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Assessment Of The Discriminative Stimulus Effects And Time Courses Of Salvinorin A And Two Synthetic Salvinorin B Derivatives, Methoxylmethyl (Mom) And Ethoxymethyl (Eom), Ethers In Rats Trained To Discriminate U69,593, Lisa M. Bell

Masters Theses

Research regarding the psychopharmacology of salvinorin A, the main psychoactive ingredient in the hallucinogenic plant Salvia divinorum, has been motivated largely by a recent increase in its recreational use and widespread media attention focused on this plant and its extracts. In addition, there is considerable evidence that drugs acting on kappa opioid receptors (KOR) may have therapeutic potential in the treatment of some neuropsychiatric conditions, including drug dependence and mood disorders. Although the neuropharmacological actions of salvinorin A are well established, only a few studies have explored the behavioral effects of this substance in comparison to the KOR agonist, …

Early Arrest Mutant Ogre: A Defect In Cytokineis Caused By A Mutation In The Gene Racgap1, April Wicklund

Masters Theses

The early arrest mutant ogre, isolated in the Tübingen screen, has a block in cytokinesis (Kane et al., 1996). Here I use genetic and molecular techniques to demonstrate that the ogre phenotype is caused by a lesion in the gene encoding Racgap1. I performed fine mapping studies using microsatellite markers to a 0.15 cM region containing the ogre locus. DNA sequence data revealed a nonsense mutation in the Racgap1 gene of ogre mutants, and in situ hybridization experiments showed a loss of racgap1 mRNA at later stages of development, likely by nonsense mediated decay. This evidence supports the abolishment …

The Problem Of Evil, Modern Calvinism And The Doctrine Of Free Will: Is John Feinberg's Theodicy A Coherent Resolution To The Problem Of Tragic Moral Evil?, Michael Obanla

Masters Theses

The thesis examines and evaluates Feinberg's theistic defense against the problem of evil with a view to determining whether it represents a coherent and consistent resolution to the problem of tragic moral evil. The thesis relies on three criteria for the evaluation: the internal consistency of Feinberg's theistic defense, its exegetical accuracy, and epistemic adequacy.

Agriculture, Influence, And Instability Under The Ancien Régime: 1708-1768, Adam J. Polk

Masters Theses

The French Revolution has been studied from myriad perspectives. The majority of scholarship focuses on the political and urban chaos of the times. Agricultural conditions and the influence of onerous taxation and stagnant agricultural options are given only a cursory examination in most research. This thesis aims to investigate the relationship between agronomic and environmental conditions and the eruption of violence in urban centers during the French Revolution and the years leading up to it (1708-1768). This period prior to the French Revolution serves as a template to investigate the nature of the rural-agricultural influences, with a particular focus paid …

The Effects Of Altering Response Effort During Data Collection On Observer Accuracy: Data Collection Procedures On Hand Hygeine Compliance, Krista Hinz

Masters Theses

When dealing with human observers and error, tight control in data collection and methodology is essential for accurate representation of compliance. Although observational studies are popular, little has been done to study the integrity of human observers and the data collection process. Incomplete analysis of data collection integrity threatens functional findings, leading to problematic interpretation and decreased replication. The purpose of the current study was to assess whether manipulating the response effort associated with data collection has an effect on the accuracy of data collection. Participants of the study were undergraduate psychology students at a Midwestern university who were enrolled …

Assessing The Impacts Of Dams On Nutrient And Sediment Loading In The Kalamazoo River Using The Soil And Water Assessment Tool (Swat), Daniel Henry Serfas

Masters Theses

The Soil and Water Assessment Tool (SWAT) was applied to the Kalamazoo River Watershed in order to evaluate the impacts that several dams within a superfund site "Area of Concern" have on the sediment, nutrients, and streamflow of the system. It was hypothesized that the SWAT model could be used to recreate the watershed in hopes of estimating the amounts of nitrogen, phosphorus, and sediment that would result from the removal of the dams. The model would then be used to evaluate dam removal scenarios to come up with a best management practice (BMP).

The model was calibrated, however, during …

"His Head Rolled Forth Onto The Floor:" Women, The Abject, And The Male Gaze In Old English Poetry, Jaime Michelle Myers

Masters Theses

Old English poetry features several female characters who challenge androcentric authority by violently killing men. I argue in this thesis that three of these women—Modthryth, Grendel’s mother, and Judith—are linked together by their rejection or reversal of the male gaze. In their forceful refusal to be visually objectified, each character is portrayed as abject—outside of normal and outcast from community. They cause disorder, illustrate the fragility of androcentric control, and force a confrontation with death. In so doing, they create ambiguity and, at times, reverse the subject/object and masculine/feminine gender binaries.

Experimental Determination Of Colburn And Friction Factors In Small Plate Heat Exchangers With High Surface Enlargement Factors, Andrew H. Pike

Masters Theses

Experiments were conducted to measure the performance of several small brazed plate heat exchangers. A test apparatus was designed and constructed that allowed for the easy switching of the plate heat exchangers, as well as having the ability to electronically monitor and record the inlet and outlet temperatures, pressures, and flow rates. The flow rates and applied electrical power were controlled electronically by the same program which recorded the data. De-ionized water was used as the heat transfer medium to reduce the uncertainty related to fluid properties.

An existing mathematical model was used to create Colburn and friction factors based …

Scopolamine-Induced Dry Eye Model In Female Rats, Ryan Alderson

Masters Theses

The objective of this study will be to establish, validate, and characterize a dry eye model in female rats induced by continuous systemic administration of scopolamine via Alzet® osmotic pumps for 28 days. This study will use female rats as a model for dry eye and will be implanted with osmotic pumps that will continuously distribute scopolamine or saline systemically over 28 days. Scopolamine will be used to induce the dry eye condition and saline will be used as a negative control. The clinical signs of dry eye will be evaluated by tear volume measurements with sterilized phenol-red thread (FCI …

The Effects Of Replacing Dispersed Trash And Recycling Bins With Integrated Waste Receptacles On The Accuracy Of Waste Sorting In An Academic Building, Katherine J. Binder

Masters Theses

Numerous researchers and theorists have attempted to explain the existence of the gap between the possession of environmental knowledge and awareness and the display of pro-environmental behavior (Glasser, 2007; Kollmuss & Agyeman, 2002). Behavior analysis is uniquely aligned to contribute to this discussion through its emphasis on the role of controlling variables in behavior change. A growing number of behavioral research studies address the challenges of group-contingencies in an effort to solve real-world gaps (Lehman & Geller, 2004). This study was designed as a continuation of the line of behavioral research designed to increase recycling rates and also as an …

How Now Shall We Consume: Widening Conception Of Political Consumption And Analysis Of The American Buyer, John Patton Chew

Masters Theses

As consumption of goods has risen, it has increasingly become a space for political activists to brand products and for the everyday consumer to voice their opinion on how businesses should be run. Through the practices of buycotting and boycotting political consumers have increasingly been able to show their support for issues as diverse as gay rights, environmental issues, funding for disease cures, and American based products.

This study attempts to gain an understanding of how prevalent political consumption is and of who are political consumers. The findings show that a large percentage of the population is knowledgeable and active …

Equipment Qualification Of Ion Mobility Spectrometry And Method Development And Validation For Pharmaceutical Equipment Cleaning Validation, Amy Lee Heiser

Masters Theses

Ion mobility spectrometry (IMS) instrumentation has been identified as a suitable technology for the detection and reporting of drug product and detergent residues from pharmaceutical manufacturing equipment. Ion mobility is not a new technology, but is entering the field of cleaning validation because of tightened requirements from the US Food and Drug Administration (FDA).

The purpose of this thesis is to outline a practical implementation of the analytical technique, Ion Mobility Spectrometry in a cleaning validation program. Ion Mobility Spectrometry (IMS) is fast and specific for the analysis of small organic molecules and has been gaining popularity in the pharmaceutical …

The Implementation Of A Versatile Pseudodynamic Hybrid Simulation For Seismic Evaluation Of Structural Systems, Chelsea Griffith

Masters Theses

Pseudodynamic hybrid simulation technique was developed to evaluate structural seismic performance by physically testing the critical portion with the remaining structure simulated using a numerical model in the computer. An incremental approach was adopted in developing the control scheme to suit multiple testing facilities and test specimens. First the small scale, predictable specimen was utilized to investigate techniques of improving stability, slowing down the loading rate and triggering the accurate force measurement in a series of at benchmark scale experiments in the Laboratory of Earthquake and Structural Simulation at Western Michigan University (WMU). A step/hold command scheme was developed and …

The Rise And Fall Of Kin Structure In The Neotropical, Family-Living Buff-Breasted Wren (Cantorchilus Leucotis) In Gamboa, Panama, Sarah C. Alessi

Masters Theses

Family-living species provide an exciting model to examine how natal dispersal and kin structure influence genetic structuring within local populations. Juvenile buff-breasted wrens (Cantorchilus leucotis) of both sexes delay dispersal and exhibit short-distance natal dispersal, which should lead to kin-structured populations in which relatives of both sexes occupy neighboring territories. Blood samples collected from juvenile and adult wrens in Gamboa, Panama were analyzed using microsatellite markers to determine whether related individuals are spatially clustered on neighboring territories, spatial clusters of relatives change over time, and if kin structure is sex-specific. Global and local spatial autocorrelation analyses detected genetic …

Laboratory Measures Of Aggression In Methadone Patients, Catherine M. Gayman

Masters Theses

Research suggests that current heroin users and individuals with a prior history of heroin dependence tend to be more aggressive than nonusers. No study has yet investigated whether opioid withdrawal affects aggressive responses on a laboratory task. The present study investigates whether mild opioid withdrawal affects aggression in six males and six females (N=12) undergoing methadone maintenance therapy. Aggressive behavior is measured using the Point Subtraction Aggression Paradigm (Cherek, 1981) computer task. Participants press buttons to earn money towards gift certificates. Money subtractions occur periodically and these are attributed to the behavior of a partner who is actually fictitious. Participants …

High Capacity Lithium-Ion Battery Characterization For Vehicular Applications, Sazzad Hossain Ahmed

Masters Theses

A lithium-ion battery is one of the key research topics in energy storage technologies. Major characterization tests such as static capacity, open circuit voltage (OCV), hybrid pulse power characterization (HPPC) have been conducted on two different chemistries, LiMnNi and LiFePO₄, high capacity lithium-ion batteries over a wide range of temperatures from 50ºC to -30ºC. Detail analysis of temperature effects on battery capacity and simple models of direct current resistance (DCR) increment and power decrement over temperatures have been proposed using the test results. Electrochemical impedance spectroscopy (EIS) tests have been performed to find out the dominant internal resistances …

Direct Analysis Of Hops By Leaf Spray And Paper Spray Mass Spectrometry, Kari Blain

Masters Theses

The objective of this research is to develop a new and innovative method of hops analysis, which is much faster than standard testing methods, as well as reduce the amount of consumables and solvent used. A detailed discussion on the development of an ambient ionization mass spectrometry method called paper spray (PS-MS) and leaf spray (LS-MS) mass spectrometry will be presented. This research investigates the use of PS-MS and LS-MS techniques to determine the α- and β- acids present in hops. PS-MS and LS-MS provide a fast way to analyze hops samples by delivering data as rapidly as a UV-Vis …

The Mouse Who Ruled His Kingdom: An Agenda Setting Analysis Of The Walt Disney World Company, Jacob Overbey

Masters Theses

People are seeking their news in more social environments, but very little research has been conducted on agenda setting and online environments. This thesis examined the agenda setting relationship between an organization on Twitter, @WaltDisneyWorld (i.e., The Walt Disney World) and public opinion on Twitter. The relationship was examined using Twitter's database of tweets to measure public opinion on Twitter. Since the news media is losing steam on the ability to break news, and social media is growing rapidly, this study tested the value of the agenda setting theory on social media. To this end, this thesis qualitatively examined the …

Operating The Silencer: Muted Group Theory In The Great Gatsby, Sarah Funderbruke

Masters Theses

This master's thesis examines gender and social roles seen in dialogue in the American classic novel, The Great Gatsby, by F. Scott Fitzgerald. The researcher conducted a coding and rhetorical analysis to determine if elements of muted group theory were in the novel. Muted group theory was developed by Edwin and Shirley Ardener after their research indicated that a culture's values and social structure were voiced through rhetoric. The theory states that dominance in certain groups mutes, or silences, others from communicating effectively. Five passages from The Great Gatsby were selected for this analysis. These passages highlighted dialogue between the …

A Narrative Life Story Of Activist Phyllis Lyon And Her Reflections On A Life With Del Martin, Dianna Lee Johnson

Masters Theses

Phyllis Lyon met the love of her life in 1953. Her name was Del Martin. When they fell in love, homosexuality was an illness that needed to be cured, a sin to be confessed and an illegal act that should be punished. Del Martin and Phyllis Lyon are legendary in the lesbian community for originating the Daughters of Bilitis--an underground lesbian social club in San Francisco formed in the 1950s. They spent the next 55 years together confronting society and policy about the inequity of gays, lesbians, and women. In each of these social movements, however, they were the minority …

Determining The Sufficiency Of The Bhlh Gene Nato3 In Dopamine Neurogenesis, Darcy Nichole Kaufman

Masters Theses

Floor plate cells of the mesencephalon have the ability to become more floor plate cells or differentiate into dopamine containing neurons. Maturation of these neurons can be marked by the stage of differentiation. When dopamine neurons of the substantia nigra pars compacta are no longer able to communicate with the corpus striatum due to a marked loss in the neurotransmitter dopamine, movement disorders such as those present in Parkinson’s disease occur. The bHLH transcription factor Nato3 is known to be necessary for normal dopamine neuron formation, however, our lab was interested in its sufficiency to drive a dopaminergic lineage. The …

High School Policy Debate As An Enduring Pathway To Political Education: Evaluating Possibilities For Political Learning, Ellen C. Zwarensteyn

Masters Theses

This paper addresses the role competitive high school policy debate participation has on key developmental markers of political learning. As identified by the Carnegie Foundation’s Political Engagement Project (PEP), political learning includes political knowledge and understanding, political identity, and the development of political skills. Based in interviews with former high school debaters, the results of this study suggest there may be a transformative, politically enduring and engaging experience surrounding policy debate.

Using grounded theory to extract analysis of debaters’ experiences, this study demonstrates how sustained competitive high school policy debate experience directly advances political learning and should be a tool …

Fabrication Of Printed Substrate For Surface Enhanced Raman Spectroscopy, Ali Eshkeiti

Masters Theses

A novel surface enhanced Raman spectroscopy (SERS) substrate was successfully fabricated on a silicon wafer using inkjet printing and on polyethylene terephthalate (PET) using gravure printing. Silver (Ag) nanoparticle (NP) based ink, was used for roughening of the surface of silicon and PET. A thickness of 400 nm was measured for the printed Ag NP printed film on silicon and the thickness of the single and double layered films on PET were measured as 340 nm and 680 nm, respectively by using vertical scanning interferometry. The Ag NP printed SERS substrate was tested for application with heavy metal compounds like …

The Dissemination And Effective Use Of Physics Education Research In Undergraduate Instruction, Trevor Stefanick

Masters Theses

Based on the results of a national survey of physics faculty, a set of interviews was conducted of 70 physics faculty from a diverse set of institutions. The interviews included questions about the dissemination and effective use of curricula and instructional strategies based on Physics Education Research (PER), focused to obtain recommendations to the PER community that might help to spread the use of these PER-based materials. Approximately half of the interviews (those with faculty who indicated knowledge about or use of Peer Instruction) have been previously analyzed. This project is the analysis of the 38 interviews that were conducted …

Statistical And Numerical Integrated Approach For Detecting Onset Of Prefabricated Bridge Component Connection Deterioration, Cem Mansiz

Masters Theses

Bridges are the substantial part of the transportation infrastructure. Most recent report shows that of the 605,086 bridges in the United States, 67,526 (11%) are deemed structurally deficient, and 76,363 (13%) are declared functionally obsolete (FHWA, 2011). Deck is the shelter of a bridge that is subjected to severe loads due to exposure and traffic. Importance of detecting deck deterioration is further highlighted with the introduction of accelerated bridge construction (ABC) where prefabricated components are brought to the site, assembled, and connected using field cast joints. However, durability performance of field cast connections is not encouraging. Hence, continuous monitoring of …

Catalytic Engineering Of The Flagellin Protein, Alexandra M. Haase

Masters Theses

Flagellin is the protein monomer that comprises the bacterial flagella for most bacteria, including Salmonella typhimurium. This protein has attracted attention for protein engineering because it is exported out of the cell, polymerized into stable fibers, is produced in large quantities and is relatively simple to purify. Using rational design with computer modeling, potential active sites in the flagellin protein structure were modeled after the human carbonic anhydrase II tetrahedral zinc binding site. In total, three locations were selected as potential active sites and the necessary mutations were successfully introduced. Flagella formation for the flagellin variants was demonstrated through …

Creating A Millennial Generation Contextualized Church Culture, Christopher Deitsch

Masters Theses

The Millennial generation, or Generation Y as some people know them, is the biggest generation in the United States of America history. As they flood schools, universities, and the job market it is easy to see that there are major differences between them and previous generations. Simultaneously, the church in America has hundreds of individual churches each year closing and tens of thousands each year declining; most churches are ceasing to grow. The inability to reach Millennials is one of the reasons for this decline. This thesis purposes to give a snapshot of the Millennial generation, overview a few of …

An Improved Custom Development Process Utilizing Lean Methods And Tools, Lisa Gay Smith

Masters Theses

Works have been written on the applications of lean principles and methods to product development, manufacturing, and the office. However, works written on the applications applied to research and development and custom product development processes have been exclude because of the inherent variability in the product design process. This work applied lean principles and tools to custom product development processes. A furniture company with $1.3 billion in annual sales, custom product development process was studied and lean principles, behaviors, and tools were applied using a traditional six step approach mixed with nontraditional practices as well. Within the six steps, the …

The Effect Of Ad Libitum Hydration On Cognitive Function Following Exercise In The Heat, Matthew Wittbrodt

Masters Theses

The purpose of this study was to quantify the effect of different hydration strategies on physiological and cognitive variables after an exercise bout in the heat. On three occasions, twelve males performed three heat stress tests of 50min at 60%VO_2peak in a hot environment (32°C; 65%RH). The heat stress tests differed in hydration strategy to be implemented during exercise (NF: no fluid, AL: ad libitum, FR: full fluid replacement). A cognitive battery was administered pre-­ and post-­exercise to examine alterations in cognition. Fluid loss during NF was greater than the AL and FR (NF: 1.54 %; AL: 0.29 …

Promoting Understanding Of Informed Consent, Michael N. Reynolds

Masters Theses

Several studies have shown that research participants who have consented to participate in a study often have limited comprehension of the information presented in the informed consent process. This study compared performance on an end-of-study consent document information retention measure between a read-and-sign consent procedure control group and an enhanced consent procedure experimental group. The enhanced consent procedure consisted of a pre-consent educational module and a question-and-answer style consent document. The control group scored an average of 78.7% correct on the multiple-choice question measure of participant retention of information contained within the consent documents. The experimental group scored an average …