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Antithrombin Perfluorocarbon Nanoparticles Improve Renal Allograft Function In A Murine Deceased Criteria Donor Model, Chandu Vemuri, Gundumi A. Upadhya, Batool Arif, Jianluo Jia, Yiing Lin, Joseph P. Gaut, Jawad Fazal, Hua Pan, Samuel A. Wickline, William C. Chapman Jan 2018

Antithrombin Perfluorocarbon Nanoparticles Improve Renal Allograft Function In A Murine Deceased Criteria Donor Model, Chandu Vemuri, Gundumi A. Upadhya, Batool Arif, Jianluo Jia, Yiing Lin, Joseph P. Gaut, Jawad Fazal, Hua Pan, Samuel A. Wickline, William C. Chapman

Open Access Publications

No abstract provided.


The Interferon-Induced Exonuclease Isg20 Exerts Antiviral Activity Through Upregulation Of Type I Interferon Response Proteins, Christopher M. Weiss, Derek W. Trobaugh, Chengqun Sun, Tiffany M. Lucas, Michael S. Diamond, Kate D. Ryman, William B. Klimstra Jan 2018

The Interferon-Induced Exonuclease Isg20 Exerts Antiviral Activity Through Upregulation Of Type I Interferon Response Proteins, Christopher M. Weiss, Derek W. Trobaugh, Chengqun Sun, Tiffany M. Lucas, Michael S. Diamond, Kate D. Ryman, William B. Klimstra

Open Access Publications

No abstract provided.


Leptin Selectively Regulates Nutrients Metabolism In Nile Tilapia Fed On High Carbohydrate Or High Fat Diet, Cai-Zhi Liu, An-Yuan He, Li-Jun Ning, Yuan Luo, Dong-Liang Li, Mei-Ling Zhang, Li-Qiao Chen, Zhen-Yu Du Jan 2018

Leptin Selectively Regulates Nutrients Metabolism In Nile Tilapia Fed On High Carbohydrate Or High Fat Diet, Cai-Zhi Liu, An-Yuan He, Li-Jun Ning, Yuan Luo, Dong-Liang Li, Mei-Ling Zhang, Li-Qiao Chen, Zhen-Yu Du

Open Access Publications

No abstract provided.


Using The A/T/N Framework To Examine Driving In Preclinical Alzheimer’S Disease, Catherine M. Roe, Ganesh M. Babulal, Sarah H. Stout, David B. Carr, Monique M. Williams, Tammie L.S Benzinger, Anne M. Fagan, David M. Holtzman, Beau M. Ances, John C. Morris Jan 2018

Using The A/T/N Framework To Examine Driving In Preclinical Alzheimer’S Disease, Catherine M. Roe, Ganesh M. Babulal, Sarah H. Stout, David B. Carr, Monique M. Williams, Tammie L.S Benzinger, Anne M. Fagan, David M. Holtzman, Beau M. Ances, John C. Morris

Open Access Publications

No abstract provided.


A Novel Cep120-Dependent Mechanism Inhibits Centriole Maturation In Quiescent Cells, Ewelina Betleja, Rashmi Nanjundappa, Tao Cheng, Moe R. Mahjoub Jan 2018

A Novel Cep120-Dependent Mechanism Inhibits Centriole Maturation In Quiescent Cells, Ewelina Betleja, Rashmi Nanjundappa, Tao Cheng, Moe R. Mahjoub

Open Access Publications

No abstract provided.


Emergency Department Hyperoxia Is Associated With Increased Mortality In Mechanically Ventilated Patients: A Cohort Study, David Page, Enyo Ablordeppey, Brian T. Wessman, Nicholas M. Mohr, Stephen Trzeciak, Marin H. Kollef, Brian W. Roberts, Brian M. Fuller Jan 2018

Emergency Department Hyperoxia Is Associated With Increased Mortality In Mechanically Ventilated Patients: A Cohort Study, David Page, Enyo Ablordeppey, Brian T. Wessman, Nicholas M. Mohr, Stephen Trzeciak, Marin H. Kollef, Brian W. Roberts, Brian M. Fuller

Open Access Publications

No abstract provided.


Genetic And Tissue Engineering Approaches To Modeling The Mechanics Of Human Heart Failure For Drug Discovery, Michael J. Greenberg, Neil J. Daily, Ann Wang, Michael K. Conway, Tetsuro Wakatsuki Jan 2018

Genetic And Tissue Engineering Approaches To Modeling The Mechanics Of Human Heart Failure For Drug Discovery, Michael J. Greenberg, Neil J. Daily, Ann Wang, Michael K. Conway, Tetsuro Wakatsuki

Open Access Publications

No abstract provided.


Anti-Jnk2 Peptide–Sirna Nanostructures Improve Plaque Endothelium And Reduce Thrombotic Risk In Atherosclerotic Mice, Hua Pan, Rohun U. Palekar, Kirk K. Hou, John Bacon, Huimin Yan, Luke E. Springer, Antonina Akk, Lihua Yang, Mark J. Miller, Christine T.N Pham, Paul H. Schlesinger, Samuel A. Wickline Jan 2018

Anti-Jnk2 Peptide–Sirna Nanostructures Improve Plaque Endothelium And Reduce Thrombotic Risk In Atherosclerotic Mice, Hua Pan, Rohun U. Palekar, Kirk K. Hou, John Bacon, Huimin Yan, Luke E. Springer, Antonina Akk, Lihua Yang, Mark J. Miller, Christine T.N Pham, Paul H. Schlesinger, Samuel A. Wickline

Open Access Publications

No abstract provided.


Endothelial Cell Cd36 Optimizes Tissue Fatty Acid Uptake, Dmitri Samovski, Terri A. Pietka, Vivek S. Peche, Kooresh I. Shoghi, Nada A. Abumrad, Et Al Jan 2018

Endothelial Cell Cd36 Optimizes Tissue Fatty Acid Uptake, Dmitri Samovski, Terri A. Pietka, Vivek S. Peche, Kooresh I. Shoghi, Nada A. Abumrad, Et Al

Open Access Publications

No abstract provided.


In Vivo Monitoring Of Intracellular Ca2+ Dynamics In The Pancreatic Β-Cells Of Zebrafish Embryos, Reka Lorincz, Christopher H. Emfinger, Andrea Walcher, Michael Giolai, Claudia Krautgasser, Maria S. Remedi, Colin G. Nichols, Dirk Meyer Jan 2018

In Vivo Monitoring Of Intracellular Ca2+ Dynamics In The Pancreatic Β-Cells Of Zebrafish Embryos, Reka Lorincz, Christopher H. Emfinger, Andrea Walcher, Michael Giolai, Claudia Krautgasser, Maria S. Remedi, Colin G. Nichols, Dirk Meyer

Open Access Publications

No abstract provided.


Using The Newer Kidney Disease: Improving Global Outcomes Criteria, Beta-2-Microglobulin Levels Associate With Severity Of Acute Kidney Injury, Kevin T. Barton, Aadil Kakajiwala, Dennis J. Dietzen, Charles W. Goss, Hongjie Gu, Vikas R. Dharnidharka Jan 2018

Using The Newer Kidney Disease: Improving Global Outcomes Criteria, Beta-2-Microglobulin Levels Associate With Severity Of Acute Kidney Injury, Kevin T. Barton, Aadil Kakajiwala, Dennis J. Dietzen, Charles W. Goss, Hongjie Gu, Vikas R. Dharnidharka

Open Access Publications

No abstract provided.


Evaluation Of Avoralstat, An Oral Kallikrein Inhibitor, In A Phase 3 Hereditary Angioedema Prophylaxis Trial: The Opus-2 Study, M. A. Riedl, H. J. Wedner, Et Al Jan 2018

Evaluation Of Avoralstat, An Oral Kallikrein Inhibitor, In A Phase 3 Hereditary Angioedema Prophylaxis Trial: The Opus-2 Study, M. A. Riedl, H. J. Wedner, Et Al

Open Access Publications

No abstract provided.


The Professionalism And Integrity In Research Program: Description And Preliminary Outcomes, James M. Dubois, John T. Chibnall, Raymond Tait, Jillon S. Vander Wal Jan 2018

The Professionalism And Integrity In Research Program: Description And Preliminary Outcomes, James M. Dubois, John T. Chibnall, Raymond Tait, Jillon S. Vander Wal

Open Access Publications

No abstract provided.


Dose-Dependent Expression Of Claudin-5 Is A Modifying Factor In Schizophrenia, C Greene, Y Gong, J Hou, Et Al. Jan 2018

Dose-Dependent Expression Of Claudin-5 Is A Modifying Factor In Schizophrenia, C Greene, Y Gong, J Hou, Et Al.

Open Access Publications

No abstract provided.


Transvaginal Fast-Scanning Optical-Resolution Photoacoustic Endoscopy, Yuan Qu, Chiye Li, Junhui Shi, Ruimin Chen, Song Xu, Hasan Rafsanjani, Konstantin Maslov, Hannah Krigman, Laura Garvey, Peng Hu, Peinan Zhao, Karen Meyers, Emily Diveley, Stephanie Pizzella, Lisa Muench, Nina Punyamurthy, Naomi Goldstein, Oji Onwumere, Mariana Alisio, Kaytelyn Meyenburg, Jennifer Maynard, Kristi Helm, Janessia Slaughter, Sabrina Barber, Tracy Burger, Christine Kramer, Jessica Chubiz, Monica Anderson, Ronald Mccarthy, Sarah K. England, George A. Macones, Qifa Zhou, K. Kirk Shung, Jun Zhou, Molly J. Stout, Methodius Tuuli, Lihong V. Wang Jan 2018

Transvaginal Fast-Scanning Optical-Resolution Photoacoustic Endoscopy, Yuan Qu, Chiye Li, Junhui Shi, Ruimin Chen, Song Xu, Hasan Rafsanjani, Konstantin Maslov, Hannah Krigman, Laura Garvey, Peng Hu, Peinan Zhao, Karen Meyers, Emily Diveley, Stephanie Pizzella, Lisa Muench, Nina Punyamurthy, Naomi Goldstein, Oji Onwumere, Mariana Alisio, Kaytelyn Meyenburg, Jennifer Maynard, Kristi Helm, Janessia Slaughter, Sabrina Barber, Tracy Burger, Christine Kramer, Jessica Chubiz, Monica Anderson, Ronald Mccarthy, Sarah K. England, George A. Macones, Qifa Zhou, K. Kirk Shung, Jun Zhou, Molly J. Stout, Methodius Tuuli, Lihong V. Wang

Open Access Publications

No abstract provided.


Capillaria Ova And Diagnosis Of Trichuris Trichiura Infection In Humans By Kato-Katz Smear, Liberia, Kerstin Fischer, Abakar Gankpala, Lincoln Gankpala, Fatorma K. Bolay, Kurt C. Curtis, Gary J. Weil, Peter U. Fischer Jan 2018

Capillaria Ova And Diagnosis Of Trichuris Trichiura Infection In Humans By Kato-Katz Smear, Liberia, Kerstin Fischer, Abakar Gankpala, Lincoln Gankpala, Fatorma K. Bolay, Kurt C. Curtis, Gary J. Weil, Peter U. Fischer

Open Access Publications

No abstract provided.


Assessing Mucosal Inflammation In A Dss-Induced Colitis Mouse Model By Mr Colonography, Inbal E. Biton, Noa Stettner, Ori Brener, Ayelet Erez, Alon Harmelin, Joel R. Garbow Jan 2018

Assessing Mucosal Inflammation In A Dss-Induced Colitis Mouse Model By Mr Colonography, Inbal E. Biton, Noa Stettner, Ori Brener, Ayelet Erez, Alon Harmelin, Joel R. Garbow

Open Access Publications

No abstract provided.


Proteomic Profiling Identifies Key Coactivators Utilized By Mutant Erα Proteins As Potential New Therapeutic Targets, Shunqiang Li, Jieya Shao, Et Al Jan 2018

Proteomic Profiling Identifies Key Coactivators Utilized By Mutant Erα Proteins As Potential New Therapeutic Targets, Shunqiang Li, Jieya Shao, Et Al

Open Access Publications

No abstract provided.


Prdx1 (Peroxiredoxin 1) Deficiency Reduces Cholesterol Efflux Via Impaired Macrophage Lipophagic Flux, Se-Jin Jeong, In-Hyuk Jung Jan 2018

Prdx1 (Peroxiredoxin 1) Deficiency Reduces Cholesterol Efflux Via Impaired Macrophage Lipophagic Flux, Se-Jin Jeong, In-Hyuk Jung

Open Access Publications

No abstract provided.


Dual Target Gene Therapy To Eml4-Alk Nsclc By A Gold Nanoshell-Based System, Siwen Li, Yuxi Liu, Yalan Rui, Liping Tang, Samuel Achilefu, Yueqiing Gu Jan 2018

Dual Target Gene Therapy To Eml4-Alk Nsclc By A Gold Nanoshell-Based System, Siwen Li, Yuxi Liu, Yalan Rui, Liping Tang, Samuel Achilefu, Yueqiing Gu

Open Access Publications

No abstract provided.


Psychometric Properties Of The Chinese (Putonghua) Version Of The Oxford Cognitive Screen (Ocs-P) In Subacute Poststroke Patients Without Neglect, Wen-Jun Hong, Jing Tao, Alex W. K. Wong, Shan-Li Yang, Man-Tak Leung, Tatia M. C. Lee, Nele Demeyere, Stephen C. L. Lau, Chi-Wen Chien, Chetwyn C. H. Chan, Li-Dian Chen Jan 2018

Psychometric Properties Of The Chinese (Putonghua) Version Of The Oxford Cognitive Screen (Ocs-P) In Subacute Poststroke Patients Without Neglect, Wen-Jun Hong, Jing Tao, Alex W. K. Wong, Shan-Li Yang, Man-Tak Leung, Tatia M. C. Lee, Nele Demeyere, Stephen C. L. Lau, Chi-Wen Chien, Chetwyn C. H. Chan, Li-Dian Chen

Open Access Publications

No abstract provided.


Three-Dimensional Printing Antimicrobial And Radiopaque Constructs, Christen J. Boyer, David H. Ballard, Jeffery A. Weisman, Spencer Hurst, David J. Mcgee, David K. Mills, Jennifer E. Woerner, Uday Jammalamadaka, Karthik Tappa, Jonathan Steven Alexander Jan 2018

Three-Dimensional Printing Antimicrobial And Radiopaque Constructs, Christen J. Boyer, David H. Ballard, Jeffery A. Weisman, Spencer Hurst, David J. Mcgee, David K. Mills, Jennifer E. Woerner, Uday Jammalamadaka, Karthik Tappa, Jonathan Steven Alexander

Open Access Publications

No abstract provided.


Antigen-Specific Antibody Fc Glycosylation Enhances Humoral Immunity Via The Recruitment Of Complement, Julie M. Fox, Michael S. Diamond, Et Al Jan 2018

Antigen-Specific Antibody Fc Glycosylation Enhances Humoral Immunity Via The Recruitment Of Complement, Julie M. Fox, Michael S. Diamond, Et Al

Open Access Publications

No abstract provided.


Patterns Of Care And Treatment Outcomes Of Patients With Astroblastoma: A National Cancer Database Analysis, Emily C. Merfeld, Sonika Dahiya, Stephanie M. Perkins Jan 2018

Patterns Of Care And Treatment Outcomes Of Patients With Astroblastoma: A National Cancer Database Analysis, Emily C. Merfeld, Sonika Dahiya, Stephanie M. Perkins

Open Access Publications

No abstract provided.


Version 3 Of The Alzheimer Disease Centers’ Neuropsychological Test Battery In The Uniform Data Set (Uds), Sandra Weintraub, John C. Morris, Et Al. Jan 2018

Version 3 Of The Alzheimer Disease Centers’ Neuropsychological Test Battery In The Uniform Data Set (Uds), Sandra Weintraub, John C. Morris, Et Al.

Open Access Publications

No abstract provided.


Version 3 Of The National Alzheimer’S Coordinating Center’S Uniform Data Set, Lilah Besser, John C. Morris, Et Al. Jan 2018

Version 3 Of The National Alzheimer’S Coordinating Center’S Uniform Data Set, Lilah Besser, John C. Morris, Et Al.

Open Access Publications

No abstract provided.


Deformation Imaging And Rotational Mechanics In Neonates: A Guide To Image Acquisition, Measurement, Interpretation, And Reference Values, Afif El-Khuffash, Ulf Schubert, Philip T. Levy, Eirik Nestaas, Willem P. De Boode, European Special Interest Group 'Neonatologist Performed Echocardiography' Jan 2018

Deformation Imaging And Rotational Mechanics In Neonates: A Guide To Image Acquisition, Measurement, Interpretation, And Reference Values, Afif El-Khuffash, Ulf Schubert, Philip T. Levy, Eirik Nestaas, Willem P. De Boode, European Special Interest Group 'Neonatologist Performed Echocardiography'

Open Access Publications

No abstract provided.


Glycolytic Requirement For Nk Cell Cytotoxicity And Cytomegalovirus Control, Annelise Y. Mah, Armin Rashidi, Molly P. Keppel, Nermina Saucier, Emily K. Moore, Joshua B. Alinger, Sandeep K. Tripathy, Sandeep K. Agarwal, Emily K. Jeng, Hing C. Wong, Jeffrey S. Miller, Todd A. Fehniger, Emily M. Mace, Anthony R. French, Megan A. Cooper Dec 2017

Glycolytic Requirement For Nk Cell Cytotoxicity And Cytomegalovirus Control, Annelise Y. Mah, Armin Rashidi, Molly P. Keppel, Nermina Saucier, Emily K. Moore, Joshua B. Alinger, Sandeep K. Tripathy, Sandeep K. Agarwal, Emily K. Jeng, Hing C. Wong, Jeffrey S. Miller, Todd A. Fehniger, Emily M. Mace, Anthony R. French, Megan A. Cooper

Open Access Publications

NK cell activation has been shown to be metabolically regulated in vitro; however, the role of metabolism during in vivo NK cell responses to infection is unknown. We examined the role of glycolysis in NK cell function during murine cytomegalovirus (MCMV) infection and the ability of IL-15 to prime NK cells during CMV infection. The glucose metabolism inhibitor 2-deoxy-ᴅ-glucose (2DG) impaired both mouse and human NK cell cytotoxicity following priming in vitro. Similarly, MCMV-infected mice treated with 2DG had impaired clearance of NK-specific targets in vivo, which was associated with higher viral burden and susceptibility to infection on the C57BL/6 …


Elevated Urinary Creld2 Is Associated With Endoplasmic Reticulum Stress-Mediated Kidney Disease, Yeawon Kim, Sun-Ji Park, Scott R. Manson, Carlos A. F. Molina, Kendrah Kidd, Heather Thiessen-Philbrook, Rebecca J. Perry, Helen Liapis, Stanislav Kmoch, Chirag R. Parikh, Anthony J. Bleyer, Ying Maggie Chen Dec 2017

Elevated Urinary Creld2 Is Associated With Endoplasmic Reticulum Stress-Mediated Kidney Disease, Yeawon Kim, Sun-Ji Park, Scott R. Manson, Carlos A. F. Molina, Kendrah Kidd, Heather Thiessen-Philbrook, Rebecca J. Perry, Helen Liapis, Stanislav Kmoch, Chirag R. Parikh, Anthony J. Bleyer, Ying Maggie Chen

Open Access Publications

ER stress has emerged as a signaling platform underlying the pathogenesis of various kidney diseases. Thus, there is an urgent need to develop ER stress biomarkers in the incipient stages of ER stress-mediated kidney disease, when a kidney biopsy is not yet clinically indicated, for early therapeutic intervention. Cysteine-rich with EGF-like domains 2 (CRELD2) is a newly identified protein that is induced and secreted under ER stress. For the first time to our knowledge, we demonstrate that CRELD2 can serve as a sensitive urinary biomarker for detecting ER stress in podocytes or renal tubular cells in murine models of podocyte …


Increased Ca2+ Signaling Through Cav1.2 Promotes Bone Formation And Prevents Estrogen Deficiency-Induced Bone Loss, Chike Cao, Yinshi Ren, Adam S. Barnett, Anthony J. Mirando, Douglas Rouse, Se Hwan Mun, Kyung-Hyun Park-Min, Amy L. Mcnulty, Farshid Guilak, Courtney M. Karner, Matthew J. Hilton, Geoffrey S. Pitt Nov 2017

Increased Ca2+ Signaling Through Cav1.2 Promotes Bone Formation And Prevents Estrogen Deficiency-Induced Bone Loss, Chike Cao, Yinshi Ren, Adam S. Barnett, Anthony J. Mirando, Douglas Rouse, Se Hwan Mun, Kyung-Hyun Park-Min, Amy L. Mcnulty, Farshid Guilak, Courtney M. Karner, Matthew J. Hilton, Geoffrey S. Pitt

Open Access Publications

While the prevalence of osteoporosis is growing rapidly with population aging, therapeutic options remain limited. Here, we identify potentially novel roles for CaV1.2 L-type voltage-gated Ca2+ channels in osteogenesis and exploit a transgenic gain-of-function mutant CaV1.2 to stem bone loss in ovariectomized female mice. We show that endogenous CaV1.2 is expressed in developing bone within proliferating chondrocytes and osteoblasts. Using primary BM stromal cell (BMSC) cultures, we found that Ca2+ influx through CaV1.2 activates osteogenic transcriptional programs and promotes mineralization. We used Prx1-, Col2a1-, or Col1a1-Cre drivers to express an inactivation-deficient CaV1.2 mutant in chondrogenic and/or osteogenic precursors in vivo …