Digital Commons Network^™

Enzymatic Activation Of Cannabinoid Pro-Drugs, Anna Theresa Margiotta

Master's Theses

Cannabinoids have been used throughout history as medical treatments spanning from menstrual cramps in ancient China to enhancing appetite in patients with AIDS or cancer in the modern day. Currently there is research indicating that cannabinoids also have anti-proliferative and pro-apoptotic effects on several strains of cancer cells (Carchman, Harris, & Munson, 1976; Glodde, Jakobs, Bald, Tüting, & Gaffal, 2015; McKallip et al., 2002; Preet, Ganju, & Groopman, 2008; Sánchez, Galve-Roperh, Canova, Brachet, & Guzmán, 1998). The traditional methods for administration of cannabinoids are inhalation or oral; however, for some cannabinoids these may result in undesirable psychoactive side effects. Cell-in-a-Box® …

Gold-Silver Core-Shell Nanoparticle Growth; Studies Towards The Development Of Biosensing Applications, Austin James Ethridge

Master's Theses

Gold and silver nanoparticles have been used since antiquity because of their unique optical properties (Amendola, Pilot, Frasconi, Mrago, & Lati, 2017) . These properties are related to a phenomenon called localized surface plasmon resonance (LSPR), which is the collective oscillation of electrons located within the conduction band of a metal upon excitation by light at a specific frequency (Amendola et al., 2017). The extinction cross section, which defines the amount of incident light scattered or absorbed by a solution, that is related to the LSPR of gold and silver nanoparticles is up to five times greater than those of …

Modifying The Mineral Profile Of Crickets (Acheta Domesticus) Using A Supplemented Diet, Rhianne Morgan Le Maxwell

Master's Theses

Captive insectivores may consume invertebrates as all, or part of their overall diet. The challenge with feeding captive insectivores involves the limited number of invertebrate species that are commercially available, and the lack of key nutrients provided by these insects. Among these insects, a naturally occurring low concentration of calcium and an inverse calcium to phosphorus ratio may put insectivores at the risk of developing hypocalcemia. A strategy to correct this nutrient imbalance involves supplementing the insect diet with high concentrations of targeted nutrients – a term referred to as gut-loading. Current industry guidelines recommend feeding a supplemented diet for …

Crossing Corridors: Wildlife Use Of Jumpouts And Undercrossings Along A Highway With Wildlife Exclusion Fencing, Alex J. Jensen

Master's Theses

Roads pose two central problems for wildlife: wildlife-vehicle collisions (WVCs) and habitat fragmentation. Wildlife exclusion fencing can reduce WVCs but can exacerbate fragmentation. In Chapter 1, I summarize the relevant studies addressing these two problems, with a focus on large mammals in North America. Chapters 2 and 3 summarize field assessments of technologies to reduce WVCs and maintain connectivity, specifically jumpout ramps and underpasses, along Highway 101 near San Luis Obispo, CA. In a fenced highway, some animals inevitably breach the fence and become trapped, which increases the risk of a wildlife-vehicle collision. Earthen escape ramps, or “jumpouts”, can allow …

Asic Design Of Rf Energy Harvester Using 0.13um Cmos Technology, Jainish K. Zaveri

Master's Theses

Recent advances in wireless sensor nodes, data acquisition devices, wearable and implantable medical devices have paved way for low power (sub 50uW) devices. These devices generally use small solid state or thin film batteries for power supply which need replacement or need to be removed for charging. RF energy harvesting technology can be used to charge these batteries without the need to remove the battery from the device, thus providing a sustainable power supply. In other cases, a battery can become unnecessary altogether. This enables us to deploy wireless network nodes in places where regular physical access to the nodes …

Iris Biometric Identification Using Artificial Neural Networks, Kevin Joseph Haskett

Master's Theses

A biometric method is a more secure way of personal identification than passwords. This thesis examines the iris as a personal identifier with the use of neural networks as the classifier. A comparison of different feature extraction methods that include the Fourier transform, discrete cosine transform, the eigen analysis method, and the wavelet transform, is performed. The robustness of each method, with respect to distortion and noise, is also studied.

The Development And Validation Of Sinatra: A Three-Dimensional Direct Simulation Monte Carlo (Dsmc) Code Written In Object-Oriented C++ And Performed On Cartesian Grids, David Matthew Galvez

Master's Theses

The field of Computational Fluid Dynamics (CFD) primarily involves the approximation of the Navier-Stokes equations. However, these equations are only valid when the flow is considered continuous such that molecular interactions are abundant and predictable. The Knudsen number, $Kn$, which is defined as the ratio of the flow's mean free path, $\lambda$, to some characteristic length, $L$, quantifies the continuity of any flow, and when this parameter is large enough, alternative methods must be employed to simulate gases. The Direct Simulation Monte Carlo (DSMC) method is one which simulates rarefied gas flows by directly simulating the particles that compose the …

Coastal Wetland Dynamics Under Sea-Level Rise And Wetland Restoration In The Northern Gulf Of Mexico Using Bayesian Multilevel Models And A Web Tool, Tyler Hardy

Master's Theses

There is currently a lack of modeling framework to predict how relative sea-level rise (SLR), combined with restoration activities, affects landscapes of coastal wetlands with uncertainties accounted for at the entire northern Gulf of Mexico (NGOM). I developed such a modeling framework – Bayesian multi-level models to study the spatial pattern of wetland loss in the NGOM, driven by relative RSLR, vegetation productivity, tidal range, coastal slope, and wave height – all interacting with river-borne sediment availability, indicated by hydrological regimes. These interactions have not been comprehensively investigated before. I further modified this model to assess the efficacy of restoration …

Mississippi’S First Statewide Teachers’ Strike, Emily Doyne Smith

Master's Theses

This thesis argues that the Education Reform Act of 1982 (ERA) inadvertently led to Mississippi’s first statewide teachers’ strike in 1985 because of the Southeastern pay average clause recommending that the teachers’ pay should reach the average of the southeastern states, if possible. The teachers’ associations in Mississippi used this clause to lobby and promote teachers’ pay to that average. However, after two years of stagnated pay raises, the teachers’ associations led a state statewide teachers’ strike. The strike successfully raised the teachers’ salaries and moved state legislators to consider the teachers’ pay issue carefully afterwards. However, the pay raise …

Spatial Distribution And Stock-Recruitment Analysis Of The Atlantic Surfclam, Spisula Solidissima, In The Mid-Atlantic Bight And On Georges Bank, Jeremy Timbs

Master's Theses

Atlantic surfclams, Spisula solidissima, are long-lived bivalve molluscs with dispersive larval stages. Surfclam patchiness throughout the U.S. Exclusive Economic Zone (EEZ) has declined from the 1980’s to the present in all assessed regions (Delmarva, New Jersey, Long Island, Southern New England, and Georges Banks). Warming of Mid-Atlantic bottom waters is driving the surfclam stock into new habitat and extirpating the surfclams from nearshore areas. Based on a species distribution function model, the small surfclams appear to inhabit a greater area than the large market-size surfclams across the entire stock. The wider distribution of recent recruits relative to the fishable …

Creating Renewable Energy Through The Pairing Of Wastewater Remediation And Biofuel Production With Two Species Of Microalgae, Laura Brown

Master's Theses

In this study, two species of microalgae, Scenedesmus sp. isolated locally and Chlorella sorokiniana (UTEX 1230) were grown in municipal wastewater collected from Stennis Space Center, MS in order to assess whether or not the microalgae could remediate the wastewater into a clean and usable form while also producing the biomaterials necessary for fuel and other useful byproducts. Each species was cultured in 16 ˚C and 30 ˚C to assess functional variabilities at different times of the year. The microalgae’s ability to decrease nutrient concentrations in the wastewater and produce lipids and protein was assessed at three different growth stages: …

Sequence Stratigraphy Of Campanian-Maastrichtian Strata In Eastern Alabama, David Simmons

Master's Theses

Eastern Alabama is an area of interest due to the transition from the Gulf Coastal Plain to the Atlantic Coastal Plain. Coastal Plain investigations have been sparse compared to research conducted in the oil rich areas down dip in the Gulf of Mexico. A sequence stratigraphic framework using the T-R cycle methodology of Embry (2002) has been established by integrating surface and subsurface lithologic data with biostratigraphic zonations into Petra ®. High sedimentation from the ancestral Chattahoochee River and lower relative sea-level formed an additional depositional sequence within the Santonian-Campanian aged Blufftown Formation in eastern Alabama. The sequence is approximately …

Cornerstone Of Union Victory: Officer Partnerships In Joint Operations In The West, Aderian Partain

Master's Theses

The American Civil War included one of the pivotal naval contests of the nineteenth century. A topic of considerable importance is the joint operations on the western waters that brought about a string of crucial victories in the conflict for the Union. The effective cooperation of the naval river fleet and the western armies was a major cornerstone of Union victory. Scholars have written biographies of the more noted admirals and narratives of the flotilla have been detailed. What has not been accomplished is an exploration of the Union officers’ professional partnerships between the Mississippi Squadron commanders and their corresponding …

Blazing Worlds, Bethany Kinney

Master's Theses

Blazing Worlds is a collection of short stories exploring themes of understanding, isolation, the world of work, and identity. These stories follow characters who are searching for connections to others, to their environments, to their work, and to themselves. The protagonists of these stories inhabit worlds that are slightly adjacent to reality, worlds cast into a near future, and worlds that operate by the logic of the campy and the fantastic. Through heightened technology, body horror, or blurred metaphysical boundaries, the residents of these blazing worlds pursue knowledge of their place in life and fight to establish and maintain their …

A System For Conducting Laser-Induced Fluorescence Measurements On Gas Mixtures Exposed To Alpha Radiation, Patrick Ables

Master's Theses

This paper documents modifications to an existing vacuum system to allow laser-induced fluorescence spectroscopy measurements within simulated atmospheres under a variety of conditions. This added capability will expand the laboratory’s ability to experimentally validate a computational model that calculates the effects of radiation within the atmosphere. The computational model could reveal radiation-induced chemical products that can be used to develop an alternative detection method that can be implemented from a safe distance. The selection of molecules for experimental validation has been limited to those which can be detected utilizing cavity ringdown spectroscopy. The current model indicates nitric oxide and ozone …

Development Of Semantic Reference For Location Symbols By Bottlenose Dolphins (Tursiops Truncatus) Using A Two-Way Communication Keyboard, Alyssa Taylor

Master's Theses

The ability for humans to communicate with another species has been an aspiration and well documented. One example is through training animals to make associations between a designated cue and conditioned response (Pryor, 1986). Two-way communication, however, in which both species can express wants/needs has been predominantly pursued with apes and dolphins. Studies conducted by Louis Herman demonstrated the capabilities of dolphins to comprehend complex semantic and syntactic commands in an artificial language system (Herman, Richards, & Wolz, 1984). Researchers working with primates have used American Sign Language, a computer keyboard system with discrete lexigrams, and a portable lexigram keyboard …

Uptake Of Common Pharmaceutical Compounds In Hydroponically Grown Lactuca Sativa, Dorottya Ida Kelemen

Master's Theses

No abstract provided.

Sh3bp2 Gain-Of-Function Mutation Exacerbates Apical Periodontitis In Cherubism Mice, Homan Javaheri

Master's Theses

Cherubism (CBM) is characterized by multiple fibro-osseous lesions in jawbones and caused by mutations in the SH3-domain binding protein 2 (SH3BP2). CBM patients also suffer from dental abnormalities. Biochemical analyses showed that mutations in CBM lead to SH3BP2 gain-of-function because mutant SH3BP2 is protected from tankyrase-mediated proteasomal degradation. A knock-in (KI) mouse model expressing a CBM substitution mutation (P416R) in Sh3bp2 has been generated. Homozygous mice (Sh3bp2^KI/KI) show increased systemic inflammation and osteopenia phenotype with high serum TNF-α level, increased numbers of macrophages and enhanced osteoclastogenesis. Heterozygous mice (Sh3bp2^+/KI) exhibit intermediate phenotype …

Characterizing Late Pleistocene And Holocene Incision And Flooding Post-Glacial Southern New England, Thomas Schenck

Master's Theses

Kettle ponds represent localized accommodation space for sediment deposition that can be reliably linked to processes following de-glaciation. In river adjacent kettle ponds the depression traps flood-born material, preserving flood frequency and alterations of the fluvial system. This study examines the sedimentary archive to explore the evidence for, and timing of, river incision in Southern New England from the Late Pleistocene into the Holocene.

The study used the sedimentary archive preserved in river adjacent kettles and sediment traps located along the Mount Hope River, Willimantic River, Quinebaug River, and Housatonic Rivers, all in Connecticut. Sediment cores were collected for study …

Extraction Of Biologically Relevant Oligopyrrolic Compounds From Nature, Randy Hamchand

Master's Theses

No abstract provided.

Δ15n And Trace Metal Records Of 17th To 20th Century Land Use Change In Upland Connecticut Watersheds, Caitlin Mcmanimon

Master's Theses

No abstract provided.

Metabarcoding Analysis Of Prey Composition Of The Copepod Calanus Finmarchicus In Regions Of The North Atlantic Ocean, Heidi Yeh

Master's Theses

The copepod Calanus finmarchicus occupies a pivotal position in the pelagic food web of the North Atlantic Ocean. Prey choice and predator-prey dynamics at this trophic level can influence energy transfer through the ecosystem. To examine the copepod prey composition and test the hypothesis that C. finmarchicus exhibit spatial variation in diet across four basins of the North Atlantic, this study used metabarcoding analysis (high throughput sequencing of orthologous gene regions) to analyze the gut contents of C. finmarchicus. Zooplankton net samples were collected during a 2013 cruise of the R/V GO Sars in the Norwegian, Icelandic, Irminger, and Labrador …

The Effects Of Spinal Cord Injury On Expression Of Pain-Relevant Genes In The Colon, Noelle Mckearney

Master's Theses

Spinal cord injury (SCI) results in varying degrees of paralysis, loss of normal sensory function and, oftentimes, chronic pain originating below the level of injury. Post-SCI pain tends to be resistant to traditional analgesic therapies and has been shown to impair recovery of function, making it a significant healthcare concern. Approximately one third of SCI patients report abdominal pain as a primary and severe symptom with marked similarity to other functional gastrointestinal pain disorders (e.g. irritable bowel). The etiology of this intense pain phenotype is unclear given that visceral organs are left uninjured in SCI. Here we examine changes in …

Evaluation Of Post-Graduate Endodontic Program Clinical Experiences: A Web-Based Survey, Jonathan David Blacher

Master's Theses

Endodontic residency programs vary in exposure to procedures, protocols and equipment across the United States. Available resources for clarifying the clinical experiences of current endodontic residents are lacking. Following Institutional Review Board approval, a survey regarding the clinical experiences of current endodontic residents was electronically distributed to all current endodontic residents that maintained an email address listed in the 2016/2017 AAE Membership Directory. The number of endodontic procedures, techniques employed, and products utilized were evaluated and described. The results of the survey included a 30% completion rate (133/437). The majority of respondents indicated completing between: 150-250 non-surgical root canals (NS-RCT), …

The American Dream(Ers): Undocumented Youth’S (Re)Interpretation Of Social Movement Frames, Kevin Zevallos

Master's Theses

The dreamer narrative and its accompanying frames have become a staple of immigration debates in the United States. Dreamer narratives afford undocumented youth organizations visibility to articulate their socio-political needs. As undocumented youth make claims for legal and social recognition, they utilize dreamer frames that highlight undocumented youth as productive, patriotic, and/or deserving members of U.S. society. Based on 18 semi-structured interviews with undocumented youth and Connecticut state legislators and participant observation of undocumented youth-led rallies, lobbying campaigns and organizational meetings, I examine how undocumented youth organizers react, respond and utilize nationally derived social movement frames in a local context. …

Comparison Of The Effect Of Mineral Trioxide Aggregate And Bioceramics Root Repair Material On Odontoblast Differentiation In Vitro, Saleh Ashkanani

Master's Theses

No abstract provided.

Oral Colonization Of Malassezia Species, Anibal Cardenas

Master's Theses

No abstract provided.

The Effect Of Destoning And Enzymatic Pretreatments On The Biofuel Production From Olive Cake, Patrick Tai

Master's Theses

More than 16,000 tons of olive cake was produced in the United States in 2017. Olive cake is a by-product of olive oil extraction, which has limited animal feed potential, and poses an environmental threat when landfilled due to its high organic load and polyphenol content. This residue has potential for biofuel (bioethanol and biomethane) production because it is rich in polysaccharides such as pectin, hemicellulose, and cellulose. Yet, olive cake contains olive stones that can impede its conversion to biofuel. Therefore, two methods of destoning, centrifugation and screening by horizontal screw press, were first compared. Both methods removed an …

Personality, Technology, And Learning, Andrew Guydish

Master's Theses

Computers continued encroachment on today’s society can be seen in a college lecture hall, where a growing number of students use laptops for their academic needs. Current academic laptop use research predominantly makes broad generalizations across users, indicating that laptop use in the classroom has negative influences on academic outcomes. However, this research neglects to take into account possible individual differences in the users. It is hypothesized that students' levels of conscientiousness and impulsivity would moderate the relationship between laptop use and academic performance, while a student’s multitasking experience would mediate this same relationship, forming a moderated mediation model. Using …

Relationship Between Aerobic Capacity And Episodic Memory In Older Adults, Nicole Henderson

Master's Theses

The goal of this research was to examine the relationship between aerobic capacity and memory in older adults. Prior research demonstrated an age-related decline in episodic memory (memory for episodes and events), which may be partially due to a decreasing ability to engage in pattern separation – the ability to form new memories that are sufficiently distinct from prior memories. Studies in rodents suggested that aerobic exercise may improve pattern separation abilities in older animals, but similar research in humans is lacking. Here, I investigated whether individual differences on a memory test that taxes pattern separation were associated with differences …