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Rna Helicase Signaling Is Critical For Type I Interferon Production And Protection Against Rift Valley Fever Virus During Mucosal Challenge, Megan E. Ermler, Ekaterina Yerukhim, Jill Schriewer, Stefan Schattgen, Zachary Traylor, Adam R. Wespiser, Daniel R. Caffrey, Zhijian J. Chen, Charles H. King, Michael Gale Jr., Marco Colonna, Katherine A. Fitzgerald, R. Mark L. Buller, Amy G. Hise Jan 2013

Rna Helicase Signaling Is Critical For Type I Interferon Production And Protection Against Rift Valley Fever Virus During Mucosal Challenge, Megan E. Ermler, Ekaterina Yerukhim, Jill Schriewer, Stefan Schattgen, Zachary Traylor, Adam R. Wespiser, Daniel R. Caffrey, Zhijian J. Chen, Charles H. King, Michael Gale Jr., Marco Colonna, Katherine A. Fitzgerald, R. Mark L. Buller, Amy G. Hise

Open Access Publications

No abstract provided.


Crystal Structure Of The Cowpox Virus-Encoded Nkg2d Ligand Omcp, Eric Lazear, Lance W. Peterson, Chris A. Nelson, Daved H. Fremont Jan 2013

Crystal Structure Of The Cowpox Virus-Encoded Nkg2d Ligand Omcp, Eric Lazear, Lance W. Peterson, Chris A. Nelson, Daved H. Fremont

Open Access Publications

No abstract provided.


A Single-Amino-Acid Change In Murine Norovirus Ns1/2 Is Sufficient For Colonic Tropism And Persistence, Timothy J. Nice, David W. Strong, Broc T. Mccune, Calvin S. Pohl, Herbert W. Virgin Jan 2013

A Single-Amino-Acid Change In Murine Norovirus Ns1/2 Is Sufficient For Colonic Tropism And Persistence, Timothy J. Nice, David W. Strong, Broc T. Mccune, Calvin S. Pohl, Herbert W. Virgin

Open Access Publications

No abstract provided.


Advancing The Translation Of Optical Imaging Agents For Clinical Imaging, Eva M. Sevick-Muraca, Walter J. Akers, Bishnu P. Joshi, Gary D. Lurker, Cathy S. Cutler, Lawrence J. Marnett, Christopher H. Contag, Thomas D. Wang, Ali Azhdarinia Jan 2013

Advancing The Translation Of Optical Imaging Agents For Clinical Imaging, Eva M. Sevick-Muraca, Walter J. Akers, Bishnu P. Joshi, Gary D. Lurker, Cathy S. Cutler, Lawrence J. Marnett, Christopher H. Contag, Thomas D. Wang, Ali Azhdarinia

Open Access Publications

No abstract provided.


Metaplastic Ltp Inhibition After Ltd Induction In Ca1 Hippocampal Slices Involves Nmda Receptor‐Mediated Neurosteroidogenesis, Yukitoshi Izumi, Kazuko A. O'Dell, Charles F. Zorumski Jan 2013

Metaplastic Ltp Inhibition After Ltd Induction In Ca1 Hippocampal Slices Involves Nmda Receptor‐Mediated Neurosteroidogenesis, Yukitoshi Izumi, Kazuko A. O'Dell, Charles F. Zorumski

Open Access Publications

No abstract provided.


Single-Level Degenerative Cervical Disc Disease And Driving Disability: Results From A Prospective, Randomized Trial, Michael P. Kelly, M. D. Mitchell, Robert J. Hacker, K. D. Riew, Rick C. Sasso Jan 2013

Single-Level Degenerative Cervical Disc Disease And Driving Disability: Results From A Prospective, Randomized Trial, Michael P. Kelly, M. D. Mitchell, Robert J. Hacker, K. D. Riew, Rick C. Sasso

Open Access Publications

No abstract provided.


Risk Factors For Mixed Complicated Skin And Skin Structure Infections To Help Tailor Appropriate Empiric Therapy, Marya Zilberberg, Scott T. Micek, Marin H. Kollef, Ahmed Shelbaya, Andrew F. Shorr Dec 2012

Risk Factors For Mixed Complicated Skin And Skin Structure Infections To Help Tailor Appropriate Empiric Therapy, Marya Zilberberg, Scott T. Micek, Marin H. Kollef, Ahmed Shelbaya, Andrew F. Shorr

Open Access Publications

No abstract provided.


Meniscal Repair Outcomes At Greater Than Five Years: A Systematic Literature Review And Meta-Analysis, Jeffrey J. Nepple, Warren R. Dunn, Rick W. Wright Dec 2012

Meniscal Repair Outcomes At Greater Than Five Years: A Systematic Literature Review And Meta-Analysis, Jeffrey J. Nepple, Warren R. Dunn, Rick W. Wright

Open Access Publications

No abstract provided.


Immune Responses To West Nile Virus Infection In The Central Nervous System, Hyelim Cho, Michael S. Diamond Dec 2012

Immune Responses To West Nile Virus Infection In The Central Nervous System, Hyelim Cho, Michael S. Diamond

Open Access Publications

No abstract provided.


The Influence Of Insurance Status On Access To And Utilization Of A Tertiary Hand Surgery Referral Center, Ryan P. Calfee, Chirag M. Shah, Colin D. Canham, Ambrose H.W. Wong, Richard H. Gelberman, Charles A. Goldfarb Dec 2012

The Influence Of Insurance Status On Access To And Utilization Of A Tertiary Hand Surgery Referral Center, Ryan P. Calfee, Chirag M. Shah, Colin D. Canham, Ambrose H.W. Wong, Richard H. Gelberman, Charles A. Goldfarb

Open Access Publications

No abstract provided.


Educating Medical Students In Musculoskeletal Surgery And Medicine: How To Get A Course Up And Running At Your Institution: Aoa Critical Issues, Charles S. Day, Joseph Bernstein, Martin I. Boyer Dec 2012

Educating Medical Students In Musculoskeletal Surgery And Medicine: How To Get A Course Up And Running At Your Institution: Aoa Critical Issues, Charles S. Day, Joseph Bernstein, Martin I. Boyer

Open Access Publications

No abstract provided.


Neonatal Diethylstilbestrol Exposure Alters The Metabolic Profile Of Uterine Epithelial Cells, Yan Yin, Congxing Lin, G. Michael Veith, Hong Chen, Maulik Dhandha, Liang Ma Nov 2012

Neonatal Diethylstilbestrol Exposure Alters The Metabolic Profile Of Uterine Epithelial Cells, Yan Yin, Congxing Lin, G. Michael Veith, Hong Chen, Maulik Dhandha, Liang Ma

Open Access Publications

No abstract provided.


Mapping A Complete Neural Population In The Retina, Olivier Marre, Dario Amodei, Nikhil Deshmukh, Kolia Sadeghi, Frederick Soo, Timothy E. Holy, Michael J. Berry Oct 2012

Mapping A Complete Neural Population In The Retina, Olivier Marre, Dario Amodei, Nikhil Deshmukh, Kolia Sadeghi, Frederick Soo, Timothy E. Holy, Michael J. Berry

Open Access Publications

Recording simultaneously from essentially all of the relevant neurons in a local circuit is crucial to understand how they collectively represent information. Here we show that the combination of a large, dense multielectrode array and a novel, mostly automated spike-sorting algorithm allowed us to record simultaneously from a highly overlapping population of >200 ganglion cells in the salamander retina. By combining these methods with labeling and imaging, we showed that up to 95% of the ganglion cells over the area of the array were recorded. By measuring the coverage of visual space by the receptive fields of the recorded cells, …


Protection Of Bone In Premenopausal Women With Breast Cancer: Focus On Zoledronic Acid, Rebecca Aft Oct 2012

Protection Of Bone In Premenopausal Women With Breast Cancer: Focus On Zoledronic Acid, Rebecca Aft

Open Access Publications

No abstract provided.


The Use Of Live Attenuated Influenza Vaccine (Laiv) In Healthcare Personnel (Hcp): Guidance From The Society For Healthcare Epidemiology Of America (Shea), Thomas R. Talbot, Hilary Babcock, Deborah Cotton, Lisa L. Maragakis, Gregory A. Poland, Edward J. Septimus, Michael L. Tapper, David J. Weber Oct 2012

The Use Of Live Attenuated Influenza Vaccine (Laiv) In Healthcare Personnel (Hcp): Guidance From The Society For Healthcare Epidemiology Of America (Shea), Thomas R. Talbot, Hilary Babcock, Deborah Cotton, Lisa L. Maragakis, Gregory A. Poland, Edward J. Septimus, Michael L. Tapper, David J. Weber

Open Access Publications

No abstract provided.


“Genomics And Translational Medicine For Information Professionals”: An Innovative Course To Educate The Next Generation Of Librarians, Ana D. Cleveland, Kristi L. Holmes, Jodi L. Philbrick Oct 2012

“Genomics And Translational Medicine For Information Professionals”: An Innovative Course To Educate The Next Generation Of Librarians, Ana D. Cleveland, Kristi L. Holmes, Jodi L. Philbrick

Open Access Publications

No abstract provided.


Metabolic Effects Of Darunavir/Ritonavir Versus Atazanavir/Ritonavir In Treatment-Naive, Hiv Type 1-Infected Subjects Over 48 Weeks, Judith A. Aberg, Pablo Tebas, Edgar Turner Overton, Samir K. Gupta, Paul E. Sax, Alan Landay, Ron Falcon, Robert Ryan, Guy De La Rosa Sep 2012

Metabolic Effects Of Darunavir/Ritonavir Versus Atazanavir/Ritonavir In Treatment-Naive, Hiv Type 1-Infected Subjects Over 48 Weeks, Judith A. Aberg, Pablo Tebas, Edgar Turner Overton, Samir K. Gupta, Paul E. Sax, Alan Landay, Ron Falcon, Robert Ryan, Guy De La Rosa

Open Access Publications

No abstract provided.


Polygenic Threshold Model With Sex Dimorphism In Adolescent Idiopathic Scoliosis: The Carter Effect, Lisa M. Kruse, Jillian G. Buchan, Christina A. Gurnett, Matthew B. Dobbs Aug 2012

Polygenic Threshold Model With Sex Dimorphism In Adolescent Idiopathic Scoliosis: The Carter Effect, Lisa M. Kruse, Jillian G. Buchan, Christina A. Gurnett, Matthew B. Dobbs

Open Access Publications

No abstract provided.


Loss Of Atm Kinase Activity Leads To Embryonic Lethality In Mice, Jeremy A. Daniel, Manuela Pellegrini, Baeck-Seung Lee, Zhi Guo, Darius Filsuf, Natalya V. Belkina, Zhongsheng You, Tanya T. Paull, Barry P. Sleckman, Lionel Feigenbaum, André Nussenzweig Aug 2012

Loss Of Atm Kinase Activity Leads To Embryonic Lethality In Mice, Jeremy A. Daniel, Manuela Pellegrini, Baeck-Seung Lee, Zhi Guo, Darius Filsuf, Natalya V. Belkina, Zhongsheng You, Tanya T. Paull, Barry P. Sleckman, Lionel Feigenbaum, André Nussenzweig

Open Access Publications

No abstract provided.


I(A) Channels Encoded By Kv1.4 And Kv4.2 Regulate Neuronal Firing In The Suprachiasmatic Nucleus And Circadian Rhythms In Locomotor Activity, Daniel Granados-Fuentes, Aaron J. Norris, Yarimar Carrasquillo, Jeanne M. Nerbonne, Erik D. Herzog Jul 2012

I(A) Channels Encoded By Kv1.4 And Kv4.2 Regulate Neuronal Firing In The Suprachiasmatic Nucleus And Circadian Rhythms In Locomotor Activity, Daniel Granados-Fuentes, Aaron J. Norris, Yarimar Carrasquillo, Jeanne M. Nerbonne, Erik D. Herzog

Open Access Publications

Neurons in the suprachiasmatic nucleus (SCN) display coordinated circadian changes in electrical activity that are critical for daily rhythms in physiology, metabolism, and behavior. SCN neurons depolarize spontaneously and fire repetitively during the day and hyperpolarize, drastically reducing firing rates, at night. To explore the hypothesis that rapidly activating and inactivating A-type (I(A)) voltage-gated K(+) (Kv) channels, which are also active at subthreshold membrane potentials, are critical regulators of the excitability of SCN neurons, we examined locomotor activity and SCN firing in mice lacking Kv1.4 (Kv1.4(-/-)), Kv4.2 (Kv4.2(-/-)), or Kv4.3 (Kv4.3(-/-)), the pore-forming (α) subunits of I(A) channels. Mice lacking …


Intermediate Outcomes Following Percutaneous Fixation Of Proximal Humeral Fractures, Alicia K. Harrison, Konrad I. Gruson, Benjamin Zmistowski, Jay Keener, Leesa Galatz, Gerald Williams, Bradford O. Parsons, Evan L. Flatgow Jul 2012

Intermediate Outcomes Following Percutaneous Fixation Of Proximal Humeral Fractures, Alicia K. Harrison, Konrad I. Gruson, Benjamin Zmistowski, Jay Keener, Leesa Galatz, Gerald Williams, Bradford O. Parsons, Evan L. Flatgow

Open Access Publications

No abstract provided.


Hunter-Gatherer Energetics And Human Obesity, Herman Pontzer, David A. Raichlen, Brian M. Wood, Audax Z. P. Mabulla, Susan B. Racette, Frank W. Marlowe Jul 2012

Hunter-Gatherer Energetics And Human Obesity, Herman Pontzer, David A. Raichlen, Brian M. Wood, Audax Z. P. Mabulla, Susan B. Racette, Frank W. Marlowe

Open Access Publications

No abstract provided.


Diagnostic Performance And Reliability Of Ultrasonography For Fatty Degeneration Of The Rotator Cuff Muscles, Lindley B. Wall, Sharlene A. Teefey, William D. Middleton, Nirvikar Dahiya, Karen Steger-May, H. Mike Kim, Daniel Wessell, Ken Yamaguchi Jun 2012

Diagnostic Performance And Reliability Of Ultrasonography For Fatty Degeneration Of The Rotator Cuff Muscles, Lindley B. Wall, Sharlene A. Teefey, William D. Middleton, Nirvikar Dahiya, Karen Steger-May, H. Mike Kim, Daniel Wessell, Ken Yamaguchi

Open Access Publications

No abstract provided.


What's New In Spine Surgery, Keith H. Bridwell, Paul A. Anderson, Scott D. Boden, Alexander R. Vaccaro, Jeffrey C. Wang Jun 2012

What's New In Spine Surgery, Keith H. Bridwell, Paul A. Anderson, Scott D. Boden, Alexander R. Vaccaro, Jeffrey C. Wang

Open Access Publications

No abstract provided.


Detection Thresholds Of Macaque Otolith Afferents, Xiong-Jie Yu, J David Dickman, Dora E. Angelaki Jun 2012

Detection Thresholds Of Macaque Otolith Afferents, Xiong-Jie Yu, J David Dickman, Dora E. Angelaki

Open Access Publications

The vestibular system is our sixth sense and is important for spatial perception functions, yet the sensory detection and discrimination properties of vestibular neurons remain relatively unexplored. Here we have used signal detection theory to measure detection thresholds of otolith afferents using 1 Hz linear accelerations delivered along three cardinal axes. Direction detection thresholds were measured by comparing mean firing rates centered on response peak and trough (full-cycle thresholds) or by comparing peak/trough firing rates with spontaneous activity (half-cycle thresholds). Thresholds were similar for utricular and saccular afferents, as well as for lateral, fore/aft, and vertical motion directions. When computed …


Multi-Institutional Analysis Of Robot-Assisted Partial Nephrectomy For Renal Tumors >4 Cm Versus ≤4 Cm In 445 Consecutive Patients, Firas Petros, Shyam Sukumar, Georges-Pascal Haber, Lori Dulabon, Sam Bhayani, Michael Stifelman, Jihad Kaouk, Craig Rogers Jun 2012

Multi-Institutional Analysis Of Robot-Assisted Partial Nephrectomy For Renal Tumors >4 Cm Versus ≤4 Cm In 445 Consecutive Patients, Firas Petros, Shyam Sukumar, Georges-Pascal Haber, Lori Dulabon, Sam Bhayani, Michael Stifelman, Jihad Kaouk, Craig Rogers

Open Access Publications

No abstract provided.


Vascular Anatomy Of The Tibiofibular Syndesmosis, Kathleen E. Mckeon, Rick W. Wright, Jeffrey E. Johnson, Jeremy J. Mccormick, Sandra E. Klein May 2012

Vascular Anatomy Of The Tibiofibular Syndesmosis, Kathleen E. Mckeon, Rick W. Wright, Jeffrey E. Johnson, Jeremy J. Mccormick, Sandra E. Klein

Open Access Publications

No abstract provided.


Synaptic Nmda Receptors Mediate Hypoxic Excitotoxic Death, Christine M. Wroge, Joshua Hogins, Larry Eisenman, Steven Mennerick May 2012

Synaptic Nmda Receptors Mediate Hypoxic Excitotoxic Death, Christine M. Wroge, Joshua Hogins, Larry Eisenman, Steven Mennerick

Open Access Publications

Excessive NMDA receptor activation and excitotoxicity underlies pathology in many neuropsychiatric and neurological disorders, including hypoxia/ischemia. Thus, the development of effective therapeutics for these disorders demands a complete understanding of NMDA receptor (NMDAR) activation during excitotoxic insults. The extrasynaptic NMDAR hypothesis posits that synaptic NMDARs are neurotrophic/neuroprotective and extrasynaptic NMDARs are neurotoxic. The extrasynaptic hypothesis is built in part on observed selectivity for extrasynaptic receptors of a neuroprotective use-dependent NMDAR channel blocker, memantine. In rat hippocampal neurons, we found that a neuroprotective concentration of memantine shows little selectivity for extrasynaptic NMDARs when all receptors are tonically activated by exogenous glutamate. …


Alix Binds A Ypx3l Motif Of The Gpcr Par1 And Mediates Ubiquitin-Independent Escrt-Iii/Mvb Sorting, Michael R. Dores, Buxin Chen, Huilan Lin, May M. Paing, William A. Montagne, Timo Meerlo, Joann Trejo Apr 2012

Alix Binds A Ypx3l Motif Of The Gpcr Par1 And Mediates Ubiquitin-Independent Escrt-Iii/Mvb Sorting, Michael R. Dores, Buxin Chen, Huilan Lin, May M. Paing, William A. Montagne, Timo Meerlo, Joann Trejo

Open Access Publications

No abstract provided.


Outcome Of Revision Anterior Cruciate Ligament Reconstruction: A Systematic Review, Rick W. Wright, Corey S. Gill, Ling Chen, Robert H. Brophy, Matthew J. Matava, Matthew V. Smith, Nathan A. Mall Mar 2012

Outcome Of Revision Anterior Cruciate Ligament Reconstruction: A Systematic Review, Rick W. Wright, Corey S. Gill, Ling Chen, Robert H. Brophy, Matthew J. Matava, Matthew V. Smith, Nathan A. Mall

Open Access Publications

No abstract provided.