Digital Commons Network^™

Functionalized Bodipy Dyes For Near-Infrared Emission Of Lanthanide Complexes, Rukshani Wickrama Arachchi

Masters Theses

For many decades, fluorophores have been used to investigate natural systems, but autofluorescence and photobleaching diminish the detection capacity. Recently, BODIPY based lanthanide complexes have been synthesized and their photophysical properties have been investigated. These complexes exhibit higher emission efficiencies at NIR region with longer NIR lifetimes upon exciting at longer wavelength.

In this study, two BODIPY based lanthanide complexes were synthesized and their photophysical properties were evaluated. BODIPY based ligands were synthesized with phenanthroline as the ligand binding group. These ligands exhibit strong absorption at 527 nm and 532 nm, fluorescence at 540 nm and 548 nm with 0.55 …

"Novel" Biopolitics: Reading Defoe And Coetzee Through Foucault, Derrida, And Esposito, Ben Cravens

Masters Theses

No abstract provided.

I Could Have Been You: Core-Self Differentiation As It Relates To Empathy And Aggression, Nazmi Cem Turker

Masters Theses

Previous research showed that the more one feels similar to a specific other, the less aggressive and the more empathic one behaves toward the other. Some people might have a self-concept that makes them prone to feel similar to others in general. Those people, despite being aware of the differences between them and others, may feel that their differences do not make them inherently or essentially different from others -they may feel their core-self is similar to others despite outer differences, while some may not feel as much so. This tendency was conceptualized as a trait related to one's self-concept …

Construct Validity Of The Teate Depression Inventory With A Black African American Sample, Samantha Rushworth

Masters Theses

The purpose of this study was to assess the construct validity of a new measure of depression, the Teate Depression Inventory (TDI), with primary focus on the Black/African American participants. Research has demonstrated that Black/African Americans experience disparity in receiving mental health care for internalizing disorders, partially due to under-detection of symptoms. Detection of internalizing disorders is an important step in receiving appropriate treatment. This research is essential to benefit mental health practices, addressing the need for professionals to be culturally competent and aware of the appropriate assessment tools available. In order to best serve ethnic minorities, validity of measurements …

On Solid Ground I Stand: Narratives On Disclosure, Resilience, And Faith Amidst Recognition Of Childhood Sexual Abuse, Wade Rhodes Dundee

Masters Theses

Childhood sexual abuse seems to be a hidden secret in American society; one of the famous, "If we don't talk about it, it won't happen" narratives. However, we know this is not true. Both the National Sexual Violence Resource Center (2012) and Center for Disease Control and Prevention (2005) state one in four girls and one in six boys will fall victim to sexual abuse before they celebrate their 18th birthday. There is a high probability that because of the alarming lack of disclosure of male survivors, these statistics could be incorrect and could hinder creating or allowing for conversations …

Detection Of Antibiotic Resistance Loci In Wastewater And Fresh Water Samples, Mohammed Hamed Almalki

Masters Theses

Proper treatment of municipal wastewater is important not only for prevention of eutrophication but also for public health concerns. One consideration for wastewater treatment is the presence of organisms carrying antibiotic resistance genes. If these organisms survive the wastewater treatment process and are released into the streams, they can pose significant risks to public health. In addition, their presence also raises concerns for lateral gene transfer events at the wastewater plant. The spread of antibiotic loci has a major impact in public health and clinical therapy because resistant organisms render conventional treatments of important illnesses difficult. Beta-lactam drugs are known …

Resilience And Thriving In Homeless College Students, Cayla C. Maurer

Masters Theses

Homeless college students face many obstacles in higher education. These students are the invisible population on campuses that are sometimes forgotten. Despite facing many challenges and barriers, these students continue to pursue a degree of higher education. The purpose of this study was to understand the experiences and obstacles homeless college students face while they word toward a degree. Understanding how successful homeless college students overcome barriers and utilize resources will provide information that may change the fate of future homeless college students. A phenomenological approach was utilized to explore the qualities and characterizes that allow homeless college students to …

The Role Of Creg1 As A Master Regulator Of Liver Function, Abdulrahman Siran Aldaghmi

Masters Theses

The liver is known as the chemical factory of the body because it performs a wide range of biochemical functions required for life. Since the liver has such an important role in regulation of normal physiological processes, liver diseases cause a high rate of morbidity and mortality. Therefore, understanding the mechanisms of liver development will shed light on the causes of liver disease. In this study, a cell line model that utilizes rat hepatoma cells (Fg14) and hepatoma variant cells (H11) was used to identify master regulators of liver gene expression. Whole genome expression studies identified the gene CREG1 (Cellular …

Bodipy-Based Red Sensitizers For Near-Infrared Emission Of Lanthanide Complexes, Priyangika Prasadini Senevirathne

Masters Theses

During the past 20 years there has been a remarkable growth in the use of the fluorescence technique in biological studies. Fluorescence and time-resolved fluorescence spectroscopy are considered primary research tools in the field of biochemistry. Currently, fluorescence spectroscopy is a dominant methodology and used widely in biotechnology and medical diagnosis process. One impediment in using fluorescent probes is the fluorescence of biological substrates and fluorescence of diagnostic probes are significantly overlapped, and it decreases the detection sensitivity. Also, commercially available probes require UV or near-UV light excitation, causing severe degradation of biological substrates. Near-infrared emitting lanthanide complexes can overcome …

The North American River Otter (Lontra Canadensis) On The Department Of Energy's Savannah River Site, Emily B. Mccallen

Masters Theses

The Department of Energy's (DOE) Savannah River Site (SRS) faces a legacy of radionuclide and metal contamination from industrial processes that occurred within the site. The risks posed to ecosystems on the site from contaminants are quantified using the ecological risk assessment process, which often uses the health of a particular species as an ecological endpoint. Northern river otters (Lontra canadensis) are appropriate receptors for studying the effects of long-term, low-level contamination because they are long-lived, higher trophic level organisms likely to accumulate high levels of pollutants. However, little information about river otters on the SRS is known; …

Molecular Recognition Profiles Of Molecular Cocrystals, Ian C. Tinsley

Masters Theses

The manner in which molecules recognize each other holds critical importance to nearly every area of science. This significance stems from the key underpinning of molecular assembly to our most basic understanding of chemical processes. Whether these interactions relate to small-molecule catalytic transformations or complex physiological processes, the structural features responsible for molecular association play into the well-known adage that form follows function where material property arises from the collective structural features of the molecular components. Because the form of chemical systems is derived from a complex blend of covalent and non-bonded contacts, codifying each contributor has become essential for …

Gauging The Importance Of Microhabitat In Qualitative Macroinvertebrate Sampling In An Effluent Dominated Stream, Samuel James Gradle

Masters Theses

In the past different sampling strategies have been used to relate macroinvertebrate assemblages with habitat quality in the Sangamon River, above and below the sanitary district effluent discharge in Decatur, IL. The standard 20 jab method of proportional sampling in multiple microhabitats, based on QHEI physical habitat score, sampled allowed for comparison between sites based on overall community composition. However, it oversampled fine sediments, which dominate the Sangamon, therefore potentially missing sensitive taxa in isolated quality habitats. In the fall of 2016 I tested an enhanced qualitative approach to better gauge the importance of microhabitat types to macroinvertebrate assemblages in …

Synthesis And Characterization Of Cu(Ii)-Cu(I) Mixed Valence Complexes, Hansani T. Lekam Wasam Liyanage

Masters Theses

Our study was focused on synthesis and characterization of new family of metal complexes that mimic the active site of copper containing enzymes. Our approach focused on preparing a series of metalloligands which vary systematically in structure and use them in combination with additional metallic centers to synthesize our desired complexes.

We synthesized a main ligand, which is named as HL^Q 2Pz, which contain a quinoline body, one amide bond and two pyrazolyl rings. We synthesized a copper complex by deprotonating HL^Q 2Pz using KOH. The ligand coordinated to the copper(II) center through its quinoline nitrogen, two of …

Macroinvertebrate Community Composition, Food Web Structure, And Emergence Rate In Neotropical Cloud-Forest Streams In Mindo, Ecuador, Anna M. Harris

Masters Theses

Tropical cloud forest streams are one of the most threatened and understudied ecosystems in the world. Understanding how these ecosystems function is essential for effective conservation. In this study, macroinvertebrate community composition, functional feeding group analysis, ecosystem attributes, and physicochemical parameters were used to evaluate biophysical stream conditions of 3 low-order Neotropical cloud forest streams at Reserva Las Gralarias in Mindo, Ecuador. Additionally, food web structure was analyzed via stable isotope analysis and aquatic insect emergence rate was also examined. As stream size increased from 1st to 3rd order, the macroinvertebrate communities shifted from being collector-gatherer dominated (65.2 to 29.8%, …

Re-Optimization Of Radiation Therapy Dose To The Prostate Using Cbct: Reducing Dose To Organs At Risk, R. Charles Keider Jr.

Masters Theses

Cancer of the prostate is the second most common cancer among American males. The prostate is small gland, located in the pelvis, posterior to the bladder and anterior/inferior to the rectum. Due to this location when irradiating the prostate the normal tissue organs at risk are the bladder and rectum. Negative effects seen when these structures are irradiated can include; bladder stricture, dysuria, hematuria, diarrhea, rectal bleeding, and proctitis.

In order to eliminate or reduce these negative effects more precise and accurate treatment techniques have been employed. Intensity Modulated Radiation Therapy (IMRT) has been successful in achieving greater precision when …

Inquiry-Based Biotechnology Education For Kent Intermediate School District Early College Program, Meāgan N. Treadway

Masters Theses

Growth in the field of biotechnology, combined with the ability to access information instantaneously, requires a new model of science education that will nurture deeper understanding and higher order thinking to develop a scientifically literate population. Inquirybased learning is a student-centered model built on the theoretical framework of constructivism, which allows students to learn in a way that reflects how scientists come to understand the natural world. This project aimed to address the need for an inquiry-based biotechnology curriculum in a local Early College program by developing, piloting, revising, and implementing an inquiry-based biotechnology unit while simultaneously evaluating the impact …

Evaluation Of The Nutritional Options For Wellness (Now) Program: Mitigating Cardiovascular Disease And Type 2 Diabetes Through Food Pantries, Sarah L. Henning

Masters Theses

Individuals with a lower socioeconomic status are at higher risk for chronic disease diagnosis and complications (Gerteis et al., 2014). The NOW Program is a social service program that was created in order to relieve some of the burden placed on these individuals utilizing the charitable food system. The purpose of the study was to perform a quantitative program evaluation on the NOW Program which is administered by pantry coordinating organization. The NOW Program connects chronically ill, low income members of Kent County with local food pantries that offer diet specific food and health education about their specific chronic disease …

‘How Yoga Are You?’: Exploring The Contemporary Practice Of Yoga In The United States, Olivia Mclaughlin

Masters Theses

In 2015, to the United States, 21 million Americans claimed to be regular practitioners of yoga. Yoga has long been studied by psychologists, therapists, and medical scientists for its ability to affect positive change in people’s lives, particularly in regards to mental and emotional health and well-being. Within the field of sociology, yoga has gained an increasing amount of attention for its ability to help treat chronic eating disorders among women, becoming extremely popular within the subfields of sociology of the body and gender. Additionally, the cultural impact of the transmission of yoga has fascinated social scientists interested in studying …

The Oncolytic Potential Of Tanapoxvirus To Treat Retinoblastoma, John D. Christie

Masters Theses

Retinoblastoma is the leading cause of intraocular malignancy in children under 2 years of age. Current treatments, while generally effective in eliminating the tumor, have many negative side effects. Oncolytic virotherapy is the use of either wild type or recombinant viruses, to destroy tumor cells. There are currently several viruses being engineered as potential therapeutics for a wide range of cancers. They offer tumor specific alternative to current therapies with lesser toxicity. This study looked at the oncolytic efficacy of multiple tanapoxviruses (TPV) recombinants in an in vitro retinoblastoma. Here we have tested recombinants of TPV for their ability to …

Experimental Characterization And Simulation Of Carbon Nanotube Strain Sensing Films, Nagendra Krishna Chaitanya Tummalapalli

Masters Theses

Carbon Nanotubes (CNTs) have excellent mechanical, electrical and electromechanical properties. These properties led to a lot of novel applications. Due to change in electrical properties under mechanical loading, these composites have potential applications in strain sensors, when these are fabricated as films. CNT-based films are commonly fabricated using different physical and chemical techniques based on the property requirements governing those applications. In this work, CNT films were prepared using wet chemical based methods and chemical vapor deposition techniques.

Plasma chemical vapor deposition using microwave power is used in the first method to deposit films on silicon substrates, using Nickel film …

Physiology And Genetics Shape The Microbiome Of A Seabird Species (Oceanodroma Leucorhoa) More Than Environmental And Social Factors, Douglas Steven Pearce

Masters Theses

The microbiome provides multiple benefits to animal hosts that can profoundly impact health and behavior. Microbiomes are well-characterized in humans and animals in controlled settings, yet assessments of wild bird microbial communities remain vastly understudied. This study examines the multiple factors that affect the microbiome of a burrow-nesting Procellariiform bird species, Leach’s storm-petrel. 16S rRNA-based Illumina Mi-Seq analyses are used to assess the composition and structure of bird and burrow-associated bacterial communities. Results indicate that sex and skin site contribute to bird-associated bacterial community variation, and MHC heterozygosity impacts these bacterial assemblages in a sex and site-specific manner, potentially having …

Development Of Fully Printed And Flexible Strain, Pressure And Electrochemical Sensors, Dinesh Maddipatla

Masters Theses

In recent years, considerable research has been put into the development of printed electronics (PE) as well as the best ways to effectively and efficiently print electronic devices on flexible substrates. This thesis focuses majorly on the design and fabrication of novel flexible sensors using conventional printing processes.

Initially, a flexible printed strain gauge was fabricated successfully on a flexible paper substrate using flexography printing process. Silver (Ag) ink was printed on the paper substrate as metallization layer. The performance of the printed device was investigated by subjecting the strain gauge to a 3-point bend test, with a displacement of …

Measurement Of Activity And Stability Of Physical Vapor Deposition (Pvd) Coated Crystal Surfaces, Anuradha Krishnan

Masters Theses

The overall objective of this research work is to investigate the hydrophilic and hydrophobic forces acting on organic crystal planes and understanding the interaction of functional groups with additive molecular nanolayers. Crystals of acetaminophen and lactose were made and the surface forces were tested on Atomic Force Microscope (AFM). Uniformity of crystal surface was confirmed from the AFM study in the first stage. The growth factors of crystal planes as a function of time were studied. Adhesion forces on plain crystals were measured on both two different organic crystals made of acetaminophen and lactose. In the second stage, …

Electrostatic Nanosmearing Architecture Of Additive Functional Groups During High Shear Mixing Of Pharmaceutical Blends, Sajan Kumar Chatarla

Masters Theses

The main objective of the research project is to detect and quantify the rate and extent of nanosmearing of hydrophobic functional groups of additives on multiple pharmaceutical particles during high shear mixing of formulations due to electrostatics affecting critical blend properties on the bulk scale. We accomplished this task by systematically detecting the electrostatics during powder flow and its consequence on the nanosmearing distribution of additives during mixing. In the first stage, the electrostatic behavior of particles was correlated to the powder flow. Secondly, its relative influence on nanosmearing of additives during mixing was determined by developing a methodology to …

The Failure Of Westphalia: A Constructivist Examination Of Western And Middle Eastern Relations, Jayson Warren

Masters Theses

This thesis is not intended to be a dogmatic or pedantic endorsement of any one religion, ethic, or culture. To the contrary, it is the intent of the author to examine a number of competing ideas, philosophies, and belief systems in order to extrapolate their geopolitical implications and to pursue them to their logical (albeit sometimes inevitable) conclusions. Too often, any number of presuppositions at work within a given situation go overlooked and subsequently skew geopolitical analysis and resulting policy decisions. This thesis seeks to transcend mere opinion or speculation and achieve instead a framework of Constructivism for pragmatic comprehension …

The Application Of Chitosan On An Experimental Infection Of Pseudogymnoascus Destructans Increases Survival In Little Brown Bats, Torin C. Kulhanek

Masters Theses

This research builds upon a previous study conducted that tested the efficacy of chitosan on experimentally-infected bats as a laboratory model of White-nose syndrome. White-nose syndrome is a fungal infection caused by Pseudogymnoascus destructans, formerly known as Geomyces destructans. The pathology of this disease is not yet fully understood, but it is devastating bats throughout Northeastern America and continues to spread. Here we tested multiple application time points and concentrations of chitosan on the wings of experimentally-infected bats and compared them with the controls. We grossly viewed the wings first to get a sense of the amount of …

Nightmare In The City Of Dreams: Civic Consciousness And Industrialization In Imperial Vienna, 1848-1881, J. Alexander Killion

Masters Theses

Since the onset of the Industrial Revolution, a distinct trend toward urbanization has continually reshaped history and society, yet the development and evolution of urban spaces has been largely overlooked by scholars until recent decades. This is especially true for the cities of the Habsburg Empire, although Vienna provides a good case study of industrialization’s impact on the urban landscape due to its history of rapid population growth, extensive environmental change, and established administrative structures. Although the logistical challenges associated with urban administration, such as importing adequate food, accessing clean water, and disposing of waste in a prompt manner were …

A Location Allocation Model For Retention Basin Placement On Vacant Land In Detroit, Mi, Keith Chapman

Masters Theses

The principal objective of this research is to develop a location-allocation model for vacant lots in the City of Detroit, MI, to analyze for the suitability of retention basin placement. The model will place the retention basins in areas that will effectively reduce the amount of stormwater runoff that reaches the surrounding storm drains. Detroit needs stormwater mitigation to relieve the burden that is currently on the outdated combined sewer system (CSS). The Detroit Future City strategic framework suggests the use of blue infrastructure controls to alleviate the sewer system and reduce the number of combined sewer overflows (CSOs). The …

Toward A Thomistic Environmental Ethic: How Aquinas's Metaethic Provides The Groundwork For An Environmentally And Zoologically Responsible Moral System, William Merle Green

Masters Theses

While the trend in contemporary discussions of environmental ethics is often to dispense with traditional anthropocentric conceptions of morality in favor of more biologically and ecologically inclusive perspectives, I will argue that Natural Law Theory and Virtue Ethics, both integral components of the moral philosophy of Thomas Aquinas, provide the groundwork for an ecologically and zoologically responsible ethic. Thus, utilizing the core of Aquinas’s ethical system, I will attempt to construct a robust moral framework that is Thomistic in every important sense while at the same time satisfies the sufficiency conditions for a successful environmental code of conduct.

Approved For All Audiences: A Longitudinal Content Analysis Of The Portrayal Of Women In Movie Trailers, Brooke S. O’Neil

Masters Theses

Movie trailers are ever present in our society and impactful in the way society constructs views about various aspects of life. Trailers are unique in that they are specifically tailored and edited to entice audiences to buy tickets to the film. Further, prior research has indicated that in various forms of media, women are continuously underrepresented, disproportionately sexualized, stereotyped, and victimized. The present study examines the portrayal of women through a content analysis of 230 of the top grossing trailers across seven decades: 1950-2015. The research focuses on women’s representation, sexualization, gender roles, and violence. The analysis reveals that in …