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Symptomatic Progression Of Asymptomatic Rotator Cuff Tears A Prospective Study Of Clinical And Sonographic Variables, Nathan A. Mall, H. Mike Kim, Jay D. Keener, Karen Steger-May, Sharlene A. Teefey, William D. Middleton, Georgia Stobbs, Ken Yamaguchi Nov 2010

Symptomatic Progression Of Asymptomatic Rotator Cuff Tears A Prospective Study Of Clinical And Sonographic Variables, Nathan A. Mall, H. Mike Kim, Jay D. Keener, Karen Steger-May, Sharlene A. Teefey, William D. Middleton, Georgia Stobbs, Ken Yamaguchi

Open Access Publications

No abstract provided.


Membrane Anchoring Subunits Specify Selective Regulation Of Rgs9·Gbeta5 Gap Complex In Photoreceptor Neurons, Yan Cao, Alexander V. Kolesnikov, Ikuo Masuho, Vladimir J. Kefalov, Kirill A. Martemyanov Oct 2010

Membrane Anchoring Subunits Specify Selective Regulation Of Rgs9·Gbeta5 Gap Complex In Photoreceptor Neurons, Yan Cao, Alexander V. Kolesnikov, Ikuo Masuho, Vladimir J. Kefalov, Kirill A. Martemyanov

Open Access Publications

The RGS9·Gβ5 complex is the key regulator of neuronal G-protein signaling and shows remarkable selectivity of subunit composition. In retinal photoreceptors, RGS9·Gβ5 is bound to the membrane anchor R9AP and the complex regulates visual signaling. In the basal ganglia neurons, RGS9·Gβ5 is instead associated with a homologous protein, R7BP, and regulates reward circuit. Switching this selective subunit composition of the complex in rod photoreceptors allowed us to study the molecular underpinning of signaling specificity in diverse G-protein pathways. We have found that both membrane anchoring subunits play a conserved role in regulating protein levels of RGS9·Gβ5 and enhancing the ability …


Report From The 2009 Aoa North American Traveling Fellowship, Ryan T. Bicknell, Gregory J. Della Rocca, Wellington K. Hsu, Amanda D. Marshall, Robert H. Brophy Oct 2010

Report From The 2009 Aoa North American Traveling Fellowship, Ryan T. Bicknell, Gregory J. Della Rocca, Wellington K. Hsu, Amanda D. Marshall, Robert H. Brophy

Open Access Publications

No abstract provided.


Protein Turnover Of The Wallenda/Dlk Kinase Regulates A Retrograde Response To Axonal Injury, Xin Xiong, Xin Wang, Ronny Ewanek, Pavan Bhat, Aaron Diantonio, Catherine A. Collins Oct 2010

Protein Turnover Of The Wallenda/Dlk Kinase Regulates A Retrograde Response To Axonal Injury, Xin Xiong, Xin Wang, Ronny Ewanek, Pavan Bhat, Aaron Diantonio, Catherine A. Collins

Open Access Publications

No abstract provided.


Age-Related Deterioration Of Rod Vision In Mice, Alexander V. Kolesnikov, Jie Fan, Rosalie K. Crouch, Vladimir J. Kefalov Aug 2010

Age-Related Deterioration Of Rod Vision In Mice, Alexander V. Kolesnikov, Jie Fan, Rosalie K. Crouch, Vladimir J. Kefalov

Open Access Publications

Even in healthy individuals, aging leads to deterioration in visual acuity, contrast sensitivity, visual field, and dark adaptation. Little is known about the neural mechanisms that drive the age-related changes of the retina and, more specifically, photoreceptors. According to one hypothesis, the age-related deterioration in rod function is due to the limited availability of 11-cis-retinal for rod pigment formation. To determine how aging affects rod photoreceptors and to test the retinoid-deficiency hypothesis, we compared the morphological and functional properties of rods of adult and aged B6D2F1/J mice. We found that the number of rods and the length of their outer …


What's New In Spine Surgery, Keith H. Bridwell, Paul A. Anderson, Scott D. Boden, Alexander R. Vaccaro, Jeffrey C. Wang Aug 2010

What's New In Spine Surgery, Keith H. Bridwell, Paul A. Anderson, Scott D. Boden, Alexander R. Vaccaro, Jeffrey C. Wang

Open Access Publications

No abstract provided.


Combined Hip Arthroscopy And Limited Open Osteochondroplasty For Anterior Femoroacetabular Impingement, John C. Clohisy, Lukas P. Zebala, Jeffrey J. Nepple, Gail Pashos Jul 2010

Combined Hip Arthroscopy And Limited Open Osteochondroplasty For Anterior Femoroacetabular Impingement, John C. Clohisy, Lukas P. Zebala, Jeffrey J. Nepple, Gail Pashos

Open Access Publications

No abstract provided.


Vestibular Heading Discrimination And Sensitivity To Linear Acceleration In Head And World Coordinates, Paul R. Macneilage, Martin S. Banks, Gregory C. Deangelis, Dora E. Angelaki Jul 2010

Vestibular Heading Discrimination And Sensitivity To Linear Acceleration In Head And World Coordinates, Paul R. Macneilage, Martin S. Banks, Gregory C. Deangelis, Dora E. Angelaki

Open Access Publications

Effective navigation and locomotion depend critically on an observer's ability to judge direction of linear self-motion, i.e., heading. The vestibular cue to heading is the direction of inertial acceleration that accompanies transient linear movements. This cue is transduced by the otolith organs. The otoliths also respond to gravitational acceleration, so vestibular heading discrimination could depend on (1) the direction of movement in head coordinates (i.e., relative to the otoliths), (2) the direction of movement in world coordinates (i.e., relative to gravity), or (3) body orientation (i.e., the direction of gravity relative to the otoliths). To quantify these effects, we measured …


Brain Specificity Of Diffuse Optical Imaging: Improvements From Superficial Signal Regression And Tomography, Nicholas M. Gregg, Brian R. White, Benjamin W. Zeff, Andrew J. Berger, Joseph P. Culver Jul 2010

Brain Specificity Of Diffuse Optical Imaging: Improvements From Superficial Signal Regression And Tomography, Nicholas M. Gregg, Brian R. White, Benjamin W. Zeff, Andrew J. Berger, Joseph P. Culver

Open Access Publications

No abstract provided.


Dynamic Contact Mechanics Of The Medial Meniscus As A Function Of Radial Tear, Repair, And Partial Meniscectomy, Asheesh Bedi, Natalie H. Kelly, Michael Baad, Alice J.S. Fox, Robert H. Brophy, Russell F. Warren, Suzanne A. Maher Jun 2010

Dynamic Contact Mechanics Of The Medial Meniscus As A Function Of Radial Tear, Repair, And Partial Meniscectomy, Asheesh Bedi, Natalie H. Kelly, Michael Baad, Alice J.S. Fox, Robert H. Brophy, Russell F. Warren, Suzanne A. Maher

Open Access Publications

No abstract provided.


Identifying Basal Ganglia Divisions In Individuals Using Resting-State Functional Connectivity Mri, Kelly Anne Barnes, Alexander L. Cohen, Jonathan D. Power, Steven M. Nelson, Yannic B.L. Dosenbach, Francis M. Miezin, Steven E. Petersen, Bradley L. Schlaggar Jun 2010

Identifying Basal Ganglia Divisions In Individuals Using Resting-State Functional Connectivity Mri, Kelly Anne Barnes, Alexander L. Cohen, Jonathan D. Power, Steven M. Nelson, Yannic B.L. Dosenbach, Francis M. Miezin, Steven E. Petersen, Bradley L. Schlaggar

Open Access Publications

No abstract provided.


Location And Initiation Of Degenerative Rotator Cuff Tears: An Analysis Of Three Hundred And Sixty Shoulders, H. Mike Kim, Nirvikar Dahiya, Sharlene A. Teefey, William D. Middleton, Georgia Stobbs, Karen Steger-May, Ken Yamaguchi, Jay D. Keener May 2010

Location And Initiation Of Degenerative Rotator Cuff Tears: An Analysis Of Three Hundred And Sixty Shoulders, H. Mike Kim, Nirvikar Dahiya, Sharlene A. Teefey, William D. Middleton, Georgia Stobbs, Karen Steger-May, Ken Yamaguchi, Jay D. Keener

Open Access Publications

No abstract provided.


Molecular Dissection Of I(A) In Cortical Pyramidal Neurons Reveals Three Distinct Components Encoded By Kv4.2, Kv4.3, And Kv1.4 Alpha-Subunits, Aaron J. Norris, Jeanne M. Nerbonne Apr 2010

Molecular Dissection Of I(A) In Cortical Pyramidal Neurons Reveals Three Distinct Components Encoded By Kv4.2, Kv4.3, And Kv1.4 Alpha-Subunits, Aaron J. Norris, Jeanne M. Nerbonne

Open Access Publications

The rapidly activating and inactivating voltage-gated K(+) (Kv) current, I(A), is broadly expressed in neurons and is a key regulator of action potential repolarization, repetitive firing, backpropagation (into dendrites) of action potentials, and responses to synaptic inputs. Interestingly, results from previous studies on a number of neuronal cell types, including hippocampal, cortical, and spinal neurons, suggest that macroscopic I(A) is composed of multiple components and that each component is likely encoded by distinct Kv channel alpha-subunits. The goals of the experiments presented here were to test this hypothesis and to determine the molecular identities of the Kv channel alpha-subunits that …


Improving Prefrontal Cortex Function In Schizophrenia Through Focused Training Of Cognitive Control, Bethany G. Edwards, Deanna M. Barch, Todd S. Braver Apr 2010

Improving Prefrontal Cortex Function In Schizophrenia Through Focused Training Of Cognitive Control, Bethany G. Edwards, Deanna M. Barch, Todd S. Braver

Open Access Publications

No abstract provided.


Relationship Of Tear Size And Location To Fatty Degeneration Of The Rotator Cuff, H. Mike Kim, Nirvikar Dahiya, Sharlene A. Teefey, Jay D. Keener, Leesa M. Galatz, Ken Yamaguchi Apr 2010

Relationship Of Tear Size And Location To Fatty Degeneration Of The Rotator Cuff, H. Mike Kim, Nirvikar Dahiya, Sharlene A. Teefey, Jay D. Keener, Leesa M. Galatz, Ken Yamaguchi

Open Access Publications

No abstract provided.


Orthopaedic Surgeons And The Medical Device Industry: The Threat To Scientific Integrity And The Public Trust, Richard H. Gelberman, David Samson, Sohail K. Mirza, John J. Callaghan, Vincent D. Pellegrini Mar 2010

Orthopaedic Surgeons And The Medical Device Industry: The Threat To Scientific Integrity And The Public Trust, Richard H. Gelberman, David Samson, Sohail K. Mirza, John J. Callaghan, Vincent D. Pellegrini

Open Access Publications

No abstract provided.


Soluble Amyloid-Β, Effect On Cerebral Arteriolar Regulation And Vascular Cells, Hans H. Dietrich, Chuanxi Xiang, Byung H. Han, Gregory J. Zipfel, David M. Holtzman Jan 2010

Soluble Amyloid-Β, Effect On Cerebral Arteriolar Regulation And Vascular Cells, Hans H. Dietrich, Chuanxi Xiang, Byung H. Han, Gregory J. Zipfel, David M. Holtzman

Open Access Publications

No abstract provided.


26s Proteasome Activity Is Down-Regulated In Lung Cancer Stem-Like Cells Propagated In Vitro, Jing Pan, Qi Zhang, Yian Wang, Ming You Jan 2010

26s Proteasome Activity Is Down-Regulated In Lung Cancer Stem-Like Cells Propagated In Vitro, Jing Pan, Qi Zhang, Yian Wang, Ming You

Open Access Publications

No abstract provided.


Reducing The Incidence Of Intraventricular Catheter-Related Ventriculitis In The Neurology-Neurosurgical Intensive Care Unit At A Tertiary Care Center In St Louis, Missouri: An 8-Year Follow-Up Study, Hitoshi Honda, Jeffrey C. Jones, Martha C. Craighead, Michael N. Diringer, Ralph G. Dacey, David K. Warren Jan 2010

Reducing The Incidence Of Intraventricular Catheter-Related Ventriculitis In The Neurology-Neurosurgical Intensive Care Unit At A Tertiary Care Center In St Louis, Missouri: An 8-Year Follow-Up Study, Hitoshi Honda, Jeffrey C. Jones, Martha C. Craighead, Michael N. Diringer, Ralph G. Dacey, David K. Warren

Open Access Publications

No abstract provided.


Role Of Abl Kinase And The Wave2 Signaling Complex In Hiv-1 Entry At A Post-Hemifusion Step, Brooke Harmon, Nancy Campbell, Lee Ratner Jan 2010

Role Of Abl Kinase And The Wave2 Signaling Complex In Hiv-1 Entry At A Post-Hemifusion Step, Brooke Harmon, Nancy Campbell, Lee Ratner

Open Access Publications

No abstract provided.


Coordinated Progression Through Two Subtranscriptomes Underlies The Tachyzoite Cycle Of Toxoplasma Gondii, Michael S. Behnke, John C. Wootton, Margaret M. Lehmann, Josh B. Radke, Olivier Lucas, Julie Nawas, L. David Sibley, Michael W. White Jan 2010

Coordinated Progression Through Two Subtranscriptomes Underlies The Tachyzoite Cycle Of Toxoplasma Gondii, Michael S. Behnke, John C. Wootton, Margaret M. Lehmann, Josh B. Radke, Olivier Lucas, Julie Nawas, L. David Sibley, Michael W. White

Open Access Publications

No abstract provided.


A Genome-Wide Association Study Of Self-Rated Health, Miriam A. Mosing, Karin J.H. Verweij, Sarah E. Medland, Jodie Painter, Scott D. Gordon, Andrew C. Heath, Pamela A. Madden, Grant W. Montgomery, Nicholas G. Martin Jan 2010

A Genome-Wide Association Study Of Self-Rated Health, Miriam A. Mosing, Karin J.H. Verweij, Sarah E. Medland, Jodie Painter, Scott D. Gordon, Andrew C. Heath, Pamela A. Madden, Grant W. Montgomery, Nicholas G. Martin

Open Access Publications

No abstract provided.


Detection Rates Of Congenital Heart Disease In Guatemala, Sara M. Trucco, Joaquin Barnoya, Luis A. Larrazabal, Aldo Castañeda, David F. Teitel Jan 2010

Detection Rates Of Congenital Heart Disease In Guatemala, Sara M. Trucco, Joaquin Barnoya, Luis A. Larrazabal, Aldo Castañeda, David F. Teitel

Open Access Publications

No abstract provided.


Major Depression And The Metabolic Syndrome, Debra L. Foley, Katherine I. Morley, Pamela A.F. Madden, Andrew C. Heath, John B. Whitfield, Nicholas G. Martin Jan 2010

Major Depression And The Metabolic Syndrome, Debra L. Foley, Katherine I. Morley, Pamela A.F. Madden, Andrew C. Heath, John B. Whitfield, Nicholas G. Martin

Open Access Publications

No abstract provided.


Tata Is A Modular Component Of Synthetic Promoters, Ilaria Mogno, Francesco Vallania, Robi D. Mitra, Barak A. Cohen Jan 2010

Tata Is A Modular Component Of Synthetic Promoters, Ilaria Mogno, Francesco Vallania, Robi D. Mitra, Barak A. Cohen

Open Access Publications

No abstract provided.


Genetic Evidence Implicates The Immune System And Cholesterol Metabolism In The Aetiology Of Alzheimer's Disease, Alison M. Goate, Carlos Cruchaga, Petra Nowotny, John C. Morris, Kevin Mayo, Et Al. Jan 2010

Genetic Evidence Implicates The Immune System And Cholesterol Metabolism In The Aetiology Of Alzheimer's Disease, Alison M. Goate, Carlos Cruchaga, Petra Nowotny, John C. Morris, Kevin Mayo, Et Al.

Open Access Publications

No abstract provided.


Lipidomics Analysis Reveals Efficient Storage Of Hepatic Triacylglycerides Enriched In Unsaturated Fatty Acids After One Bout Of Exercise In Mice, Chunxiu Hu, Miriam Hoene, Xinjie Zhao, Hans U. Haring, Erwin Schleicher, Rainer Lehmann, Xianlin Han, Guowang Xu, Cora Weigert Jan 2010

Lipidomics Analysis Reveals Efficient Storage Of Hepatic Triacylglycerides Enriched In Unsaturated Fatty Acids After One Bout Of Exercise In Mice, Chunxiu Hu, Miriam Hoene, Xinjie Zhao, Hans U. Haring, Erwin Schleicher, Rainer Lehmann, Xianlin Han, Guowang Xu, Cora Weigert

Open Access Publications

No abstract provided.


The Perilipin Homologue, Lipid Storage Droplet 2, Regulates Sleep Homeostasis And Prevents Learning Impairments Following Sleep Loss, Matthew S. Thimgan, Yasuko Suzuki, Laurent Seugnet, Laura Gottschalk, Paul J. Shaw Jan 2010

The Perilipin Homologue, Lipid Storage Droplet 2, Regulates Sleep Homeostasis And Prevents Learning Impairments Following Sleep Loss, Matthew S. Thimgan, Yasuko Suzuki, Laurent Seugnet, Laura Gottschalk, Paul J. Shaw

Open Access Publications

No abstract provided.


Mhc Class I–Deficient Natural Killer Cells Acquire A Licensed Phenotype After Transfer Into An Mhc Class I–Sufficient Environment, Julie M. Elliott, Joseph A. Wahle, Wayne M. Yokoyama Jan 2010

Mhc Class I–Deficient Natural Killer Cells Acquire A Licensed Phenotype After Transfer Into An Mhc Class I–Sufficient Environment, Julie M. Elliott, Joseph A. Wahle, Wayne M. Yokoyama

Open Access Publications

No abstract provided.


Comparison Of Amounts And Types Of Practice During Rehabilitation For Traumatic Brain Injury And Stroke, Teresa Jacobson Kimberley, Sharyl Samargia, Lisa G. Moore, Josefin K. Shakya, Catherine E. Lang Jan 2010

Comparison Of Amounts And Types Of Practice During Rehabilitation For Traumatic Brain Injury And Stroke, Teresa Jacobson Kimberley, Sharyl Samargia, Lisa G. Moore, Josefin K. Shakya, Catherine E. Lang

Open Access Publications

No abstract provided.