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Articles 3061 - 3090 of 4253
Full-Text Articles in Entire DC Network
A Single-Amino-Acid Change In Murine Norovirus Ns1/2 Is Sufficient For Colonic Tropism And Persistence, Timothy J. Nice, David W. Strong, Broc T. Mccune, Calvin S. Pohl, Herbert W. Virgin
A Single-Amino-Acid Change In Murine Norovirus Ns1/2 Is Sufficient For Colonic Tropism And Persistence, Timothy J. Nice, David W. Strong, Broc T. Mccune, Calvin S. Pohl, Herbert W. Virgin
Open Access Publications
No abstract provided.
Advancing The Translation Of Optical Imaging Agents For Clinical Imaging, Eva M. Sevick-Muraca, Walter J. Akers, Bishnu P. Joshi, Gary D. Lurker, Cathy S. Cutler, Lawrence J. Marnett, Christopher H. Contag, Thomas D. Wang, Ali Azhdarinia
Advancing The Translation Of Optical Imaging Agents For Clinical Imaging, Eva M. Sevick-Muraca, Walter J. Akers, Bishnu P. Joshi, Gary D. Lurker, Cathy S. Cutler, Lawrence J. Marnett, Christopher H. Contag, Thomas D. Wang, Ali Azhdarinia
Open Access Publications
No abstract provided.
Immune Responses To West Nile Virus Infection In The Central Nervous System, Hyelim Cho, Michael S. Diamond
Immune Responses To West Nile Virus Infection In The Central Nervous System, Hyelim Cho, Michael S. Diamond
Open Access Publications
No abstract provided.
Neonatal Diethylstilbestrol Exposure Alters The Metabolic Profile Of Uterine Epithelial Cells, Yan Yin, Congxing Lin, G. Michael Veith, Hong Chen, Maulik Dhandha, Liang Ma
Neonatal Diethylstilbestrol Exposure Alters The Metabolic Profile Of Uterine Epithelial Cells, Yan Yin, Congxing Lin, G. Michael Veith, Hong Chen, Maulik Dhandha, Liang Ma
Open Access Publications
No abstract provided.
Zebrafish Neurofibromatosis Type 1 Genes Have Redundant Functions In Tumorigenesis And Embryonic Development, Jimann Shin, Arun Padmanabhan, Eric D. De Groh, Jeong-Soo Lee, Sam Haidar, Suzanne Dahlberg, Feng Guo, Shuning He, Marc A. Wolman, Michael Granato, Nathan D. Lawson, Scot A. Wolfe, Seok-Hyung Kim, Lilianna Solnica-Krezel, John P. Kanki, Keith L. Ligon, Jonathan A. Epstein, A. Thomas Look
Zebrafish Neurofibromatosis Type 1 Genes Have Redundant Functions In Tumorigenesis And Embryonic Development, Jimann Shin, Arun Padmanabhan, Eric D. De Groh, Jeong-Soo Lee, Sam Haidar, Suzanne Dahlberg, Feng Guo, Shuning He, Marc A. Wolman, Michael Granato, Nathan D. Lawson, Scot A. Wolfe, Seok-Hyung Kim, Lilianna Solnica-Krezel, John P. Kanki, Keith L. Ligon, Jonathan A. Epstein, A. Thomas Look
Open Access Publications
No abstract provided.
Mapping A Complete Neural Population In The Retina, Olivier Marre, Dario Amodei, Nikhil Deshmukh, Kolia Sadeghi, Frederick Soo, Timothy E. Holy, Michael J. Berry
Mapping A Complete Neural Population In The Retina, Olivier Marre, Dario Amodei, Nikhil Deshmukh, Kolia Sadeghi, Frederick Soo, Timothy E. Holy, Michael J. Berry
Open Access Publications
Recording simultaneously from essentially all of the relevant neurons in a local circuit is crucial to understand how they collectively represent information. Here we show that the combination of a large, dense multielectrode array and a novel, mostly automated spike-sorting algorithm allowed us to record simultaneously from a highly overlapping population of >200 ganglion cells in the salamander retina. By combining these methods with labeling and imaging, we showed that up to 95% of the ganglion cells over the area of the array were recorded. By measuring the coverage of visual space by the receptive fields of the recorded cells, …
Loss Of Atm Kinase Activity Leads To Embryonic Lethality In Mice, Jeremy A. Daniel, Manuela Pellegrini, Baeck-Seung Lee, Zhi Guo, Darius Filsuf, Natalya V. Belkina, Zhongsheng You, Tanya T. Paull, Barry P. Sleckman, Lionel Feigenbaum, André Nussenzweig
Loss Of Atm Kinase Activity Leads To Embryonic Lethality In Mice, Jeremy A. Daniel, Manuela Pellegrini, Baeck-Seung Lee, Zhi Guo, Darius Filsuf, Natalya V. Belkina, Zhongsheng You, Tanya T. Paull, Barry P. Sleckman, Lionel Feigenbaum, André Nussenzweig
Open Access Publications
No abstract provided.
I(A) Channels Encoded By Kv1.4 And Kv4.2 Regulate Neuronal Firing In The Suprachiasmatic Nucleus And Circadian Rhythms In Locomotor Activity, Daniel Granados-Fuentes, Aaron J. Norris, Yarimar Carrasquillo, Jeanne M. Nerbonne, Erik D. Herzog
I(A) Channels Encoded By Kv1.4 And Kv4.2 Regulate Neuronal Firing In The Suprachiasmatic Nucleus And Circadian Rhythms In Locomotor Activity, Daniel Granados-Fuentes, Aaron J. Norris, Yarimar Carrasquillo, Jeanne M. Nerbonne, Erik D. Herzog
Open Access Publications
Neurons in the suprachiasmatic nucleus (SCN) display coordinated circadian changes in electrical activity that are critical for daily rhythms in physiology, metabolism, and behavior. SCN neurons depolarize spontaneously and fire repetitively during the day and hyperpolarize, drastically reducing firing rates, at night. To explore the hypothesis that rapidly activating and inactivating A-type (I(A)) voltage-gated K(+) (Kv) channels, which are also active at subthreshold membrane potentials, are critical regulators of the excitability of SCN neurons, we examined locomotor activity and SCN firing in mice lacking Kv1.4 (Kv1.4(-/-)), Kv4.2 (Kv4.2(-/-)), or Kv4.3 (Kv4.3(-/-)), the pore-forming (α) subunits of I(A) channels. Mice lacking …
What's New In Spine Surgery, Keith H. Bridwell, Paul A. Anderson, Scott D. Boden, Alexander R. Vaccaro, Jeffrey C. Wang
What's New In Spine Surgery, Keith H. Bridwell, Paul A. Anderson, Scott D. Boden, Alexander R. Vaccaro, Jeffrey C. Wang
Open Access Publications
No abstract provided.
Detection Thresholds Of Macaque Otolith Afferents, Xiong-Jie Yu, J David Dickman, Dora E. Angelaki
Detection Thresholds Of Macaque Otolith Afferents, Xiong-Jie Yu, J David Dickman, Dora E. Angelaki
Open Access Publications
The vestibular system is our sixth sense and is important for spatial perception functions, yet the sensory detection and discrimination properties of vestibular neurons remain relatively unexplored. Here we have used signal detection theory to measure detection thresholds of otolith afferents using 1 Hz linear accelerations delivered along three cardinal axes. Direction detection thresholds were measured by comparing mean firing rates centered on response peak and trough (full-cycle thresholds) or by comparing peak/trough firing rates with spontaneous activity (half-cycle thresholds). Thresholds were similar for utricular and saccular afferents, as well as for lateral, fore/aft, and vertical motion directions. When computed …
Synaptic Nmda Receptors Mediate Hypoxic Excitotoxic Death, Christine M. Wroge, Joshua Hogins, Larry Eisenman, Steven Mennerick
Synaptic Nmda Receptors Mediate Hypoxic Excitotoxic Death, Christine M. Wroge, Joshua Hogins, Larry Eisenman, Steven Mennerick
Open Access Publications
Excessive NMDA receptor activation and excitotoxicity underlies pathology in many neuropsychiatric and neurological disorders, including hypoxia/ischemia. Thus, the development of effective therapeutics for these disorders demands a complete understanding of NMDA receptor (NMDAR) activation during excitotoxic insults. The extrasynaptic NMDAR hypothesis posits that synaptic NMDARs are neurotrophic/neuroprotective and extrasynaptic NMDARs are neurotoxic. The extrasynaptic hypothesis is built in part on observed selectivity for extrasynaptic receptors of a neuroprotective use-dependent NMDAR channel blocker, memantine. In rat hippocampal neurons, we found that a neuroprotective concentration of memantine shows little selectivity for extrasynaptic NMDARs when all receptors are tonically activated by exogenous glutamate. …
A Model Of Toxic Neuropathy In Drosophila Reveals A Role For Morn4 In Promoting Axonal Degeneration, Martha R.C. Bhattacharya, Josiah Gerdts, Sarah A. Naylor, Emily X. Royse, Sarah Y. Ebstein, Yo Sasaki, Jeffrey Milbrandt, Aaron Diantonio
A Model Of Toxic Neuropathy In Drosophila Reveals A Role For Morn4 In Promoting Axonal Degeneration, Martha R.C. Bhattacharya, Josiah Gerdts, Sarah A. Naylor, Emily X. Royse, Sarah Y. Ebstein, Yo Sasaki, Jeffrey Milbrandt, Aaron Diantonio
Open Access Publications
Axonal degeneration is a molecular self-destruction cascade initiated following traumatic, toxic, and metabolic insults. Its mechanism underlies a number of disorders including hereditary and diabetic neuropathies and the neurotoxic side effects of chemotherapy drugs. Molecules that promote axonal degeneration could represent potential targets for therapy. To identify such molecules, we designed a screening platform based on intoxication of Drosophila larvae with paclitaxel (taxol), a chemotherapeutic agent that causes neuropathy in cancer patients. In Drosophila, taxol treatment causes swelling, fragmentation, and loss of axons in larval peripheral nerves. This axonal loss is not due to apoptosis of neurons. Taxol-induced axonal degeneration …
Neuronal Encoding Of Subjective Value In Dorsal And Ventral Anterior Cingulate Cortex, Xinying Cai, Camillo Padoa-Schioppa
Neuronal Encoding Of Subjective Value In Dorsal And Ventral Anterior Cingulate Cortex, Xinying Cai, Camillo Padoa-Schioppa
Open Access Publications
We examined the activity of individual cells in the primate anterior cingulate cortex during an economic choice task. In the experiments, monkeys chose between different juices offered in variables amounts and subjective values were inferred from the animals' choices. We analyzed neuronal firing rates in relation to a large number of behaviorally relevant variables. We report three main results. First, there were robust differences between the dorsal bank (ACCd) and the ventral bank (ACCv) of the cingulate sulcus. Specifically, neurons in ACCd but not in ACCv were modulated by the movement direction. Furthermore, neurons in ACCd were most active before …
Molecular Analysis Of Age And Sex-Related Gene Expression In Meniscal Tears With And Without A Concomitant Anterior Cruciate Ligament Tear, Robert H. Brophy, Muhammad Farooq Rai, Zhiqi Zhang, Adelina Torgomyan, Linda J. Sandell
Molecular Analysis Of Age And Sex-Related Gene Expression In Meniscal Tears With And Without A Concomitant Anterior Cruciate Ligament Tear, Robert H. Brophy, Muhammad Farooq Rai, Zhiqi Zhang, Adelina Torgomyan, Linda J. Sandell
Open Access Publications
No abstract provided.
Expression Of Sialic Acids And Other Nonulosonic Acids In Leptospira, Jessica N. Ricaldi, Michael A. Matthias, Joseph M. Vinetz, Amanda L. Lewis
Expression Of Sialic Acids And Other Nonulosonic Acids In Leptospira, Jessica N. Ricaldi, Michael A. Matthias, Joseph M. Vinetz, Amanda L. Lewis
Open Access Publications
No abstract provided.
The Sodium Channel Accessory Subunit Navβ1 Regulates Neuronal Excitability Through Modulation Of Repolarizing Voltage-Gated K+ Channels, Céline Marionneau, Yarimar Carrasquillo, Aaron J. Norris, R. Reid Townsend, Lori L. Isom, Andrew J. Link, Jeanne M. Nerbonne
The Sodium Channel Accessory Subunit Navβ1 Regulates Neuronal Excitability Through Modulation Of Repolarizing Voltage-Gated K+ Channels, Céline Marionneau, Yarimar Carrasquillo, Aaron J. Norris, R. Reid Townsend, Lori L. Isom, Andrew J. Link, Jeanne M. Nerbonne
Open Access Publications
No abstract provided.
Pa From An H5n1 Highly Pathogenic Avian Influenza Virus Activates Viral Transcription And Replication And Induces Apoptosis And Interferon Expression At An Early Stage Of Infection, Qiang Wang, Shijian Zhang, Hongbing Jiang, Jinlan Wang, Leiyun Weng, Yingying Mao, Satoshi Sekiguchi, Fumihiko Yasui, Michinori Kohara, Philippe Buchy, Vincent Deubel, Ke Xu, Bing Sun, Tetsuya Toyoda
Pa From An H5n1 Highly Pathogenic Avian Influenza Virus Activates Viral Transcription And Replication And Induces Apoptosis And Interferon Expression At An Early Stage Of Infection, Qiang Wang, Shijian Zhang, Hongbing Jiang, Jinlan Wang, Leiyun Weng, Yingying Mao, Satoshi Sekiguchi, Fumihiko Yasui, Michinori Kohara, Philippe Buchy, Vincent Deubel, Ke Xu, Bing Sun, Tetsuya Toyoda
Open Access Publications
No abstract provided.
Multi-Species Data Integration And Gene Ranking Enrich Significant Results In An Alcoholism Genome-Wide Association Study, Arpana Agrawal, Et Al
Multi-Species Data Integration And Gene Ranking Enrich Significant Results In An Alcoholism Genome-Wide Association Study, Arpana Agrawal, Et Al
Open Access Publications
No abstract provided.
A Tetravalent Dengue Nanoparticle Stimulates Antibody Production In Mice, Elisangela F. Silva, Mariana Orsi, Angela L. Andrade, Rosana Z. Domingues, Breno M. Silva, Helena Rc De Araujo, Paulo Fp Pimenta, Michael S. Diamond, Eliseu So Rocha, Erna G. Kroon, Luiz Cc Malaquias, Luiz Fl Coelho
A Tetravalent Dengue Nanoparticle Stimulates Antibody Production In Mice, Elisangela F. Silva, Mariana Orsi, Angela L. Andrade, Rosana Z. Domingues, Breno M. Silva, Helena Rc De Araujo, Paulo Fp Pimenta, Michael S. Diamond, Eliseu So Rocha, Erna G. Kroon, Luiz Cc Malaquias, Luiz Fl Coelho
Open Access Publications
No abstract provided.
Metabotropic Glutamate Receptor 5 (Mglur5) Regulates Bladder Nociception, Lara W. Crock, Kristina M. Stemler, David G. Song, Philip Abbosh, Sherri K. Vogt, Chang-Shen Qiu, H Henry Lai, Indira U. Mysorekar, Robert W. Gereau Iv
Metabotropic Glutamate Receptor 5 (Mglur5) Regulates Bladder Nociception, Lara W. Crock, Kristina M. Stemler, David G. Song, Philip Abbosh, Sherri K. Vogt, Chang-Shen Qiu, H Henry Lai, Indira U. Mysorekar, Robert W. Gereau Iv
Open Access Publications
No abstract provided.
Development Of A Novel Xenotransplantation Strategy For Treatment Of Diabetes Mellitus In Rat Hosts And Translation To Non-Human Primates, Marc R. Hammerman
Development Of A Novel Xenotransplantation Strategy For Treatment Of Diabetes Mellitus In Rat Hosts And Translation To Non-Human Primates, Marc R. Hammerman
Open Access Publications
No abstract provided.
Organization Of Vomeronasal Sensory Coding Revealed By Fast Volumetric Calcium Imaging, Diwakar Turaga, Timothy E. Holy
Organization Of Vomeronasal Sensory Coding Revealed By Fast Volumetric Calcium Imaging, Diwakar Turaga, Timothy E. Holy
Open Access Publications
No abstract provided.
Critical Role For Interferon Regulatory Factor 3 (Irf-3) And Irf-7 In Type I Interferon-Mediated Control Of Murine Norovirus Replication, Larissa B. Thackray, Erning Duan, Helen M. Lazear, Amal Kambal, Robert D. Schreiber, Michael S. Diamond, Herbert W. Virgin
Critical Role For Interferon Regulatory Factor 3 (Irf-3) And Irf-7 In Type I Interferon-Mediated Control Of Murine Norovirus Replication, Larissa B. Thackray, Erning Duan, Helen M. Lazear, Amal Kambal, Robert D. Schreiber, Michael S. Diamond, Herbert W. Virgin
Open Access Publications
No abstract provided.
Glaucoma-Induced Degeneration Of Retinal Ganglion Cells Prevented By Hypoxic Preconditioning: A Model Of Glaucoma Tolerance, Yanli Zhu, Lihong Zhang, Jimena F. Schmidt, Jeffrey M. Gidday
Glaucoma-Induced Degeneration Of Retinal Ganglion Cells Prevented By Hypoxic Preconditioning: A Model Of Glaucoma Tolerance, Yanli Zhu, Lihong Zhang, Jimena F. Schmidt, Jeffrey M. Gidday
Open Access Publications
No abstract provided.
Neural Correlates Of Prior Expectations Of Motion In The Lateral Intraparietal And Middle Temporal Areas, Vinod Rao, Gregory C. Deangelis, Lawrence H. Snyder
Neural Correlates Of Prior Expectations Of Motion In The Lateral Intraparietal And Middle Temporal Areas, Vinod Rao, Gregory C. Deangelis, Lawrence H. Snyder
Open Access Publications
No abstract provided.
Complete Genome Sequence Of Enterococcus Faecium Strain Tx16 And Comparative Genomic Analysis Of Enterococcus Faecium Genomes, Erica Sodergren, George M. Weinstock, Et Al
Complete Genome Sequence Of Enterococcus Faecium Strain Tx16 And Comparative Genomic Analysis Of Enterococcus Faecium Genomes, Erica Sodergren, George M. Weinstock, Et Al
Open Access Publications
No abstract provided.
Astrocyte-Derived Thrombospondins Mediate The Development Of Hippocampal Presynaptic Plasticity In Vitro, Devon C. Crawford, Xiaoping Jiang, Amanda Taylor, Steven Mennerick
Astrocyte-Derived Thrombospondins Mediate The Development Of Hippocampal Presynaptic Plasticity In Vitro, Devon C. Crawford, Xiaoping Jiang, Amanda Taylor, Steven Mennerick
Open Access Publications
No abstract provided.
Novel Modeling Of Combinatorial Mirna Targeting Identifies Snp With Potential Role In Bone Density, Claudia Coronnello, Ryan Hartmaier, Arshi Arora, Luai Huleihel, Kusum V. Padit, Abha S. Bais, Michael Butterworth, Naftali Kaminski, Gary D. Stormo, Steffi Oesterreich, Panayiotis V. Benos
Novel Modeling Of Combinatorial Mirna Targeting Identifies Snp With Potential Role In Bone Density, Claudia Coronnello, Ryan Hartmaier, Arshi Arora, Luai Huleihel, Kusum V. Padit, Abha S. Bais, Michael Butterworth, Naftali Kaminski, Gary D. Stormo, Steffi Oesterreich, Panayiotis V. Benos
Open Access Publications
No abstract provided.
Absence Of Ca2+-Stimulated Adenylyl Cyclases Leads To Reduced Synaptic Plasticity And Impaired Experience-Dependent Fear Memory, L. Wieczorek, D. Majumdar, T. A. Wills, L. Hu, D. G. Winder, D. J. Webb, L. J. Muglia
Absence Of Ca2+-Stimulated Adenylyl Cyclases Leads To Reduced Synaptic Plasticity And Impaired Experience-Dependent Fear Memory, L. Wieczorek, D. Majumdar, T. A. Wills, L. Hu, D. G. Winder, D. J. Webb, L. J. Muglia
Open Access Publications
No abstract provided.
Mitochondrial Dysfunction And Β-Cell Failure In Type 2 Diabetes Mellitus, Zhongmin Alex Ma, Zhengshan Zhao, John Turk
Mitochondrial Dysfunction And Β-Cell Failure In Type 2 Diabetes Mellitus, Zhongmin Alex Ma, Zhengshan Zhao, John Turk
Open Access Publications
No abstract provided.