Digital Commons Network^™

Study Of Environmental Enteropathy And Malnutrition (Seem) In Pakistan: Protocols For Biopsy Based Biomarker Discovery And Validation, Najeeha T. Iqbal, Ta-Chiang Liu, Michael J. Barratt, Vanderlene L. Kung, Jeffrey I. Gordon, Et Al

Open Access Publications

No abstract provided.

International Meta-Analysis Of Ptsd Genome-Wide Association Studies Identifies Sex- And Ancestry-Specific Genetic Risk Loci, Laura J. Bierut, Elliot C. Nelson, John P. Rice, Nancy L. Saccone, Andrew C. Heath, Et Al.

Open Access Publications

No abstract provided.

Updated Results From The Phase 3 Helios Study Of Ibrutinib, Bendamustine, And Rituximab In Relapsed Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Nancy Lee Bartlett, Et Al.

Open Access Publications

No abstract provided.

Shared Autonomic Pathways Connect Bone Marrow And Peripheral Adipose Tissues Across The Central Neuraxis, Natalie K Y Wee, Madelyn R Lorenz, Yusuf Bekirov, Mark F Jacquin, Erica L Scheller

Open Access Publications

Bone marrow adipose tissue (BMAT) is increased in both obesity and anorexia. This is unique relative to white adipose tissue (WAT), which is generally more attuned to metabolic demand. It suggests that there may be regulatory pathways that are common to both BMAT and WAT and also those that are specific to BMAT alone. The central nervous system (CNS) is a key mediator of adipose tissue function through sympathetic adrenergic neurons. Thus, we hypothesized that central autonomic pathways may be involved in BMAT regulation. To test this, we first quantified the innervation of BMAT by tyrosine hydroxylase (TH) positive nerves …

Perturbing Cohesin Dynamics Drives Mre11 Nuclease-Dependent Replication Fork Slowing, Denisse Carvajal-Maldonado, Andrea K. Byrum, Jessica Jackson, Sarah Wessel, Delphine Lemacon, Laure Guitton-Sert, Annabel Quinet, Stephanie Tirman, Simona Graziano, Jean-Yves Masson, David Cortez, Susana Gonzalo, Nima Mosammaparast, Alessandro Vindigni

Open Access Publications

No abstract provided.

Need To Improve Availability Of "Access" Group Antibiotics And Reduce The Use Of "Watch" Group Antibiotics In India For Optimum Use Of Antibiotics To Contain Antimicrobial Resistance, Sumanth Gandra, Anita Kotwani

Open Access Publications

No abstract provided.

Protocol For The Electroencephalography Guidance Of Anesthesia To Alleviate Geriatric Syndromes (Engages-Canada) Study: A Pragmatic, Randomized Clinical Trial [Version 1; Peer Review: 2 Approved], Alain Deschamps, Jordan Oberhaus, Angela Mickle, Arbi Ben Abdallah, Michael S Avidan, Et Al

Open Access Publications

No abstract provided.

Five-Year Outcomes Of The S1106 Study Of R-Hyper-Cvad Vs R-Bendamustine In Transplant-Eligible Patients With Mantle Cell Lymphoma, Manali Kamdar, Hongli Li, Robert W. Chen, Lisa M. Rimsza, Michael L. Leblanc, Timothy S. Fenske, Thomas C. Shea, Paul M. Barr, Tycel J. Phillips, John P. Leonard, Brad S. Kahl, Jonathan W. Friedberg, Sonali M. Smith

Open Access Publications

No abstract provided.

Clinical Variables And Genetic Risk Factors Associated With The Acute Outcome Of Ischemic Stroke: A Systematic Review, Nuria P. Torres-Aguila, Laura Ibañez, Laura Heitsch, Carlos Cruchaga, Jin-Moo Lee, Et Al.

Open Access Publications

No abstract provided.

Evaluating Park Use And Satisfaction: The Case Of Trojan Park In St. Louis Missouri, Diana C. Parra, Alexandria Van Zandt, Peter Wang, Micah Goodman, Janardan Abhishek, Debra Haire-Joshu, Ross C. Brownson

Open Access Publications

No abstract provided.

Variation In The Delivery Of Inpatient Orthopaedic Care To Medicaid Beneficiaries Within A Single Metropolitan Region, Christopher J. Dy, Andrew D. Tipping, Katelin B. Nickel, Winston Jiang, Regis J. O'Keefe, Margaret A. Olsen

Open Access Publications

No abstract provided.

Hyper-Activation Of Stat3 Sustains Progression Of Non-Papillary Basal-Type Bladder Cancer Via Fosl1 Regulome, William Vermi, Et Al

Open Access Publications

No abstract provided.

A Randomized Phase Ii Trial Of Nab‐Paclitaxel And Gemcitabine With Tarextumab Or Placebo In Patients With Untreated Metastatic Pancreatic Cancer, Zishuo Ian Hu, Andrea Wang-Gillam, Et Al

Open Access Publications

No abstract provided.

Are Patients With Perforated Peptic Ulcers Who Are Negative For Helicobacter Pylori At A Greater Risk?, Rohit K. Rasane, Christopher B. Horn, Adrian A. Coleoglou Centeno, Nicholas B. Fiore, Marlon Torres Barboza, Qiao Zhang, Kelly M. Bochicchio, Laurie J. Punch, Grant V. Bochicchio, Obeid N. Ilahi

Open Access Publications

No abstract provided.

Type-2-Diabetes Alters Csf But Not Plasma Metabolomic And Ad Risk Profiles In Vervet Monkeys, Kylie Kavanagh, Stephen M. Day, Morgan C. Pait, William R. Mortiz, Christopher B. Newgard, Olga Ilkayeva, Donald A. Mcclain, Shannon L. Macauley

Open Access Publications

No abstract provided.

Web-Based Prescription Opioid Abuse Prevention For Adolescents: Program Development And Formative Evaluation, Sarah K. Moore, Michael Grabinski, Sarah Bessen, Jacob T. Borodovsky, Lisa A. Marsch

Open Access Publications

No abstract provided.

Inhibition Of E-Selectin (Gmi-1271) Or E-Selectin Together With Cxcr4 (Gmi-1359) Re-Sensitizes Multiple Myeloma To Therapy, Barbara Muz, Feda Azab, Mark Fiala, Justin King, Daniel Kohnen, William E. Fogler, Ted Smith, John L. Magnani, Ravi Vij, Abdel Kareem Azab

Open Access Publications

No abstract provided.

Differential Neural Dynamics Underling Pragmatic And Semantic Affordance Processing In Macaque Ventral Premotor Cortex, Monica Maranesi, Stefania Bruni, Alessandro Livi, Francesco Donnarumma, Giovanni Pezzulo, Luca Bonini

Open Access Publications

No abstract provided.

Synthetic Molecular Recognition Nanosensor Paint For Microalbuminuria, Januka Budhathoki-Uprety, Janki Shah, Joshua A. Korsen, Alysandria E. Wayne, Thomas V. Galassi, Joseph R. Cohen, Jackson D. Harvey, Prakrit V. Jena, Lakshmi V. Ramanathan, Edgar A. Jaimes, Daniel A. Heller

Open Access Publications

No abstract provided.

Targeting Innate Immunity For Tuberculosis Vaccination, Shabaana A. Khader, Maziar Divangahi, Willem Hanekom, Philip C. Hill, Markus Maeurer, Karen W. Makar, Katrin D. Mayer-Barber, Musa M. Mhlanga, Elisa Nemes, Larry S. Schlesinger, Reinout Van Crevel, Ramakrishna Vankalayapati, Ramnik J. Xavier, Mihai G. Netea, On Behalf Of The Bill And Melinda Gates Foundation Collaboration For Tb Vaccine Discovery Innate Immunity Working Group

Open Access Publications

No abstract provided.

Behavioral Predictors Of Autism Recurrence Are Genetically Independent And Influence Social Reciprocity: Evidence That Polygenic Asd Risk Is Mediated By Separable Elements Of Developmental Liability, Alexa Pohl, Warren R. Jones, Natasha Marrus, Yi Zhang, Ami Klin, John N. Constantino

Open Access Publications

No abstract provided.

Related And Unrelated Donor Transplantation For B-Thalassemia Major: Results Of An International Survey, Chunfu Li, Shalini Shenoy, Et Al.

Open Access Publications

No abstract provided.

Oral Selinexor–Dexamethasone For Triple-Class Refractory Multiple Myeloma, Ravi Vij, Et Al.

Open Access Publications

No abstract provided.

A Window On The Lung: Molecular Imaging As A Tool To Dissect Pathophysiologic Mechanisms Of Acute Lung Disease, Guido Musch

Open Access Publications

No abstract provided.

Maternal Pomegranate Juice Intake And Brain Structure And Function In Infants With Intrauterine Growth Restriction: A Randomized Controlled Pilot Study., Lillian G. Matthews, Christopher D. Smyser, Sara Cherkerzian, Dimitrios Alexopoulos, Jeanette Kenley, Methodius G. Tuuli, D. Michael Nelson, Terrie E. Inder

Open Access Publications

Polyphenol-rich pomegranate juice has been shown to have benefit as a neuroprotectant in animal models of neonatal hypoxic-ischemia. No published studies have investigated maternal polyphenol administration as a potential neuroprotectant in at-risk newborns, such as those with intrauterine growth restriction (IUGR). This was a randomized, placebo-controlled, double-blind pilot study to investigate the impact of maternal pomegranate juice intake in pregnancies with IUGR, on newborn brain structure and function at term-equivalent age (TEA). Mothers with IUGR at 24-34 weeks' gestation were recruited from Barnes-Jewish Hospital obstetrical clinic. Consented mothers were randomized to treatment (8 oz. pomegranate juice) or placebo (8 oz. …

Dosing Pole Recommendations For Lymphatic Filariasis Elimination: A Height-Weight Quantile Regression Modeling Approach, Charles W. Goss, Katiuscia O'Brian, Christine Dubray, Peter U. Fischer, Myra Hardy, Purushothaman Jambulingam, Christopher L. King, Moses Laman, Jean Frantz Lemoine, Leanne J. Robinson, Josaia Samuela, Swaminathan Subramanian, Taniawati Supali, Gary J. Weil, Kenneth B. Schechtman

Open Access Publications

BACKGROUND: The World Health Organization (WHO) currently recommends height or age-based dosing as alternatives to weight-based dosing for mass drug administration lymphatic filariasis (LF) elimination programs. The goals of our study were to compare these alternative dosing strategies to weight-based dosing and to develop and evaluate new height-based dosing pole scenarios.

METHODOLOGY/PRINCIPAL FINDINGS: Age, height and weight data were collected from >26,000 individuals in five countries during a cluster randomized LF clinical trial. Weight-based dosing for diethylcarbamazine (DEC; 6 mg/kg) and ivermectin (IVM; 200 ug/kg) with tablet numbers derived from a table of weight intervals was treated as the "gold …

Trial Of Sage-217 In Patients With Major Depressive Disorder, Handan Gunduz-Bruce, Christopher Silber, Inder Kaul, Anthony J. Rothschild, Robert Riesenberg, Abdul J. Sankoh, Haihong Li, Robert Lasser, Charles F. Zorumski, David R. Rubinow, Steven M. Paul, Jeffrey Jonas, James J. Doherty, Stephen J. Kanes

Open Access Publications

No abstract provided.

Longitudinal Evaluation Of Cognition After Stroke - A Systematic Scoping Review, Juan Pablo Saa, Tamara Tse, Carolyn Baum, Toby Cumming, Naomi Josman, Miranda Rose, Leeanne Carey

Open Access Publications

BACKGROUND: Cognitive impairment affects up to 80 percent of the stroke population, however, both the available evidence about post-stroke cognition and the measures used to evaluate it longitudinally have not been well described. The aims of this systematic scoping review were: to identify and characterize studies evaluating cognition longitudinally after stroke; to summarize the cognitive instruments used and the domains they target; and to organize cognitive domains assessed using the International Classification of Functioning, Disability and Health (ICF).

METHODS: We used a systematic scoping approach to search for peer-reviewed articles involving adults with stroke that evaluated cognition longitudinally. Screening of …

Evaluating Multisite Rcbv Consistency From Dsc-Mri Imaging Protocols And Postprocessing Software Across The Nci Quantitative Imaging Network Sites Using A Digital Reference Object (Dro), Laura C. Bell, Hongyu An, Cihat Eldeniz, Richard Wahl, Et Al

Open Access Publications

No abstract provided.

Tourette Syndrome Research Highlights From 2018 [Version 1; Peer Review: 2 Approved], Olivia Rose, Andreas Hartmann, Yulia Worbe, Jeremiah M. Scharf, Kevin J. Black

Open Access Publications

No abstract provided.