Digital Commons Network^™

Phosphatidylcholine Synthesis Through Cholinephosphate Cytidylyltransferase Is Dispensable In Leishmania Major, Samrat Moitra, Mattie C. Pawlowic, Fong-Fu Hsu, Kai Zhang

Open Access Publications

No abstract provided.

Association Of High Birth Weight With Incident Heart Failure In The Aric Study, Abdirahim Rashid, Anandita Agarwala, Eric Novak, David L. Brown

Open Access Publications

No abstract provided.

Estimates Of The 2016 Global Burden Of Kidney Disease Attributable To Ambient Fine Particulate Matter Air Pollution, Benjamin Bowe, Yan Xie, Tingting Li, Yan Yan, Hong Xian, Ziyad Al-Aly

Open Access Publications

No abstract provided.

Hospital Revisits Within 30 Days After Discharge For Medical Conditions Targeted By The Hospital Readmissions Reduction Program In The United States: National Retrospective Analysis, Rishi K. Wadhera, Karen E. Joynt Maddox, Dhruv S. Kazi, Changyu Shen, Robert W. Yeh

Open Access Publications

No abstract provided.

The Single-Cell Transcriptomic Landscape Of Early Human Diabetic Nephropathy, Parker C. Wilson, Haojia Wu, Yuhei Kirita, Kohei Uchimura, Nicolas Ledru, Helmut G. Rennke, Paul A. Welling, Sushrut S. Waikar, Benjamin D. Humphreys

Open Access Publications

No abstract provided.

Deficiency Of Dietary Fiber In Slc5a8-Null Mice Promotes Bacterial Dysbiosis And Alters Colonic Epithelial Transcriptome Towards Proinflammatory Milieu, Sathish Sivaprakasam, Pramodh K. Ganapathy, Mohd Omar Faruk Sikder, Moamen Elmassry, Sabarish Ramachandran, Kameswara Rao Kottapalli, Vadivel Ganapathy

Open Access Publications

No abstract provided.

Reduction Of Leukocyte Microvascular Adherence And Preservation Of Blood-Brain Barrier Function By Superoxide-Lowering Therapies In A Piglet Model Of Neonatal Asphyxia, Jacob B. Ruden, Kevin L. Quick, Ernesto R. Gonzales, Aarti R. Shah, T. S. Park, Nan Kennedy, Laura L. Dugan, Jeffrey M. Gidday

Open Access Publications

No abstract provided.

Increased Mtdna Abundance And Improved Function In Human Barth Syndrome Patient Fibroblasts Following Aav-Taz Gene Delivery, Silveli Suzuki-Hatano, Mughil Sriramvenugopal, Manash Ramanathan, Meghan Soustek, Barry J. Byrne, W. T. Cade, Peter B. Kang, Christina A. Pacak

Open Access Publications

No abstract provided.

Promising Recent Strategies With Potential Clinical Translational Value To Combat Antibacterial Resistant Surge, Partha Karmakar, Vishwanath Gaitonde

Open Access Publications

No abstract provided.

Comorbid Conditions Explain The Association Between Posttraumatic Stress Disorder And Incident Cardiovascular Disease, Jeffrey F. Scherrer, Joanne Salas, Beth E. Cohen, Paula P. Schnurr, F. David Schneider, Kathleen M. Chard, Peter Tuerk, Matthew J. Friedman, Sonya B. Norman, Carissa Van Den Berk-Clark, Patrick J. Lustman

Open Access Publications

No abstract provided.

Monthly Extended-Release Risperidone (Rbp-7000) In The Treatment Of Schizophrenia, Anne Andorn, Jay Graham, John Csernansky, John W. Newcomer, Sunita Shinde, Gilbert Muma, Christian Heidbreder, Maurizio Fava

Open Access Publications

No abstract provided.

Palatine Tonsillar Metastasis Of Lung Adenocarcinoma: An Unusual Immunohistochemical Phenotype And A Potential Diagnostic Pitfall, Ying Tian, Yunan Han, Jiang Du, Yao Zhang, Nan Liu, Xin Du, Bo Li

Open Access Publications

Metastasis rarely occurs to the palatine tonsils. Herein, we present an exceedingly rare case of palatine tonsillar metastasis from poorly differentiated lung adenocarcinoma with anaplastic lymphoma kinase (ALK) mutation in a 51-year-old woman. The patient manifested clinically as pharyngalgia without obvious respiratory symptoms, with swelling tonsil histomorphologically resembling lymphoma and partially expressing the markers of epithelial and squamous cell carcinoma (CK5/6, P63, and P40). Due to the non-specific immunohistochemical expression, it is easily misdiagnosed as a primary poorly differentiated squamous cell carcinoma of the tonsil. This case highlights the importance of a comprehensive assessment of suspicious tonsillar lesions, that may …

Comparison Of Voxel-Wise And Histogram Analyses Of Glioma Adc Maps For Prediction Of Early Therapeutic Change, Thomas L. Chenevert, Dariya I. Malyarenko, Craig J. Galban, Diana M. Gomez-Hassan, Pia C. Sundgren, Christina I. Tsien, Brian D. Ross

Open Access Publications

No abstract provided.

Toward A Comprehensive View Of Cancer Immune Responsiveness: A Synopsis From The Sitc Workshop, Davide Bedognetti, David G. Denardo, Et Al

Open Access Publications

No abstract provided.

Multiplatform Urinary Metabolomics Profiling To Discriminate Cachectic From Non-Cachectic Colorectal Cancer Patients: Pilot Results From The Colocare Study, Jennifer Ose, Adetunji T Toriola, Et Al

Open Access Publications

Cachexia is a multifactorial syndrome that is characterized by loss of skeletal muscle mass in cancer patients. The biological pathways involved remain poorly characterized. Here, we compare urinary metabolic profiles in newly diagnosed colorectal cancer patients (stage I-IV) from the ColoCare Study in Heidelberg, Germany. Patients were classified as cachectic (

Low Dose Chloroquine Decreases Insulin Resistance In Human Metabolic Syndrome But Does Not Reduce Carotid Intima-Media Thickness, Janet B Mcgill, Mariko Johnson, Stacy Hurst, William T Cade, Kevin E Yarasheski, Richard E Ostlund, Kenneth B Schechtman, Babak Razani, Michael B Kastan, Donald A Mcclain, Lisa De Las Fuentes, Victor G Davila-Roman, Daniel S Ory, Samuel A Wickline, Clay F Semenkovich

Open Access Publications

Background: Metabolic syndrome, an obesity-related condition associated with insulin resistance and low-grade inflammation, leads to diabetes, cardiovascular diseases, cancer, osteoarthritis, and other disorders. Optimal therapy is unknown. The antimalarial drug chloroquine activates the kinase ataxia telangiectasia mutated (ATM), improves metabolic syndrome and reduces atherosclerosis in mice. To translate this observation to humans, we conducted two clinical trials of chloroquine in people with the metabolic syndrome.

Methods: Eligibility included adults with at least 3 criteria of metabolic syndrome but who did not have diabetes. Subjects were studied in the setting of a single academic health center. The specific hypothesis: chloroquine improves …

Sedentary Behaviors, Tv Viewing Time, And Risk Of Young-Onset Colorectal Cancer, Long H. Nguyen, Po-Hong Liu, Xiaobin Zheng, Nana Keum, Xiaoyu Zong, Xiao Li, Kana Wu, Charles S. Fuchs, Shuji Ogino, Kimmie Ng, Walter C. Willett, Andrew T. Chan, Edward L. Giovannucci, Yin Cao

Open Access Publications

No abstract provided.

N-Acyl-O-Phosphocholineserines: Structures Of A Novel Class Of Lipids That Are Biomarkers For Niemann-Pick C1 Disease, Rohini Sidhu, Yawo Mondjinou, Mingxing Qian, Fong-Fu Hsu, Dennis J. Dietzen, Jean E. Schaffer, Daniel S. Ory, Xuntian Jiang, Et Al.

Open Access Publications

No abstract provided.

Transcriptomic Analysis Of Enteropathy In Zambian Children With Severe Acute Malnutrition, Mubanga Chama, Beatrice C. Amadi, Kanta Chandwe, Kanekwa Zyambo, Ellen Besa, Nurmohammad Shaikh, I. Malick Ndao, Phillip I. Tarr, Chad Storer, Richard Head, Paul Kelly

Open Access Publications

No abstract provided.

The Role Of Small Or Single-Institution Prospective Studies In Thoracic Research, Tara R. Semenkovich, C. Corbin Frye, M. Shea Harrison, Melanie Subramanian, Benjamin D. Kozower, Bryam F. Meyers, Varun Puri

Open Access Publications

No abstract provided.

The Safety Of Double- And Triple-Drug Community Mass Drug Administration For Lymphatic Filariasis: A Multicenter, Open-Label, Cluster-Randomized Study, Gary J. Weil, Joshua Bogus, Peter U. Fischer, Charles W. Goss, K. O'Brian, Kenneth B. Schechtman, Dolf Ida Safety Study Group, Et Al.

Open Access Publications

No abstract provided.

The Factor Structure Of The Boston Diagnostic Aphasia Examination, Third Edition, Mandy W.M Fong, Ryan Van Patten, Robert P. Fucetola

Open Access Publications

No abstract provided.

Screening For Barrett’S Esophagus: Balancing Clinical Value And Cost-Effectiveness, Amit Patel, C Prakash Gyawali

Open Access Publications

No abstract provided.

A Mixture Of U.S. Food And Drug Administration–Approved Monoaminergic Drugs Protects The Retina From Light Damage In Diverse Models Of Night Blindness, Henri Leinonen, Elliot H. Choi, Anthony Gardella, Vladimir J. Kefalov, Krzysztof Palczewski

Open Access Publications

No abstract provided.

Quantification Of White Matter Cellularity And Damage In Preclinical And Early Symptomatic Alzheimer's Disease, Qing Wang, Yong Wang, Jingxia Liu, Courtney L. Sutphen, Carlos Cruchaga, Tyler Blazey, Brian A. Gordon, Yi Su, Charlie Chen, Joshua S. Shimony, Beau M. Ances, Nigel J. Cairns, Anne M. Fagan, John C. Morris, Tammie L.S. Benzinger

Open Access Publications

No abstract provided.

Comparative Evaluation Of Enteric Bacterial Culture And A Molecular Multiplex Syndromic Panel In Children With Acute Gastroenteritis, Thomas Kellner, Brandon Parsons, Linda Chui, Byron M. Berenger, Jianling Xie, Carey-Ann D. Burnham, Phillip I. Tarr, Bonita E. Lee, Alberto Nettel-Aguirre, Jonas Szelewicki, Otto G. Vanderkooi, Xiao-Li Pang, Nathan Zelyas, Stephen B. Freedman, Alberta Provincial Pediatric Enteric Infection Team (Appetite)

Open Access Publications

No abstract provided.

Lung Transplant Referral For Individuals With Cystic Fibrosis: Cystic Fibrosis Foundation Consensus Guidelines, Kathleen J. Ramos, Patrick J. Smith, Edward F. Mckone, Joseph M. Pilewski, Amy Lucy, Sarah E. Hempstead, Erin Tallarico, Albert Faro, Daniel B. Rosenbluth, Alice L. Gray, Jordan M. Dunitz, Cf Lung Transplant Referral Guidelines Committee

Open Access Publications

No abstract provided.

Potential Impact Of Interventions To Enhance Retention In Care During Real-World Hiv Pre-Exposure Prophylaxis Implementation, Philip A. Chan, William C. Goedel, Amy S. Nunn, Genoviva Sowemimo-Coker, Omar Galárraga, Mattia Prosperi, Rupa Patel, Leandro Mena, Madeline C. Montgomery, Brandon D.L. Marshall

Open Access Publications

No abstract provided.

Potential Role Of Gut Microbiota In Induction And Regulation Of Innate Immune Memory, Shikha Negi, Deepjyoti Kumar Das, Susanta Pahari, Sajid Nadeem, Javed N Agrewala

Open Access Publications

The gut microbiota significantly regulates the development and function of the innate and adaptive immune system. The attribute of immunological memory has long been linked only with adaptive immunity. Recent evidence indicates that memory is also present in the innate immune cells such as monocytes/macrophages and natural killer cells. These cells exhibit pattern recognition receptors (PRRs) that recognize microbe- or pathogen-associated molecular patterns (MAMPs or PAMPs) expressed by the microbes. Interaction between PRRs and MAMPs is quite crucial since it triggers the sequence of signaling events and epigenetic rewiring that not only play a cardinal role in modulating the activation …

Gestational Weight Gain And Group Prenatal Care: A Systematic Review And Meta-Analysis, Michelle A. Kominiarek, Adam K. Lewkowitz, Ebony Carter, Susan A. Fowler, Melissa Simon

Open Access Publications

No abstract provided.