Digital Commons Network^™

Role Of Toll-Like Receptor 2 In Macrophage Recognition And Response To Borrelia Burgdorferi, Yukiye A. Koide

Master's Theses

Lyme disease is the most common vector-borne disease in the US and will experience an uptick as the insect host, the ixodid tick, gains habitat with climate change. The causative agent of Lyme disease, Borrelia burgdorferi, is recognized by Toll-like receptor 2 (TLR2), which initiates the innate immune response. Here, I used ELISA and SEAP detection assays to determine that knocking out TLR2 in THP-1 macrophages reduces the amount of NFkB activation, as well as IL-10 and IL-1β secretion. Then, I used fluorescence microscopy and Incucyte assays to quantify the amount of phagocytosis performed by wild-type and knock-out THP-1 cells. …

3d Pano Inpainting: Scene Construction Using A Single Input Panorama, Shivam Asija

Master's Theses

Creating 360-degree 3D content has gained traction in the past few years, being used for Virtual Reality environments. However, creating such content is challenging because it requires a multi-camera setup or a collection of images from different perspectives. This paper proposes 3D Pano Inpainting, a pipeline capable of transforming a single equirectangular panoramic RGBD image into a complete 360° 3D virtual reality scene represented as a textured mesh. Our methodology is as follows: we estimate a consistent depth map for the input panorama; we use a pre built framework to convert the image and its depth map into a textured …

Coralai: Emergent Ecosystems Of Neural Cellular Automata, Aidan A. Barbieux, Aidan A. Barbieux

Master's Theses

Artificial intelligence has traditionally been approached through centralized architectures and optimization of specific metrics on large datasets. However, the frontiers of fields spanning cognitive science, biology, physics, and computer science suggest that intelligence is better understood as a multi-scale, decentralized, emergent phenomenon. As such, scaling up approaches that mirror the natural world may be one of the next big advances in AI. This thesis presents Coralai, a framework for efficiently simulating the emergence of diverse artificial life ecosystems integrated with modular physics. The key innovations of Coralai include: 1) Hosting diverse Neural Cellular Automata organisms in the same simulation that …

Mary Ann Starkey: Domesticity & Political Leadership In New Bern, North Carolina During The Civil War, Julie A. Zafiratos

Master's Theses

Mary Ann Starkey was a pivotal change agent in New Bern, North Carolina during the Civil War. She was born into slavery, yet by 1863 was in a position to bring together abolitionists and recruiters from the North and refugees and freedom fighters from her community. She was president of the 400-member Colored Women’s Union Relief Association of Newbern, North Carolina which worked to heal, feed and support the first colored regiments in North Carolina in their fight for freedom. This thesis looks closely at the Civil War through the life of this one woman, by examining the archival evidence …

An Exploratory Framework For Benchmarking Vehicle Miles Traveled (Vmt) Estimates Associated With University Campuses, Troy Kawahara

Master's Theses

Although vehicle miles traveled (VMT) has become the standard for assessing transportation related impacts in California, some have concerns that many VMT estimates are not properly grounded or informed by real world data, potentially resulting in flawed estimates and impact assessments. This is especially true of special generators, like college and university campuses, which have complex travel patterns distinct from that of the general public. This thesis attempts to resolve a significant disparity observed between two credible VMT estimates for Cal Poly’s campus wide VMT. As part of a campus master planning effort, a VMT estimate was produced in 2019 …

Synthesizing Physiology With Aquaculture For Olympia Oyster Restoration In Elkhorn Slough, Ca, Jacob Harris

Master's Theses

Conservation aquaculture is an emerging restoration strategy for depleted and low-density foundation species. It was recently applied for Olympia oysters in California. The only native oyster species is at risk of local extinction in much of its range. Conservation aquaculture can support oyster abundance, but long-term restoration success will be constrained by habitat conditions that suppress early growth and reproductive fitness. Following years of reproduction failure in Elkhorn Slough, CA, we examined these two critical life stages: juvenile and brooding. Our aim was to improve restoration by evaluating aquaculture methods and studying their physiology. We tested site parameters, oyster size, …

Analysis Of Solid Phase Mineralogy To Explore Past Biogeochemical Conditions Of The Deep Biosphere In The Guaymas Basin, Rachel W. Clifford

Master's Theses

The International Ocean Discovery Program (IODP) Expedition 385 to the Guaymas Basin in the Gulf of California explored carbon cycling in the hot subseafloor of a nascent ocean basin. Roughly 50 km from the modern spreading axis, we compared adjacent sites U1545 and U1546. While the sites are ~1 km apart and have highly similar sediment compositions, a ~70 m igneous sill crosses U1546 at ~300 mbsf. The depth of the sulfate-methane transition zone (SMTZ) at U1546 is 100 mbsf, while at U1545 it is 50 mbsf. Solid phase carbonates capture geochemical conditions of porewater over time. Using smear slide …

Posttraumatic Symptoms As Predictors Of Mobile App Engagement: An Evaluation Of Usage Data From Public Users Of An App For Military Sexual Trauma, Shilpa Hampole

Master's Theses

Veterans who have experienced military sexual trauma (MST) often face barriers to help-seeking. Mental health mobile applications (apps) such as Beyond MST, developed by the National Center for PTSD, can expand access to evidence-based coping tools, psychoeducation, and resources. However, user engagement is crucial for these apps to be effective. Researchers are exploring factors impacting app engagement, with emerging evidence suggesting that symptom severity may play a key role. This study examined whether the severity of posttraumatic stress disorder (PTSD) symptoms and posttraumatic negative cognitions, as well as level of well-being, are associated with app engagement. Anonymous app usage data …

Ethics Of The Other Through Theodicy: A Study Of Emmanuel Levinas, Sunghun Choi

Master's Theses

The Problem

Drawing upon Emmanuel Levinas’s Judaic, philosophical, and experiential influences, Levinas formulates an “ethics of the Other” as a response to the quandary of suffering and evil, presenting it as an alternative to theodicy.

The Purpose

The purpose of this study is to explore Levinas’s philosophy by examining his response to the criticisms levied against theodicy, while also investigating the potential coexistence of his philosophy with theodicy and the warrant for such a critique, as well as the claim that an “ethics of the Other” can function as a legitimate replacement for theodicy.

Conclusions

This thesis argues that while …

The Nature And Role Of Health Laws In The Writings Of Ellen G. White, Lehel Somogyi

Master's Theses

The Topic

Since the founding of their denomination, Seventh-day Adventists have advocated a particular concept of health based on the visions and writings of denominational co-founder Ellen G. White (1827–1915). According to her writings, certain natural laws are crucial for maintaining health. These laws are often called “the laws of health” or “the eight laws of health” and include principles such as diet, exercise, water, temperance, and hygiene. In Seventh-day Adventist circles, Ellen G. White is usually perceived as the originator of these health principles. Some scholars suggest that she simply borrowed her health principles from other contemporary health reformers. …

Senegambia And The American South: Where Identity Belongs, Malika David

Master's Theses

When you think of identity, what is the first thing that comes to mind? While I knew the dictionary definition, the actual meaning of identity remained unclear to me. I couldn't quite grasp the concept or how it related to me. That changed when I visited my mother’s homeland of Senegambia in December 2022. There was always a hunch that identity was connected to a sense of belonging and self-discovery, and I was surprised to realize how similar Senegambian. culture. was to my own southern upbringing. Ultimately, that provided a lot of curiosity and shaped my perspective on identity and …

How A Study Abroad Program Supports Its Students Of Color: A Case Study, Hannah E. L. Bloom

Master's Theses

Students of Color study abroad at rates lower than their white peers, thus missing out on the academic, personal, and intercultural benefits one can gain from studying abroad. The purpose of this thesis was to conduct a qualitative case study to examine how a study abroad program supports its Students of Color during the pre-departure phase of study abroad. This case study uses Critical Race Theory as its theoretical lens. Research for this case study included interviews with four study abroad practitioners from one study abroad program, and a review of the study abroad program’s online spaces. This thesis endeavored …

Geospatial Business Location Implications For Mississippi-Based Nissan Group Changing To Electrical Vehicle (Ev) Production, Sudheer Galla

Master's Theses

This research examines the shift from conventional Internal Combustion Engine (ICE) to Electric Vehicle (EV) production in the automotive industry. Utilizing the JobsEQ Input-Output model, it reveals complex economic interdependencies and highlights the concentration of Nissan Tier 1 suppliers around its Canton manufacturing operations in the Midwest and Southern U.S., indicating an efficient supply chain and regional economic impact.

In Mississippi, the transition to EV production is projected to create 4,415 jobs and increase compensation by $295.5 million, presenting a competitive edge in automotive employment opportunities. However, it emphasizes the need to retain and upskill the existing workforce, especially for …

Whose Woods These Are: Human-Environment Relationships Among Stakeholders Of South Mississippi's Longleaf Pine Ecosystem, Helen Greene

Master's Theses

Between 1870 and 1920, the longleaf pine belt of the southeastern United States experienced an extensive and unsustainable period of logging. In the years after the logging boom the landscape of the Southeast was reforested, but fire suppression and a preference among landowners for loblolly pine resulted in a dense and less resilient forest with reduced biodiversity. This research looks at the human geography of remnants of the longleaf pine ecosystem in South Mississippi and the nature of contemporary relationships between South Mississippi residents and this ecosystem.

In an effort to make sense of the complex relationships between people and …

Brunet: Disruption-Tolerant Tcp And Decentralized Wi-Fi For Small Systems Of Vehicles, Nicholas Brunet

Master's Theses

Reliable wireless communication is essential for small systems of vehicles. However, for small-scale robotics projects where communication is not the primary goal, programmers frequently choose to use TCP with Wi-Fi because of their familiarity with the sockets API and the widespread availability of Wi-Fi hardware. However, neither of these technologies are suitable in their default configurations for highly mobile vehicles that experience frequent, extended disruptions. BRUNET (BRUNET Really Useful NETwork) provides a two-tier software solution that enhances the communication capabilities for Linux-based systems. An ad-hoc Wi-Fi network permits decentralized peer-to-peer and multi-hop connectivity without the need for dedicated network infrastructure. …

Decentralized Machine Learning On Blockchain: Developing A Federated Learning Based System, Nikhil Sridhar

Master's Theses

Traditional Machine Learning (ML) methods usually rely on a central server to per-
form ML tasks. However, these methods have problems like security risks, data
storage issues, and high computational demands. Federated Learning (FL), on the
other hand, spreads out the ML process. It trains models on local devices and then
combines them centrally. While FL improves computing and customization, it still
faces the same challenges as centralized ML in security and data storage.

This thesis introduces a new approach combining Federated Learning and Decen-
tralized Machine Learning (DML), which operates on an Ethereum Virtual Machine
(EVM) compatible blockchain. The …

Diet Induced Metabolic Alterations In The Brain Tissues Of Juvenile Pigs With Non-Alcoholic Fatty Liver Disease, Rhesa Lacanienta

Master's Theses

The objective of this study was to investigate the diet-induced metabolic changes that affect the brain tissue of juvenile pigs with NAFLD. This study explored the liver- brain axis and metabolic markers in the frontal cortex (FC) affected by liver damage. 18 male (M) and 20 female (F) Iberian pigs were randomly allocated to 1 of 3 high-fructose high-fat liquid diets (lard, olive oil, and coconut oil) and fed for 10 consecutive weeks. “Healthy” Iberian pigs were fed a eucaloric diet to establish a physiological baseline. Protein precipitation extraction using ultra-performance liquid chromatography-tandem quadrupole mass spectrometry was performed for primary …

Nanoparticles And The Environment: Biopolymer Grafted Cellulose And Screen-Printed Carbon Nanotube Composites, Dominique Henry Porcincula

Master's Theses

A host of environmental issues will define the state of the environment in the 21^st century, with plastic pollution and water shortages among them. While solutions to these problems require large-scale, multipronged solutions, one way we can address them is through material innovation and the use of nanoparticles.

In the first project, we address the issue of plastic pollution by creating nanocomposites of biodegradable polymers (PLA and PCL) with cellulose nanofibrils. Here, PLA and PCL are grafted from the surface of cellulose nanofibrils via ring-opening polymerization of cyclic ester monomers. Polymer-grafted cellulose (PGC) is characterized with structural analysis, solubility …

Facilitating Artistic Growth In Athletically Trained Contemporary Dancers: Using Brain-Compatible Dance Education And Flow State Psychology To Promote Autonomous Movement Choices In Contemporary Movement Practice, Paige Alexis St John

Master's Theses

The primary purpose of this study was to investigate the ability of a curriculum based on Brain-Compatible Dance Education (BCDE) and Flow State Psychology to influence and inform the training of artistry within athletically and competitively trained contemporary dancers – specifically the collegiate dance athlete population. Through this study, participants worked to understand how to texturize and deepen their movement through guided improvisation exercises and contemporary movement practice. Lesson plans were developed within the framework of Gilbert’s BCDE, primarily following her inspiration from Bartenieff Fundamentals and Laban movement concepts. Based on conclusions drawn from journal reflections, survey results, and researcher …

Investigating The Role Of The Metabolite Je As An Inflammatory Modulator, Rim Ahmed Noufal

Master's Theses

Innate immunity represents the first line of defense against pathogens that invade our bodies. It greatly relies on a family of abundant receptors called pathogen recognition receptors (PRRs). These are germ-line encoded proteins abundant in immune cells like macrophages, dendritic cells, and natural killer cells. PRRs encompass five categories, one of which includes toll-like receptors (TLRs). TLRs could either be located on the surface of the cells or intracellularly. The mechanism by which TLRs act is through recognizing a myriad of foreign structures derived from microbes, such as proteins, lipids, and carbohydrates as well as their genetic material. Generally, these …

Novel Method Of The Quantification Of Turbulent Fluid Flow In Silicone Artery Phantoms Using Acoustic Analysis, Julia Wong

Master's Theses

Cardiovascular disease is the leading cause of death globally and is responsible for taking 17.9 million lives per year. Despite the use of clinical treatments and detection methods, there remains a large population of individuals that suffer from CVD whose symptoms are left undetected and untreated prior to a life-threatening cardiac event. This highlights a need for an early detection method that can prevent the manifestation and worsening of the disease as well as address limitations of current early detection methods. An area of interest for early detection of CVD is subclinical atherosclerosis, which is the long, early, asymptomatic stage …

Development Of An Angiogenic Tissue-On-A-Chip Microenvironment, Eric Stuehr

Master's Theses

Preclinical testing is necessary to investigate the safety and efficacy of novel therapeutics before moving to clinical trials, yet approximately 90% of these therapies fail once tested in humans. This has led to increased interest in developing robust preclinical models that accurately mimic the complex human in vivo physiology. Microfluidic devices that can introduce dynamic conditions to 3D cell/organoid cultures, also known as tissue-on-a-chip, have emerged as physiologically relevant in vitro preclinical models that can achieve high throughput screening of therapeutics. The research presented here aimed to develop an angiogenic environment within a novel microfluidic device to stimulate formation of …

Guilty As Charged: The Role Of Judge Instructions On Metaphor Produced Biases In Jury Decision Making, Gina N. Rita

Master's Theses

In this study, we hope to determine if the placement of judge instructions mitigates our previous study’s effect of metaphors on memory and verdict decisions. Our previous study showed in the metaphor condition, participants were more likely to vote guilty and remember more metaphor-related evidence compared to those in the control group. In addition to replicating the previous study’s results, we hypothesize judge instructions stated at the beginning of the trial will have little influence on the metaphor effects, and judge instructions at the end of the trial will weaken these effects. Participants will be randomly assigned to one of …

The Unhappy Specter: The Buried Remains Of Self And Other, Kirt Henry Broesche

Master's Theses

In this paper, we argue that Derrida’s account of the uncanny experience of being haunted by a specter reveals consciousness to be constitutively haunted. From Derrida’s account in Specters of Marx, we locate the cause to the possibility of haunting from the inability to complete a so-called work of mourning. We note primarily the development of Derrida’s account of specters with respect to the psychoanalytic distinction between mourning and melancholia. We go on to compare Derrida’s characterization of a haunted subject to Hegel’s conception of Unhappy Consciousness to discuss the possibility for a haunted consciousness to be assimilated into a …

Characterizing The Utility Of A Near Infrared Click Beetle Luciferase For Bli Applications, Giovanni Duca

Master's Theses

Bioluminescent imaging systems (BLI) have become a valuable tool for doing real-time in vivo studies. BLI systems typically allow for the imaging of surface and subsurface level tissues but as depth increases, the resolution decreases while the signal to noise ratio increases. Deep tissue imaging is therefore a major limitation for BLI. To address this limitation there has been a consistent movement in luciferase research to create long wavelength emitting luciferases that still have a high photon emission rate. Longer wavelengths of light are able to penetrate deeper tissues due to having a lower amount of absorbance and scattering from …

Design And Synthesis Of N-Succinyl-L,L-2.6-Diaminopimelic Acid Desuccinylase Inhibitors As Potential Novel Antibiotics, Thomas Dipuma

Master's Theses

N-Succinyl-L,L-2,6-Diaminopimelic Acid Desuccinylase (DapE) is a bacterial enzyme located in the lysine biosynthetic pathway of all Gram-negative and most Gram-positive species of bacteria including the notorious ESKAPE pathogens, or pathogenic strains of bacteria that have developed significant levels of resistance to currently available antibiotics. As a means to combat this challenge of growing antimicrobial resistance, we have identified the bacterial enzyme DapE as a conserved, novel enzymate target within these resistant bacterial strains,as DapE is responsible for the production of m-DAP and lysine which are ultimately employed in bacterial cell wall synthesis. The overall aim of this research is to …

Nira Ya Mtumwa Aliye Huru: Granville Kachipumo's Life Of Slavery And Redemption In Nineteenth-Century East Africa, Zachary Tyler Levy

Master's Theses

Granville Kachipumo was the Universities Mission to Central Africa’s African-born teacher at Mkului in East Africa near today’s Muheza district of Tanga, Tanzania. He was taken from his home along River Lintipe at 10 to 12 years old. Granville Kachipumo’s life began with his family west of Lake Nyasa. Ripped from the arms of his parents, Granville Kachipumo faced two inland journeys, each with its complex forms of slave trade. From the inland environment, Granville Kachipumo navigated to the mission halls of Masasi and beyond. Kachipumo’s story is, as Arthur Cornwallis Madan stated, “a story of an intelligent boy who …

Non-Planar 3d Printing Of Thermosetting Prepolymers, Junaid Abid Ali

Master's Theses

Additive manufacturing or three-dimensional (3D) printing is an advanced process of manufacturing that challenges traditional manufacturing methodologies. However, the current 3D printing process does exhibit specific limitations. It generates printing paths that are in a horizontal plane, proving inadequate for printing curved or non-flat structures. This study established a printing procedure capable of simultaneously executing printing in X, Y, and Z directions. The limitations posed by conventional 3D printing lead to the poor surface quality of curved printed objects. In contrast, non-planar 3D printing provides smoother surfaces. This work developed a program capable of producing non-planar print paths for the …

Hedgehog Signaling As An Underlying Mechanism For Midline Modification During Asexual Reproduction In Convolutriloba Longifissura Acoels, James M. Sikes Ph.D., Jaclyn Cherry

Master's Theses

The mechanisms that control midline specification and modification during post-embryonic development are some of the least understood in developmental biology.  Because acoel flatworms have varied modes of asexual reproduction which can involve the dramatic modification of their orthogonal axes and midline, we have chosen the acoel species Convolutriloba longifissura as a model to study the mechanisms behind midline modification.  C. longifissura asexually reproduces through a double fission process where novel midlines arise within laterally located tissues while the adult midline is destroyed prior to an initial transverse fission event, which is then followed by a second longitudinal fission.  Previous work …

Mate Choice And Sexual Conflict In A Livebearing Fish, Julia C. Kasper

Master's Theses

Eavesdropping occurs when a receiver extracts information from an interaction without directly engaging with the signaler. Eavesdropping has been shown to be an effective way of evaluating the quality of potential mates and their abilities in male-male competition, without having to directly interact with them, thereby reducing energy costs and mating harassment. Girardinus metallicus is a livebearing poeciliid fish endemic to Cuba whose mating system is dominated by mating harassment in the form of sneak copulations, persistent displaying, and male-male aggression. G. metallicus has a male specific polymorphism in both melanin coloration and behavior. Males with melanin coloration are known …