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Articles 3271 - 3300 of 4253
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Interaction Of Card With Rna Polymerase Mediates Mycobacterium Tuberculosis Viability, Rifampin Resistance, And Pathogenesis, Leslie A. Weiss, Phillip G. Harrison, Bryce E. Nickels, Michael S. Glickman, Elizabeth A. Campbell, Seth A. Darst, Christina L. Stallings
Interaction Of Card With Rna Polymerase Mediates Mycobacterium Tuberculosis Viability, Rifampin Resistance, And Pathogenesis, Leslie A. Weiss, Phillip G. Harrison, Bryce E. Nickels, Michael S. Glickman, Elizabeth A. Campbell, Seth A. Darst, Christina L. Stallings
Open Access Publications
No abstract provided.
Β-Cell Metabolic Alterations Under Chronic Nutrient Overload In Rat And Human Islets, Stephanie Vernier, Angela Chiu, Joseph Schober, Theresa Weber, Phuong Nguyen, Mark Luer, Timothy Mcpherson, Paul E. Wanda, Connie A. Marshall, Nidhi Rohatgi, Michael L. Mcdaniel, Andrew S. Greenberg, Guim Kwon
Β-Cell Metabolic Alterations Under Chronic Nutrient Overload In Rat And Human Islets, Stephanie Vernier, Angela Chiu, Joseph Schober, Theresa Weber, Phuong Nguyen, Mark Luer, Timothy Mcpherson, Paul E. Wanda, Connie A. Marshall, Nidhi Rohatgi, Michael L. Mcdaniel, Andrew S. Greenberg, Guim Kwon
Open Access Publications
No abstract provided.
The New Nucleoporin: Regulator Of Transcriptional Repression And Beyond, Nayan J. Sarma, Kristine Willis
The New Nucleoporin: Regulator Of Transcriptional Repression And Beyond, Nayan J. Sarma, Kristine Willis
Open Access Publications
No abstract provided.
Cross-Priming For Antitumor Ctl Induced By Soluble Ag + Polyi:C Depends On The Ticam-1 Pathway In Mouse Cd11c+ /Cd8Α+ Dendritic Cells, Masahiro Azuma, Takashi Ebihara, Hiroyuki Oshiumi, Misako Matsumoto, Tsukasa Seya
Cross-Priming For Antitumor Ctl Induced By Soluble Ag + Polyi:C Depends On The Ticam-1 Pathway In Mouse Cd11c+ /Cd8Α+ Dendritic Cells, Masahiro Azuma, Takashi Ebihara, Hiroyuki Oshiumi, Misako Matsumoto, Tsukasa Seya
Open Access Publications
No abstract provided.
Immune Modulation By Group B Streptococcus Influences Host Susceptibility To Urinary Tract Infection By Uropathogenic Escherichia Coli, Kimberly A. Kline, Drew J. Schwartz, Nicole M. Gilbert, Scott J. Hultgren, Amanda L. Lewis
Immune Modulation By Group B Streptococcus Influences Host Susceptibility To Urinary Tract Infection By Uropathogenic Escherichia Coli, Kimberly A. Kline, Drew J. Schwartz, Nicole M. Gilbert, Scott J. Hultgren, Amanda L. Lewis
Open Access Publications
No abstract provided.
Differential Replication Of Pathogenic And Nonpathogenic Strains Of West Nile Virus Within Astrocytes, Katherine L. Hussmann, Melanie A. Samuel, Kwang S. Kim, Michael S. Diamond, Brenda L. Fredericksen
Differential Replication Of Pathogenic And Nonpathogenic Strains Of West Nile Virus Within Astrocytes, Katherine L. Hussmann, Melanie A. Samuel, Kwang S. Kim, Michael S. Diamond, Brenda L. Fredericksen
Open Access Publications
No abstract provided.
No Evidence Of Xenotropic Murine Leukemia Virus-Related Virus Transmission By Blood Transfusion From Infected Rhesus Macaques, Dhanya K. Williams, Teresa A. Galvin, Yamei Gao, Christina O'Neill, Dustin Glasner, Arifa S. Khan
No Evidence Of Xenotropic Murine Leukemia Virus-Related Virus Transmission By Blood Transfusion From Infected Rhesus Macaques, Dhanya K. Williams, Teresa A. Galvin, Yamei Gao, Christina O'Neill, Dustin Glasner, Arifa S. Khan
Open Access Publications
No abstract provided.
Essential Cell-Autonomous Role For Interferon (Ifn) Regulatory Factor 1 In Ifn-Γ-Mediated Inhibition Of Norovirus Replication In Macrophages, Nicole S. Maloney, Larissa B. Thackray, Gautam Goel, Seungmin Hwang, Erning Duan, Punit Vachharajani, Ramnik Xavier, Herbert W. Virgin
Essential Cell-Autonomous Role For Interferon (Ifn) Regulatory Factor 1 In Ifn-Γ-Mediated Inhibition Of Norovirus Replication In Macrophages, Nicole S. Maloney, Larissa B. Thackray, Gautam Goel, Seungmin Hwang, Erning Duan, Punit Vachharajani, Ramnik Xavier, Herbert W. Virgin
Open Access Publications
No abstract provided.
Induction Of Alternatively Activated Macrophages Enhances Pathogenesis During Severe Acute Respiratory Syndrome Coronavirus Infection, Carly Page, Lindsay Golcohea, Krystal Matthews, Yong Zhang, Peter Klover, Michael J. Holtzman, Lothar Hennighausen, Matthew Frieman
Induction Of Alternatively Activated Macrophages Enhances Pathogenesis During Severe Acute Respiratory Syndrome Coronavirus Infection, Carly Page, Lindsay Golcohea, Krystal Matthews, Yong Zhang, Peter Klover, Michael J. Holtzman, Lothar Hennighausen, Matthew Frieman
Open Access Publications
No abstract provided.
Singular Value Decomposition Based Regularization Prior To Spectral Mixing Improves Crosstalk In Dynamic Imaging Using Spectral Diffuse Optical Tomography, Yuxuan Zhan, Adam T. Eggebrecht, Joseph P. Culver, Hamid Dehghani
Singular Value Decomposition Based Regularization Prior To Spectral Mixing Improves Crosstalk In Dynamic Imaging Using Spectral Diffuse Optical Tomography, Yuxuan Zhan, Adam T. Eggebrecht, Joseph P. Culver, Hamid Dehghani
Open Access Publications
No abstract provided.
What's New In Orthopaedic Trauma, William M. Ricci, Christopher Mcandrew, David Merriman, Michael J. Gardner
What's New In Orthopaedic Trauma, William M. Ricci, Christopher Mcandrew, David Merriman, Michael J. Gardner
Open Access Publications
No abstract provided.
In Vivo Microdialysis Reveals Age-Dependent Decrease Of Brain Interstitial Fluid Tau Levels In P301s Human Tau Transgenic Mice, Kaoru Yamada, John R. Cirrito, Floy R. Stewart, Hong Jiang, Mary Beth Finn, Brandon B. Holmes, Lester I. Binder, Eva-Maria Mandelkow, Marc I. Diamond, Virginia M.-Y. Lee, David M. Holtzman
In Vivo Microdialysis Reveals Age-Dependent Decrease Of Brain Interstitial Fluid Tau Levels In P301s Human Tau Transgenic Mice, Kaoru Yamada, John R. Cirrito, Floy R. Stewart, Hong Jiang, Mary Beth Finn, Brandon B. Holmes, Lester I. Binder, Eva-Maria Mandelkow, Marc I. Diamond, Virginia M.-Y. Lee, David M. Holtzman
Open Access Publications
Although tau is a cytoplasmic protein, it is also found in brain extracellular fluids, e.g., CSF. Recent findings suggest that aggregated tau can be transferred between cells and extracellular tau aggregates might mediate spread of tau pathology. Despite these data, details of whether tau is normally released into the brain interstitial fluid (ISF), its concentration in ISF in relation to CSF, and whether ISF tau is influenced by its aggregation are unknown. To address these issues, we developed a microdialysis technique to analyze monomeric ISF tau levels within the hippocampus of awake, freely moving mice. We detected tau in ISF …
Neural Correlates Of Visual–Spatial Attention In Electrocorticographic Signals In Humans, Aysegul Gunduz, Peter Brunner, Amy Daitch, Eric C. Leuthardt, Anthony L. Ritaccio, Bijan Pesaran, Gerwin Schalk
Neural Correlates Of Visual–Spatial Attention In Electrocorticographic Signals In Humans, Aysegul Gunduz, Peter Brunner, Amy Daitch, Eric C. Leuthardt, Anthony L. Ritaccio, Bijan Pesaran, Gerwin Schalk
Open Access Publications
No abstract provided.
Spinal Reconstruction With Pedicle Screw-Based Instrumentation And Rhbmp-2 In Patients With Neurofibromatosis And Severe Dural Ectasia And Spinal Deformity: Report Of Two Cases And A Review Of The Literature, Samuel K. Cho, Geoffrey E. Stoker, Keith H. Bridwell
Spinal Reconstruction With Pedicle Screw-Based Instrumentation And Rhbmp-2 In Patients With Neurofibromatosis And Severe Dural Ectasia And Spinal Deformity: Report Of Two Cases And A Review Of The Literature, Samuel K. Cho, Geoffrey E. Stoker, Keith H. Bridwell
Open Access Publications
No abstract provided.
Ethanol Enhances Neurosteroidogenesis In Hippocampal Pyramidal Neurons By Paradoxical Nmda Receptor Activation, Kazuhiro Tokuda, Yukitoshi Izumi, Charles F. Zorumski
Ethanol Enhances Neurosteroidogenesis In Hippocampal Pyramidal Neurons By Paradoxical Nmda Receptor Activation, Kazuhiro Tokuda, Yukitoshi Izumi, Charles F. Zorumski
Open Access Publications
Using an antibody against 5α-reduced neurosteroids, predominantly allopregnanolone, we found that immunostaining in the CA1 region of rat hippocampal slices was confined to pyramidal neurons. This neurosteroid staining was increased following 15 min administration of 60 mm but not 20 mm ethanol, and the enhancement was blocked by finasteride and dutasteride, selective inhibitors of 5α-reductase, a key enzyme required for allopregnanolone synthesis. Consistent with a prior report indicating that N-methyl-D-aspartate (NMDA) receptor (NMDAR) activation can promote steroid production, we observed that D-2-amino-5-phosphonovalerate (APV), a competitive NMDAR antagonist, blocked the effects of 60 mm ethanol on staining. We previously reported that …
Controlled Cortical Impact Traumatic Brain Injury In 3xtg-Ad Mice Causes Acute Intra-Axonal Amyloid-Β Accumulation And Independently Accelerates The Development Of Tau Abnormalities, Hien T. Tran, Frank M. Laferla, David M. Holtzman, David L. Brody
Controlled Cortical Impact Traumatic Brain Injury In 3xtg-Ad Mice Causes Acute Intra-Axonal Amyloid-Β Accumulation And Independently Accelerates The Development Of Tau Abnormalities, Hien T. Tran, Frank M. Laferla, David M. Holtzman, David L. Brody
Open Access Publications
Alzheimer's disease (AD) is a neurodegenerative disorder characterized pathologically by progressive neuronal loss, extracellular plaques containing the amyloid-β (Aβ) peptides, and neurofibrillary tangles composed of hyperphosphorylated tau proteins. Aβ is thought to act upstream of tau, affecting its phosphorylation and therefore aggregation state. One of the major risk factors for AD is traumatic brain injury (TBI). Acute intra-axonal Aβ and diffuse extracellular plaques occur in ∼30% of human subjects after severe TBI. Intra-axonal accumulations of tau but not tangle-like pathologies have also been found in these patients. Whether and how these acute accumulations contribute to subsequent AD development is not …
Role Of Guanylyl Cyclase Modulation In Mouse Cone Phototransduction, Keisuke Sakurai, Jeannie Chen, Vladimir J. Kefalov
Role Of Guanylyl Cyclase Modulation In Mouse Cone Phototransduction, Keisuke Sakurai, Jeannie Chen, Vladimir J. Kefalov
Open Access Publications
A negative phototransduction feedback in rods and cones is critical for the timely termination of their light responses and for extending their function to a wide range of light intensities. The calcium feedback mechanisms that modulate phototransduction in rods have been studied extensively. However, the corresponding modulation mechanisms that enable cones to terminate rapidly their light responses and to adapt in bright light, properties critical for our daytime vision, are still not understood. In cones, calcium feedback to guanylyl cyclase is potentially a key step in phototransduction modulation. The guanylyl cyclase activity is modulated by the calcium-binding guanylyl cyclase activating …
Dehydroepiandrosterone (Dhea) Replacement Decreases Insulin Resistance And Lowers Inflammatory Cytokines In Aging Humans, Edward P. Weiss, Dennis T. Villareal, Luigi Fontana, Dong-Ho Han, John O. Holloszy
Dehydroepiandrosterone (Dhea) Replacement Decreases Insulin Resistance And Lowers Inflammatory Cytokines In Aging Humans, Edward P. Weiss, Dennis T. Villareal, Luigi Fontana, Dong-Ho Han, John O. Holloszy
Open Access Publications
Plasma dehydroepiandrosterone (DHEA) decreases ~80% between ages 25 and 75 yr. In a preliminary study, we found that 6 mo of DHEA replacement improved insulin action in elderly individuals. The purpose of the present larger, randomized double-blind study was to determine whether a longer period of DHEA replacement improves glucose tolerance. Fifty-seven men and 68 women aged 65 to 75 yr were randomly assigned to 50 mg DHEA or placebo once daily. Year one was a randomized, double blind trial. Year 2 was an open label continuation. DHEA replacement improved glucose tolerance in participants who had abnormal GT initially, reduced …
Congenital Bone Marrow Failure In Dna-Pkcs Mutant Mice Associated With Deficiencies In Dna Repair, Shichuan Zhang, Hirohiko Yajima, Hoangdinh Huynh, Junke Zheng, Elsa Callen, Hua-Tang Chen, Nancy Wong, Samuel Bunting, Yu-Fen Lin, Mengxia Li, Kyung-Jone Lee, Michael Story, Eric Gapud, Barry P. Sleckman, André Nussenzweig, Cheng Cheng Zhang, David J. Chen, Benjamin P.C. Chen
Congenital Bone Marrow Failure In Dna-Pkcs Mutant Mice Associated With Deficiencies In Dna Repair, Shichuan Zhang, Hirohiko Yajima, Hoangdinh Huynh, Junke Zheng, Elsa Callen, Hua-Tang Chen, Nancy Wong, Samuel Bunting, Yu-Fen Lin, Mengxia Li, Kyung-Jone Lee, Michael Story, Eric Gapud, Barry P. Sleckman, André Nussenzweig, Cheng Cheng Zhang, David J. Chen, Benjamin P.C. Chen
Open Access Publications
No abstract provided.
Long-Term Calorie Restriction, But Not Endurance Exercise, Lowers Core Body Temperature In Humans, Andreea Soare, Roberto Cangemi, Daniela Omodei, John O. Holloszy, Luigi Fontana
Long-Term Calorie Restriction, But Not Endurance Exercise, Lowers Core Body Temperature In Humans, Andreea Soare, Roberto Cangemi, Daniela Omodei, John O. Holloszy, Luigi Fontana
Open Access Publications
Reduction of body temperature has been proposed to contribute to the increased lifespan in calorie restricted animals and mice overexpressing the uncoupling protein-2 in hypocretin neurons. However, nothing is known regarding the long-term effects of calorie restriction (CR) with adequate nutrition on body temperature in humans. In this study, 24-hour core body temperature was measured every minute by using ingested telemetric capsules in 24 men and women (mean age 53.7 ± 9.4 yrs) consuming a CR diet for an average of 6 years, 24 age- and sex-matched sedentary (WD) and 24 body fat-matched exercise-trained (EX) volunteers, who were eating Western …
The Cytoplasmic Adaptor Protein Caskin Mediates Lar Signal Transduction During Drosophila Motor Axon Guidance, Yi-Lan Weng, Nan Liu, Aaron Diantonio, Heather T. Broihier
The Cytoplasmic Adaptor Protein Caskin Mediates Lar Signal Transduction During Drosophila Motor Axon Guidance, Yi-Lan Weng, Nan Liu, Aaron Diantonio, Heather T. Broihier
Open Access Publications
The multiprotein complexes that receive and transmit axon pathfinding cues during development are essential to circuit generation. Here, we identify and characterize the Drosophila sterile α-motif (SAM) domain-containing protein Caskin, which shares homology with vertebrate Caskin, a CASK [calcium/calmodulin-(CaM)-activated serine-threonine kinase]-interacting protein. Drosophila caskin (ckn) is necessary for embryonic motor axon pathfinding and interacts genetically and physically with the leukocyte common antigen-related (Lar) receptor protein tyrosine phosphatase. In vivo and in vitro analyses of a panel of ckn loss-of-function alleles indicate that the N-terminal SAM domain of Ckn mediates its interaction with Lar. Like Caskin, Liprin-α is a neuronal adaptor …
Functional Analysis Of Novel Analogues Of E3330 That Block The Redox Signaling Activity Of The Multifunctional Ap Endonuclease/Redox Signaling Enzyme Ape1/Ref-1, Mark R. Kelley, Meihua Luo, April Reed, Dian Su, Sarah Delaplane, Richard F. Borch, Rodney L. Nyland Ii, Michael L. Gross, Millie M. Georgiadis
Functional Analysis Of Novel Analogues Of E3330 That Block The Redox Signaling Activity Of The Multifunctional Ap Endonuclease/Redox Signaling Enzyme Ape1/Ref-1, Mark R. Kelley, Meihua Luo, April Reed, Dian Su, Sarah Delaplane, Richard F. Borch, Rodney L. Nyland Ii, Michael L. Gross, Millie M. Georgiadis
Open Access Publications
No abstract provided.
Renal Tumor Models: Evaluation Of Ease Of Implementation, Quality Of Composition, And Imaging Characteristics, Brian M. Benway, Jose M. Cabello, Alana C. Desai, Robert S. Figenshaw, Sam B. Bhayani
Renal Tumor Models: Evaluation Of Ease Of Implementation, Quality Of Composition, And Imaging Characteristics, Brian M. Benway, Jose M. Cabello, Alana C. Desai, Robert S. Figenshaw, Sam B. Bhayani
Open Access Publications
No abstract provided.
Effect Of Short-Duration Low-Magnitude Cyclic Loading Versus Immobilization On Tendon-Bone Healing After Acl Reconstruction In A Rat Model, Robert H. Brophy, David Kovacevic, Carl W. Imhauser, Mark Stasiak, Asheesh Bedi, Alice J.S. Fox, Xiang-Hua Deng, Scott A. Rodeo
Effect Of Short-Duration Low-Magnitude Cyclic Loading Versus Immobilization On Tendon-Bone Healing After Acl Reconstruction In A Rat Model, Robert H. Brophy, David Kovacevic, Carl W. Imhauser, Mark Stasiak, Asheesh Bedi, Alice J.S. Fox, Xiang-Hua Deng, Scott A. Rodeo
Open Access Publications
No abstract provided.
Calcium-Independent Inhibitory G-Protein Signaling Induces Persistent Presynaptic Muting Of Hippocampal Synapses, Devon C. Crawford, Chun Yun Chang, Krzysztof L. Hyrc, Steven Mennerick
Calcium-Independent Inhibitory G-Protein Signaling Induces Persistent Presynaptic Muting Of Hippocampal Synapses, Devon C. Crawford, Chun Yun Chang, Krzysztof L. Hyrc, Steven Mennerick
Open Access Publications
Adaptive forms of synaptic plasticity that reduce excitatory synaptic transmission in response to prolonged increases in neuronal activity may prevent runaway positive feedback in neuronal circuits. In hippocampal neurons, for example, glutamatergic presynaptic terminals are selectively silenced, creating "mute" synapses, after periods of increased neuronal activity or sustained depolarization. Previous work suggests that cAMP-dependent and proteasome-dependent mechanisms participate in silencing induction by depolarization, but upstream activators are unknown. We, therefore, tested the role of calcium and G-protein signaling in silencing induction in cultured hippocampal neurons. We found that silencing induction by depolarization was not dependent on rises in intracellular calcium, …
In Vitro And In Vivo Evaluation Of 64cu-Radiolabeled Kccysl Peptides For Targeting Epidermal Growth Factor Receptor-2 In Breast Carcinomas, Senthil R. Kumar, Fabio A. Gallazzi, Riccardo Ferdani, Carolyn J. Anderson, Thomas P. Quinn, Susan L. Deutscher
In Vitro And In Vivo Evaluation Of 64cu-Radiolabeled Kccysl Peptides For Targeting Epidermal Growth Factor Receptor-2 In Breast Carcinomas, Senthil R. Kumar, Fabio A. Gallazzi, Riccardo Ferdani, Carolyn J. Anderson, Thomas P. Quinn, Susan L. Deutscher
Open Access Publications
No abstract provided.
Improving Salmonella Vector With Rec Mutation To Stabilize The Dna Cargoes, Xiangmin Zhang, Soo-Young Wanda, Karen Brenneman, Wei Kong, Xin Zhang, Kenneth Roland, Roy Curtiss Iii
Improving Salmonella Vector With Rec Mutation To Stabilize The Dna Cargoes, Xiangmin Zhang, Soo-Young Wanda, Karen Brenneman, Wei Kong, Xin Zhang, Kenneth Roland, Roy Curtiss Iii
Open Access Publications
No abstract provided.
Pcr-Based Genotyping Of Helicobacter Pylori Of Gambian Children And Adults Directly From Biopsy Specimens And Bacterial Cultures, Ousman Secka, Martin Antonio, Mary Tapgun, Douglas E. Berg, Christian Bottomley, Vivat Thomas, Robert Walton, Tumani Corrah, Richard A. Adegbola, Julian E. Thomas
Pcr-Based Genotyping Of Helicobacter Pylori Of Gambian Children And Adults Directly From Biopsy Specimens And Bacterial Cultures, Ousman Secka, Martin Antonio, Mary Tapgun, Douglas E. Berg, Christian Bottomley, Vivat Thomas, Robert Walton, Tumani Corrah, Richard A. Adegbola, Julian E. Thomas
Open Access Publications
No abstract provided.
Vacuolization Of Mucolipidosis Type Ii Mouse Exocrine Gland Cells Represents Accumulation Of Autolysosomes, Marielle Boonen, Eline Van Meel, Viola Oorschot, Judith Klumperman, Stuart Kornfeld
Vacuolization Of Mucolipidosis Type Ii Mouse Exocrine Gland Cells Represents Accumulation Of Autolysosomes, Marielle Boonen, Eline Van Meel, Viola Oorschot, Judith Klumperman, Stuart Kornfeld
Open Access Publications
No abstract provided.
Differential Regional And Subtype-Specific Vulnerability Of Enteric Neurons To Mitochondrial Dysfunction, Andreu Viader, Elizabeth C. Wright-Jin, Bhupinder P.S Vohra, Robert O. Heuckeroth, Jeffrey Milbrandt
Differential Regional And Subtype-Specific Vulnerability Of Enteric Neurons To Mitochondrial Dysfunction, Andreu Viader, Elizabeth C. Wright-Jin, Bhupinder P.S Vohra, Robert O. Heuckeroth, Jeffrey Milbrandt
Open Access Publications
No abstract provided.