Digital Commons Network^™

Characterization Of Cd11c-Expressing Gut-Associated T Cells, Ana Cvetkovic

Master's Theses

Our immune system is a remarkable defense network that protects our bodies from a range of threats. Its’ intricate machinery comprises of messenger and effector cells that work together to coordinate an effective immune response. Traditionally, T lymphocytes have been considered effectors: they receive instructions from messengers, known as Antigen Presenting Cells (APCs), that alter T-cell activation state and behavior. In the gut, Dendritic Cells (DCs) are the APCs that most often instruct T cells. To accomplish their messenger role, DCs express CD11c at high levels, a surface marker involved in cell-to-cell signaling and phagocytosis. As such, CD11c expression has …

The Effects Of Conditional Loss Of Myosin Binding Protein H-Like On Cardiac Function, Hope Victoria Burnham

Master's Theses

Dilated cardiomyopathy (DCM) is a common cause of heart failure with a strong hereditary component. Mutations in the myosin-binding protein H-like (MYBPHL) gene are linked to hereditary DCM, atrial fibrillation, and atrioventricular arrhythmias. MyBP-HL is a sarcomeric protein that is highly expressed in the atria with only scarce, distinct clusters of MyBP-HL positive cells in the ventricles, mostly in or surrounding the ventricular conduction system (VCS). Constitutive knock-out of MyBP-HL in mice causes atrial dilation, ventricular dysfunction, arrhythmia, and DCM. Whether MyBP-HL plays a developmental role, or if knock-down in adulthood will recapitulate a similar phenotype has yet to be …

Absolute Quantification Of Human Myosin And Titin Isoforms In Disease By A Mass Spectrometry Approach, Nitha Aima Muntu

Master's Theses

Heart failure (HF) is the leading cause of death worldwide and produces an immense economic burden. Dilated cardiomyopathy (DCM), characterized by contractile weakness and chamber dilation, is a significant cause of HF. The sarcomeric proteins play a crucial role in regulating the contractile properties of the heart. As the primary motor protein, the expression of cardiac myosin isoforms (α-MHC and β-MHC) dictates the performance and cardiac energy utilization of the sarcomere. Titin is the giant spring protein in the sarcomere, and titin isoform expression impacts the passive stiffness of the myocardium. Small changes in the α-MHC/β-MHC and titin isoform ratios …

Remote Work And The Desire For Meaningful Work: The Unexpected Moderating Effects Of Age And Childrearing, Adriana Rae Meredith

Master's Theses

The COVID-19 pandemic sent the world into lock down. Since then, organizations have been wrestling with how to navigate the many opinions, as well as research-backed advantages and disadvantages of in-office work, hybrid work, and remote work. In addition to shaking up the ways in which work is done, the pandemic shutdowns caused some to re-evaluate why they do the work they do. The current study aimed to examine the relationship between remote work and an employee’s desire for meaningful work to increase understanding of how remote work can be used as a strategic element of job design rather than …

Deep-Learning Approaches To Predict Remaining Useful Life Of Hard Disks, Rohan Mohapatra

Master's Theses

On a daily basis, data centers process huge volumes of data using inexpensive hard disks. Data stored in these disks serve a range of critical functional needs from financial, and healthcare to aerospace. As such, premature disk failure and consequent loss of data can be catastrophic. To mitigate the risk of failures, cloud storage providers perform condition-based monitoring and replace hard disks before they fail. By estimating the remaining useful life (RUL) of hard disk drives, one can predict the time-to-failure of a particular device and replace it at the right time, ensuring maximum utilization whilst reducing operational costs. We …

“It Makes Me Wonder, How I Keep From Goin’ Under:” Deconstructing Cultural Strengths In The Stories Of Black College And University Students, Sikeza C. Fowlks

Master's Theses

To deconstruct conceptualizations of Black cultural resiliency outside of the perception of the current dominant culture, the present study interviewed Black university and college students for their narratives about their perceptions of Black culture and how they navigate systemic oppression. To create a full conceptualization of Black issues and cultural resilience this study explored the current literature around Black experiences of racism and its relationship to Race-Based Trauma. Additionally, the researcher expanded upon current interventions used to mitigate Race-Based Trauma and how Black culture is currently defined within systemic oppression. To answer the study’s research question framework around Black cultural …

Confronting The Myths Of “Classical” Keyboard Improvisation: A Historical Evaluation, Examination, And Re-Incorporation Of Improvisation In Contemporary Piano Education And Performance, Kiefer Taylor

Master's Theses

Improvisation has been a highly valued skill in all periods of Western keyboard music. Many composers were also famous as keyboard improvisers and demonstrate the importance of improvisation as a tradition in “classical” keyboard performance. Strangely, today’s pianists, who perform the canonical eighteenth- and nineteenth-century works of these composers, no longer practice or incorporate improvisation into performance and instead play “only from the score.” Improvisation has also disappeared from the modern education of “classical” piano performers. Since improvisation was central to the performance practice of past keyboard repertoire, why does modern piano education not teach improvisation as a standard part …

A Broadband, Dual Polarized Antenna For The Radio Neutrino Observatory In Greenland, Danny Maas

Master's Theses

The Radio Neutrino Observatory in Greenland (RNO-G) is a multidisciplinary, multinational collaboration which uses antennas to detect neutrino interactions with arctic ice sheets. Neutrinos are formed from nuclear reactions; predominant sources include nuclear reactors, stars, supernovae, and the big bang. They rarely interact with normal matter and thus travel from origin to destination relatively unimpeded, with applications including tracking nuclear weapons tests and supernovae. Measurements of galactic neutrino flux can provide information about how the universe developed and its current evolution. Neutrino interactions produce signals from 100 to 1000MHz. Current RNO-G antennas operate over only a portion of this band; …

Effect Of Enzymatic Pretreatment On Biomethane Production From Olive Pomace, Ningjing Zhong

Master's Theses

In 2023, approximately 2.36 million metric tons of olive oil were produced globally. Olive pomace, a byproduct of the flesh and pits left after olive oil extraction, presents environmental challenges when used as landfill due to its high polyphenol and organic contents, or when combusted due to greenhouse gas emissions. Its potential as animal feed is limited, yet it holds promise for methane production via anaerobic digestion (AD), providing a source of renewable energy. However, the highly crystallized polysaccharides in olive pomace, such as cellulose, hemicellulose, and pectin, impede its conversion to methane, and the high polyphenol content inhibits methanogen …

Identification Of Bacterial Transcriptomic Signatures In Breast Cancer Tissues Using Publicly Available Datasets, Rasaq Awosemo

Master's Theses

Breast cancer remains a significant global health concern, with increasing evidence suggesting a link between bacterial infections and cancer progression. This study aims to identify bacterial transcriptomic signatures within breast cancer tissues using publicly available datasets. While previous work in our lab has extensively explored the role of Borrelia burgdorferi in cancer, this research broadens the focus to investigate the presence of various bacterial species across different breast cancer samples.

Employing advanced bioinformatics methodologies, including the STAR aligner and MetaPhlAn for metatranscriptomics analysis, we analyzed RNA-sequencing data from the Gene Expression Omnibus (GEO). Our findings reveal diverse bacterial communities within …

Youtube Influencers In Bangladesh: Analyzing Message Strategies Of Sponsored Ads In Vlogs, Monira Begum

Master's Theses

Social media influencers, particularly YouTube influencers marketing emerged as a growing industry in Bangladesh. However, research on this topic is limited. This study effectively addresses this gap and following quantitative methods and content analysis, this study mainly examines Influencers and brand categories, the narration of sponsored brands in advertising, influencers’ interactivities, and engagement with the followers, and message strategies in ads employing Taylor’s six-segment message strategy wheel, advertising appeals, and message formats. Results indicate that influencers' dominant vlog content is entertainment, as well as technology as prevalent brand characteristics in the study.

Regarding the narration of the sponsored ads, this …

Remembering, Forgetting, And Artifact Deposition In Late Prehistoric Florida, Andrew Bowen

Master's Theses

Material culture plays a fundamental role in memory processes. Artifacts are an important means of both connecting with and cutting ties with a real or imagined past. They can be reminders or symbols of connection to other people, places, things, powers, or memories, making them key components within networks and relations. The way materials are deposited or destroyed often follows specific customs or responds to environmental factors. Specific situations, like interactions with outside groups or socio-political changes, prompt particular depositional events. During the Mississippi period, such circumstances were prevalent throughout the Southeast. By treating artifacts in specific ways during deposition, …

Effects Of Increasing Cycling Cadence On Post-Cycling Gait Velocity: An Experimental Study, Nitu Lama

Master's Theses

Previous research has shown that increasing cycling cadence, rather than the workrate, can result in improved post-cycling gait velocity. However, the specific threshold of cycling cadence required to bring about clinically meaningful changes in gait velocity remains unknown. To address this knowledge gap, our study aimed to determine the minimum incremental increase in cycling cadence that would lead to a significant improvement in post-cycling gait velocity. A total of 42 young adults participated in our study and were randomly assigned to one of three groups: TEN, TWENTY, and THIRTY. Each group was assigned to cycle at a cadence at the …

Effects Of Extreme Starvation On The Fasting-Adapted Western Rattlesnake (Crotalus Oreganus), Brandon R. Kong

Master's Theses

Ambush-hunting snakes have long been of great interest in the biology of fasting and starvation, as they are adapted to withstand well over a year without taking a meal. Well-justified ethical constraints have limited our understanding of their biology at the limits of these abilities. Unfortunate circumstances, in which the California Department of Fish and Wildlife confiscated over 50 Western Rattlesnakes (Crotalus oreganus) from an animal hoarder that had long neglected them, culminated in the euthanized animals ending up in the hands of our lab. Some of these snakes were extremely starved, being only one-half to one-third of …

Enhancing Refugee Resettlement And Displaced Population Support Through Elder Communities In The United States: A Model For Sustainable Solutions, Ponnaka Pok

Master's Theses

This thesis paper is inspired by the current world crisis of exploding numbers of refugees and the obstacles they face seeking somewhere to resettle. We present here an effort to address these pressing issues and to advocate for meaningful change. This paper explores the challenges and opportunities associated with refugee resettlement and displaced population issues in the United States. It investigates how Elder communities might play a pivotal role in addressing these challenges and offers a trial model for implement and continued development, and potentially for other countries and organizations to follow. This paper also has a secondary focus on …

Biometric Assessment Of Spotted Seatrout (Cynoscion Nebulosus) From Recreational And Commercial Fisheries In Mississippi, Usa, Nimah Folake Osho-Abdulgafar

Master's Theses

Quantitative stock assessments for Mississippi’s Spotted Seatrout use length-, age-, and sex-composition data from fishery-independent sources as proxies to estimate biostatistical characteristics of fisheries harvests due to lack of sector-specific data. In Chapter 2, I examined the age, length, and sex composition of Spotted Seatrout from three fishery-dependent sectors. Between April and December 2023, I collected 210 fish (n = 19, 124, and 67 from private, charter, and commercial sectors, respectively). The length ranged between 373-535mm, 285-523mm, and 345-568mm TL, with mean ± SD lengths of 453 ± 51mm, 393 ± 57mm, and 442 ± 53mm TL, respectively. Age ranged …

Loverboy Rules: A Transtheoretical Exploration Of Andy Bernard's Failed Masculinity, Jessie Marta Olstad

Master's Theses

NBC's U.S adaptation of The Office is one of the most well-known sitcoms to come out of modern television, surpassing its original British counterpart’s two seasons with its own nine. It is a representation, as well, of the time it aired (2005-2013), reflecting on the modern American workplace and the everyday person. Within it, The Office also reflected how society was constructed at the time with its humor surrounding gender, homosexuality, and race – as a tolerant but not welcoming atmosphere to people who were not white, heterosexual, men. More specifically, The Office presents multiple adaptations of masculinity to teach …

Neurogenomics Of Competition And Parental Care In A Socially Polyandrous Shorebird, Tessa Mathur Patton

Master's Theses

Despite sharing largely similar genomes, females and males of the same species exhibit morphological, physiological, and behavioral differences. Sex-role reversal stems from a unique case of sexual selection in which females compete for mates and males conduct the majority of parental duties. We examined the extent to which aggression and parenting may be mediated by different neurogenomic mechanisms by comparing females versus males in the northern jacana (Jacana spinosa), a sex-role reversed shorebird. We hypothesized that sex differences in neural transcriptomic profiles explain sexual dimorphism in behavior. We conducted RNA-Seq in two brain regions within the social behavior network: the …

Neuroinflammation And Gut Barrier Function Post Traumatic Brain Injury, Anne Sullivan

Master's Theses

Traumatic Brain Injury (TBI) is a major cause of morbidity and mortality that afflicts millions of people in the United States annually. TBI mice had significantly increased expression of the pro-inflammatory cytokines and decreased expression of tight junction proteins CLDN5, CLDN12, and OCLD in brain lesion tissue. TBI mice exhibited a significant accumulation of FITC in the middle and distal part of the small intestine compared to sham mice. TBI mice exhibited an increase in pathogenic bacteria Enterobacteriaceae and a decrease in beneficial bacteria lactobacillus. TBI mice exhibited a trend toward an increase in permeability compared to no treatment. These …

Investigating Car T Cell Persistence, Functional Phenotype, And The Associations With Clinical Response In Cd19 Car T Cell Treated Patients, Oliwia Bochnacka

Master's Theses

CAR T cell therapy is the adoptive transfer of autologous T cells genetically engineered to express an artificial T cell receptor. In the clinic, CAR T cells have been most effective in treating hematological malignancies and there have been many efforts to continue improving both the safety and efficacy of CAR T cells. Using patient blood samples from the Loyola CD19 CAR T clinical trial, we studied CD19 CAR T persistence and the cell surface phenotype to identify how CD19 CAR T cells change over time in the blood of treated patients and determine whether there were trends associated with …

Thermal Preconditioning Effects On Perforation Propensity Of Transvenous Implantable Cardiac Leads Used For Pacing And Defibrillation, Diane Muff

Master's Theses

Thermal preconditioning to simulate shipping, handling and storage conditions did not affect distal tip stiffness values for permanently implantable cardiac leads used for pacing and defibrillation. Leads that were subjected to extreme temperatures and temperature cycling did not show changes in buckle force values compared with control specimens which were maintained at ambient room conditions. Absolute differences between all measurements were small, generally under 0.05 N and were attributable to measurement variability.

Buckle force values are used to assess the propensity of leads to perforate the heart, a rare but potentially serious complication of implantable pacing and defibrillation systems. Since …

A Hardware-In-The-Loop Star Tracker Test Bed, Ashley Haraguchi

Master's Theses

As the use of small satellites for advanced space missions continues to grow, the importance of low mass and cost three-axis attitude stabilization systems increases as well, with these systems requiring high accuracy attitude knowledge. Star trackers provide the most accurate attitude knowledge of any type of attitude sensor, but the high cost, size, and weight of commercial star trackers can be prohibitive to small satellite missions. Many simple star trackers have been developed using commercial off-the-shelf camera sensors and processing hardware, but the challenge remains in testing and characterizing these devices. A common solution is night sky tests, in …

Power Flow Modeling And Analysis Of A Green Seaport Power System, Alejandra Zapata

Master's Theses

Indonesia has committed to achieving Net-Zero emissions by 2060, signaling a significant shift towards sustainability, which includes impactful initiatives such as the implementation of Green Seaports. This thesis focuses on designing and developing a model for a proposed Green Seaport power system and the subsequent performance of power flow analysis under various operating conditions. The model, constructed using MATLAB Simulink, underwent extensive testing and analysis, with a specific emphasis on the Battery Energy Storage System (BESS) operating modes, including individual charging, discharging, and simultaneous charging and discharging. This comprehensive investigation and analysis, involving 62 separate simulations, evaluated the impact of …

A Study On Privacy Over Security And Privacy Enhancing Networks, Everett Lee Conway

Master's Theses

With rapid developments in communication technologies and awareness of security and privacy risks online, Security and Privacy Enhancing Networks (SPENs) have become increasingly popular. Especially during the COVID-19 pandemic, workplaces encouraged employees to take additional security measures, such as VPNs. In this work, we conduct a comprehensive study on website fingerprinting attacks. A comprehensive system model and threat model based on two types of SPENs (Virtual Private Networks and Tor Networks) are presented. Moreover, we demonstrate a website fingerprinting attack by ethically collecting website fetch data and analyzing the collected data using five different machine learning classification models including k …

Sustaining Sustainable Farming: An Evaluation Of The Reasoned Action And Comprehensive Action Determination Frameworks For Persistence, Jet J. Tan

Master's Theses

This paper investigates the persistence of agricultural practices funded by the California Department of Food and Agriculture's Office of Environmental Farming and Innovation (CDFA OEFI). The central inquiry revolves around determining the most effective behavior model for analyzing persistence, comparing the Reasoned Action Approach (RAA), Comprehensive Action Determination Model (CADM), and CADM augmented with structural variables. The study's methodology integrates literature review, analysis of OEFI-funded practices, and statistical modeling to assess persistence levels. Contrary to existing literature, our findings reveal significantly higher levels of persistence than anticipated. Moreover, through model comparison, CADM augmented with political economic variables emerges as the …

Improving Aerospace System Robustness Integration Of Singular Value Decomposition And Network Centrality, Ricardo S. Contreras

Master's Theses

This thesis presents an approach to understanding and enhancing the robustness of aerospace systems through the integration of network analysis, Design Structure Matrix (DSM), Singular Value Decomposition (SVD), and robustness simulation techniques. This methodology called the Importance Hierarchy method, provides a comprehensive framework for decomposing the interactions of aerospace systems, focusing on identifying and evaluating critical components and interactions.

The Importance Hierarchy method was used to study the Autonomous Flight Termination Unit (AFTU) by analyzing its components and interdependencies. The AFTU was selected because it recently completed a Preliminary Design Review (PDR), and its design and operational functions were well-known. …

Harmonic Flow Modeling And Analysis Of A Green Hybrid Ac/Dc Seaport Power System, Krishan Kaushal Ram, Taufik, Helen Yu, Siddharth Vyas

Master's Theses

This thesis aims to design and develop a model for a proposed Green Seaport power system and perform harmonic analysis. The model was developed using MATLAB Simulink and tests were performed by dividing the system into several Battery Energy Storage System (BESS) operating modes such as simultaneous charging and discharging, simultaneous charging, and simultaneous discharging. For each mode, BESS state of charge and other factors such as solar irradiance for the PV system, load levels and power factor were varied to observe the impact on system’s voltage Total Harmonic Distortion (THD) level and current Total Demand Distortion (TDD). 62 separate …

Generative Data Augmentation: Using Dcgan To Expand Training Datasets For Chest X-Ray Pneumonia Detection, Ryan D. Maier

Master's Theses

Recent advancements in computer vision have demonstrated remarkable success in image classification tasks, particularly when provided with an ample supply of accurately labeled images for training. These techniques have also exhibited significant potential in revolutionizing computer-aided medical diagnosis by enabling the segmentation and classification of medical images, leveraging Convolutional Neural Networks (CNNs) and similar models. However, the integration of such technologies into clinical practice faces notable challenges. Chief among these is the obstacle of acquiring high-quality medical imaging data for training purposes. Patient privacy concerns often hinder researchers from accessing large datasets, while less common medical conditions pose additional hurdles …

Predicting Rheology Of Uv-Curable Nanoparticle Ink Components And Compositions For Inkjet Additive Manufacturing, Cameron D. Lutz

Master's Theses

Inkjet additive manufacturing is the next step toward ubiquitous manufacturing by enabling multi-material printing that can exhibit various mechanical, electronic, and thermal properties. These characteristics are realized in the careful formulation of the inks and their functional materials, but there are many constraints that need to be satisfied to allow optimal jetting performance and build quality when used in an inkjet 3-D printer. Previous research has addressed the desirable rheology characteristics to enable stable drop formation and how the metallic nanoparticles affect the viscosity of inks. The contending goals of increasing nanoparticle-loading to improve material deposition rates while trying to …

Sizing Wind Tunnel Heater For High Enthalpy Conditions, Justin M. Slavick

Master's Theses

This paper determines the feasibility of adding a heater to an existing blowdown supersonic wind tunnel to unlock new high-enthalpy test applications, considering cost and power requirements at a variety of different states. This process includes both modeling the current range of test section properties in Cal Poly's blowdown wind tunnel and determining the new range of properties that a heat exchanger could induce. These results are verified with a computational fluid dynamics study. Additionally, sublimation and ablation properties of materials are explored to create appropriate models to study atmospheric re-entry once the heat exchanger is implemented.

It is found …