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Normalized Neutral Lipid Quantitation By Flow Cytometry, Nathan E. Wolins, Katerina N. Dehaan, Vincenza Cifarelli, Angela K. Stoeckman Jan 2018

Normalized Neutral Lipid Quantitation By Flow Cytometry, Nathan E. Wolins, Katerina N. Dehaan, Vincenza Cifarelli, Angela K. Stoeckman

Open Access Publications

No abstract provided.


Concentration Of 2c-Methyladenosine Triphosphate By Leishmania Guyanensis Enables Specific Inhibition Of Leishmania Rna Virus 1 Via Its Rna Polymerase, John I. Robinson, Stephen M. Beverley Jan 2018

Concentration Of 2c-Methyladenosine Triphosphate By Leishmania Guyanensis Enables Specific Inhibition Of Leishmania Rna Virus 1 Via Its Rna Polymerase, John I. Robinson, Stephen M. Beverley

Open Access Publications

No abstract provided.


Ybtt Is A Low-Specificity Type Ii Thioesterase That Maintains Production Of The Metallophore Yersiniabactin In Pathogenic Enterobacteria, Shannon I. Ohlemacher, Yiquan Xu, Daniel L. Kober, Mahnoor Malik, Jay C. Nix, Tom J. Brett, Jeffrey P. Henderson Jan 2018

Ybtt Is A Low-Specificity Type Ii Thioesterase That Maintains Production Of The Metallophore Yersiniabactin In Pathogenic Enterobacteria, Shannon I. Ohlemacher, Yiquan Xu, Daniel L. Kober, Mahnoor Malik, Jay C. Nix, Tom J. Brett, Jeffrey P. Henderson

Open Access Publications

No abstract provided.


Changes In Cytokine, Filarial Antigen, And Dna Levels Associated With Adverse Events Following Treatment Of Lymphatic Filariasis, Britt J. Andersen, Jessica Kumar, Kurt Curtis, Nelly Sanuku, Samson Satofan, Christopher L. King, Peter U. Fischer, Gary J. Weil Jan 2018

Changes In Cytokine, Filarial Antigen, And Dna Levels Associated With Adverse Events Following Treatment Of Lymphatic Filariasis, Britt J. Andersen, Jessica Kumar, Kurt Curtis, Nelly Sanuku, Samson Satofan, Christopher L. King, Peter U. Fischer, Gary J. Weil

Open Access Publications

No abstract provided.


Walking, Gross Motor Development, And Brain Functional Connectivity In Infants And Toddlers, Natasha Marrus, Adam T. Eggebrecht, Alexandre Todorov, Lyndsey Cole, Cheryl L. Klohr, Chloe M. Adams, Kelly N. Botteron, Robert C. Mckinstry, John N. Constantino, The Ibis Network, Bradley L. Schlaggar, John R. Pruett Jr, Et Al Jan 2018

Walking, Gross Motor Development, And Brain Functional Connectivity In Infants And Toddlers, Natasha Marrus, Adam T. Eggebrecht, Alexandre Todorov, Lyndsey Cole, Cheryl L. Klohr, Chloe M. Adams, Kelly N. Botteron, Robert C. Mckinstry, John N. Constantino, The Ibis Network, Bradley L. Schlaggar, John R. Pruett Jr, Et Al

Open Access Publications

No abstract provided.


Regulation Of Amyloid-Β Dynamics And Pathology By The Circadian Clock, Geraldine J. Kress, Fan Liao, Julie Dimitry, Michelle R. Cedeno, Garret A Fitzgerald, David M. Holtzman, Erik S. Musiek Jan 2018

Regulation Of Amyloid-Β Dynamics And Pathology By The Circadian Clock, Geraldine J. Kress, Fan Liao, Julie Dimitry, Michelle R. Cedeno, Garret A Fitzgerald, David M. Holtzman, Erik S. Musiek

Open Access Publications

Nighttime restlessness and daytime drowsiness are common and early symptoms of Alzheimer's Disease (AD). This symptomology implicates dysfunctional biological timing, yet the role of the circadian system in AD pathogenesis is unknown. To evaluate the role of the circadian clock in amyloid-β (Aβ) dynamics and pathology, we used a mouse model of β-amyloidosis and disrupted circadian clock function either globally or locally in the brain via targeted deletion of the core clock gene


Selective Inhibition Of The P38Α Mapk-Mk2 Axis Inhibits Inflammatory Cues Including Inflammasome Priming Signals, Chun Wang, Yael Alippe, Yousef Abu-Amer, Gabriel Mbalaviele, Et Al Jan 2018

Selective Inhibition Of The P38Α Mapk-Mk2 Axis Inhibits Inflammatory Cues Including Inflammasome Priming Signals, Chun Wang, Yael Alippe, Yousef Abu-Amer, Gabriel Mbalaviele, Et Al

Open Access Publications

p38α activation of multiple effectors may underlie the failure of global p38α inhibitors in clinical trials. A unique inhibitor (CDD-450) was developed that selectively blocked p38α activation of the proinflammatory kinase MK2 while sparing p38α activation of PRAK and ATF2. Next, the hypothesis that the p38α-MK2 complex mediates inflammasome priming cues was tested. CDD-450 had no effect on NLRP3 expression, but it decreased IL-1β expression by promoting IL-1β mRNA degradation. Thus, IL-1β is regulated not only transcriptionally by NF-κB and posttranslationally by the inflammasomes but also posttranscriptionally by p38α-MK2. CDD-450 also accelerated TNF-α and IL-6 mRNA decay, inhibited inflammation in …


Combination Anti-Aβ Treatment Maximizes Cognitive Recovery And Rebalances Mtor Signaling In App Mice, Angie C.A. Chiang, Stephanie W. Fowler, Ricky R. Savjani, Susan G. Hilsenbeck, Clare E. Wallace, John R. Cirrito, Pritam Das, Joanna L. Jankowsky Jan 2018

Combination Anti-Aβ Treatment Maximizes Cognitive Recovery And Rebalances Mtor Signaling In App Mice, Angie C.A. Chiang, Stephanie W. Fowler, Ricky R. Savjani, Susan G. Hilsenbeck, Clare E. Wallace, John R. Cirrito, Pritam Das, Joanna L. Jankowsky

Open Access Publications

Drug development for Alzheimer's disease has endeavored to lower amyloid β (Aβ) by either blocking production or promoting clearance. The benefit of combining these approaches has been examined in mouse models and shown to improve pathological measures of disease over single treatment; however, the impact on cellular and cognitive functions affected by Aβ has not been tested. We used a controllable APP transgenic mouse model to test whether combining genetic suppression of Aβ production with passive anti-Aβ immunization improved functional outcomes over either treatment alone. Compared with behavior before treatment, arresting further Aβ production (but not passive immunization) was sufficient …


Emergency Department Time Course For Mild Traumatic Brain Injury Workup, Edward A. Michelson, J. Stephen Huff, Mae Loparo, Rosanne R. Naunheim, Andrew Perron, Martha Rahm, David W. Smith, Joseph A. Stone, Ariel Berger Jan 2018

Emergency Department Time Course For Mild Traumatic Brain Injury Workup, Edward A. Michelson, J. Stephen Huff, Mae Loparo, Rosanne R. Naunheim, Andrew Perron, Martha Rahm, David W. Smith, Joseph A. Stone, Ariel Berger

Open Access Publications

No abstract provided.


Hypothalamic Sirt1 Protects Terminal Schwann Cells And Neuromuscular Junctions From Age‐Related Morphological Changes, Alison K. Snyder-Warwick, Akiko Satoh, Katherine B. Santosa, Shin-Ichiro Imai, Albina Jablonka-Shariff Jan 2018

Hypothalamic Sirt1 Protects Terminal Schwann Cells And Neuromuscular Junctions From Age‐Related Morphological Changes, Alison K. Snyder-Warwick, Akiko Satoh, Katherine B. Santosa, Shin-Ichiro Imai, Albina Jablonka-Shariff

Open Access Publications

No abstract provided.


Lifelong Reduction In Complex Iv Induces Tissue‐Specific Metabolic Effects But Does Not Reduce Lifespan Or Healthspan In Mice, Sathyaseelan S. Deepa, Gavin Pharaoh, Michael Kinter, Vivian Diaz, Wilson C. Fok, Kaitlyn Riddle, Daniel Pulliam, Shauna Hill, Kathleen E. Fischer, Vanessa Soto, Constantin Georgescu, Jonathan D. Wren, Carlo Viscomi, Arlan Richardson, Holly Van Remmen Jan 2018

Lifelong Reduction In Complex Iv Induces Tissue‐Specific Metabolic Effects But Does Not Reduce Lifespan Or Healthspan In Mice, Sathyaseelan S. Deepa, Gavin Pharaoh, Michael Kinter, Vivian Diaz, Wilson C. Fok, Kaitlyn Riddle, Daniel Pulliam, Shauna Hill, Kathleen E. Fischer, Vanessa Soto, Constantin Georgescu, Jonathan D. Wren, Carlo Viscomi, Arlan Richardson, Holly Van Remmen

Open Access Publications

No abstract provided.


Examining The Reversibility Of Long-Term Behavioral Disruptions In Progeny Of Maternal Ssri Exposure, Susan E. Maloney, Shyam Akula, Michael A. Rieger, Katherine B. Mccullough, Krystal Chandler, Adrian M. Corbett, Audrey E. Mcgowin, Joseph D. Dougherty Jan 2018

Examining The Reversibility Of Long-Term Behavioral Disruptions In Progeny Of Maternal Ssri Exposure, Susan E. Maloney, Shyam Akula, Michael A. Rieger, Katherine B. Mccullough, Krystal Chandler, Adrian M. Corbett, Audrey E. Mcgowin, Joseph D. Dougherty

Open Access Publications

No abstract provided.


Comparing Knowledge, Accessibility, And Use Of Evidence-Based Chronic Disease Prevention Processes Across Four Countries, Anna J. Deruyter, Xiangji Ying, Elizabeth L. Budd, Karishma Furtado, Rodrigo Reis, Zhaoxin Wang, Pauline Sung-Chan, Rebecca Armstrong, Tahna Pettman, Leonardo Becker, Tabitha Mui, Jianwei Shi, Tahnee Saunders, Ross C. Brownson Jan 2018

Comparing Knowledge, Accessibility, And Use Of Evidence-Based Chronic Disease Prevention Processes Across Four Countries, Anna J. Deruyter, Xiangji Ying, Elizabeth L. Budd, Karishma Furtado, Rodrigo Reis, Zhaoxin Wang, Pauline Sung-Chan, Rebecca Armstrong, Tahna Pettman, Leonardo Becker, Tabitha Mui, Jianwei Shi, Tahnee Saunders, Ross C. Brownson

Open Access Publications

No abstract provided.


Nitro-Fatty Acids Are Formed In Response To Virus Infection And Are Potent Inhibitors Of Sting Palmitoylation And Signaling, Cathrine A. Miner, Wei Qian, Jonathan J. Miner Jan 2018

Nitro-Fatty Acids Are Formed In Response To Virus Infection And Are Potent Inhibitors Of Sting Palmitoylation And Signaling, Cathrine A. Miner, Wei Qian, Jonathan J. Miner

Open Access Publications

No abstract provided.


Metabolic Importance Of Adipose Tissue Monoacylglycerol Acyltransferase 1 In Mice And Humans, Kim H. H. Liss, Andrew J. Lutkewitte, Terri Pietka, Brian N. Finck, Michael Franczyk, Jun Yoshino, Samuel Klein, Angela M. Hall Jan 2018

Metabolic Importance Of Adipose Tissue Monoacylglycerol Acyltransferase 1 In Mice And Humans, Kim H. H. Liss, Andrew J. Lutkewitte, Terri Pietka, Brian N. Finck, Michael Franczyk, Jun Yoshino, Samuel Klein, Angela M. Hall

Open Access Publications

No abstract provided.


Reference Effect Measures For Quantifying, Comparing And Visualizing Variation From Random And Fixed Effects In Non-Normal Multilevel Models, With Applications To Site Variation In Medical Procedure Use And Outcomes, Thomas J. Glorioso, Gary K. Grunwald, P. Michael Ho, Thomas M. Maddox Jan 2018

Reference Effect Measures For Quantifying, Comparing And Visualizing Variation From Random And Fixed Effects In Non-Normal Multilevel Models, With Applications To Site Variation In Medical Procedure Use And Outcomes, Thomas J. Glorioso, Gary K. Grunwald, P. Michael Ho, Thomas M. Maddox

Open Access Publications

No abstract provided.


Learning Curve With A New Primary Total Knee Arthroplasty Implant: A Multicenter Perspective With More Than 2000 Patients, John-Paul Whittaker, Kimberly A. Dwyer, James Howard, Verdonna Huey, James Lesko, Ryan Nunley, Peter Verdonk Jan 2018

Learning Curve With A New Primary Total Knee Arthroplasty Implant: A Multicenter Perspective With More Than 2000 Patients, John-Paul Whittaker, Kimberly A. Dwyer, James Howard, Verdonna Huey, James Lesko, Ryan Nunley, Peter Verdonk

Open Access Publications

No abstract provided.


Immunosuppressants And Risk Of Parkinson Disease, Brad A. Racette, Anat Gross, Scott Martin Vouri, Alejandra Camacho-Soto, Allison W. Willis, Susan Searles Nielsen Jan 2018

Immunosuppressants And Risk Of Parkinson Disease, Brad A. Racette, Anat Gross, Scott Martin Vouri, Alejandra Camacho-Soto, Allison W. Willis, Susan Searles Nielsen

Open Access Publications

No abstract provided.


Use Of A Video Scoring Anchor For Rapid Serial Assessment Of Social Communication In Toddlers, Natasha Marrus, Stefanie Kennon-Mcgill, Brooke Harris, Yi Zhang, Anne L. Glowinski, John N. Constantino Jan 2018

Use Of A Video Scoring Anchor For Rapid Serial Assessment Of Social Communication In Toddlers, Natasha Marrus, Stefanie Kennon-Mcgill, Brooke Harris, Yi Zhang, Anne L. Glowinski, John N. Constantino

Open Access Publications

No abstract provided.


The Acyl-Coa Synthetase, Pudgy, Promotes Sleep And Is Required For The Homeostatic Response To Sleep Deprivation, Matthew S. Thimgan, Natalie Kress, Josh Lisse, Courtney Fiebelman, Thomas Hilderbrand Jan 2018

The Acyl-Coa Synthetase, Pudgy, Promotes Sleep And Is Required For The Homeostatic Response To Sleep Deprivation, Matthew S. Thimgan, Natalie Kress, Josh Lisse, Courtney Fiebelman, Thomas Hilderbrand

Open Access Publications

No abstract provided.


Effect Of Concussions On Lower Extremity Injury Rates At A Division I Collegiate Football Program, Matthew L. Krill, Christopher Nagelli, James Borchers, Michael K. Krill, Timothy E. Hewett Jan 2018

Effect Of Concussions On Lower Extremity Injury Rates At A Division I Collegiate Football Program, Matthew L. Krill, Christopher Nagelli, James Borchers, Michael K. Krill, Timothy E. Hewett

Open Access Publications

No abstract provided.


Hepatocyte Aloxe3 Is Induced During Adaptive Fasting And Enhances Insulin Sensitivity By Activating Hepatic Pparγ, Cassandra B. Higgins, Yiming Zhang, Allyson L. Mayer, Hideji Fujiwara, Alicyn I. Stothard, Mark J. Graham, Benjamin M. Swarts, Brian J. Debosch Jan 2018

Hepatocyte Aloxe3 Is Induced During Adaptive Fasting And Enhances Insulin Sensitivity By Activating Hepatic Pparγ, Cassandra B. Higgins, Yiming Zhang, Allyson L. Mayer, Hideji Fujiwara, Alicyn I. Stothard, Mark J. Graham, Benjamin M. Swarts, Brian J. Debosch

Open Access Publications

No abstract provided.


Health Education Advanced Leadership For Zimbabwe (Healz): Developing The Infrastructure To Support Curriculum Reform, Eva M. Aagaard, Susan C. Connors, Amelia Challender, Jonathan Gandari, Kusum Nathoo, Margaret Borok, Midion Chidzonga, Michele Barry, Thomas Campbell, James Hakim Jan 2018

Health Education Advanced Leadership For Zimbabwe (Healz): Developing The Infrastructure To Support Curriculum Reform, Eva M. Aagaard, Susan C. Connors, Amelia Challender, Jonathan Gandari, Kusum Nathoo, Margaret Borok, Midion Chidzonga, Michele Barry, Thomas Campbell, James Hakim

Open Access Publications

No abstract provided.


Mechanism Of High-Level Daptomycin Resistance In Corynebacterium Striatum, Nicholas K. Goldner, Christopher Bulow, Kevin Cho, Meghan Wallace, Fong-Fu Hsu, Gary J. Patti, Carey-Ann Burnham, Paul Schlesinger, Gautam Dantas Jan 2018

Mechanism Of High-Level Daptomycin Resistance In Corynebacterium Striatum, Nicholas K. Goldner, Christopher Bulow, Kevin Cho, Meghan Wallace, Fong-Fu Hsu, Gary J. Patti, Carey-Ann Burnham, Paul Schlesinger, Gautam Dantas

Open Access Publications

No abstract provided.


Multicenter Evaluation Of The Etest Gradient Diffusion Method For Ceftolozane-Tazobactam Susceptibility Testing Of Enterobacteriaceae And Pseudomonas Aeruginosa, Adam L. Bailey, Tom Armstrong, Hari-Prakash Dwivedi, Gerald A. Denys, Janet Hindler, Shelley Campeau, Maria Traczewski, Romney Humphries, Carey-Ann D. Burnham Jan 2018

Multicenter Evaluation Of The Etest Gradient Diffusion Method For Ceftolozane-Tazobactam Susceptibility Testing Of Enterobacteriaceae And Pseudomonas Aeruginosa, Adam L. Bailey, Tom Armstrong, Hari-Prakash Dwivedi, Gerald A. Denys, Janet Hindler, Shelley Campeau, Maria Traczewski, Romney Humphries, Carey-Ann D. Burnham

Open Access Publications

No abstract provided.


Differences In Hearing Acuity Among “Normal-Hearing” Young Adults Modulate The Neural Basis For Speech Comprehension, Yune S. Lee, Arthur Wingfield, Nam-Eun Min, Ethan Kotloff, Murray Grossman, Jonathan E. Peelle Jan 2018

Differences In Hearing Acuity Among “Normal-Hearing” Young Adults Modulate The Neural Basis For Speech Comprehension, Yune S. Lee, Arthur Wingfield, Nam-Eun Min, Ethan Kotloff, Murray Grossman, Jonathan E. Peelle

Open Access Publications

No abstract provided.


Muscle Mri In Patients With Dysferlinopathy: Pattern Recognition And Implications For Clinical Trialp, Matthew Harms, Alan Pestronk, Et Al Jan 2018

Muscle Mri In Patients With Dysferlinopathy: Pattern Recognition And Implications For Clinical Trialp, Matthew Harms, Alan Pestronk, Et Al

Open Access Publications

No abstract provided.


Comprehensive Assessment Of A Hotspot With Persistent Bancroftian Filariasis In Coastal Sri Lanka, Ramakrishna U. Rao, Sandhya D. Samarasekera, Kumara C. Nagodavithana, Charles W. Goss, Manjula W. Punchihewa, Tharanga D. M. Dassanayaka, Udaya S. B. Ranasinghe, Devika Mendis, Gary J. Weil Jan 2018

Comprehensive Assessment Of A Hotspot With Persistent Bancroftian Filariasis In Coastal Sri Lanka, Ramakrishna U. Rao, Sandhya D. Samarasekera, Kumara C. Nagodavithana, Charles W. Goss, Manjula W. Punchihewa, Tharanga D. M. Dassanayaka, Udaya S. B. Ranasinghe, Devika Mendis, Gary J. Weil

Open Access Publications

No abstract provided.


Steroid Receptor Coactivator-2 Controls The Pentose Phosphate Pathway Through Rpia In Human Endometrial Cancer Cells, Maria M. Szwarc, Ramakrishna Kommagani, Vasanta Putluri, Julien Dubrulle, Fabio Stossi, Michael A. Mancini, Cristian Coarfa, Rainer B. Lanz, Nagireddy Putluri, Francesco J. Demayo, John P. Lydon, Bert W. O'Malley Jan 2018

Steroid Receptor Coactivator-2 Controls The Pentose Phosphate Pathway Through Rpia In Human Endometrial Cancer Cells, Maria M. Szwarc, Ramakrishna Kommagani, Vasanta Putluri, Julien Dubrulle, Fabio Stossi, Michael A. Mancini, Cristian Coarfa, Rainer B. Lanz, Nagireddy Putluri, Francesco J. Demayo, John P. Lydon, Bert W. O'Malley

Open Access Publications

No abstract provided.


Effect Of Cowpea Flour Processing On The Chemical Properties And Acceptability Of A Novel Cowpea Blended Maize Porridge, Theresa N. Ngoma, Ulema K. Chimimba, Agnes M. Mwangwela, Chrissie Thakwalakwa, Kenneth M. Maleta, Mark Manary, Indi Trehan Jan 2018

Effect Of Cowpea Flour Processing On The Chemical Properties And Acceptability Of A Novel Cowpea Blended Maize Porridge, Theresa N. Ngoma, Ulema K. Chimimba, Agnes M. Mwangwela, Chrissie Thakwalakwa, Kenneth M. Maleta, Mark Manary, Indi Trehan

Open Access Publications

No abstract provided.