Digital Commons Network^™

Recent Positive Selection In Genes Of The Mammalian Epidermal Differentiation Complex Locus, Zane A. Goodwin, Cristina De Guzman Strong

Open Access Publications

No abstract provided.

Perceived Barriers To Achieving A Healthy Weight: A Qualitative Study Using Focus Groups At Public And Private Schools In Guatemala City, Luisa Madrigal, Inez Adams, Violeta Chacon, Joaqin Barnoya

Open Access Publications

No abstract provided.

Knockout Of Lysosomal Enzyme-Targeting Gene Causes Abnormalities In Mouse Pup Isolation Calls, Terra D. Barnes, Timothy E. Holy

Open Access Publications

No abstract provided.

Animal Models Of Zika Virus Infection, Pathogenesis, And Immunity, Thomas E. Morrison, Michael S. Diamond

Open Access Publications

No abstract provided.

Stress-Induced Reinstatement Of Nicotine Preference Requires Dynorphin/Kappa Opioid Activity In The Basolateral Amygdala, Stephanie K. Nygard, Nicholas J. Hourguettes, Gabe G. Sobczak, William A. Carlezon, Michael R. Bruchas

Open Access Publications

UNLABELLED: The dynorphin (DYN)/kappa-opioid receptor (KOR) system plays a conserved role in stress-induced reinstatement of drug seeking for prototypical substances of abuse. Due to nicotine's high propensity for stress-induced relapse, we hypothesized that stress would induce reinstatement of nicotine seeking-like behavior in a KOR-dependent manner. Using a conditioned place preference (CPP) reinstatement procedure in mice, we show that both foot-shock stress and the pharmacological stressor yohimbine (2 mg/kg, i.p.) induce reinstatement of nicotine CPP in a norbinaltorphimine (norBNI, a KOR antagonist)-sensitive manner, indicating that KOR activity is necessary for stress-induced nicotine CPP reinstatement. After reinstatement testing, we visualized robust c-fos …

De Novo And Inherited Mutations In The X-Linked Gene Clcn4 Are Associated With Syndromic Intellectual Disability And Behavior And Seizure Disorders In Males And Females, E E Palmer, D K Grange, L Manwaring, Et Al

Open Access Publications

No abstract provided.

Adam17 Substrate Release In Proximal Tubule Drives Kidney Fibrosis, Eirini Kefaloyianni, Muthu Lakshmi Muthu, Jakob Kaeppler, Xiaoming Sun, Venkata Sabbisetti, Athena Chalaris, Stefan Rose-John, Eitan Wong, Irit Sagi, Sushrut S. Waikar, Helmut Rennke, Benjamin D. Humphreys, Joseph V. Bonventre, Andreas Herrlich

Open Access Publications

Kidney fibrosis following kidney injury is an unresolved health problem and causes significant morbidity and mortality worldwide. In a study into its molecular mechanism, we identified essential causative features. Acute or chronic kidney injury causes sustained elevation of a disintegrin and metalloprotease 17 (ADAM17); of its cleavage-activated proligand substrates, in particular of pro-TNFα and the EGFR ligand amphiregulin (pro-AREG); and of the substrates' receptors. As a consequence, EGFR is persistently activated and triggers the synthesis and release of proinflammatory and profibrotic factors, resulting in macrophage/neutrophil ingress and fibrosis. ADAM17 hypomorphic mice, specific ADAM17 inhibitor-treated WT mice, or mice with inducible …

Using Diffusion Tractography To Predict Cortical Connection Strength And Distance: A Quantitative Comparison With Tracers In The Monkey, Chad J. Donahue, Stamatios N. Sotiropoulos, Saad Jbabdi, Moises Hernandez-Fernandez, Timothy E. Behrens, Tim B. Dyrby, Timothy Coalson, Henry Kennedy, Kenneth Knoblauch, David C. Van Essen, Matthew F. Glasser

Open Access Publications

UNLABELLED: Tractography based on diffusion MRI offers the promise of characterizing many aspects of long-distance connectivity in the brain, but requires quantitative validation to assess its strengths and limitations. Here, we evaluate tractography's ability to estimate the presence and strength of connections between areas of macaque neocortex by comparing its results with published data from retrograde tracer injections. Probabilistic tractography was performed on high-quality postmortem diffusion imaging scans from two Old World monkey brains. Tractography connection weights were estimated using a fractional scaling method based on normalized streamline density. We found a correlation between log-transformed tractography and tracer connection weights …

Asfotase Alfa Therapy For Children With Hypophosphatasia, Michael P. Whyte, Katherine L. Madson, Dawn Phillips, Amy L. Reeves, William H. Mcalister, Amy Yakimoski, Karen E. Mack, Kim Hamilton, Kori Kagan, Kenji P. Fujita, David D. Thompson, Scott Moseley, Tatjana Odrljin, Cheryl Rockman-Greenberg

Open Access Publications

No abstract provided.

Tmem184b Promotes Axon Degeneration And Neuromuscular Junction Maintenance, Martha R.C. Bhattacharya, Stefanie Geisler, Sara K. Pittman, Ryan A. Doan, Conrad C. Weihl, Jeffrey Milbrandt, Aaron Diantonio

Open Access Publications

UNLABELLED: Complex nervous systems achieve proper connectivity during development and must maintain these connections throughout life. The processes of axon and synaptic maintenance and axon degeneration after injury are jointly controlled by a number of proteins within neurons, including ubiquitin ligases and mitogen activated protein kinases. However, our understanding of these molecular cascades is incomplete. Here we describe the phenotype resulting from mutation of TMEM184b, a protein identified in a screen for axon degeneration mediators. TMEM184b is highly expressed in the mouse nervous system and is found in recycling endosomes in neuronal cell bodies and axons. Disruption of TMEM184b expression …

Functional Significance Of The Discordance Between Transcriptional Profile And Left Ventricular Structure/Function During Reverse Remodeling, Veli K. Topkara, Kari T. Chambers, Kai-Chien Yang, Huei-Ping Tzeng, Sarah Evans, Carla Weinheimer, Attila Kovacs, Jeffrey Robbins, Philip Barger, Douglas L. Mann

Open Access Publications

To elucidate the mechanisms for reverse LV remodeling, we generated a conditional (doxycycline [dox] off) transgenic mouse tetracycline transactivating factor-TRAF2 (tTA-TRAF2) that develops a dilated heart failure (HF) phenotype upon expression of a proinflammatory transgene, TNF receptor-associated factor 2 (TRAF2), and complete normalization of LV structure and function when the transgene is suppressed. tTA-TRAF2 mice developed a significant increase in LV dimension with decreased contractile function, which was completely normalized in the tTA-TRAF2 mice fed dox for 4 weeks (tTA-TRAF2

Provisional Tic Disorder: What To Tell Parents When Their Child First Starts Ticcing, Kevin J. Black, Elizabeth Rose Black, Deanna J. Greene, Bradley L. Schlaggar

Open Access Publications

No abstract provided.

Oncomodulin, An Ef-Hand Ca2+ Buffer, Is Critical For Maintaining Cochlear Function In Mice, Benton Tong, Aubrey J. Hornak, Stéphane F. Maison, Kevin K. Ohlemiller, M Charles Liberman, Dwayne D. Simmons

Open Access Publications

UNLABELLED: Oncomodulin (Ocm), a member of the parvalbumin family of calcium binding proteins, is expressed predominantly by cochlear outer hair cells in subcellular regions associated with either mechanoelectric transduction or electromotility. Targeted deletion of Ocm caused progressive cochlear dysfunction. Although sound-evoked responses are normal at 1 month, by 4 months, mutants show only minimal distortion product otoacoustic emissions and 70-80 dB threshold shifts in auditory brainstem responses. Thus, Ocm is not critical for cochlear development but does play an essential role for cochlear function in the adult mouse.

SIGNIFICANCE STATEMENT: Numerous proteins act as buffers, sensors, or pumps to control …

Getting To More Effective Weight Management In Antipsychotic-Treated Youth: A Survey Of Barriers And Preferences, Ginger Nicol, Elizabeth Worsham, Debra Haire-Joshu, Alexis Duncan, Julia Schweiger, Michael Yingling, Eric Lenze

Open Access Publications

No abstract provided.

Ability Of Serum Glial Fibrillary Acidic Protein, Ubiquitin C-Terminal Hydrolase-L1, And S100b To Differentiate Normal And Abnormal Head Computer Tomography Findings In Patients With Suspected Mild Or Moderate Traumatic Brain Injury, Lawrence M. Lewis, Et Al

Open Access Publications

No abstract provided.

Clearance Of Vancomycin- Resistant Enterococcus Concomitant With Administration Of A Microbiota -Based Drug Targeted At Recurrent Clostridium Difficile Infection, Erik R. Dubberke, Kathleen M. Mullane, Dale N. Gerding, Christine H. Lee, Thomas J. Louie, Harriet Guthertz, Courtney Jones

Open Access Publications

No abstract provided.

Chemical Chaperone Tudca Prevents Apoptosis And Improves Survival During Polymicrobial Sepsis In Mice, Marcel Doerflinger, Jason Glab, Christina Nedeva, Irvin Jose, Ann Lin, Lorraine O’Reilly, Cody Allison, Marc Pellegrini, Richard S. Hotchkiss, Hamsa Puthalakath

Open Access Publications

No abstract provided.

Coa Protects Against The Deleterious Effects Of Caloric Overload In Drosophila, Laura Palanker Musselman, Jill L. Fink, Thomas J. Baranski

Open Access Publications

No abstract provided.

Human Metabolome-Derived Cofactors Are Required For The Antibacterial Activity Of Siderocalin In Urine, Robin R. Shields-Cutler, Jan R. Crowley, Connelly D. Miller, Ann E. Stapleton, Weidong Cui, Jeffery P. Henderson

Open Access Publications

No abstract provided.

Subversion Of Host Innate Immunity By Uropathogenic Escherichia Coli, Patrick D. Olson, David A. Hunstad

Open Access Publications

No abstract provided.

Tourette Syndrome Research Highlights 2015 [Version 1; Referees: 3 Approved], Cheryl A. Richards, Kevin J. Black

Open Access Publications

No abstract provided.

A Recurrent Mosaic Mutation In Smo, Encoding The Hedgehog Signal Transducer Smoothened, Is The Major Cause Of Curry-Jones Syndrome, Dorothy K. Grange, Et Al

Open Access Publications

No abstract provided.

Human Central Nervous System (Cns) Apoe Isoforms Are Increased By Age, Differentially Altered By Amyloidosis, And Relative Amounts Reversed In The Cns Compared With Plasma, Alaina T. Baker-Nigh, Kwasi G. Mawuenyega, James G. Bollinger, Vitaliy Ovod, Tom Kasten, Erin E. Franklin, Fan Liao, Hong Jiang, David Holtzman, Nigel J. Cairns, John C. Morris, Randall J. Bateman

Open Access Publications

No abstract provided.

Behavioral Weight Loss Treatment For Youth Treated With Antipsychotic Medications, Ginger E. Nicol, Rachel P. Kolko, Monica Mills, Thrudur Gunnarsdottir, Michael D. Yingling, Julia A. Schweiger, Eric J. Lenze, John W. Newcomer, Denise Wilfley

Open Access Publications

No abstract provided.

Predicting All-Cause Mortality From Basic Physiology In The Framingham Heart Study, William B. Zhang, Zachary Pincus

Open Access Publications

No abstract provided.

Changes In The Relative Abundance Of Two Saccharomyces Species From Oak Forests To Wine Fermentations, Sofia Dashko, Ping Liu, Helena Volk, Lorena Butinar, Jure Piškur, Justin C. Fay

Open Access Publications

No abstract provided.

Genseed-Hmm: A Tool For Progressive Assembly Using Profile Hmms As Seeds And Its Application In Alpavirinae Viral Discovery From Metagenomic Data, João M.P. Alves, Andre L. De Oliveira, Tatiana O.M. Sandberg, Jaime L. Moreno-Gallego, Marcelo A.F. De Toledo, Elisabeth M.M. De Moura, Liliane S. Oliveira, Alan M. Durham, Dolores U. Mehnert, Paolo M. De A. Zanotto, Alejandro Reyes, Arthur Gruber

Open Access Publications

No abstract provided.

The Brief Case: A Reactive Hiv Rapid Antibody Test In A Pregnant Woman, Melanie L. Yarbrough, Neil W. Anderson

Open Access Publications

No abstract provided.

Genome-Wide Association Study Of Lifetime Cannabis Use Based On A Large Meta-Analytic Sample Of 32,330 Subjects From The International Cannabis Consortium, A C. Heath, Et Al

Open Access Publications

No abstract provided.

Critical Evaluation Of The Expression Of Gastrin-Releasing Peptide In Dorsal Root Ganglia And Spinal Cord, Devin M. Barry, Hui Li, Xian-Yu Liu, Kai-Feng Shen, Xue-Ting Liu, Zhen-Yu Wu, Admire Munanairi, Xiao-Jun Chen, Jun Yin, Yan-Gang Sun, Yun-Qing Li, Zhou-Feng Chen

Open Access Publications

No abstract provided.