Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Life Sciences (194)
- Physical Sciences and Mathematics (162)
- Engineering (122)
- Chemistry (70)
- Biochemistry, Biophysics, and Structural Biology (68)
-
- Social and Behavioral Sciences (49)
- Biology (37)
- Medicine and Health Sciences (37)
- Biochemistry (35)
- Biomedical Engineering and Bioengineering (33)
- Biophysics (28)
- Agriculture (27)
- Analytical Chemistry (26)
- Electrical and Computer Engineering (26)
- Plant Sciences (26)
- Environmental Sciences (25)
- Mechanical Engineering (25)
- Molecular Biology (24)
- Ecology and Evolutionary Biology (23)
- Education (23)
- Bioresource and Agricultural Engineering (19)
- Microbiology (18)
- Psychology (18)
- Animal Sciences (17)
- Oceanography and Atmospheric Sciences and Meteorology (17)
- Cell and Developmental Biology (16)
- Bioinformatics (15)
- Cell Biology (15)
- Civil and Environmental Engineering (15)
- Computer Sciences (15)
- Institution
- Keyword
-
- Biological sciences (87)
- Applied sciences (71)
- Pure sciences (59)
- Health and environmental sciences (31)
- Cancer (26)
-
- Social sciences (18)
- Climate change (15)
- Depression (14)
- Earth sciences (14)
- Education (14)
- Evolution (14)
- Mitochondria (14)
- Psychology (13)
- Epigenetics (12)
- Mass spectrometry (12)
- Aging (11)
- Breast cancer (11)
- Genomics (11)
- Metastasis (11)
- Metabolism (10)
- Modeling (10)
- Calcium (9)
- Coral (9)
- Development (9)
- Genetics (9)
- Inflammation (9)
- Nanoparticles (9)
- Phosphorylation (9)
- Stress (9)
- Autism (8)
- Publication Year
Articles 781 - 810 of 3760
Full-Text Articles in Entire DC Network
Epidemiological Importance Of Neglected Malaria Vector Behaviors And Evaluating Novel Tools For Controlling Residual Malaria Transmission In Africa ---- Individual-Based Modeling Study, Lin Zhu
Open Access Dissertations
Malaria elimination remain a worldwide public health challenge. Residual malaria transmission has been consistently reported even in areas with adequate coverage of the two World Health Organization (WHO) recommended vector control interventions of long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS). Sugar-feeding and resting are two neglected yet crucial behaviors in malaria vector biology, and the corresponding environmental resources can play a huge role on the vector biology, and consequently on malaria transmission. However, there are few research on these two behaviors. The wide use of the indoor vector control tools has increased insecticide resistance in malaria vectors and …
Histone Modification Chip-Seq Algorithm Engineering And High Performance Bioinformatics Graphics And Analysis Software For Computational Epigenetics, Bohdan Bohdanovich Khomtchouk
Histone Modification Chip-Seq Algorithm Engineering And High Performance Bioinformatics Graphics And Analysis Software For Computational Epigenetics, Bohdan Bohdanovich Khomtchouk
Open Access Dissertations
Novel algorithm design, implementation, and optimization in histone modification ChIP-seq analysis of broad chromatin mark data is the subject of part I of this dissertation, focusing on data-driven precision medicine computational strategies for mapping ChIP-seq peaks to genomic features (and biological function) as well as coverage island analysis of low-sample size ChIP-seq experiments within individual biological replicates. Part II of this dissertation focuses on novel algorithm design, implementation, and analysis of high performance visualization techniques for histone modification ChIP-seq data using static and interactive biological gene expression heatmaps.
Apoptosis And Atherosclerosis: From Modeling Sudden Cardiac Death To Bioluminescence-Based Detection Of Programmed Cell Death, Trajen Rex Head
Apoptosis And Atherosclerosis: From Modeling Sudden Cardiac Death To Bioluminescence-Based Detection Of Programmed Cell Death, Trajen Rex Head
Open Access Dissertations
Cardiovascular disease (CVD) is the leading cause of mortality globally, responsible for over 17.3 million deaths annually (~31% of all deaths). Over the next decade, this value is projected to increase, surpassing 23.6 million annual deaths by 2030. The vast majority of these deaths are caused by complications resulting from progressive thickening of the arterial wall, and the formation and growth of arterial plaques within the vessel lumen. Subsequent plaque rupture may potentially lead to blood clot (thrombus) formation. The combined effect of these processes is the reduction of vessel diameter (stenosis) and subsequent reduction in blood flow (ischemia), while …
Parkinson Disease Related Phenotypes And Gene Expression Modeled In Induced Pluripotent Stem Cells, Kinsley Belle
Parkinson Disease Related Phenotypes And Gene Expression Modeled In Induced Pluripotent Stem Cells, Kinsley Belle
Open Access Dissertations
Parkinson disease (PD) is a neurodegenerative disease characterized by the loss of dopaminergic neurons of the substantia nigra. Parkinson disease related variants have been identified in many different genes, and the products of these genes are involved in autophagy, mitochondria and cell stability pathways. However, these identified variants are responsible for only 15% of PD cases, with the bulk of these cases being idiopathic PD. While genes do play a role, the most important risk factor in PD is age. Though the average age of onset for PD is 62, early onset forms of PD have been diagnosed in patients …
Assessing The Conserved Behavior Of Dissolved Organic Carbon In The Deep Ocean, Sarah Kathryn Jirikowic Bercovici
Assessing The Conserved Behavior Of Dissolved Organic Carbon In The Deep Ocean, Sarah Kathryn Jirikowic Bercovici
Open Access Dissertations
The global ocean contains a massive reservoir (662±32 Pg C) of dissolved organic carbon (DOC), and its dynamics, particularly in the deepest zones, are only slowly being understood. DOC in the deep ocean is ubiquitously low in concentration (~35 to 48 μmol kg-1) and aged (4000 to 6000 years), persisting for multiple meridional overturning circulation cycles. Deep waters relatively enriched in DOC form in the North Atlantic. They migrate to the Southern Ocean (SO) to mix with waters from Antarctic shelves and the deep Pacific and Indian Oceans, in turn forming the voluminous circumpolar waters. The latter ultimately feed back …
Transport Properties In Porcine Meniscus Fibrocartilage, Kelsey L. Kleinhans
Transport Properties In Porcine Meniscus Fibrocartilage, Kelsey L. Kleinhans
Open Access Dissertations
The knee meniscus is a complex structure that has been the focus of important and extensive research for many years. The most common areas of study include meniscal structure, meniscal tears, regeneration, and the biomechanical and anatomical forces endured by the meniscus. Although much research has been done regarding these tissues, more is needed in order to fully understand the role that menisci plays in the function and pathophysiology of the human knee. The fibrocartilaginous meniscus plays an essential role in distributing the majority of the load and maintaining not only congruency, but also lubrication in the knee joint. Degeneration …
Targeting Nedd8 Conjugation For Therapeutic Gain In Acute Lymphoblastic Leukemia, Shuhua Zheng
Targeting Nedd8 Conjugation For Therapeutic Gain In Acute Lymphoblastic Leukemia, Shuhua Zheng
Open Access Dissertations
Development of resistance and relapse remains a major challenge for acute lymphoblastic leukemia (ALL) treatment. Results from our lab and others showed that ALL cells are specifically vulnerable towards disturbance of endoplasmic reticulum (ER) protein homeostasis, which will cause proteotoxic ER stress/unfolded protein response (UPR). The typical ER stress inducer bortezomib (VELCADE) has been approved as a front-line treatment for multiple myeloma. Clinical trials of bortezomib in combination with other therapeutic agents demonstrated its potent anti-leukemic efficacy in relapsed/refractory pediatric ALL patients. Bortezomib functions by inhibiting the proteasome in the ubiquitin-proteasome system (UPS) to impede protein turnover in cancer cells, …
Regulation Of Cholesterol Homeostasis In Atherosclerosis And Alport Syndrome, Wen Ding
Regulation Of Cholesterol Homeostasis In Atherosclerosis And Alport Syndrome, Wen Ding
Open Access Dissertations
Cholesterol (C27H46O) is the precursor of steroid hormones, Vitamin D and bile acid and is a key component of the plasma membrane. Cholesterol levels are tightly regulated through biosynthesis, cellular uptake or efflux pathways to remain within a certain range for normal cell survival and function. Disturbed cholesterol homeostasis can be an independent risk factor for human diseases including cardiovascular disease, neurodegenerative disorder and chronic kidney disease. Understanding the molecular mechanisms that govern cholesterol homeostasis has the potential to reveal important insights into disease pathogenesis and new therapeutics. Elevated plasma LDL cholesterol is a major risk factor for cardiovascular events …
Embryonic Stem Cell Differentiation And Morphogenesis, Yue Meng
Embryonic Stem Cell Differentiation And Morphogenesis, Yue Meng
Open Access Dissertations
The primitive endoderm (PrE) appears as an epithelium on the surface of inner cell mass (ICM) at the late blastocyst stage (E4.5). This is the second lineage segregation event in mouse development. The transcription factor gata6 and the Ras/MAPK signaling pathway are essential for the commitment of PrE. To further study the PrE lineage establishment, we generated a mutant mouse line by replacing gata6-coding exons with H2BGFP and monitored gata6 promoter activity in PrE development. We observed that the gata6 promoter driven GFP fluorescence signal was uniformly present initially in heterozygous blastocysts (gata6H2BGFP/+) at the 32-cell stage. However, the signal …
Cognitive Behavioral Stress Management Effects On Social Well-Being, Negative Affect, And Inflammation After Surgery For Breast Cancer, Devika R. Jutagir
Cognitive Behavioral Stress Management Effects On Social Well-Being, Negative Affect, And Inflammation After Surgery For Breast Cancer, Devika R. Jutagir
Open Access Dissertations
Many women experience distress during diagnosis and treatment of breast cancer, and research suggests that satisfaction with access to social resources both decreases psychological distress and improves duration of survival after breast cancer diagnosis. However, biobehavioral mechanisms linking interpersonal processes to mental and physical health are poorly understood. Studies are also needed to elucidate whether psychosocial interventions that improve social well-being and psychological health affect biological outcomes known to promote cancer disease progression (e.g., inflammation). This study examined a subsample of 78 women enrolled in a 10-week randomized controlled trial of cognitive behavioral stress management (CBSM) at the University of …
A Randomized Controlled Pilot Trial Of The Unified Protocol For The Treatment Of Emotional Disorders In Children (Up-C), Sarah Michelle Kennedy
A Randomized Controlled Pilot Trial Of The Unified Protocol For The Treatment Of Emotional Disorders In Children (Up-C), Sarah Michelle Kennedy
Open Access Dissertations
Although cognitive-behavioral therapy (CBT) is a well established treatment for anxiety and depressive disorders in children (Chorpita et al., 2011), a significant proportion of children do not respond to existing CBT protocols, and many protocols do not adequately address high rates of comorbidity among emotional disorders. Transdiagnostic approaches may help to improve treatment response in children, particularly for clinical or sub-clinical comorbid conditions not adequately targeted by disorder-specific CBT, and to prevent the later development of commonly occurring comorbid conditions. The Unified Protocol for the Treatment of Emotional Disorders in Children (UP-C; Ehrenreich-May et al., in press) is a transdiagnostic …
Analytical Improvements For Assessing Dissolved Organic Carbon Concentrations And Dynamics In The Ocean, Meredith K. Jennings
Analytical Improvements For Assessing Dissolved Organic Carbon Concentrations And Dynamics In The Ocean, Meredith K. Jennings
Open Access Dissertations
Marine dissolved organic carbon (DOC) represents a large and dynamic reservoir of reduced carbon (662 x 1015g C) comparable in size to the Earth’s reservoir of atmospheric CO2. Our knowledge on the transformation and removal of DOC through various sinks and processes is often obscured by a lack of observable and quantifiable mechanisms. For example, self-assembling microgels, transitional in size between dissolved and particulate matter, have been suggested to play a key intermediary role in organic matter bioreactivity. Microgel formation is the first step in creating a particulate sink for dissolved organic matter, with up to 10% of DOC in …
A Novel Role Of Lmo2 In Dna Repair Control In Diffuse Large B-Cell Lymphoma, Salma Parvin
A Novel Role Of Lmo2 In Dna Repair Control In Diffuse Large B-Cell Lymphoma, Salma Parvin
Open Access Dissertations
LMO2 serves as one of the best prognostic markers for longer survival of diffuse large B cell lymphoma (DLBCL) patients. However, little it is known about its molecular function in normal B cells and DLBCL cells. Our study reveals a novel role for LMO2 in the control of DNA repair. We found that LMO2 inhibits the homologous recombination repair pathway, an essential mechanism for the repair of DNA double-strand breaks (DSB). The lack of activity of the homologous recombination pathway causes an accumulation of DSB in LMO2 expressing B cells, thus providing explanation for increased chemo-sensitivity of LMO2+ DLBCL tumors …
Characterization Of The Organic Matrix Associated With Carbonate Mineral Formed In The Marine Teleost Intestine, Kevin L. Schauer
Characterization Of The Organic Matrix Associated With Carbonate Mineral Formed In The Marine Teleost Intestine, Kevin L. Schauer
Open Access Dissertations
Marine fish must constantly work to maintain proper salt and water balance, as they live in an environment with a salt concentration approximately three-fold higher than their body fluids. Living in such a hyperosmotic environment results in the continual passive loss of water and gain of salts, which must be compensated for to maintain osmotic balance. Replacing lost water is particularly challenging, as the only source of water available is seawater. Marine teleosts possess a suite of adaptations in order to extract water from imbibed seawater, one of which is the precipitation of inorganic CaCO3 in the intestinal lumen, which …
Localized Therapeutic Hypothermia To Preserve Residual Hearing Against Cochlear Implantation: Analytical And Experimental Studies, Ilmar Tamames
Localized Therapeutic Hypothermia To Preserve Residual Hearing Against Cochlear Implantation: Analytical And Experimental Studies, Ilmar Tamames
Open Access Dissertations
Objective: Cochlear implants are the most successful neuroprostheses. Unfortunately, the trauma caused during cochlear implant insertion can lead to a loss of residual hair cells in the cochlea. Localized therapeutic hypothermia has the potential to be the standard of clinical care for neuroprotective intervention. This study demonstrates the design, operation and protocols, in an animal and a cadaver temporal bone model, for efficacious delivery of mild therapeutic hypothermia to the cochlea that can be translated to clinical practice in patients undergoing surgical cochlear implantation to preserve residual hearing. Main Results: The study found that localized hypothermia protects cochlear hair cells …
The Role Of Phosphodiesterase 4b In Inflammation After Traumatic Brain Injury, Nicole Marie Wilson
The Role Of Phosphodiesterase 4b In Inflammation After Traumatic Brain Injury, Nicole Marie Wilson
Open Access Dissertations
Traumatic brain injury (TBI) initiates a deleterious inflammatory response that exacerbates pathology and worsens outcome. This inflammatory response is partially mediated by a reduction in cAMP and a concomitant upregulation of cAMP-hydrolyzing phosphodiesterases (PDEs) acutely after TBI. The PDE4B subfamily, specifically PDE4B2, has been found to regulate cAMP in inflammatory cells, such as neutrophils, macrophages and microglia. Given the detrimental effects of the acute inflammatory response after TBI and the role of PDE4B in other models of inflammation, we hypothesized that acute PDE4B inhibition would reduce inflammation and improve cognitive and histopathological outcome after TBI. To test this hypothesis, adult …
Comparative Genomics Of Mechanisms Underlying Adaptation To High-Altitude Environments In Andean Waterfowl, Allie Marie Graham
Comparative Genomics Of Mechanisms Underlying Adaptation To High-Altitude Environments In Andean Waterfowl, Allie Marie Graham
Open Access Dissertations
Organisms which reside in high-altitude environments represent ideal species for the study of physiological adaptation, as well as for elucidating the underlying genetic mechanisms associated with such a strong selective constraint (ie. hypoxia). Therefore, the variety of waterfowl species who have independently invaded the altiplano plateaus of the Andean mountains provide crucial representative study organisms in answering such questions. The research encompassed by this dissertation sought to answer questions about [1] the specificity of genetic mechanisms involved in high-altitude adaptation, [2] the potential for evidence of how these molecular adaptations were acquired, either through de novo mutations (convergence, parallel evolution) …
Tmi: The Data-Driven Literature Of The American Renaissance, Brad Christopher Rittenhouse
Tmi: The Data-Driven Literature Of The American Renaissance, Brad Christopher Rittenhouse
Open Access Dissertations
This dissertation posits that much of the aesthetic innovation associated with the American Renaissance stemmed from a wide range of sociocultural and technological that transformed nineteenth-century America into an urban, consumerist society grappling with an ocean of print, products, and people. Reacting to these new modern landscapes, New York writers like Herman Melville and Walt Whitman produced highly anomalous texts that prioritized the aggregation, aestheticization, and transmission of unprecedented volumes of cultural data. Borrowing from and building upon the contemporary information management strategies of rationalist fields like descriptive biology, accounting, and library science, these writers in particular developed a “data-driven” …
Ubiquitination Of Sting On Lysine 224 Facilitates Cytosolic Dna Activated Host Defense, Guoxin Ni
Ubiquitination Of Sting On Lysine 224 Facilitates Cytosolic Dna Activated Host Defense, Guoxin Ni
Open Access Dissertations
Conserved structures among microbial species, known as pathogen associated molecular patterns (PAMPs), are recognized by host pattern recognition receptors (PRRs), which then initiate a serial of innate immune signaling transductions to protect the host from pathogen invading. A recently identified endoplasmic reticulum-associated protein STING (stimulator of interferon genes) has been shown to be an essential component of the innate immunity, especially with regard to the cytosolic DNA sensing pathway. Cytosolic DNA species derived from invading microbes or leaked from the nuclear or mitochondrial compartments of the cell can potently trigger the induction of host defense genes by activating STING-dependent pathway. …
Regulation Of C-X-C Chemokine Receptor 7 By Androgen Receptor In Prostate Cancer, James Joseph Hoy
Regulation Of C-X-C Chemokine Receptor 7 By Androgen Receptor In Prostate Cancer, James Joseph Hoy
Open Access Dissertations
The atypical C-X-C chemokine receptor 7 (CXCR7) is implicated in supporting aggressive cancer phenotypes in several cancers including prostate cancer. However, the mechanisms driving overexpression of this receptor in cancer are poorly understood. The aim of this current study was to investigate the role of CXCR7 in the progression to lethal castration resistant prostate cancer (CRPC). CXCR7 expression was measured after androgen receptor (AR) signaling was modulated through androgen deprivation, siRNA-mediated depletion of AR or antiandrogen treatment. Chromatin immunoprecipitation (ChIP) assays were performed to investigate the interaction of AR with the CXCR7 promoter. Clustered regularly interspaced short palindromic repeats (CRISPR) …
Dna Hydroxymethylation In Non-Coding Repeat Expansion Disorders, Rustam Esanov
Dna Hydroxymethylation In Non-Coding Repeat Expansion Disorders, Rustam Esanov
Open Access Dissertations
Hexanucleotide repeat expansion in C9ORF72 gene has recently been shown to cause familial amyotrophic lateral sclerosis, a neurodegenerative disease caused by global death of motor neurons. The expansion leads to partial heterochromatinization of the locus, yet mutant RNAs and dipeptide repeat proteins are still produced in sufficient quantities to confer neurotoxicity. So far several research groups have identified DNA hypermethylation at C9ORF72 promoter CpG sites in a fraction of patients, but the developmental timing and the reason of its occurrence only in a subset of individuals remains unknown. In order to model the acquisition of C9ORF72 hypermethylation, we generated induced …
Adaptive Capacity And Governance Effectiveness Of Wetfish Fisheries, Stacy Elizabeth Aguilera
Adaptive Capacity And Governance Effectiveness Of Wetfish Fisheries, Stacy Elizabeth Aguilera
Open Access Dissertations
Fisheries contribute a wide variety of ecosystem services, from food provisioning to shaping community identity to bolstering local economies. The sustainability of these benefits is under threat due to global and local stressors, including climate change, rising demand for animal protein, and habitat destruction. The dynamic climate, governance, and market drivers influencing fisheries present social and ecological challenges and opportunities that form the focus of this dissertation. Examining the adaptive capacity of a fishery offers insight into diverse aspects of the system that influence outcomes, such as trends in landings, social stability, and habitat condition. Additionally, academic theories, including Ostrom’s …
Decoding Russian Foreign Policy, Dina Moulioukova
Decoding Russian Foreign Policy, Dina Moulioukova
Open Access Dissertations
The traditional notion of security in international relations theory assumes that nation-states have one driving goal in their relations with other states – their own survival. Therefore states should calculate their foreign policy decisions solely with that goal in mind. While physical security is important to states, sometimes, however, states structure their actions in materially costly ways. These actions satisfy the self-identity needs of the states. In case states avoided these actions their sense of self-identity would be radically disrupted, and such a disruption is just as important to the states as threats to their physical integrity. While physical security …
Ecology And Evolution Of Soft Song, A Complex Behavior, In Turdus Thrushes, Luis Esteban Vargas-Castro
Ecology And Evolution Of Soft Song, A Complex Behavior, In Turdus Thrushes, Luis Esteban Vargas-Castro
Open Access Dissertations
The development and evolution of low amplitude "soft song" was investigated in thrushes of the genus Turdus. Sharing of soft song was studied in the white-throated thrush (T. assimilis) and compared to sharing of broadcast song in the same species, in order to draw inferences about how both song modes are acquired. It was found that most of the song repertoires of each song mode are unique to particular white-throated thrushes, suggesting that this species relies more on invention than imitation during song development. The spatial pattern of sharing between local males differed between song modes. Broadcast song sharing peaks …
Environmental Controls On The Reassembly Of Symbiodinium Communities In Reef Corals Following Perturbation: Implications For Reef Futures Under Climate Change, Rivah Norwood Winter
Environmental Controls On The Reassembly Of Symbiodinium Communities In Reef Corals Following Perturbation: Implications For Reef Futures Under Climate Change, Rivah Norwood Winter
Open Access Dissertations
The persistence of coral reef ecosystems, valued in the hundreds of billions of dollars annually, relies on the survival and growth of the coral colonies that build the habitat. However, these ecosystem engineers are threatened by a host of stressors, including warming ocean temperatures due to global climate change. Anomalously high sea surface temperatures can result in coral bleaching, the breakdown in the obligate symbiosis between the coral host and its community of single-celled, dinoflagellate algae in the genus Symbiodinium. Bleaching stress that is too prolonged or too severe can result in coral mortality, and increasingly frequent and severe bleaching …
The Mathematical Modelling Of Spatial Structure Of Ecological System In Heterogeneous Environment, Bo Zhang
The Mathematical Modelling Of Spatial Structure Of Ecological System In Heterogeneous Environment, Bo Zhang
Open Access Dissertations
Why do we need mathematical modelling Ecological modelling yields more general understanding and theory and provides testable and robust predictions. In particular, it is currently reaching the “next level” towards predictive and re-usable theory that can support environmental decision-making (Evans et al. 2013b). Therefore, in this dissertation work, I applied mathematical modelling to bridge pure mathematic theory with real ecology problems into two sections: (1) testing and understanding the impact of dispersal on total population size in a heterogeneous environment; (2) understanding and simulating the impact of biological control on an invasive plant and the long term dynamic change of …
The Impact Of Intrathecal Baclofen On Growth Among Children With Spasticity Ages 2-20 Years, Amy Lynn Malmsberry Kaye
The Impact Of Intrathecal Baclofen On Growth Among Children With Spasticity Ages 2-20 Years, Amy Lynn Malmsberry Kaye
Open Access Dissertations
Spasticity is present in 80% of children experiencing Cerebral Palsy (CP) and 50% of those having sustained a Traumatic Brain Injury (TBI) (Tilton, 2015; O'Shea, 2008). Growth impairment among children with motor disabilities secondary to a Central Nervous System (CNS) insult is common and interferes with mobility, functioning comfort, and Quality of Life (QOL) (Vles, 2011; Mallarkey, 2009; Krick, Murphy-Miller, Zeger, & Wright, 1996). Spasticity may range fro mild to severe involving any body part (Mallarkey, 2009). There are a broad range of treatment modalities for managing spasticity impacting the child, parent or caregiver, and a multidisciplinary healthcare team (Brashear …
Monitoring Of Electroencephalographic And Multi-Rate Auditory Evoked Response Changes During Altered Levels Of Consciousness, Alexander Castro-Llanos
Monitoring Of Electroencephalographic And Multi-Rate Auditory Evoked Response Changes During Altered Levels Of Consciousness, Alexander Castro-Llanos
Open Access Dissertations
Background: There is a need to expand the research on intraoperative awareness to better understand the patient’s neurologic responses and effectively predict and prevent unintended awareness. Previous studies in altered levels of consciousness in anesthesia and sleep have only focused on either electroencephalogram (EEG) or evoked potentials (EP) analysis. Additionally, EP studies only focused on either transient or steady-state response. Purpose: To investigate the inherent patterns associated with altered levels of consciousness in both anesthesia and sleep models as extracted from the simultaneous acquisition of both multi-rate auditory EPs and EEG spectral descriptors. Methods: Anesthesia recordings were acquired from five …
Genetic And Molecular Biomarkers Associated With Radiotherapy-Related Pain Among Breast Cancer Patients, Eunkyung Lee
Genetic And Molecular Biomarkers Associated With Radiotherapy-Related Pain Among Breast Cancer Patients, Eunkyung Lee
Open Access Dissertations
Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer death in American women. Compared to surgery alone, post-surgery adjuvant radiotherapy (RT) significantly reduces local-regional recurrence and mortality, and currently there are more than 3.5 million breast cancer survivors in the United States. Therefore, it is important to address quality of life issues related to RT-induced side effects and pain is one of the most prevalent side effects from cancer treatments. However, predictors and molecular mechanisms for the development of RT-related pain in breast cancer survivors have not been well defined. Therefore, to achieve our …
Vesicular Stomatitis Virus Is A Malleable Oncolytic Vector For The Treatment Of Various Malignancies, Dillon M. Betancourt
Vesicular Stomatitis Virus Is A Malleable Oncolytic Vector For The Treatment Of Various Malignancies, Dillon M. Betancourt
Open Access Dissertations
Oncolytic virotherapy is an exciting field that is currently generating a significant amount of interest. Several viruses have recently been approved for clinical use and there are many more in clinical trials awaiting approval. Vesicular Stomatitis Virus (VSV) has performed remarkably well in many preclinical studies and several strains have entered clinical trials across the world. VSV is a negative strand ssRNA virus in the Rhabdoviridae family and mainly infects livestock which produce sores on the mucus membranes. VSV infection in humans is extremely rare and most often asymptomatic due to its inability to overcome the innate and adaptive immune …