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Structural And Biochemical Characterization Of Deubiquitinating Enzymes, Sst2 And Ssel, Rashmi Kalicharan Shrestha
Structural And Biochemical Characterization Of Deubiquitinating Enzymes, Sst2 And Ssel, Rashmi Kalicharan Shrestha
Open Access Dissertations
Associated molecule with SH3 domain of molecule (STAM), or AMSH, is a
The Role Of The Set1 Rna Polymerase Ii Interacting Motif (Srim) In Set1 Recruitment And Histone H3k4 Methylation, Yueping Zhang
The Role Of The Set1 Rna Polymerase Ii Interacting Motif (Srim) In Set1 Recruitment And Histone H3k4 Methylation, Yueping Zhang
Open Access Dissertations
In eukaryotes, gene expression is regulated by epigenetic modifications. Among these modifications, histone H3 lysine 4 (H3K4) methylation has been associated with transcription activation. Set1 is the sole H3K4 histone methyltransferase in Saccharomyces cerevisiae and functions in a multi-subunit protein complex (Set1C) to catalyze H3K4 mono-, di-, and trimethylation. In addition, mis-regulation of Set1 human orthologs such as MLL (1 to 4) or SETD1A/B have been linked to a variety of cancers such as leukemia and early embryonic development defects. The current model indicates that the Paf1 complex (RNA polymerase II associated factor I) recruits Set1C to the phosphorylated CTD …
Structural Elucidation Of Deprotonated Analytes Via Tandem Mass Spectrometry Based On Ion-Molecule Reactions And Collision-Activated Dissociation, Hanyu Zhu
Open Access Dissertations
Mass Spectrometry has emerged as a powerful analytical tool for the characterization of unknown molecules. Molecular weight information and chemical formulas of the unknowns can be derived by measuring the m/z value of the ionized analyte. In addition, structural information can be obtained via tandem mass spectrometry methods such as collision-activated dissociation (CAD). However, CAD does not always guarantee unambiguously assignment of chemical structures, therefore, additional tandem mass spectrometric methods such as ion-molecule reactions were developed.
Characterization Of Water Mediated Hydrophobic And Ionic Interactions Using Raman Spectroscopy, Samual Robert Zukowski
Characterization Of Water Mediated Hydrophobic And Ionic Interactions Using Raman Spectroscopy, Samual Robert Zukowski
Open Access Dissertations
Raman spectroscopy can be combined with multivariate curve resolution (MCR),
Linear And Nonlinear Fluorescence Lifetime Imaging For Biosensing Applications, Nur Pradani Damayanti
Linear And Nonlinear Fluorescence Lifetime Imaging For Biosensing Applications, Nur Pradani Damayanti
Open Access Dissertations
Fluorescence techniques, based on both linear and non-linear excitation, have been widely used in biosensing application. Among fluorescence techniques, Fluorescence Lifetime Imaging (FLIM) has gained increased importance because of their robust and versatile feature. FLIM is a technique to visualize the spatial distribution of picosecond to nanosecond excited state lifetimes within microscopic images. In this work, FLIM technique combined with Time Correlated Single Photon Counting (TCPSC) Technology was used to develop several novel biosensing approaches. Using linear or nonlinear excitation source, TCSPC-FLIM enabled real time monitoring of cellular metabolite profiles, as well as longitudinal observation of post-translational enzyme activity such …
Deciphering The Role Of Hsp31 As A Multitasking Chaperone, Kiran Aslam
Deciphering The Role Of Hsp31 As A Multitasking Chaperone, Kiran Aslam
Open Access Dissertations
Among different type of protein aggregation, amyloids are biochemically well characterized state of protein aggregation that is commonly associated with a large number of neurodegenerative diseases in mammals and cause heritable traits in Saccharomyces cerevisiae. Among many other neurodegenerative diseases linked with amyloids, Parkinson’s disease is the second most common disorder that is caused by progressive deterioration of dopaminergic neurons in substantia nigra. Cellular stresses such as accumulation of high level of reactive oxygen species, mitochondrial dysfunction and α-syn aggregation lead to toxicity and neuronal cell death in Parkinson’s disease patients. Mutations in certain genes are also involved in the …
A Mechanistic-Based Approach To Reduce Biological Adhesion, Chelsey Del Grosso
A Mechanistic-Based Approach To Reduce Biological Adhesion, Chelsey Del Grosso
Open Access Dissertations
Since the early ages of oceanic transportation, ship hulls have been encrusted with foulers including barnacles, oysters, and mussels. With the attachment of these animals, vessels exhibit a decrease in top speed while fuel consumption increases. This not only becomes expensive, but also has contributions to climate change. Current antifouling coatings function by releasing toxic copper into the water, keeping hulls clean at the expense of marine life. Consequently, there is great need to develop environmentally benign coatings to reduce biological adhesion. Recent mechanistic insights suggest that the marine mussel, Mytilus edulis, adheres with proteins that undergo oxidative cross-linking. Our …
Lake Michigan Tributary Characteristics, Nutrient Loading Trends, And River Plume Dynamics, Rebecca Rose Essig
Lake Michigan Tributary Characteristics, Nutrient Loading Trends, And River Plume Dynamics, Rebecca Rose Essig
Open Access Dissertations
In response to the increasing frequency of water quality impairment near tributary outlets, understanding the delivery of nutrients to the nearshore region of the Great Lakes is becoming increasingly important. This study assessed the transport of nutrients from tributaries to the nearshore region of lakes by evaluating the dynamics of tributaries and river plumes. Analysis focused on answering the following questions: (1) How do hydrologic characteristics of Lake Michigan tributaries vary historically and in comparison to each other; (2) How do nutrient concentrations vary episodically and chemostatically within Lake Michigan tributaries, and how does this impact nutrient loading; (3) How …
Women Writers And The Genealogy Of The Gentleman: Masculinity, Authority, And Male Characters In Eighteenth-Century English Novels By Women, Mary Elizabeth Harris
Women Writers And The Genealogy Of The Gentleman: Masculinity, Authority, And Male Characters In Eighteenth-Century English Novels By Women, Mary Elizabeth Harris
Open Access Dissertations
This dissertation demonstrates that women authors in the eighteenth century carved out a space for their authority not by overtly opposing their male critics and society’s patriarchal structure, but by rewriting the persona of the gentleman—the poster boy for eighteenth-century society’s moral, masculine, and patriarchal values—and thereby advocating for novels as an important site for cultivating proper masculine behavior as well as a means of renegotiating gender relationships. Eighteenth-century feminist criticism has charted the wide-ranging and creative avenues women carved out for themselves within a male-dominated, patriarchal culture. However, critics have typically dismissed the male characters of eighteenth-century female authors …
Structure, Geology, And Engineering Properties Of Two Carbonatic Fine-Grained Soils, Alain El Howayek
Structure, Geology, And Engineering Properties Of Two Carbonatic Fine-Grained Soils, Alain El Howayek
Open Access Dissertations
Soft, carbonate-rich, fine-grained soils are commonly found in the glaciated regions of the northern United States and throughout Canada. In addition to the high compressibility potential and low shear strength, these sediments are typically characterized by alternating layers of silts and clays as well as high calcium carbonate content. The unique properties of these deposits make them challenging soils for geotechnical engineers. Despite the prevalence of soft carbonatic soils in Indiana and the concerns associated with their behavior, very limited work has been done to study their engineering properties. This was the motivation for the research, which is founded on …
Identification And Quantification Of Greenhouse Gas Emissions From Oil And Natural Gas Operations Using An Aircraft-Based Mass Balance Technique, Tegan Noel Lavoie
Identification And Quantification Of Greenhouse Gas Emissions From Oil And Natural Gas Operations Using An Aircraft-Based Mass Balance Technique, Tegan Noel Lavoie
Open Access Dissertations
Rapid advancements in horizontal drilling and hydraulic fracturing techniques have led to a booming natural gas industry. Natural gas is considered a cleaner fuel alternative to coal, producing less carbon dioxide (CO2) upon combustion per unit energy produced, and therefore has been hailed as a bridge fuel during conversion from fossil fuels to renewable energies for electricity production. The primary component of natural gas is methane (CH4), a potent greenhouse gas with 28 times the global warming potential of CO2 on a 100 year timescale. At oil and natural gas facilities, CH4 leaks are common due to changes in operational …
Co-Orthologs Of Katanin1 Impact Plant Morphology And Show Differential Evolution In Maize, Kin Ho Lau
Co-Orthologs Of Katanin1 Impact Plant Morphology And Show Differential Evolution In Maize, Kin Ho Lau
Open Access Dissertations
Understanding how the size and shape of crop plants and their specific organs are genetically controlled may allow for the development of cultivars with improved plant architecture. A microtubule-severing enzyme called katanin p60 is encoded by KATANIN1 (KTN1) in Arabidopsis or by an ortholog, dwarf and gladius leaf1 (dgl1), in rice. Katanin p60 has been implicated in the control of anisotropic cell growth, which is cell growth directed in a specific direction instead of equally in all directions. Anisotropic cell growth is crucial for proper plant shape and its disruption in ktn1/dgl1 mutants leads to morphological changes such as stunted …
Fundamental Studies Of Collision-Activated Dissociation (Cad) Of Deprotonated Model Compounds Relevant To Lignin Degradation Products, Christopher Louis Marcum
Fundamental Studies Of Collision-Activated Dissociation (Cad) Of Deprotonated Model Compounds Relevant To Lignin Degradation Products, Christopher Louis Marcum
Open Access Dissertations
ABSTRACT
Development Of Dendrimer-Based Technologies For Phosphoproteomics And Glycoproteomics In Biomarker Discovery, Li Pan
Open Access Dissertations
The dynamics of post-translational modifications (PTMs) of proteins keeps cells adapting to the ever-changing microenvironment by regulating protein structure and function in the real-time mode. Of all PTMs, protein phosphorylation and glycosylation are undoubtedly two of the most common and important PTMs and have been demonstrated to be closely linked to the onset and progression of various human diseases. Our lab has been focusing on developing novel and more efficient technologies by taking advantage of the properties of dendrimers – a soluble nanopolymer with chemically well-defined structure and functional surface groups – to facilitate the detection and quantification of PTMs …
Assessing The Impact Of Emerging Contaminants On Anaerobic Microbial Communities, Leila M. Nyberg
Assessing The Impact Of Emerging Contaminants On Anaerobic Microbial Communities, Leila M. Nyberg
Open Access Dissertations
The impact of emerging contaminants on anaerobic microbial communities is critical and
Being And Literature: The Disclosure Of Place In Modernity, Donovan Irven Martin
Being And Literature: The Disclosure Of Place In Modernity, Donovan Irven Martin
Open Access Dissertations
The dissertation develops an original ontology of place by reading Modernist literature (1864-1950) as a critical reaction to Modern philosophy (1641-1800), and builds a platform upon movements implicit in literature from which future metaphysical and epistemological inquiries can begin. Western metaphysics and epistemology have been conditioned by the Cartesian commitment to the ego cogito, primarily understood as a subject to which the world appears as represented in concepts or ideas. The postmodern and deconstructive criticisms of such philosophical foundations – and indeed, on the very notion of foundation itself – have become well worn, but have failed to offer a …
Investigating Rheological Techniques To Model And Predict Operating Conditions Of A Single Screw Extruder With Internal Restrictions, Amudhan Ponrajan
Investigating Rheological Techniques To Model And Predict Operating Conditions Of A Single Screw Extruder With Internal Restrictions, Amudhan Ponrajan
Open Access Dissertations
Understanding rheology of raw materials and the numerous transformations they undergo is an essential aspect of modeling and predicting extrusion conditions. Both off-line capillary rheometry and in-line extruder fed rheometry techniques have been used to model rheology of materials during extrusion. Investigations on use of an off-line capillary rheometer to model apparent viscosity of full fat soy flours revealed inability of the capillary rheometer to handle food/biological materials high in oil content (20%) at high temperature (80C) and low moisture content (15% wet basis). The lack shear degradation in the capillary rheometer also resulted in over-prediction of corn flour viscosities …
Protein Kinase A Regulates Hyphal Growth By Relieving The Interaction Of Mosfl1 With The Cyc8-Tup1 Co-Repressor In Magnaporthe Oryzae, Yang Li
Open Access Dissertations
The cAMP-dependent protein kinase A (PKA) signal transduction pathway plays an important role in morphogenesis and virulence in plant pathogenic fungi. In the rice blast fungus Magnaporthe oryzae, it regulates surface recognition, appressorium turgor generation, and invasive growth. Two genes in M. oryzae named CPKA and CPK2 encode the catalytic subunits of cAMP-dependent protein kinase A. Previous studies have shown that deletion of CPKA failed to block response to exogenous cAMP, suggesting the involvement of CPK2 in cAMP signaling. To further characterize the function of the catalytic subunits of PKA in infection-related development in M. oryzae, we generated the cpkA …
Insights Into Substrate Recognition By The Anaphase Promoting Complex (Apc), Liang Qin
Insights Into Substrate Recognition By The Anaphase Promoting Complex (Apc), Liang Qin
Open Access Dissertations
Mitotic exit depends on the proper degradation of numerous cell cycle-regulated proteins, which is executed by an E3 ubiquitin ligase called the anaphase promoting complex (APC). APC adds polyubiquitin chains to numerous substrates, which leads to their subsequent degradation in late mitosis and G1 phase. The selective and timely recognition and degradation of APC substrates is essential for proper cell cycle progression and maintenance of genome stability. However, a key question is how APC specifically recognizes such a diversity of substrates. The activation of APC requires binding to one of its co-activators, Cdh1 or Cdc20. The co-activators directly facilitate APC …
Investigation Of Novel Displacement-Controlled Hydraulic Architectures For Railway Construction And Maintenance Machines, Damiano Padovani
Investigation Of Novel Displacement-Controlled Hydraulic Architectures For Railway Construction And Maintenance Machines, Damiano Padovani
Open Access Dissertations
This dissertation aims at showing how to transform hydraulic systems of railway multi-actuator machinery characterized by inefficient state-of-the-art systems into the 21st Century. Designing machines that are highly efficient, productive, reliable, and cost affordable represents the target of this research. In this regard, migrating from valve-controlled architectures to displacement-controlled layouts is the proper answer. Displacement-controlled systems remove the losses generated by flow throttling typical of conventional circuits, allow an easy implementation of energy recovery (e.g. during regenerative braking), and create the possibility for the use of hybrid systems capable of maximizing the downsizing of the combustion engine. One portion of …
Nested Association Mapping To Identify Seed Composition Qtl In Diverse Soybean Lines, Mohammad Wali Salari
Nested Association Mapping To Identify Seed Composition Qtl In Diverse Soybean Lines, Mohammad Wali Salari
Open Access Dissertations
Soybeans are economically the most important legume grown worldwide. It provides quality protein and oil to food and feed markets in addition to being used for industrial products. The value of soybean could be enhanced by increasing protein, oil, and sucrose contents, while lowering anti-nutritional compounds such as oligosaccharides. Understanding the genetic and environmental factors controlling soybean seed composition is an essential prerequisite for such an endeavor. Three separate studies were initiated to understand the underlying genetics governing soybean seed compositional traits.
The Mechanism Of Vitamin D Meidated Protection From Experimental Colitis, Fa Wang
The Mechanism Of Vitamin D Meidated Protection From Experimental Colitis, Fa Wang
Open Access Dissertations
ABSTRACT
1,25-Dihydroxyvitamin D Regulation Of Triacylglycerol Accumulation In Differentiated Adipocytes, Brienna Larrick
1,25-Dihydroxyvitamin D Regulation Of Triacylglycerol Accumulation In Differentiated Adipocytes, Brienna Larrick
Open Access Dissertations
Obesity is a major public health concern, both in the United States and worldwide. Therefore, identification of measures by which obesity may be prevented and reversed is of high priority. Epidemiological studies consistently demonstrate an inverse relationship between serum 25(OH)D levels, an indicator of vitamin D status, and measures of adiposity. These data suggest that vitamin D may play a role in the prevention of excessive adiposity. However, whether vitamin D impacts lipid storage and metabolism in terminally differentiated adipocytes is not yet known. The purpose of this work was to determine the impact of 1,25-dihydroxyvitamin D (1,25(OH)2D), the bioactive …
Africa Is Always Bringing Forth Something New: African Worlds And Worldviews In British Enlightenment Literature, 1660-1780, Rebekah Kurtz Mitsein
Africa Is Always Bringing Forth Something New: African Worlds And Worldviews In British Enlightenment Literature, 1660-1780, Rebekah Kurtz Mitsein
Open Access Dissertations
This dissertation argues that African worlds and worldviews left an indelible mark on British Enlightenment texts, whether their authors encountered the continent first or secondhand. As eighteenth-century thinkers began experimenting with empirical and categorical strategies for making sense of the globe, Africa was an important testing ground for these burgeoning epistemological methodologies. Travelers and writers tried to reconcile observer-based methods of knowledge production with the continent’s reputedly impenetrable landscapes, unfamiliar cultures, and strange animals. Such inquiries engendered broader philosophical debates about the natures of nature, the body, and the self. Yet, I contend Africa was not a passive participant in …
Approaching Dna Methylation At The Nanoscale, Yi Cui
Approaching Dna Methylation At The Nanoscale, Yi Cui
Open Access Dissertations
Epigenetics involves a variety of biochemical modifications occurring on chromatin that are able to regulate and fine-tune genetic activities without altering the underlying DNA sequence. So far, four types of epigenetic modulation have been extensively studied: DNA methylation, histone post-translational modification, non-coding RNA, and nuclear organization. A fast-growing body of evidence suggests that epigenetic mechanism plays a fundamental role in physiology and pathology. Of the elucidated epigenetic processes, DNA methylation is the one under intense research due to its direct impact on gene expression, which dynamically bridges the microscale genotype and macroscale phenotype. However, to date our understanding of DNA …
Hookless1 Regulates Responses To Pathogens And Abscisic Acid Through Interaction With Mediator18 And Acetylation Of Wrky33 And Abi5 Chromatin, Chao-Jan Liao
Open Access Dissertations
Arabidopsis histone acetyltransferase HLS1 has been implicated in the control of seedling development in response to ethylene. Here, we demonstrate that the loss of function hls1 mutant plants have broad effects on the plant development such as early senescence and flowering, seed insensitivity to ABA as well as plant defense responses including enhanced susceptibility to the necrotrophic pathogen Botrytis cinerea and the hemi-biotrophic pathogen Pseudomonas syringae DC3000 strain expressing the effector protein AvrRpm1 strain. We show that HLS1 modulates the expression of WRKY33 gene, a known defense regulator, as well as ABI5 in modulating ABA signaling pathway. The regulation of …
Light Localization In Biological Media, Seung Ho Choi
Light Localization In Biological Media, Seung Ho Choi
Open Access Dissertations
Light in natural and biological media is known as freely diffusing. When light undergoes multiple scattering through inhomogeneous dielectric biomacromolecules, interference is ignored. If scattered waves return to their origin points along the time-reversed paths for constructive interference, outgoing waves can be forbidden, occasionally being on-resonance or off-resonance with Anderson localized modes. However, such a phenomenon in optics requires high-refractive-index contrasts, which intrinsically do not exist in organic molecules (e.g. proteins, lipids, carbohydrates, and nucleic acids). Here we predict and show experimentally that the long-standing perception of diffusive nature of light in biological media is broken by an exquisite distribution …
Manufacture Of Individualized Dosing: Development And Control Of A Dropwise Additive Manufacturing Process For Melt Based Pharmaceutical Products, Elcin Icten
Open Access Dissertations
The improvements in healthcare systems and the advent of precision medicine initiative have created the need to develop more innovative manufacturing methods for the delivery of individualized dosing and personalized treatments. In recent years, the US Food and Drug Administration (FDA) introduced the Quality by Design (QbD) and Process Analytical Technology (PAT) guidelines to encourage innovation and efficiency in pharmaceutical development, manufacturing and quality assurance. As a result of emerging technologies and encouragement from the regulatory authorities, the pharmaceutical industry has begun to develop more efficient production systems with more intensive use of on-line measurement and sensing, real time quality …
Dissecting The Spatiotemporal Regulation Of Yeast Kinetochore Interactions, Kriti Shrestha Thapa
Dissecting The Spatiotemporal Regulation Of Yeast Kinetochore Interactions, Kriti Shrestha Thapa
Open Access Dissertations
Kinetochores are conserved protein complexes that bind the centromeres in replicated chromosomes to the mitotic spindle and then direct their segregation. To better comprehend Saccharomyces cerevisiae kinetochore function, we investigated the phospho-regulated dynamic interaction between the conserved kinetochore protein Cnn1CENP-T, the centromere region and the Ndc80 complex through the cell cycle. Cnn1 localizes to kinetochores at basal levels from G1 through metaphase but accumulates abruptly at anaphase onset. How Cnn1 is recruited and which activities regulate its dynamic localization is unclear. We show that Cnn1 harbors two kinetochore-localization activities: a C-terminal histone-fold domain that associates with centromere region, and a …
Design Of Mixed-Solvent Extraction And Size-Exclusion Simulated Moving Bed Chromatography To Recover Valuable Compounds From Electronic Waste, George S. Weeden Jr.
Design Of Mixed-Solvent Extraction And Size-Exclusion Simulated Moving Bed Chromatography To Recover Valuable Compounds From Electronic Waste, George S. Weeden Jr.
Open Access Dissertations
More than one million tons of polycarbonates and over 500,000 tons of flame retardants are consigned to landfills each year in the form of waste electrical and electronic equipment. Electronic waste is the fasting growing waste steam at a rate of 3-5% per year. Two separation processes are developed to efficiently recover these valuable compounds.