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Articles 4051 - 4080 of 7412
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A Case Study In The History Of Neurology, Gregory S. Day, David F. Tang-Wai, Michel C.F. Shamy
A Case Study In The History Of Neurology, Gregory S. Day, David F. Tang-Wai, Michel C.F. Shamy
Open Access Publications
No abstract provided.
Polyglycine Acts As A Rejection Signal For Protein Transport At The Chloroplast Envelope, Joshua K. Endow, Agostinho Gomes Rocha, Amy J. Baldwin, Rebecca L. Roston, Toshio Yamaguchi, Hironari Kamikubo, Kentaro Inoue
Polyglycine Acts As A Rejection Signal For Protein Transport At The Chloroplast Envelope, Joshua K. Endow, Agostinho Gomes Rocha, Amy J. Baldwin, Rebecca L. Roston, Toshio Yamaguchi, Hironari Kamikubo, Kentaro Inoue
Open Access Publications
No abstract provided.
Heritable Dna Methylation In Cd4+ Cells Among Complex Families Displays Genetic And Non-Genetic Effects, Kenneth Day, Lindsay L. Waite, Amald Alonso, Marguerite R. Irvin, Degui Zhi, Krista S. Thibeault, Stella Aslibekyan, Bertha Hidalgo, Ingrid B. Borecki, Jose M. Ordovas, Donna K. Arnett, Hemant K. Tiwari, Devin M. Absher
Heritable Dna Methylation In Cd4+ Cells Among Complex Families Displays Genetic And Non-Genetic Effects, Kenneth Day, Lindsay L. Waite, Amald Alonso, Marguerite R. Irvin, Degui Zhi, Krista S. Thibeault, Stella Aslibekyan, Bertha Hidalgo, Ingrid B. Borecki, Jose M. Ordovas, Donna K. Arnett, Hemant K. Tiwari, Devin M. Absher
Open Access Publications
No abstract provided.
Abuse And Diversion Of Immediate Release Opioid Analgesics As Compared To Extended Release Formulations In The United States, Janetta L. Iwanicki, S. Geoff Severtson, Heather Mcdaniel, Andrew Rosenblum, Chunki Fong, Theodore J. Cicero, Matthew S. Ellis, Steven P. Kurtz, Mance E. Buttram, Richard C. Dart
Abuse And Diversion Of Immediate Release Opioid Analgesics As Compared To Extended Release Formulations In The United States, Janetta L. Iwanicki, S. Geoff Severtson, Heather Mcdaniel, Andrew Rosenblum, Chunki Fong, Theodore J. Cicero, Matthew S. Ellis, Steven P. Kurtz, Mance E. Buttram, Richard C. Dart
Open Access Publications
No abstract provided.
Rab43 Facilitates Cross-Presentation Of Cell-Associated Antigens By Cd8 Alpha(+) Dendritic Cells, Nicole M. Kretzer, Derek J. Theisen, Roxane Tussiwand, Carlos G. Briseno, Gary E. Grajales-Reyes, Xiaodi Wu, Vivek Durai, Jorn Albring, Prachi Bagadia, Theresa L. Murphy, Kenneth M. Murphy
Rab43 Facilitates Cross-Presentation Of Cell-Associated Antigens By Cd8 Alpha(+) Dendritic Cells, Nicole M. Kretzer, Derek J. Theisen, Roxane Tussiwand, Carlos G. Briseno, Gary E. Grajales-Reyes, Xiaodi Wu, Vivek Durai, Jorn Albring, Prachi Bagadia, Theresa L. Murphy, Kenneth M. Murphy
Open Access Publications
No abstract provided.
Elevated Fibroblast Growth Factor Signaling Is Critical For The Pathogenesis Of The Dwarfism In Evc2/Limbin Mutant Mice, Honghao Zhang, Nobuhiro Kamiya, Takehito Tsuji, Haruko Takeda, Greg Scott, Sudha Rajderkar, Manas K. Ray, Yoshiyuki Mochida, Benjamin Allen, Veronique Lefebvre, Irene H. Hung, David M. Omitz, Tetsuo Kunieda, Yuji Mishina
Elevated Fibroblast Growth Factor Signaling Is Critical For The Pathogenesis Of The Dwarfism In Evc2/Limbin Mutant Mice, Honghao Zhang, Nobuhiro Kamiya, Takehito Tsuji, Haruko Takeda, Greg Scott, Sudha Rajderkar, Manas K. Ray, Yoshiyuki Mochida, Benjamin Allen, Veronique Lefebvre, Irene H. Hung, David M. Omitz, Tetsuo Kunieda, Yuji Mishina
Open Access Publications
No abstract provided.
Distinct Firing Properties Of Vasoactive Intestinal Peptide-Expressing Neurons In The Suprachiasmatic Nucleus, Tracey O. Hermanstyne, Carrie L. Simms, Yarimar Carrasquillo, Erik D. Herzog, Jeanne M. Nerbonne
Distinct Firing Properties Of Vasoactive Intestinal Peptide-Expressing Neurons In The Suprachiasmatic Nucleus, Tracey O. Hermanstyne, Carrie L. Simms, Yarimar Carrasquillo, Erik D. Herzog, Jeanne M. Nerbonne
Open Access Publications
No abstract provided.
Cmtm2 Is Essential For Spermiogenesis In Mice, Xiaowei Zhang, Zhe Chen, Nannan Huang, Ling Kuang, Huaqi Yin, Ke Lan, Qing Li, Yongping Zhao, Kite Brandes, Tao Xu
Cmtm2 Is Essential For Spermiogenesis In Mice, Xiaowei Zhang, Zhe Chen, Nannan Huang, Ling Kuang, Huaqi Yin, Ke Lan, Qing Li, Yongping Zhao, Kite Brandes, Tao Xu
Open Access Publications
No abstract provided.
A Critical Review Of Perfluorooctanoate And Perfluorooctanesulfonate Exposure And Immunological Health Conditions In Humans, Ellen T. Chang, Hans-Olov Adami, Paolo Boffetta, H. James Wedner, Jack S. Mandel
A Critical Review Of Perfluorooctanoate And Perfluorooctanesulfonate Exposure And Immunological Health Conditions In Humans, Ellen T. Chang, Hans-Olov Adami, Paolo Boffetta, H. James Wedner, Jack S. Mandel
Open Access Publications
No abstract provided.
Pilot Clinical Observations Between Food And Drug Seeking Derived From Fifty Cases Attending An Eating Disorder Clinic, Harriet Beitscher-Campbell, Kenneth Blum, Marcelo Febo, Margaret A. Madigan, John Giordano, Rajendra D. Badgaiyan, Eric R. Braverman, Kristina Dushaj, Mona Li, Mark S. Gold
Pilot Clinical Observations Between Food And Drug Seeking Derived From Fifty Cases Attending An Eating Disorder Clinic, Harriet Beitscher-Campbell, Kenneth Blum, Marcelo Febo, Margaret A. Madigan, John Giordano, Rajendra D. Badgaiyan, Eric R. Braverman, Kristina Dushaj, Mona Li, Mark S. Gold
Open Access Publications
No abstract provided.
Advances In Cholangiocarcinoma Research: Report From The Third Cholangiocarcinoma Foundation Annual Conference, William Chapman, Et Al
Advances In Cholangiocarcinoma Research: Report From The Third Cholangiocarcinoma Foundation Annual Conference, William Chapman, Et Al
Open Access Publications
No abstract provided.
Distinct Effects Of Obesity And Puberty On Risk And Age At Onset Of Pediatric Ms, Soe Mar, Et Al
Distinct Effects Of Obesity And Puberty On Risk And Age At Onset Of Pediatric Ms, Soe Mar, Et Al
Open Access Publications
No abstract provided.
Finely Tuned Temporal And Spatial Delivery Of Gdnf Promotes Enhanced Nerve Regeneration In A Long Nerve Defect Model, Laura M. Marquardt, Xueping Ee, Nisha Iyer, Daniel Hunter, Susan E. Mackinnon, Matthew D. Wood, Shelly E. Sakiyama-Elbert
Finely Tuned Temporal And Spatial Delivery Of Gdnf Promotes Enhanced Nerve Regeneration In A Long Nerve Defect Model, Laura M. Marquardt, Xueping Ee, Nisha Iyer, Daniel Hunter, Susan E. Mackinnon, Matthew D. Wood, Shelly E. Sakiyama-Elbert
Open Access Publications
No abstract provided.
Progressive Hearing Loss In Mice Carrying A Mutation In Usp53, Marcin Kazmierczak, Suzan L. Harris, Piotr Kazmierczak, Prahar Shah, Valentin Starovoytov, Kevin K. Ohlemiller, Martin Schwander
Progressive Hearing Loss In Mice Carrying A Mutation In Usp53, Marcin Kazmierczak, Suzan L. Harris, Piotr Kazmierczak, Prahar Shah, Valentin Starovoytov, Kevin K. Ohlemiller, Martin Schwander
Open Access Publications
UNLABELLED: Disordered protein ubiquitination has been linked to neurodegenerative disease, yet its role in inner ear homeostasis and hearing loss is essentially unknown. Here we show that progressive hearing loss in the ethylnitrosourea-generated mambo mouse line is caused by a mutation in Usp53, a member of the deubiquitinating enzyme family. USP53 contains a catalytically inactive ubiquitin-specific protease domain and is expressed in cochlear hair cells and a subset of supporting cells. Although hair cell differentiation is unaffected in mambo mice, outer hair cells degenerate rapidly after the first postnatal week. USP53 colocalizes and interacts with the tight junction scaffolding proteins …
In Vivo Evaluation Of Adipose-Derived Stromal Cells Delivered With A Nanofiber Scaffold For Tendon-To-Bone Repair, Justin Lipner, Hua Shen, Leonardo Cavinatto, Wenying Liu, Necat Havlioglu, Younan Xia, Leesa M. Galatz, Stavros Thomopoulos
In Vivo Evaluation Of Adipose-Derived Stromal Cells Delivered With A Nanofiber Scaffold For Tendon-To-Bone Repair, Justin Lipner, Hua Shen, Leonardo Cavinatto, Wenying Liu, Necat Havlioglu, Younan Xia, Leesa M. Galatz, Stavros Thomopoulos
Open Access Publications
No abstract provided.
A Consensus-Based Interpretation Of The Benchmark Evidence From South American Trials: Treatment Of Intracranial Pressure Trial, Michael N. Diringer, Et Al
A Consensus-Based Interpretation Of The Benchmark Evidence From South American Trials: Treatment Of Intracranial Pressure Trial, Michael N. Diringer, Et Al
Open Access Publications
No abstract provided.
Using Knowledge Exchange To Build And Sustain Community Support To Reduce Cancer Screening Inequities, Aisha Lofters, Tazim Virani, Gurpeet Grewal, Rebecca Lobb
Using Knowledge Exchange To Build And Sustain Community Support To Reduce Cancer Screening Inequities, Aisha Lofters, Tazim Virani, Gurpeet Grewal, Rebecca Lobb
Open Access Publications
No abstract provided.
Human And Murine Ifit1 Proteins Do Not Restrict Infection Of Negative-Sense Rna Viruses Of The Orthomyxoviridae, Bunyaviridae, And Filoviridae Families, Amelia K. Pinto, Graham D. Williams, Kristy J. Szretter, James P. White, José Luiz Proença-Módena, Gai Liu, Judith Olejnik, James D. Brien, Hideki Ebihara, Elke Mühlberger, Gaya Amarasinghe, Michael S. Diamond, Adrianus C.M. Boon
Human And Murine Ifit1 Proteins Do Not Restrict Infection Of Negative-Sense Rna Viruses Of The Orthomyxoviridae, Bunyaviridae, And Filoviridae Families, Amelia K. Pinto, Graham D. Williams, Kristy J. Szretter, James P. White, José Luiz Proença-Módena, Gai Liu, Judith Olejnik, James D. Brien, Hideki Ebihara, Elke Mühlberger, Gaya Amarasinghe, Michael S. Diamond, Adrianus C.M. Boon
Open Access Publications
UNLABELLED: Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) is a host protein with reported cell-intrinsic antiviral activity against several RNA viruses. The proposed basis for the activity against negative-sense RNA viruses is the binding to exposed 5'-triphosphates (5'-ppp) on the genome of viral RNA. However, recent studies reported relatively low binding affinities of IFIT1 for 5'-ppp RNA, suggesting that IFIT1 may not interact efficiently with this moiety under physiological conditions. To evaluate the ability of IFIT1 to have an impact on negative-sense RNA viruses, we infected Ifit1(-/-) and wild-type control mice and primary cells with four negative-sense RNA viruses (influenza …
Hepatocyte Growth Factor And Met Support Mouse Enteric Nervous System Development, The Peristaltic Response, And Intestinal Epithelial Proliferation In Response To Injury, Marina Avetisyan, Hongtao Wang, Ellen Merrick Schill, Saya Bery, John R. Grider, John A. Hassell, Thaddeus Stappenbeck, Robert O. Heuckeroth
Hepatocyte Growth Factor And Met Support Mouse Enteric Nervous System Development, The Peristaltic Response, And Intestinal Epithelial Proliferation In Response To Injury, Marina Avetisyan, Hongtao Wang, Ellen Merrick Schill, Saya Bery, John R. Grider, John A. Hassell, Thaddeus Stappenbeck, Robert O. Heuckeroth
Open Access Publications
UNLABELLED: Factors providing trophic support to diverse enteric neuron subtypes remain poorly understood. We tested the hypothesis that hepatocyte growth factor (HGF) and the HGF receptor MET might support some types of enteric neurons. HGF and MET are expressed in fetal and adult enteric nervous system. In vitro, HGF increased enteric neuron differentiation and neurite length, but only if vanishingly small amounts (1 pg/ml) of glial cell line-derived neurotrophic factor were included in culture media. HGF effects were blocked by phosphatidylinositol-3 kinase inhibitor and by MET-blocking antibody. Both of these inhibitors and MEK inhibition reduced neurite length. In adult mice, …
Biphenotypic (Hepatobiliary) Primary Liver Carcinomas: The Work In Progress, Elizabeth M. Brunt, Valerie Paradis, Christine Sempoux, Neil D. Theise
Biphenotypic (Hepatobiliary) Primary Liver Carcinomas: The Work In Progress, Elizabeth M. Brunt, Valerie Paradis, Christine Sempoux, Neil D. Theise
Open Access Publications
Recent WHO classification for combined hepatocellular-cholangiocarcinoma and recognized stem cell subtypes has increased attention to such tumors; however, the resulting burst of reporting and research indicates that this classification, while provocative, is incomplete for description of the full array of primary liver carcinomas with biphenotypic (hepatobiliary) differentiation. We review the history of such lesions and consider the wider array of such tumors previously described. Mixed hepatobiliary phenotypes and immunophenotypes are found in individual tumors at the tissue level - with architectural and cytologic features supportive of both differentiation states - and at the cellular level, with individual cells that display …
Temperatures Achieved In Human And Canine Neocortex During Intraoperative Passive Or Active Focal Cooling, Matthew D. Smyth, Rowland H. Han, Chester K. Yarbrough, Edward E. Patterson, Xiao-Feng Yang, John W. Miller, Steven M. Rothman, Raimondo D'Ambrosio
Temperatures Achieved In Human And Canine Neocortex During Intraoperative Passive Or Active Focal Cooling, Matthew D. Smyth, Rowland H. Han, Chester K. Yarbrough, Edward E. Patterson, Xiao-Feng Yang, John W. Miller, Steven M. Rothman, Raimondo D'Ambrosio
Open Access Publications
No abstract provided.
Selective Deletion Of Cochlear Hair Cells Causes Rapid Age-Dependent Changes In Spiral Ganglion And Cochlear Nucleus Neurons, Ling Tong, Melissa K. Strong, Tejbeer Kaur, Jose M. Juiz, Elizabeth C. Oesterle, Clifford Hume, Mark E. Warchol, Richard D. Palmiter, Edwin W. Rubel
Selective Deletion Of Cochlear Hair Cells Causes Rapid Age-Dependent Changes In Spiral Ganglion And Cochlear Nucleus Neurons, Ling Tong, Melissa K. Strong, Tejbeer Kaur, Jose M. Juiz, Elizabeth C. Oesterle, Clifford Hume, Mark E. Warchol, Richard D. Palmiter, Edwin W. Rubel
Open Access Publications
During nervous system development, critical periods are usually defined as early periods during which manipulations dramatically change neuronal structure or function, whereas the same manipulations in mature animals have little or no effect on the same property. Neurons in the ventral cochlear nucleus (CN) are dependent on excitatory afferent input for survival during a critical period of development. Cochlear removal in young mammals and birds results in rapid death of target neurons in the CN. Cochlear removal in older animals results in little or no neuron death. However, the extent to which hair-cell-specific afferent activity prevents neuronal death in the …
Mechanism-Based Combination Treatment Dramatically Increases Therapeutic Efficacy In Murine Globoid Cell Leukodystrophy, Jacqueline A. Hawkins-Salsbury, Lauren Shea, Xuntian Jiang, Daniel A. Hunter, A Miguel Guzman, Adarsh S. Reddy, Elizabeth Y. Qin, Yedda Li, Steven J. Gray, Daniel S. Ory, Mark S. Sands
Mechanism-Based Combination Treatment Dramatically Increases Therapeutic Efficacy In Murine Globoid Cell Leukodystrophy, Jacqueline A. Hawkins-Salsbury, Lauren Shea, Xuntian Jiang, Daniel A. Hunter, A Miguel Guzman, Adarsh S. Reddy, Elizabeth Y. Qin, Yedda Li, Steven J. Gray, Daniel S. Ory, Mark S. Sands
Open Access Publications
Globoid cell leukodystrophy (GLD, Krabbe disease) is a lysosomal storage disease (LSD) caused by a deficiency in galactocerebrosidase (GALC) activity. In the absence of GALC activity, the cytotoxic lipid, galactosylsphingosine (psychosine), accumulates in the CNS and peripheral nervous system. Oligodendrocytes and Schwann cells are particularly sensitive to psychosine, thus leading to a demyelinating phenotype. Although hematopoietic stem-cell transplantation provides modest benefit in both presymptomatic children and the murine model (Twitcher), there is no cure for GLD. In addition, GLD has been relatively refractory to virtually every experimental therapy attempted. Here, Twitcher mice were simultaneously treated with CNS-directed gene therapy, substrate …
Pain Treatment And Antiretroviral Medication Adherence Among Vulnerable Hiv-Positive Patients, Hilary L. Surratt, Steven P. Kurtz, Maria A. Levi-Minzi, Theodore J. Cicero, Kiyomi Tsuyuki, Catherine L. O'Grady
Pain Treatment And Antiretroviral Medication Adherence Among Vulnerable Hiv-Positive Patients, Hilary L. Surratt, Steven P. Kurtz, Maria A. Levi-Minzi, Theodore J. Cicero, Kiyomi Tsuyuki, Catherine L. O'Grady
Open Access Publications
No abstract provided.
Adamtsl2 Deletion Results In Bronchial Fibrillin Microfibril Accumulation And Bronchial Epithelial Dysplasia: A Novel Mouse Model Providing Insights On Geleophysic Dysplasia, Dirk Hubmacher, Lauren W. Wang, Robert P. Mecham, Dieter P. Reinhardt, Suneel S. Apte
Adamtsl2 Deletion Results In Bronchial Fibrillin Microfibril Accumulation And Bronchial Epithelial Dysplasia: A Novel Mouse Model Providing Insights On Geleophysic Dysplasia, Dirk Hubmacher, Lauren W. Wang, Robert P. Mecham, Dieter P. Reinhardt, Suneel S. Apte
Open Access Publications
No abstract provided.
Uni-Directional Ciliary Membrane Protein Trafficking By A Cytoplasmic Retrograde Ift Motor And Ciliary Ectosome Shedding, Muqing Cao, Jue Ning, Carmen I. Hernandez-Lara, Olivier Belzile, Qian Wang, Susan K. Dutcher, Yanjie Liu, William J. Snell
Uni-Directional Ciliary Membrane Protein Trafficking By A Cytoplasmic Retrograde Ift Motor And Ciliary Ectosome Shedding, Muqing Cao, Jue Ning, Carmen I. Hernandez-Lara, Olivier Belzile, Qian Wang, Susan K. Dutcher, Yanjie Liu, William J. Snell
Open Access Publications
The role of the primary cilium in key signaling pathways depends on dynamic regulation of ciliary membrane protein composition, yet we know little about the motors or membrane events that regulate ciliary membrane protein trafficking in existing organelles. Recently, we showed that cilium-generated signaling in Chlamydomonas induced rapid, anterograde IFT-independent, cytoplasmic microtubule-dependent redistribution of the membrane polypeptide, SAG1-C65, from the plasma membrane to the periciliary region and the ciliary membrane. Here, we report that the retrograde IFT motor, cytoplasmic dynein 1b, is required in the cytoplasm for this rapid redistribution. Furthermore, signaling-induced trafficking of SAG1-C65 into cilia is unidirectional and …
Evidence-Based Diabetes Prevention And Control Programs And Policies In Local Health Departments, Melissa Zwald, Lindsay Elliott, Ross C. Brownson, Mahree Skala
Evidence-Based Diabetes Prevention And Control Programs And Policies In Local Health Departments, Melissa Zwald, Lindsay Elliott, Ross C. Brownson, Mahree Skala
Open Access Publications
No abstract provided.
Clostridium Difficile Infection Among Veterans Health Administration Patients, Yinong Young-Xu, Jennifer L. Kuntz, Dale N. Gerding, Julia Neily, Peter Mills, Erik R. Dubberke, Margaret A. Olsen, Ciarán P. Kelly, Cédric Mahé
Clostridium Difficile Infection Among Veterans Health Administration Patients, Yinong Young-Xu, Jennifer L. Kuntz, Dale N. Gerding, Julia Neily, Peter Mills, Erik R. Dubberke, Margaret A. Olsen, Ciarán P. Kelly, Cédric Mahé
Open Access Publications
No abstract provided.
Highly Sensitive Image-Derived Indices Of Water-Stressed Plants Using Hyperspectral Imaging In Swir And Histogram Analysis, David M. Kim, Hairong Zhang, Haiying Zhou, Tommy Du, Qian Wu, Todd C. Mockler, Mikhail Y. Berezin
Highly Sensitive Image-Derived Indices Of Water-Stressed Plants Using Hyperspectral Imaging In Swir And Histogram Analysis, David M. Kim, Hairong Zhang, Haiying Zhou, Tommy Du, Qian Wu, Todd C. Mockler, Mikhail Y. Berezin
Open Access Publications
No abstract provided.
Fast And Efficient Image Reconstruction For High Density Diffuse Optical Imaging Of The Human Brain, Xue Wu, Adam T. Eggebrecht, Silvina L. Ferradal, Joseph P. Culver, Hamid Dehghani
Fast And Efficient Image Reconstruction For High Density Diffuse Optical Imaging Of The Human Brain, Xue Wu, Adam T. Eggebrecht, Silvina L. Ferradal, Joseph P. Culver, Hamid Dehghani
Open Access Publications
No abstract provided.