Digital Commons Network^™

Development Of Aplastic Anemia During Treatment Of Anaplastic Astrocytoma With Temozolomide, Karam Khaddour, Nigel Harrison, Ashwin Govindan, Jian L. Campian

Open Access Publications

No abstract provided.

Cerebral Small Vessel Disease Genomics And Its Implications Across The Lifespan, Muralidharan Sargurupremraj, Andrew C. Heath, Pamela A.F. Madden, Et Al.

Open Access Publications

No abstract provided.

Dendritic And Parallel Processing Of Visual Threats In The Retina Control Defensive Responses, T Kim, N Shen, J-C Hsiang, K P Johnson, D Kerschensteiner

Open Access Publications

Approaching predators cast expanding shadows (i.e., looming) that elicit innate defensive responses in most animals. Where looming is first detected and how critical parameters of predatory approaches are extracted are unclear. In mice, we identify a retinal interneuron (the VG3 amacrine cell) that responds robustly to looming, but not to related forms of motion. Looming-sensitive calcium transients are restricted to a specific layer of the VG3 dendrite arbor, which provides glutamatergic input to two ganglion cells (W3 and OFFα). These projection neurons combine shared excitation with dissimilar inhibition to signal approach onset and speed, respectively. Removal of VG3 amacrine cells …

Antibodies Targeting Epitopes On The Cell-Surface Form Of Ns1 Protect Against Zika Virus Infection During Pregnancy, Alex W. Wessel, Nurgun Kose, Robin G. Bombardi, Vicky Roy, Warangkana Chantima, Juthathip Mongkolsapaya, Melissa A. Edeling, Christopher A. Nelson, Irene Bosch, Galit Alter, Gavin R. Screaton, David H. Fremont, James E. Crowe Jr, Michael S. Diamond

Open Access Publications

No abstract provided.

Algorithm For Management Of Mandibular Condylar Base Fractures, Erin C. Peterson, Dennis C. Nguyen, Ethan J. Baughman, Gary B. Skolnick, John J. Chi, Kamlesh B. Patel

Open Access Publications

No abstract provided.

Mapping Language Function With Task-Based Vs. Resting-State Functional Mri, Ki Yun Park, John J. Lee, Donna Dierker, Laura M. Marple, Carl D. Hacker, Jarod L. Roland, Daniel S. Marcus, Mikhail Milchenko, Michelle M. Miller-Thomas, Tammie L. Benzinger, Joshua S. Shimony, Abraham Z. Snyder, Eric C. Leuthardt

Open Access Publications

BACKGROUND: Use of functional MRI (fMRI) in pre-surgical planning is a non-invasive method for pre-operative functional mapping for patients with brain tumors, especially tumors located near eloquent cortex. Currently, this practice predominantly involves task-based fMRI (T-fMRI). Resting state fMRI (RS-fMRI) offers an alternative with several methodological advantages. Here, we compare group-level analyses of RS-fMRI vs. T-fMRI as methods for language localization.

PURPOSE: To contrast RS-fMRI vs. T-fMRI as techniques for localization of language function.

METHODS: We analyzed data obtained in 35 patients who had both T-fMRI and RS-fMRI scans during the course of pre-surgical evaluation. The RS-fMRI data were analyzed …

Genetic Loci Associated With Prevalent And Incident Myocardial Infarction And Coronary Heart Disease In The Cohorts For Heart And Aging Research In Genomic Epidemiology (Charge) Consortium, Julie Hahn, Mary F. Feitosa, Et Al.

Open Access Publications

BACKGROUND: Genome-wide association studies have identified multiple genomic loci associated with coronary artery disease, but most are common variants in non-coding regions that provide limited information on causal genes and etiology of the disease. To overcome the limited scope that common variants provide, we focused our investigation on low-frequency and rare sequence variations primarily residing in coding regions of the genome.

METHODS AND RESULTS: Using samples of individuals of European ancestry from ten cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, both cross-sectional and prospective analyses were conducted to examine associations between genetic variants …

The Current State Of Hiv And Aging: Findings Presented At The 10th International Workshop On Hiv And Aging, Stephanie Shiau, Jane A. O'Halloran, Et Al.

Open Access Publications

No abstract provided.

Adherence To Updated Childcare Nutrition Regulations In Colorado, United States, Amy A Eyler, Cheryl R Valko, Katherine A Curoe, Ramya Ramadas, Jamie F Chriqui

Open Access Publications

No abstract provided.

Chemical Inhibition Of Papd5/7 Rescues Telomerase Function And Hematopoiesis In Dyskeratosis Congenita, Siddharth Shukla, Ho-Chang Jeong, Christopher M. Sturgeon, Roy Parker, Luis Francisco Zirnberger Batista

Open Access Publications

No abstract provided.

A Systematic Review Examining Associations Between Cardiovascular Conditions And Driving Outcomes Among Older Drivers, Ganesh M Babulal, Ramana Kolady, Sarah H Stout, Catherine M Roe

Open Access Publications

There is a vast literature on stroke as a cardiovascular disease and driving outcomes, however little is known about other cardiovascular conditions and driving. The purpose of this review is to examine the literature for studies assessing the effect of non-stroke, vascular conditions on daily driving, reported crash risk and driving decline in older adult drivers as captured by naturalistic methodologies. A systematic review of Embase, Ovid and Scopus Plus examined articles on driving and vascular conditions among older adults. A search yielded 443 articles and, following two screenings, no articles remained that focused on non-stroke, vascular conditions and naturalistic …

Alterations In Plasma Triglycerides And Ceramides: Links With Cardiac Function In Humans With Type 2 Diabetes, Linda R. Peterson, Xuntian Jiang, Ling Chen, Anne C. Goldberg, Marsha S. Farmer, Daniel S. Ory, Jean E. Schaffer

Open Access Publications

No abstract provided.

A Role For Malignant Brain Tumor Domain-Containing Protein 1 In Human Endometrial Stromal Cell Decidualization, Sangappa B Chadchan, Vineet K Maurya, Gwendalyn L Krekeler, Emily S Jungheim, Ramakrishna Kommagani

Open Access Publications

Up to 30% of women experience early miscarriage due to impaired decidualization. For implantation to occur, the uterine endometrial stromal fibroblast-like cells must differentiate into decidual cells, but the genes required for decidualization have not been fully defined. Here, we show that Malignant Brain Tumor Domain-containing Protein 1 (MBTD1), a member of the polycomb group protein family, is critical for human endometrial stromal cell (HESC) decidualization. MBTD1 predominantly localized to HESCs during the secretory phase and the levels were significantly elevated during

The Tethering Function Of Mitofusin2 Controls Osteoclast Differentiation By Modulating The Ca2+–Nfatc1 Axis, Anna Ballard, Rong Zeng, Allahdad Zarei, Christine Shao, Linda Cox, Hui Yan, Antonietta Franco, Gerald W. Dorn Ii, Roberta Faccio, Deborah J. Veis

Open Access Publications

No abstract provided.

A Prospective Study Of Weight Gain In Women Diagnosed With Early-Stage Invasive Breast Cancer, Ductal Carcinoma In Situ, And Women Without Breast Cancer, Christine C. Ekenga, Xiaoyan Wang, Maria Pérez, Mario Schootman, Donna B. Jeffe

Open Access Publications

No abstract provided.

Revisiting The Spectrum Of Bladder Health: Relationships Between Lower Urinary Tract Symptoms And Multiple Measures Of Well-Being, Siobhan Sutcliffe, Charles Cain, Tamara Bavendam, C. Neill Epperson, Colleen M. Fitzgerald, Sheila Gahagan, Alayne D. Markland, David A. Shoham, Ariana L. Smith, Kyle Rudser, Prevention Of Lower Urinary Tract Symptoms Research Consortium

Open Access Publications

No abstract provided.

Impact Of Gender And Caregiving Responsibilities On Academic Success In Hematology, Allison A. King, Sara K. Vesely, Emily Vettese, Sadie Cook, Adam Cuker, Wendy Stock, Morgan Homer, Josel Fritz, Lilian Sung

Open Access Publications

No abstract provided.

Effects Of Remote Limb Ischemic Conditioning On Muscle Strength In Healthy Young Adults: A Randomized Controlled Trial, Swati M. Surkar, Marghuretta D. Bland, Anna E. Mattlage, Ling Chen, Jeffrey M. Gidday, Jin-Moo Lee, Tamara Hershey, Catherine E. Lang

Open Access Publications

Remote limb ischemic conditioning (RLIC) is a clinically feasible method in which brief, sub-lethal bouts of ischemia protects remote organs or tissues from subsequent ischemic injury. A single session of RLIC can improve exercise performance and increase muscle activation. The purpose of this study, therefore, was to assess the effects of a brief, two-week protocol of repeated RLIC combined with strength training on strength gain and neural adaptation in healthy young adults. Participants age 18-40 years were randomized to receive either RLIC plus strength training (n = 15) or sham conditioning plus strength training (n = 15). Participants received RLIC …

Refined National Institutes Of Health Response Algorithm For Chronic Graft-Versus-Host Disease In Joints And Fascia, Yoshihiro Inamoto, Stephanie J. Lee, Lynn E. Onstad, Mary E.D. Flowers, Betty K. Hamilton, Madan H. Jagasia, Paul J. Martin, Steven Z. Pavletic, Joseph A. Pidala, Iskra Pusic, Georgia B. Vogelsang, Daniel Wolff, Paul A. Carpenter

Open Access Publications

No abstract provided.

Uncovering Tumour Heterogeneity Through Pkr And Nc886 Analysis In Metastatic Colon Cancer Patients Treated With 5-Fu-Based Chemotherapy, María Belén Ortega-García, Igor Zwir, Et Al

Open Access Publications

Colorectal cancer treatment has advanced over the past decade. The drug 5-fluorouracil is still used with a wide percentage of patients who do not respond. Therefore, a challenge is the identification of predictive biomarkers. The protein kinase R (PKR also called EIF2AK2) and its regulator, the non-coding pre-mir-nc886, have multiple effects on cells in response to numerous types of stress, including chemotherapy. In this work, we performed an ambispective study with 197 metastatic colon cancer patients with unresectable metastases to determine the relative expression levels of both nc886 and PKR by qPCR, as well as the location of PKR by …

Photoreceptor Responses To Light In The Pathogenesis Of Diabetic Retinopathy, Shahriyar P Majidi, Rithwick Rajagopal

Open Access Publications

Vision loss, among the most feared complications of diabetes, is primarily caused by diabetic retinopathy, a disease that manifests in well-recognized, characteristic microvascular lesions. The reasons for retinal susceptibility to damage in diabetes are unclear, especially considering that microvascular networks are found in all tissues. However, the unique metabolic demands of retinal neurons could account for their vulnerability in diabetes. Photoreceptors are the first neurons in the visual circuit and are also the most energy-demanding cells of the retina. Here, we review experimental and clinical evidence linking photoreceptors to the development of diabetic retinopathy. We then describe the influence of …

Bet Bromodomain Inhibition Attenuates Cardiac Phenotype In Myocyte-Specific Lamin A/C-Deficient Mice, Gaelle Auguste, Leila Rouhi, Scot J Matkovich, Cristian Coarfa, Matthew J Robertson, Grazyna Czernuszewicz, Priyatansh Gurha, Ali J Marian

Open Access Publications

Mutation in the LMNA gene, encoding lamin A/C, causes a diverse group of diseases called laminopathies. Cardiac involvement is the major cause of death and manifests as dilated cardiomyopathy, heart failure, arrhythmias, and sudden death. There is no specific therapy for LMNA-associated cardiomyopathy. We report that deletion of Lmna in cardiomyocytes in mice leads to severe cardiac dysfunction, conduction defect, ventricular arrhythmias, fibrosis, apoptosis, and premature death within 4 weeks. The phenotype is similar to LMNA-associated cardiomyopathy in humans. RNA sequencing, performed before the onset of cardiac dysfunction, led to identification of 2338 differentially expressed genes (DEGs) in Lmna-deleted cardiomyocytes. …

Development And Evaluation Of A Computerized Clinical Outcome Assessment Tool For Head And Neck Cancer Patients, Ching-Rong Lin, Kang-Hsing Fan, Chien-Yu Lin, Tsung-Min Hung, Bing-Shen Huang, Eric Yen-Chao Chen, Chung-Jan Kang, Shiang-Fu Huang, Joseph Tung-Chieh Chang, Chih-Hung Chang

Open Access Publications

No abstract provided.

Effects Of Hypoxic And Ischemic Clinical Conditions On The Outcomes Of Acute Ischemic Stroke Patients, Umeshkumar Athiraman, Rene Tempelhoff, Menelaos Karanikolas

Open Access Publications

No abstract provided.

Deficiency Of Peroxiredoxin 2 Exacerbates Angiotensin Ii-Induced Abdominal Aortic Aneurysm, Se-Jin Jeong, Min Ji Cho, Na Young Ko, Sinai Kim, In-Hyuk Jung, Jeong-Ki Min, Sang Hak Lee, Jong-Gil Park, Goo Taeg Oh

Open Access Publications

No abstract provided.

Technical Note: Comparison Of The Internal Target Volume (Itv) Contours And Dose Calculations On 4dct, Average Cbct, And 4dcbct Imaging For Lung Stereotactic Body Radiation Therapy (Sbrt), Michael Dumas, Eric Laugeman, Parag Sevak, Karen C Snyder, Weihua Mao, Indrin J Chetty, Munther Ajlouni, Ning Wen

Open Access Publications

PURPOSE: To investigate the differences between internal target volumes (ITVs) contoured on the simulation 4DCT and daily 4DCBCT images for lung cancer patients treated with stereotactic body radiotherapy (SBRT) and determine the dose delivered on 4D planning technique.

METHODS: For nine patients, 4DCBCTs were acquired before each fraction to assess tumor motion. An ITV was contoured on each phase of the 4DCBCT and a union of the 10 ITVs was used to create a composite ITV. Another ITV was drawn on the average 3DCBCT (avgCBCT) to compare with current clinical practice. The Dice coefficient, Hausdorff distance, and center of mass …

Neutrophil Swarming Delays The Growth Of Clusters Of Pathogenic Fungi, Alex Hopke, Allison Scherer, Samantha Kreuzburg, Michael S. Abers, Christa S. Zerbe, Mary C. Dinauer, Michael K. Mansour, Daniel Irimia

Open Access Publications

No abstract provided.

Subsequent Neoplasms And Late Mortality In Children Undergoing Allogeneic Transplantation For Nonmalignant Diseases, Justine M. Kahn, Robert J. Hayashi, Et Al.

Open Access Publications

No abstract provided.

Contraception Provision In The Emergency Department: Are We Ready To Overcome The Obstacles?, Kayleigh Fischer, Lauren S. Chernick

Open Access Publications

No abstract provided.

Maternal Race/Ethnicity And Postpartum Diabetes Screening: A Systematic Review And Meta-Analysis, Cynthia J. Herrick, Ritika Puri, Rana Rahaman, Angela Hardi, Karyn Stewart, Graham A. Colditz

Open Access Publications

No abstract provided.