gain Or Handicap: Magical Ideation And Self-Absorption In Clinical And Non-Clinical Participants, János Kállai, Gábor Vincze, Imre András Török, Rita Hargitai, Sándor Rózsa, István Hartung, István Tamás, András Láng, Róbert Herold

Open Access Publications

No abstract provided.

Correspondence Between Perceived Pubertal Development And Hormone Levels In 9-10 Year-Olds From The Adolescent Brain Cognitive Development Study, Megan M. Herting, Andrey P. Anokhin, Deanna M. Barch, Nico Dosenbach, Paul E.A. Glaser, Andrew C. Heath, Nicole R. Karcher, Et Al

Open Access Publications

No abstract provided.

Cxcl17 Is A Specific Diagnostic Biomarker For Severe Pandemic Influenza A(H1n1) That Predicts Poor Clinical Outcome, Jose Alberto Choreño-Parra, Shabaana A Khader, Et Al

Open Access Publications

The C-X-C motif chemokine ligand 17 (CXCL17) is chemotactic for myeloid cells, exhibits bactericidal activity, and exerts anti-viral functions. This chemokine is constitutively expressed in the respiratory tract, suggesting a role in lung defenses. However, little is known about the participation of CXCL17 against relevant respiratory pathogens in humans. Here, we evaluated the serum levels and lung tissue expression pattern of CXCL17 in a cohort of patients with severe pandemic influenza A(H1N1) from Mexico City. Peripheral blood samples obtained on admission and seven days after hospitalization were processed for determinations of serum CXCL17 levels by enzyme-linked immunosorbent assay (ELISA). The …

Mr-Guided Adaptive Radiotherapy For Bladder Cancer, Adham Hijab, Boris Tocco, Ian Hanson, Hanneke Meijer, Christina Junker Nyborg, Anders Smedegaard Bertelsen, Robert Jan Smeenk, Gillian Smith, Jeff Michalski, Brian C Baumann, Shaista Hafeez

Open Access Publications

Radiotherapy has an important role in the curative and palliative treatment settings for bladder cancer. As a target for radiotherapy the bladder presents a number of technical challenges. These include poor tumor visualization and the variability in bladder size and position both between and during treatment delivery. Evidence favors the use of magnetic resonance imaging (MRI) as an important means of tumor visualization and local staging. The availability of hybrid systems incorporating both MRI scanning capabilities with the linear accelerator (MR-Linac) offers opportunity for in-room and real-time MRI scanning with ability of plan adaption at each fraction while the patient …

Gestational Age-Specific Complete Blood Count Signatures In Necrotizing Enterocolitis, Julia M Pantalone, Silvia Liu, Oluwabunmi O Olaloye, Erica C Prochaska, Toby Yanowitz, Melissa M Riley, Justin R Buland, Beverly S Brozanski, Misty Good, Liza Konnikova

Open Access Publications

No abstract provided.

Machine Learning Analytics Of Resting-State Functional Connectivity Predicts Survival Outcomes Of Glioblastoma Multiforme Patients, Bidhan Lamichhane, Andy G S Daniel, John J Lee, Daniel S Marcus, Joshua S Shimony, Eric C Leuthardt

Open Access Publications

Glioblastoma multiforme (GBM) is the most frequently occurring brain malignancy. Due to its poor prognosis with currently available treatments, there is a pressing need for easily accessible, non-invasive techniques to help inform pre-treatment planning, patient counseling, and improve outcomes. In this study we determined the feasibility of resting-state functional connectivity (rsFC) to classify GBM patients into short-term and long-term survival groups with respect to reported median survival (14.6 months). We used a support vector machine with rsFC between regions of interest as predictive features. We employed a novel hybrid feature selection method whereby features were first filtered using correlations between …

Ontogenetic Oxycodone Exposure Affects Early Life Communicative Behaviors, Sensorimotor Reflexes, And Weight Trajectory In Mice, Elena Minakova, Simona Sarafinovska, Marwa O Mikati, Kia M Barclay, Katherine B Mccullough, Joseph D Dougherty, Ream Al-Hasani, Susan E Maloney

Open Access Publications

Nationwide, opioid misuse among pregnant women has risen four-fold from 1999 to 2014, with commensurate increase in neonates hospitalized for neonatal abstinence syndrome (NAS). NAS occurs when a fetus exposed to opioids

Mitofusin Activation Enhances Mitochondrial Motility And Promotes Neuroregeneration In Cmt2a, Gerald W. Dorn Ii

Open Access Publications

No abstract provided.

Srf Is Required For Maintenance Of Astrocytes In Non-Reactive State In The Mammalian Brain, Monika Jain, Soumen Das, Paul P Y Lu, Garima Virmani, Sumitha Soman, Surya Chandra Rao Thumu, David H Gutmann, Narendrakumar Ramanan

Open Access Publications

Astrocytes play several critical roles in the normal functioning of the mammalian brain, including ion homeostasis, synapse formation, and synaptic plasticity. Following injury and infection or in the setting of neurodegeneration, astrocytes become hypertrophic and reactive, a process termed astrogliosis. Although acute reactive gliosis is beneficial in limiting further tissue damage, chronic gliosis becomes detrimental for neuronal recovery and regeneration. Several extracellular factors have been identified that generate reactive astrocytes; however, very little is known about the cell-autonomous transcriptional mechanisms that regulate the maintenance of astrocytes in the normal non-reactive state. Here, we show that conditional deletion of the stimulus-dependent …

Brain Volumetric Deficits In Mapt Mutation Carriers: A Multisite Study, Stephanie A. Chu, Nupur Ghoshal, Et Al

Open Access Publications

No abstract provided.

Defining Intermediates And Redundancies In Coenzyme Q Precursor Biosynthesis, Kyle P. Robinson, Adam Jochem, Sheila E. Johnson, Thiruchelvi R. Reddy, Jason D. Russell, Joshua J. Coon, David J. Pagliarini

Open Access Publications

No abstract provided.

Proportion And Number Of Upper-Extremity Musculoskeletal Disorders Attributable To The Combined Effect Of Biomechanical And Psychosocial Risk Factors In A Working Population, Aboubakari Nambiema, Julie Bodin, Susan Stock, Agnès Aublet-Cuvelier, Alexis Descatha, Bradley Evanoff, Yves Roquelaure

Open Access Publications

The objective of this paper is to assess the combined effect of occupational biomechanical and psychosocial risk factors on the incidence of work-related upper-extremity musculoskeletal disorders (UEMSDs) and estimate the proportion and number of incident cases attributable to these risk factors in a working population. Using data from the French COSALI (COhorte des SAlariés LIgériens) cohort (enrolment phase: 2002-2005; follow-up phase: 2007-2010), a complete case analysis including 1246 workers (59% men, mean age: 38 years ± 8.6 at baseline) was performed. All participants underwent a standardized clinical examination at enrolment and 1611 workers were re-examined at follow-up. Population attributable fractions …

The Position Of Single-Base Deletions In The Vntr Sequence Of The Carboxyl Ester Lipase (Cel) Gene Determines Proteotoxicity, Anny Gravdal, Xunjun Xiao, Miriam Cnop, Khadija El Jellas, Stefan Johansson, Pål R. Njølstad, Mark E. Lowe, Bente B. Johansson, Anders Molven, Karianne Fjeld

Open Access Publications

No abstract provided.

High-Fat Diet Activates Liver Ipla2Γ Generating Eicosanoids That Mediate Metabolic Stress, Sung Ho Moon, Beverly Gibson Dilthey, Xinping Liu, Shaoping Guan, Harold F. Sims, Richard W. Gross

Open Access Publications

No abstract provided.

Generation Of A Gene-Corrected Human Isogenic Ipsc Line From An Alzheimer’S Disease Ipsc Line Carrying The London Mutation In App (V717i), Damian Hernandez, Stephanie Morgan Schlicht, Maciej Daniszewski, Celeste M. Karch, Dominantly Inherited Network (Dian), Alison M. Goate, Alice Pebay

Open Access Publications

No abstract provided.

Familial Lipomas Without Classic Neurofibromatosis-1 Caused By A Missense Germline Nf1 Mutation, Erika Ramirez, Stephanie M. Morris, Tychele N. Turner, David H. Gutmann

Open Access Publications

No abstract provided.

Cytokine Profiling In Plasma From Patients With Brain Tumors Versus Healthy Individuals Using 2 Different Multiplex Immunoassay Platforms, Diane Elizabeth Bender, Maximilian O. Schaettler, Kathleen C.F. Sheehan, Tanner M. Johanns, Gavin P. Dunn

Open Access Publications

No abstract provided.

Resting-State Functional Connectivity Disruption As A Pathological Biomarker In Autosomal Dominant Alzheimer Disease, Robert X. Smith, Jeremy F. Strain, Aaron Tanenbaum, Anne M. Fagan, Jason Hassenstab, Eric Mcdade, Suzanne E. Schindler, Brian A. Gordon, Chengjie Xiong, Celeste Karch, David M. Holtzman, Daniel S. Marcus, John C. Morris, Tammie L.S. Benzinger, Randall J. Bateman, Beau M. Ances, Et Al.

Open Access Publications

No abstract provided.

Apathy, Cognitive Impairment, And Social Support Contribute To Participation In Cognitively Demanding Activities Poststroke, Amy Ho, Marjorie L. Nicholas, Chaitali Dagli, Lisa Tabor Connor

Open Access Publications

No abstract provided.

Toward A More Comprehensive Assessment Of School Age Children With Hemiplegic Cerebral Palsy, Catherine R. Hoyt, Sarah K. Sherman, Shelby K. Brown, Dillan J. Newbold, Ryland L. Miller, Andrew N. Van, Joshua S. Shimony, Mario Ortega, Annie L. Nguyen, Bradley L. Schlaggar, Nico U.F. Dosenbach

Open Access Publications

No abstract provided.

Calcium Carbonate Nanoparticles Stimulate Cancer Cell Reprogramming To Suppress Tumor Growth And Invasion In An Organ‑On‑A‑Chip System, Sandra F. Lam, Kevin W. Bishop, Rachel Mintz, Lei Fang, Samuel Achilefu

Open Access Publications

No abstract provided.

The Impact Of Covid-19 On Dual-Physician Couples: A Disproportionate Burden On Women Physicians, Andrea Soares, Prashanth Thakker, Elena Deych, Shikha Jain, Rakhee K. Bhayani

Open Access Publications

No abstract provided.

Old Vaccines For New Infections: Exploiting Innate Immunity To Control Covid-19 And Prevent Future Pandemics, Konstantin Chumakov, Michael S. Avidan, Christine S. Benn, Stefano M. Bertozzi, Lawrence Blatt, Angela Y. Chang, Dean T. Jamison, Shabaana A. Khader, Shyam Kottilil, Mihai G. Netea, Annie Sparrow, Robert C. Gallo

Open Access Publications

No abstract provided.

Paroxysmal Kinesigenic Dyskinesia In Twins With Chromosome 16p11.2 Duplication Syndrome, Keisuke Ueda, Marwan Shinawi, Toni S. Pearson

Open Access Publications

No abstract provided.