Digital Commons Network^™

Investigating The Therapeutic Potential Of Cannabigerol (Cbg) In Female Nonalcoholic Steatohepatitis (Nash) Mouse Model, Raznin A. Joly

Master's Theses

Nonalcoholic Steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease (NAFLD) characterized by inflammation, fibrosis, steatosis, and oxidative stress, in addition to excessive fat accumulation in the liver. Cannabigerol (CBG), a precursor molecule of Cannabidiol (CBD), has demonstrated anti-inflammatory and anti-oxidative effects in various studies. Our previous data showed that a low dosage of CBG reduced inflammation and fibrosis in male NASH mice. However, the impact of CBG on female mice remains unknown. Recent studies have identified changes in immune cell populations in NAFLD patients. The goal of this project was to test the impact of CBG treatment …

Rhythm And Meter As Text Expression: Jake Runestad's "Come To The Woods", Samantha Brewer

Master's Theses

Core to Western music education curriculum is the teaching and history of “word painting,” or text expression particularly as it pertains to the sixteenth-century madrigal. This approach to text expression is explored primarily through the lens of melodic and harmonic movement through a vocal line and the manner in which the line allows for better portrayal of the text or poem. The purpose of this thesis is to take a new approach to text expression in contemporary choral literature through the viewpoint of rhythm and meter. In this thesis, various analytical techniques from decades past and present are applied to …

The Creation And Application Of A Fundamental Hip-Hop Curriculum: What Are The Benefits And Drawbacks Of Codifying Classic Hip-Hop Technique?, Julie Wolfrum

Master's Theses

In this study, the researcher proposed using knowledge collected of hip-hop dance experts and pioneers to create a curriculum applicable for the youth. Using interviews with various experts and research on hip-hop pioneers, the researcher tested the proposed curriculum on third, fourth, and fifth grade participants in a Colorado private school. The curriculum was tested over a span of five weeks with seventy-four participants. Within the study, the participants were given historical knowledge, various vocabulary, creative prompts, and were introduced to different hip-hop musical artists. The participants were required to participate in cyphers, Battles, various hip-hop dance exercises, and create …

Integrating Braindance Inspired Movement Into The Classroom: Elementary Teachers Respond To The Outcomes Of Student Involvement, Callie Taylor

Master's Theses

The purpose of this study was to reveal the benefits of BrainDance and to guide teachers on appropriate and tangible methods to intentionally integrate movement into their non-movement lessons to aid in student engagement. The researcher analyzed responses from surveys from ten participants regarding their comfort level in using movement as part of a lesson and the benefits they see in using movement. Next, the researcher taught the participants about BrainDance and how to integrate it into the subjects they taught. After being given time to implement BrainDance into their rooms, the researcher surveyed the participants again and analyzed the …

The Construction Of Khovanov Homology, Shiaohan Liu

Master's Theses

Knot theory is a rich topic in topology that studies the how circles can be embedded in Euclidean 3-space. One of the main questions in knot theory is how to distinguish between different types of knots efficiently. One way to approach this problem is to study knot invariants, which are properties of knots that do not change under a standard set of deformations. We give a brief overview of basic knot theory, and examine a specific knot invariant known as Khovanov homology. Khovanov homology is a homological invariant that refines the Jones polynomial, another knot invariant that assigns a Laurent …

An Analysis On Wildfire Mitigations Employed By Utilities In California, Evan Luu

Master's Theses

As climate change continues to worsen, environmental effects are felt by many people around the world. In California, some of its most damaging wildfires have been found to be started by utilities. As the state continues to suffer from worsening wildfire conditions, the utilities need to implement a variety of wildfire mitigations to help reduce the risk of wildfires that can affect the state and its residents. This paper analyzes the effectiveness of four mitigations employed across three California utilities and suggests potential ways for the mitigations to be used together. The technologies evaluated are covered conductor, rapid earth fault …

Polluting The Senses: The Impact Of Noise And Light Pollution On Fledgling Movement And Evolution Within The Avian Eye, Margaret C. Mackinlay

Master's Theses

There is more human-generated noise and light today than ever before, a trend tied to ongoing urbanization and with reverberating impacts on a wide range of organisms. While research on these impacts is mounting and particularly plentiful when it comes to birds, there is still much to explore within its effects on avian behavior, fitness, and evolution. In chapter 1, we investigated how fledgling movement is influenced by noise and light pollution. While adult birds have well-documented species-specific responses to these stimuli, fledglings are sorely understudied in this context. We experimentally manipulated light levels and took advantage of an existing …

Improvement Of Rotation Capacity Of Composite Beam-To-Hss Column Connections Using External Horizontal Stiffeners, Mahdi Afshar Arjmand

Master's Theses

Improvement of Rotation Capacity of Composite Beam-to-HSS Column Connections Using External Horizontal Stiffeners

Mahdi Afshar Arjmand

This thesis focuses on the analysis of out-of-plane deformation (OOP) in column flange located in the panel zone of composite beam-to-column steel connection, as a critical aspect of steel structural engineering. This type of connection is an integral component of steel structures, and understanding their behavior is essential for ensuring safety and performance. The investigation involves examining the causes, factors influencing, and potential mitigation strategies for out-of-plane deformation of HSS flange column in these connections. Beam-to-column connections play a vital role in transferring loads …

Development Of Load Measurement Technique For Arbitrary Shapes, Quintin J. Cockrell

Master's Theses

Obtaining aerodynamic forces and moments about all three orthogonal axes for arbitrary shapes at arbitrary orientations in a fast manner via a measurement technique specific to Cal Poly’s low-speed wind tunnel to continually obtain the forces and moments under quasi-steady conditions is explored. A Continuous Rotation Technique (CR) uses a 6-DOF load cell and stepper motor to rotate an object about an axis for a complete rotation. The forces and moments acting upon the object pass through the stepper motor and interface plates and recorded by the load cell as the object is rotated continuously a finite number of rotations. …

An Ecological Assessment Of An Endangered Lichen From Central California: Sulcaria Isidiifera, The Splitting Yarn Lichen, Elijah C. Balderas

Master's Theses

Lichens are an underrepresented group of organisms when it comes to both research and conservation efforts. At the same time, lichens face increasing threats from anthropogenic sources including wildfires, climate change and urbanization. With this thesis, I seek to ascertain and publish ecological data on a critically endangered lichen to inform future conservation designations and efforts to preserve and protect the species in perpetuity.

In Chapter 1, I provide an ecological overview of the known range of Sulcaria isidiifera and assess the status of Sulcaria isidiifera via a population count. Sulcaria isidiifera occurs in maritime chaparral habitat in the Los …

Complex Dimensions Of 100 Different Sierpinski Carpet Modifications, Gregory Parker Leathrum

Master's Theses

We used Dr. M. L. Lapidus's Fractal Zeta Functions to analyze the complex fractal dimensions of 100 different modifications of the Sierpinski Carpet fractal construction. We will showcase the theorems that made calculations easier, as well as Desmos tools that helped in classifying the different fractals and computing their complex dimensions. We will also showcase all 100 of the Sierpinski Carpet modifications and their complex dimensions.

Foundations Of Memory Capacity In Models Of Neural Cognition, Chandradeep Chowdhury

Master's Theses

A central problem in neuroscience is to understand how memories are formed as a result of the activities of neurons. Valiant’s neuroidal model attempted to address this question by modeling the brain as a random graph and memories as subgraphs within that graph. However the question of memory capacity within that model has not been explored: how many memories can the brain hold? Valiant introduced the concept of interference between memories as the defining factor for capacity; excessive interference signals the model has reached capacity. Since then, exploration of capacity has been limited, but recent investigations have delved into the …

Parametric Optimization Of A Wing-Fuselage System Using A Vorticity-Based Panel Solver, Chino Cruz

Master's Theses

Aerodynamic topology optimization is a useful tool in the aerodynamic design pro-
cess, especially when looking for marginal gains within a design. One example is
a turboprop racer concept aircraft that is designed with the goal of breaking world
speed records. An optimization framework was developed with the intention of later
being applied to this design. In the early design stages, the optimization framework
must focus on quicker methods of drag estimation, such as a panel codes. The large
number of design variables in topology optimization can exponentially increase func-
tion evaluations and thus computational cost. A vorticity-based panel solver …

The Tidal Prism, Viable Eelgrass Habitat, And The Effects Of Sea Level Rise In Morro Bay, Kaden A. Caliendo

Master's Theses

The tidal prism, or the volume of water exchanged from the sea to an estuary from mean low to mean high tide, influences system hydrodynamics and ecological functioning. Since 1884, the tidal prism in Morro Bay, California has been estimated to be decreasing over time due to sedimentation from upstream practices. What is the current tidal prism in Morro Bay and how will that change with sea level rise? How will eelgrass respond to rising sea levels?

For this study, inexpensive tidal gauges were deployed at four locations in Morro Bay from March to August 2023 to measure spatially varying …

The Biological, Physical And Chemical Response Of The Little Creek Watershed To The 2020 Czu Lighting Complex Fire, Natalie Fontana

Master's Theses

This post-fire study was conducted to characterize and observe fire induced changes in physical habitat parameters, water-quality conditions and macroinvertebrate assemblages in the Little Creek watershed, a tributary to Scotts Creek located in Cal Poly’s Swanton Pacific Ranch in Davenport, California. Pre-fire data was collected by a Cal Poly student, John Hardy, for his 2017 thesis. Post-burn bioassessment surveys for this study were repeated at four of the same study sites used by Hardy to provide comparisons to the California Stream Condition Index via a modified version of the State of California’s Surface Water Ambient Monitoring Program protocol. Macroinvertebrates were …

Diet Induced Metabolic Alterations In The Brain Tissues Of Juvenile Pigs With Non-Alcoholic Fatty Liver Disease, Rhesa Lacanienta

Master's Theses

The objective of this study was to investigate the diet-induced metabolic changes that affect the brain tissue of juvenile pigs with NAFLD. This study explored the liver- brain axis and metabolic markers in the frontal cortex (FC) affected by liver damage. 18 male (M) and 20 female (F) Iberian pigs were randomly allocated to 1 of 3 high-fructose high-fat liquid diets (lard, olive oil, and coconut oil) and fed for 10 consecutive weeks. “Healthy” Iberian pigs were fed a eucaloric diet to establish a physiological baseline. Protein precipitation extraction using ultra-performance liquid chromatography-tandem quadrupole mass spectrometry was performed for primary …

Exploring The Interactions Of Copper High Aspect Ratio Structures (Cuhars), A Novel Metal-Organic Biohybrid Nanocomposite, With Chondrocytes, Tasneem Khasru

Master's Theses

Osteoarthritis (OA) is a prevalent degenerative joint disorder characterized by cartilage lesions and subchondral bone destruction (1). Addressing OA is challenging due to cartilage's avascular and aneural nature, unique cellular arrangement, and dense extracellular matrix (ECM). Current pharmacological treatments are mainly symptomatic and are unable to halt disease progression or reverse cartilage damage . Surgical interventions also come with complications. Tissue-engineered grafts using biomaterials and molecular manipulation have emerged as potential treatments for cartilage regeneration. Copper-containing scaffolds have shown promise in bone and cartilage regeneration. Nanotechnology offers new avenues, with nanoparticles and nanofibers being used in tissue engineering research. However, …

Investigating The Role Of The Metabolite Je As An Inflammatory Modulator, Rim Ahmed Noufal

Master's Theses

Innate immunity represents the first line of defense against pathogens that invade our bodies. It greatly relies on a family of abundant receptors called pathogen recognition receptors (PRRs). These are germ-line encoded proteins abundant in immune cells like macrophages, dendritic cells, and natural killer cells. PRRs encompass five categories, one of which includes toll-like receptors (TLRs). TLRs could either be located on the surface of the cells or intracellularly. The mechanism by which TLRs act is through recognizing a myriad of foreign structures derived from microbes, such as proteins, lipids, and carbohydrates as well as their genetic material. Generally, these …

Novel Method Of The Quantification Of Turbulent Fluid Flow In Silicone Artery Phantoms Using Acoustic Analysis, Julia Wong

Master's Theses

Cardiovascular disease is the leading cause of death globally and is responsible for taking 17.9 million lives per year. Despite the use of clinical treatments and detection methods, there remains a large population of individuals that suffer from CVD whose symptoms are left undetected and untreated prior to a life-threatening cardiac event. This highlights a need for an early detection method that can prevent the manifestation and worsening of the disease as well as address limitations of current early detection methods. An area of interest for early detection of CVD is subclinical atherosclerosis, which is the long, early, asymptomatic stage …

Development Of An Angiogenic Tissue-On-A-Chip Microenvironment, Eric Stuehr

Master's Theses

Preclinical testing is necessary to investigate the safety and efficacy of novel therapeutics before moving to clinical trials, yet approximately 90% of these therapies fail once tested in humans. This has led to increased interest in developing robust preclinical models that accurately mimic the complex human in vivo physiology. Microfluidic devices that can introduce dynamic conditions to 3D cell/organoid cultures, also known as tissue-on-a-chip, have emerged as physiologically relevant in vitro preclinical models that can achieve high throughput screening of therapeutics. The research presented here aimed to develop an angiogenic environment within a novel microfluidic device to stimulate formation of …

The Evaluation Of Calsporin And Imw50 On Production Performance, Microbial Population, And Immune Function Of The Laying Hen, Kayla N. Kleist

Master's Theses

The use of antibiotics as growth promotors in the food animal industry has led to the generation of antibiotic resistant microorganisms, which are a major health risk to humans. Therefore, bans and limitations, including the FDA’s veterinary feed directive, have been placed on the use of antibiotics as growth promotors, and there has been a push to find an adequate alternative. In the laying hen, probiotics and/or prebiotics have shown promise as they help promote the colonization of beneficial bacteria in the GI tract of the host, increase feed efficiency, increase egg production, and provide protection against pathogenic bacteria.

In …

Design And Scale Model Of Wave Generator For The Testing Of Wave Energy Conversion Devices, Amanda Olla

Master's Theses

As the climate crisis draws more concern, research and development in wave energy as a renewable energy source has increased. Devices such as wave energy converters (WECs) are being researched, tested, and implemented to make wave energy a competitive power source. Testing of these devices is limited due to environmental concerns such as weather, location, and other issues. WECs require testing in a marine environment, however, performing testing in the actual environment may be difficult due to weather, access, mounting, and other issues. To eliminate environmental unknowns from testing, a wave simulator device can mimic wave behavior without the need …

Smartphone Based Object Detection For Shark Spotting, Darrick W. Oliver

Master's Theses

Given concern over shark attacks in coastal regions, the recent use of unmanned aerial vehicles (UAVs), or drones, has increased to ensure the safety of beachgoers. However, much of city officials' process remains manual, with drone operation and review of footage still playing a significant role. In pursuit of a more automated solution, researchers have turned to the usage of neural networks to perform detection of sharks and other marine life. For on-device solutions, this has historically required assembling individual hardware components to form an embedded system to utilize the machine learning model. This means that the camera, neural processing …

Guilty As Charged: The Role Of Judge Instructions On Metaphor Produced Biases In Jury Decision Making, Gina N. Rita

Master's Theses

In this study, we hope to determine if the placement of judge instructions mitigates our previous study’s effect of metaphors on memory and verdict decisions. Our previous study showed in the metaphor condition, participants were more likely to vote guilty and remember more metaphor-related evidence compared to those in the control group. In addition to replicating the previous study’s results, we hypothesize judge instructions stated at the beginning of the trial will have little influence on the metaphor effects, and judge instructions at the end of the trial will weaken these effects. Participants will be randomly assigned to one of …

"It's Good To Doubt Saints, Vladim.": Medieval Constructions Of Sainthood, Their Histories, And Their Cults In Leigh Bardugo's Shadow And Bone, Kacie Barrett

Master's Theses

The Grishaverse is the fictional world created by author Leigh Bardugo that encompasses three separate series and ten different books. First published in 2012, the Shadow and Bone trilogy introduces readers to the world of Ravka, its Grisha, and its saints. The story follows Alina as she moves from orphan and soldier to saint and martyr. Sankta Alina becomes a character of its own – a version of Alina communicated to the people of Ravka as a banner to rally behind. She is made into living saint. The questions raised by Leigh Bardugo are echoed in church history. Sainthood is …

Feigning Goodness: Considering The Presence And Absence Of Aristotelian Ideas In Character Education Through Thematic Analysis, Mylo Apollo Parker-Emerson

Master's Theses

In the past 15+ years in the fields of psychology, philosophy, education, and at a federal level within the U.S. Department of Education, there has been a push to incorporate social emotional learning in schools, namely through character education (Berkowitz, 2021; Federal Commission on School Safety, 2018; Hatchimonji et al., 2020; Jubilee Centre for Character and Virtues, 2022). Character education as an educational reform works to accomplish the functions of education through a focus on building good character, sometimes categorized as soft skills. Many schools have incorporated curriculums of character education to provide a more holistic education. Through the many …

“But You Don't Look Sick…:” Shedding Light On The Socially Constructed Problems Of Invisible Chronic Illness And The Benefits Of Shifting To A Dynamic Illness Framework, Samantha Susan Ropski

Master's Theses

Invisible chronic illness is a common, complex phenomenon that applies to any illness, disease, or collection of symptoms that is not always or ever outwardly apparent or discernable to onlookers, even in biomedical contexts. Interestingly, despite 96% of those with chronic illness fitting under the “invisible” umbrella, patients are frequently misdiagnosed, invalidated, dismissed and marginalized because they do not “look sick” enough within the context of the disease-focused medical model. This thesis aims to argue that many of the most significant and damaging problems associated with chronic illness are not due to the actual illnesses themselves but rather, are socially …

The Unhappy Specter: The Buried Remains Of Self And Other, Kirt Henry Broesche

Master's Theses

In this paper, we argue that Derrida’s account of the uncanny experience of being haunted by a specter reveals consciousness to be constitutively haunted. From Derrida’s account in Specters of Marx, we locate the cause to the possibility of haunting from the inability to complete a so-called work of mourning. We note primarily the development of Derrida’s account of specters with respect to the psychoanalytic distinction between mourning and melancholia. We go on to compare Derrida’s characterization of a haunted subject to Hegel’s conception of Unhappy Consciousness to discuss the possibility for a haunted consciousness to be assimilated into a …

Characterizing The Utility Of A Near Infrared Click Beetle Luciferase For Bli Applications, Giovanni Duca

Master's Theses

Bioluminescent imaging systems (BLI) have become a valuable tool for doing real-time in vivo studies. BLI systems typically allow for the imaging of surface and subsurface level tissues but as depth increases, the resolution decreases while the signal to noise ratio increases. Deep tissue imaging is therefore a major limitation for BLI. To address this limitation there has been a consistent movement in luciferase research to create long wavelength emitting luciferases that still have a high photon emission rate. Longer wavelengths of light are able to penetrate deeper tissues due to having a lower amount of absorbance and scattering from …

Using Noninvasive Calibrated Cuff Plethysmography To Observe The Effects Of Cold-Water Immersion On Arterial Compliance, Rita M. Grigorian

Master's Theses

As the prevalence of cardiovascular diseases continues to exponentially grow in populations across the globe, the necessity of determining underlying factors, effective methods of diagnoses, and universally available preventive measures also grows. Early detection of endothelial dysfunction, a proven precursor of cardiovascular diseases, can be extremely impactful in encouraging preventative measures and early intervention before medical conditions become chronic. In recent years, ice plunging, a form of cryotherapy involving full body immersion in cold water, has gained popularity within circles of fitness and health practitioners, gaining the interest of people of all backgrounds. Certain parallels observed between the human physiological …