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Articles 931 - 960 of 4253
Full-Text Articles in Entire DC Network
Huntingtin-Interacting Protein Family Members Have A Conserved Pro-Viral Function From Caenorhabditis Elegans To Humans, Hongbing Jiang, Luis Enrique Sandoval Del Prado, Christian Leung, David Wang
Huntingtin-Interacting Protein Family Members Have A Conserved Pro-Viral Function From Caenorhabditis Elegans To Humans, Hongbing Jiang, Luis Enrique Sandoval Del Prado, Christian Leung, David Wang
Open Access Publications
No abstract provided.
Discovery Of A Novel Simian Pegivirus In Common Marmosets (Callithrix Jacchus) With Lymphocytic Enterocolitis, Anna S. Heffron, Michael Lauck, Elizabeth D. Somsen, Elizabeth C. Townsend, Adam L. Bailey, Megan Sosa, Jens Eickhoff, Saverio Capuano Iii, Christina M. Newman, Jens H. Kuhn, Andres Mejia, Heather A. Simmons, David H. O'Connor
Discovery Of A Novel Simian Pegivirus In Common Marmosets (Callithrix Jacchus) With Lymphocytic Enterocolitis, Anna S. Heffron, Michael Lauck, Elizabeth D. Somsen, Elizabeth C. Townsend, Adam L. Bailey, Megan Sosa, Jens Eickhoff, Saverio Capuano Iii, Christina M. Newman, Jens H. Kuhn, Andres Mejia, Heather A. Simmons, David H. O'Connor
Open Access Publications
No abstract provided.
Mitochondrial Calcium Uniporter (Mcu) Defciency Reveals An Alternate Path For Ca2+ Uptake In Photoreceptor Mitochondria, Celia M. Bisbach, Rachel A. Hutto, Deepak Poria, Whitney M. Cleghorn, Fatima Abbas, Frans Vinberg, Vladimir J. Kefalov, James B. Hurley, Susan E. Brockerhoff
Mitochondrial Calcium Uniporter (Mcu) Defciency Reveals An Alternate Path For Ca2+ Uptake In Photoreceptor Mitochondria, Celia M. Bisbach, Rachel A. Hutto, Deepak Poria, Whitney M. Cleghorn, Fatima Abbas, Frans Vinberg, Vladimir J. Kefalov, James B. Hurley, Susan E. Brockerhoff
Open Access Publications
No abstract provided.
Six-Year Follow-Up Of A Trial Of Antenatal Vitamin D For Asthma Reduction, Augusto A. Litonjua, Vincent J. Carey, Nancy Laranjo, Benjamin J. Stubbs, Hooman Mirzakhani, George T. O'Connor, Megan Sandel, Avraham Beigelman, Leonard B. Bacharier, Robert S. Zeiger, Michael Schatz, Bruce W. Hollis, Scott T. Weiss
Six-Year Follow-Up Of A Trial Of Antenatal Vitamin D For Asthma Reduction, Augusto A. Litonjua, Vincent J. Carey, Nancy Laranjo, Benjamin J. Stubbs, Hooman Mirzakhani, George T. O'Connor, Megan Sandel, Avraham Beigelman, Leonard B. Bacharier, Robert S. Zeiger, Michael Schatz, Bruce W. Hollis, Scott T. Weiss
Open Access Publications
No abstract provided.
Self-Reported Sleep Disturbance In Crohn’S Disease Is Not Confrmed By Objective Sleep Measures, Heba N. Iskandar, Emily E. Linan, Ami Patel, Renee Moore, Yi Lasanajak, C. Prakash Gyawali, Gregory S. Sayuk, Matthew A. Ciorba
Self-Reported Sleep Disturbance In Crohn’S Disease Is Not Confrmed By Objective Sleep Measures, Heba N. Iskandar, Emily E. Linan, Ami Patel, Renee Moore, Yi Lasanajak, C. Prakash Gyawali, Gregory S. Sayuk, Matthew A. Ciorba
Open Access Publications
No abstract provided.
Generation Of Light-Producing Somatic-Transgenic Mice Using Adeno-Associated Virus Vectors, Rajvinder Karda, Jonathan D. Cooper, Et Al.
Generation Of Light-Producing Somatic-Transgenic Mice Using Adeno-Associated Virus Vectors, Rajvinder Karda, Jonathan D. Cooper, Et Al.
Open Access Publications
No abstract provided.
Lack Of Neurosteroid Selectivity At Δ Vs. Γ2-Containing Gabaa Receptors In Dentate Granule Neurons, Xinguo Lu, Charles F Zorumski, Steven Mennerick
Lack Of Neurosteroid Selectivity At Δ Vs. Γ2-Containing Gabaa Receptors In Dentate Granule Neurons, Xinguo Lu, Charles F Zorumski, Steven Mennerick
Open Access Publications
GABA
Inducible Expression Of Wnt7b Promotes Bone Formation In Aged Mice And Enhances Fracture Healing, Deye Song, Guangxu He, Fangfang Song, Zhepeng Wang, Xiaochen Liu, Lele Liao, Jiangdong Ni, Matthew J. Silva, Fanxin Long
Inducible Expression Of Wnt7b Promotes Bone Formation In Aged Mice And Enhances Fracture Healing, Deye Song, Guangxu He, Fangfang Song, Zhepeng Wang, Xiaochen Liu, Lele Liao, Jiangdong Ni, Matthew J. Silva, Fanxin Long
Open Access Publications
No abstract provided.
Improved Small Blob Detection In 3d Images Using Jointly Constrained Deep Learning And Hessian Analysis, Yanzhe Xu, Teresa Wu, Fei Gao, Jennifer R. Charlton, Kevin M. Bennett
Improved Small Blob Detection In 3d Images Using Jointly Constrained Deep Learning And Hessian Analysis, Yanzhe Xu, Teresa Wu, Fei Gao, Jennifer R. Charlton, Kevin M. Bennett
Open Access Publications
No abstract provided.
Five-Year Outcomes Of Transcatheter Or Surgical Aortic-Valve Replacement, Raj R. Makkar, Alan Zajarias, Et Al.
Five-Year Outcomes Of Transcatheter Or Surgical Aortic-Valve Replacement, Raj R. Makkar, Alan Zajarias, Et Al.
Open Access Publications
No abstract provided.
Anellovirus Dynamics Are Associated With Primary Graft Dysfunction In Lung Transplantation, Joshua A. Blatter, Tsuyoshi Takahashi, Brigitte Mittler, Ruben G. Nava, Varun Puri, Daniel Kreisel, David Wang
Anellovirus Dynamics Are Associated With Primary Graft Dysfunction In Lung Transplantation, Joshua A. Blatter, Tsuyoshi Takahashi, Brigitte Mittler, Ruben G. Nava, Varun Puri, Daniel Kreisel, David Wang
Open Access Publications
No abstract provided.
Inhibition Of Grb14, A Negative Modulator Of Insulin Signaling, Improves Glucose Homeostasis Without Causing Cardiac Dysfunction, Xunshan Ding, Rugmani Iyer, Christopher Novotny, Daniel Metzger, Heather H. Zhou, Gordon I. Smith, Mihoko Yoshino, Jun Yoshino, Samuel Klein, Gayathri Swaminath, Saswata Talukdar, Yingjiang Zhou
Inhibition Of Grb14, A Negative Modulator Of Insulin Signaling, Improves Glucose Homeostasis Without Causing Cardiac Dysfunction, Xunshan Ding, Rugmani Iyer, Christopher Novotny, Daniel Metzger, Heather H. Zhou, Gordon I. Smith, Mihoko Yoshino, Jun Yoshino, Samuel Klein, Gayathri Swaminath, Saswata Talukdar, Yingjiang Zhou
Open Access Publications
No abstract provided.
Live Neuron High-Content Screening Reveals Synaptotoxic Activity In Alzheimer Mouse Model Homogenates, Hao Jiang, Thomas J. Esparza, Terrance T. Kummer, Haining Zhong, Jens Rettig, David L. Brody
Live Neuron High-Content Screening Reveals Synaptotoxic Activity In Alzheimer Mouse Model Homogenates, Hao Jiang, Thomas J. Esparza, Terrance T. Kummer, Haining Zhong, Jens Rettig, David L. Brody
Open Access Publications
No abstract provided.
Comparison Of Three Magnetization Transfer Ratio Parameters For Assessment Of Intestinal Fibrosis In Patients With Crohn’S Disease, Jixin Meng, Siyun Huang, Canhui Sun, Zhong-Wei Zhang, Ren Mao, Yan-Hong Yang, Shi-Ting Feng, Zi-Ping Li, Xuehua Li
Comparison Of Three Magnetization Transfer Ratio Parameters For Assessment Of Intestinal Fibrosis In Patients With Crohn’S Disease, Jixin Meng, Siyun Huang, Canhui Sun, Zhong-Wei Zhang, Ren Mao, Yan-Hong Yang, Shi-Ting Feng, Zi-Ping Li, Xuehua Li
Open Access Publications
No abstract provided.
Remethylation Of Dnmt3a−/− Hematopoietic Cells Is Associated With Partial Correction Of Gene Dysregulation And Reduced Myeloid Skewing, Shamika Ketkar, Angela M. Verdoni, Amanda M. Smith, Celia V. Bangert, Elizabeth R. Leight, David Y. Chen, Meryl K. Brune, Nichole M. Helton, Mieke Hoock, Daniel R. George, Catrina Fronick, Robert S. Fulton, Sai Mukund Ramakrishnan, Gue Su Chang, Allegra A. Petti, David H. Spencer, Christopher A. Miller, Timothy J. Ley
Remethylation Of Dnmt3a−/− Hematopoietic Cells Is Associated With Partial Correction Of Gene Dysregulation And Reduced Myeloid Skewing, Shamika Ketkar, Angela M. Verdoni, Amanda M. Smith, Celia V. Bangert, Elizabeth R. Leight, David Y. Chen, Meryl K. Brune, Nichole M. Helton, Mieke Hoock, Daniel R. George, Catrina Fronick, Robert S. Fulton, Sai Mukund Ramakrishnan, Gue Su Chang, Allegra A. Petti, David H. Spencer, Christopher A. Miller, Timothy J. Ley
Open Access Publications
No abstract provided.
Exercise Training Results In Lower Amyloid Plaque Load And Greater Cognitive Function In An Intensity Dependent Manner In The Tg2576 Mouse Model Of Alzheimer's Disease, Riya Thomas, Scott D Zimmerman, Kayla M Yuede, John R Cirrito, Leon M Tai, Benjamin F Timson, Carla M Yuede
Exercise Training Results In Lower Amyloid Plaque Load And Greater Cognitive Function In An Intensity Dependent Manner In The Tg2576 Mouse Model Of Alzheimer's Disease, Riya Thomas, Scott D Zimmerman, Kayla M Yuede, John R Cirrito, Leon M Tai, Benjamin F Timson, Carla M Yuede
Open Access Publications
Three months of exercise training (ET) decreases soluble Aβ
Nutrition In Necrotizing Enterocolitis And Following Intestinal Resection, Jocelyn Ou, Cathleen M Courtney, Allie E Steinberger, Maria E Tecos, Brad W Warner
Nutrition In Necrotizing Enterocolitis And Following Intestinal Resection, Jocelyn Ou, Cathleen M Courtney, Allie E Steinberger, Maria E Tecos, Brad W Warner
Open Access Publications
This review aims to discuss the role of nutrition and feeding practices in necrotizing enterocolitis (NEC), NEC prevention, and its complications, including surgical treatment. A thorough PubMed search was performed with a focus on meta-analyses and randomized controlled trials when available. There are several variables in nutrition and the feeding of preterm infants with the intention of preventing necrotizing enterocolitis (NEC). Starting feeds later rather than earlier, advancing feeds slowly and continuous feeds have not been shown to prevent NEC and breast milk remains the only effective prevention strategy. The lack of medical treatment options for NEC often leads to …
A Single-Nucleotide Polymorphism In A Plasmodium Berghei Apiap2 Transcription Factor Alters The Development Of Host Immunity, Munir Akkaya, Patrick W Sheehan, Et Al
A Single-Nucleotide Polymorphism In A Plasmodium Berghei Apiap2 Transcription Factor Alters The Development Of Host Immunity, Munir Akkaya, Patrick W Sheehan, Et Al
Open Access Publications
The acquisition of malaria immunity is both remarkably slow and unpredictable. At present, we know little about the malaria parasite genes that influence the host's ability to mount a protective immune response. Here, we show that a single-nucleotide polymorphism (SNP) resulting in a single amino acid change (S to F) in an ApiAP2 transcription factor in the rodent malaria parasite
Mirna-Based Rapid Differentiation Of Purified Neurons From Hpscs Advancestowards Quick Screening For Neuronal Disease Phenotypes In Vitro, Mitsuru Ishikawa, Takeshi Aoyama, Shoichiro Shibata, Takefumi Sone, Hiroyuki Miyoshi, Hirotaka Watanabe, Mari Nakamura, Saori Morota, Hiroyuki Uchino, Andrew S Yoo, Hideyuki Okano
Mirna-Based Rapid Differentiation Of Purified Neurons From Hpscs Advancestowards Quick Screening For Neuronal Disease Phenotypes In Vitro, Mitsuru Ishikawa, Takeshi Aoyama, Shoichiro Shibata, Takefumi Sone, Hiroyuki Miyoshi, Hirotaka Watanabe, Mari Nakamura, Saori Morota, Hiroyuki Uchino, Andrew S Yoo, Hideyuki Okano
Open Access Publications
Obtaining differentiated cells with high physiological functions by an efficient, but simple and rapid differentiation method is crucial for modeling neuronal diseases in vitro using human pluripotent stem cells (hPSCs). Currently, methods involving the transient expression of one or a couple of transcription factors have been established as techniques for inducing neuronal differentiation in a rapid, single step. It has also been reported that microRNAs can function as reprogramming effectors for directly reprogramming human dermal fibroblasts to neurons. In this study, we tested the effect of adding neuronal microRNAs, miRNA-9/9*, and miR-124 (miR-9/9*-124), for the neuronal induction method of hPSCs …
A Spinal Neural Circuitry For Converting Touch To Itch Sensation, Sihan Chen, Xiao-Fei Gao, Yuxi Zhou, Ben-Long Liu, Xian-Yu Liu, Yufen Zhang, Devin M. Barry, Kun Liu, Yingfu Jiao, Rita Bardoni, Weifeng Yu, Zhou-Feng Chen
A Spinal Neural Circuitry For Converting Touch To Itch Sensation, Sihan Chen, Xiao-Fei Gao, Yuxi Zhou, Ben-Long Liu, Xian-Yu Liu, Yufen Zhang, Devin M. Barry, Kun Liu, Yingfu Jiao, Rita Bardoni, Weifeng Yu, Zhou-Feng Chen
Open Access Publications
No abstract provided.
Altered Outer Hair Cell Mitochondrial And Subsurface Cisternae Connectomics Are Candidate Mechanisms For Hearing Loss In Mice, Guy Perkins, Jeong Han Lee, Seojin Park, Mincheol Kang, Maria C. Perez-Flores, Saeyeon Ju, Grady Phillips, Anna Lysakowski, Michael Anne Gratton, Ebenezer N. Yamoah
Altered Outer Hair Cell Mitochondrial And Subsurface Cisternae Connectomics Are Candidate Mechanisms For Hearing Loss In Mice, Guy Perkins, Jeong Han Lee, Seojin Park, Mincheol Kang, Maria C. Perez-Flores, Saeyeon Ju, Grady Phillips, Anna Lysakowski, Michael Anne Gratton, Ebenezer N. Yamoah
Open Access Publications
Organelle crosstalk is vital for cellular functions. The propinquity of mitochondria, ER, and plasma membrane promote regulation of multiple functions, which include intracellular Ca
Myd88-Dependent Influx Of Monocytes And Neutrophils Impairs Lymph Node B Cell Responses To Chikungunya Virus Infection Via Irf5, Nos2 And Nox2, Mary K. Mccarthy, Glennys V. Reynoso, Emma S. Winkler, Matthias Mack, Michael S. Diamond, Heather D. Hickman, Thomas E. Morrison
Myd88-Dependent Influx Of Monocytes And Neutrophils Impairs Lymph Node B Cell Responses To Chikungunya Virus Infection Via Irf5, Nos2 And Nox2, Mary K. Mccarthy, Glennys V. Reynoso, Emma S. Winkler, Matthias Mack, Michael S. Diamond, Heather D. Hickman, Thomas E. Morrison
Open Access Publications
Humoral immune responses initiate in the lymph node draining the site of viral infection (dLN). Some viruses subvert LN B cell activation; however, our knowledge of viral hindrance of B cell responses of important human pathogens is lacking. Here, we define mechanisms whereby chikungunya virus (CHIKV), a mosquito-transmitted RNA virus that causes outbreaks of acute and chronic arthritis in humans, hinders dLN antiviral B cell responses. Infection of WT mice with pathogenic, but not acutely cleared CHIKV, induced MyD88-dependent recruitment of monocytes and neutrophils to the dLN. Blocking this influx improved lymphocyte accumulation, dLN organization, and CHIKV-specific B cell responses. …
Satellite Glial Cells Promote Regenerative Growth In Sensory Neurons, Oshri Avraham, Pan-Yue Deng, Sara Jones, Rejji Kuruvilla, Clay F. Semenkovich, Vitaly A. Klyachko, Valeria Cavalli
Satellite Glial Cells Promote Regenerative Growth In Sensory Neurons, Oshri Avraham, Pan-Yue Deng, Sara Jones, Rejji Kuruvilla, Clay F. Semenkovich, Vitaly A. Klyachko, Valeria Cavalli
Open Access Publications
No abstract provided.
Site-Specific Effects Of Neurosteroids On Gaba(A) Receptor Activation And Desensitization, Yusuke Sugasawa, Wayland W.L. Cheng, John R. Bracamontes, Zi-Wei Chen, Lei Wang, Allison L. Germann, Spencer R. Pierce, Thomas C. Senneff, Kathiresan Krishnan, David E. Reichert, Douglas F. Covey, Gustav Akk, Alex S. Evers
Site-Specific Effects Of Neurosteroids On Gaba(A) Receptor Activation And Desensitization, Yusuke Sugasawa, Wayland W.L. Cheng, John R. Bracamontes, Zi-Wei Chen, Lei Wang, Allison L. Germann, Spencer R. Pierce, Thomas C. Senneff, Kathiresan Krishnan, David E. Reichert, Douglas F. Covey, Gustav Akk, Alex S. Evers
Open Access Publications
This study examines how site-specific binding to three identified neurosteroid-binding sites in the α
The Probable, Possible, And Novel Functions Of Erp29, Margaret Brecker, Svetlana Khakhina, Tyler J Schubert, Zachary Thompson, Ronald C Rubenstein
The Probable, Possible, And Novel Functions Of Erp29, Margaret Brecker, Svetlana Khakhina, Tyler J Schubert, Zachary Thompson, Ronald C Rubenstein
Open Access Publications
The luminal endoplasmic reticulum (ER) protein of 29 kDa (ERp29) is a ubiquitously expressed cellular agent with multiple critical roles. ERp29 regulates the biosynthesis and trafficking of several transmembrane and secretory proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR), the epithelial sodium channel (ENaC), thyroglobulin, connexin 43 hemichannels, and proinsulin. ERp29 is hypothesized to promote ER to
Braf Alteration In Central And Peripheral Nervous System Tumors, Komal Srinivasa, Kevin A Cross, Sonika Dahiya
Braf Alteration In Central And Peripheral Nervous System Tumors, Komal Srinivasa, Kevin A Cross, Sonika Dahiya
Open Access Publications
No abstract provided.
Viral-Immune Cell Interactions At The Maternal-Fetal Interface In Human Pregnancy, Elaine L Parker, Rachel B Silverstein, Sonam Verma, Indira U Mysorekar
Viral-Immune Cell Interactions At The Maternal-Fetal Interface In Human Pregnancy, Elaine L Parker, Rachel B Silverstein, Sonam Verma, Indira U Mysorekar
Open Access Publications
The human decidua and placenta form a distinct environment distinguished for its promotion of immunotolerance to infiltrating semiallogeneic trophoblast cells to enable successful pregnancy. The maternal-fetal interface also successfully precludes transmission of most pathogens. This barrier function occurs in conjunction with a diverse influx of decidual immune cells including natural killer cells, macrophages and T cells. However, several viruses, among other microorganisms, manage to escape destruction by the host adaptive and innate immune system, leading to congenital infection and adverse pregnancy outcomes. In this review, we describe mechanisms of pathogenicity of two such viral pathogens, Human cytomegalovirus (HCMV) and Zika …
Lung Secretoglobin Scgb1a1 Influences Alveolar Macrophage-Mediated Inflammation And Immunity, Min Xu, Wei Yang, Xuanchuan Wang, Deepak Kumar Nayak
Lung Secretoglobin Scgb1a1 Influences Alveolar Macrophage-Mediated Inflammation And Immunity, Min Xu, Wei Yang, Xuanchuan Wang, Deepak Kumar Nayak
Open Access Publications
Alveolar macrophage (AM) is a mononuclear phagocyte key to the defense against respiratory infections. To understand AM's role in airway disease development, we examined the influence of Secretoglobin family 1a member 1 (SCGB1A1), a pulmonary surfactant protein, on AM development and function. In a murine model, high-throughput RNA-sequencing and gene expression analyses were performed on purified AMs isolated from mice lacking in
Characterization Of The Complete Mitochondrial Genomes Of Two Sibling Species Of Parasitic Roundworms, Haemonchus Contortus And Teladorsagia Circumcincta, Nikola Palevich, Paul H Maclean, Young-Jun Choi, Makedonka Mitreva
Characterization Of The Complete Mitochondrial Genomes Of Two Sibling Species Of Parasitic Roundworms, Haemonchus Contortus And Teladorsagia Circumcincta, Nikola Palevich, Paul H Maclean, Young-Jun Choi, Makedonka Mitreva
Open Access Publications
No abstract provided.
Phase I Study Of Vemurafenib In Children With Recurrent Or Progressive Brafv600e Mutant Brain Tumors: Pacific Pediatric Neuro-Oncology Consortium Study (Pnoc-002), Theodore Nicolaides, Karen Gauvain, Et Al
Phase I Study Of Vemurafenib In Children With Recurrent Or Progressive Brafv600e Mutant Brain Tumors: Pacific Pediatric Neuro-Oncology Consortium Study (Pnoc-002), Theodore Nicolaides, Karen Gauvain, Et Al
Open Access Publications
No abstract provided.