Digital Commons Network^™

Propagation Of Oligomeric Α-Synuclein And Amyloid-Β: Implications For Parkinson's And Alzheimer's Diseases, Matthew Stephen Planchard

Master's Theses

The aggregation of amyloidogenic proteins is a critical event in the pathology of a variety of neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). The proteins α-synuclein (αS) and amyloid-β (Aβ) are involved in the formation of amyloid lesions observed in PD and AD, respectively. Both PD and AD exhibit a significant amount of co-pathology in clinical settings, and the αS and Aβ proteins have been shown to interact in vitro. Recent experimental consensus has shown oligomeric species to be significant, if not primary, sources of toxicity in these diseases. …

De Gustibus Non Est Disputadem: The Culinary Arts, Ferran Adrià, And Documenta 12, Jean A. Nihoul

Master's Theses

No abstract provided.

A Closer Look At Violent Crimes Among Severely Mentally Ill Patients Who Use Cocaine, Deepa Jayanti Mavani

Master's Theses

It is estimated that one in four U.S. adults have a mental illness and that nearly half will develop a mental illness during their lifetime, with one in 17 people in the general population suffering from a severe mental illness (SMI). The high prevalence of SMI in conjunction with its presumed link with violence, suggests substantial risk to the public. Evidence remains inconsistent in determining if this link exists. Some suggest that specific SMI’s such as schizophrenia and other psychosis–related disorders increase risk for violence, while others have reported no association (Fazel, et al., 2009). Establishing the validity of this …

The Art Of Commerce: Self-Stratification On Etsy, Natalie K. Umsted

Master's Theses

Scholars have long shown that there are gendered hierarchies within art worlds. This research examines how those hierarchies are forming on the online marketplace Etsy. Using qualitative methodology I examine 10 in-depth interviews with artists actively selling their artwork on Etsy. Additionally, I perform a qualitative content analysis of 50 artist profiles on Etsy. I find that offline cultural frameworks affect the ways these online artists project the value of themselves, their ability, and their art pieces. Offline practices, procedures, and attitudes influence the way we value our self, and thus affect the way we present our self online.

Dna-Functionalized Gold Nanoparticles For Chemiresistive Vapor Sensing, Kan Fu

Master's Theses

Chemiresistive sensing with functionalized gold nanoparticles is a powerful new technology for vapor sensing. Utilizing changes in behavior of electron tunneling through conductive gold nanoparticles and insulating organic capping layers upon analyte adsorption, this system can achieve intrinsically high sensitivity and rapid response time. A number of thiol-based small-molecule organic ligands have already been successfully used to functionalize gold nanoparticles, yielding an array of organic sensors having various sensitivities towards different organic vapors. With the aid of chemometric analysis tools, gold nanoparticle-based chemiresistive sensors have been rapidly maturing into a vapor quantification and identification technology.

A limiting factor for its …

Compacting Loads And Stores For Code Size Reduction, Isaac Asay

Master's Theses

It is important for compilers to generate executable code that is as small as possible, particularly when generating code for embedded systems. One method of reducing code size is to use instruction set architectures (ISAs) that support combining multiple operations into single operations. The ARM ISA allows for combining multiple memory operations to contiguous memory addresses into a single operation. The LLVM compiler contains a specific memory optimization to perform this combining of memory operations, called ARMLoadStoreOpt. This optimization, however, relies on another optimization (ARMPreAllocLoadStoreOpt) to move eligible memory operations into proximity in order to perform properly. This mover optimization …

Learning About Led Lighting Technology Through Patents, Joe C. Liu

Master's Theses

Patents and published patent applications are valuable resources to students, engineers, and researchers for learning about technology. This thesis investigated the ability to learn about a technology through the disclosures that are made in published patent applications and issued patents.

This thesis first provides an overview of U.S. patent law, system, and resources that are available to the public. It is through an understanding of U.S. patent law and system that one can appreciate that patents and patent applications are a resource for learning about technology.

By providing the basic building blocks of LED lighting technology as learned through the …

Comparative Analysis Of Two Successive Vintages Of Cabernet Sauvignon Must And Pre-Barrel Wine From Two Distinct Soil Types, Jon Garret Page

Master's Theses

The objective of this study was to determine if there were significant statistical differences in the response variables of Cabernet Sauvignon must and pre-barreled wine analyzed from two vintages from two distinct soil types.

Research was conducted at California Polytechnic University, San Luis Obispo to examine the quantitative chemical analysis of 22 different response variables of Cabernet Sauvignon grapes. The same 22 variables were analyzed in must and pre-barreled wine samples harvested from both Calodo Clay Loam soil and Zaca Clay soil. The analyses were done at both California Polytechnic University, San Luis Obispo and Vinquiry Inc. Labs. The results …

Design Of Controlled Environment For Tissue Engineering, Malcolm Gerald Lapera

Master's Theses

Design of Controlled Environment for Tissue Engineering

Malcolm Lapera

Tissue engineering aims at relieving the need for donor tissue and organs by developing a process of creating viable tissues in the laboratory setting. With over 120,000 people awaiting a transplant, the need for generating tissue engineered organs is very large [3]. In order for organs to be engineered, a few issues need to be overcome. A work space that both creates an environment which maintains cell viability over an extended period of time as well as accommodates the necessary fabrication equipment will be needed to further tissue engineering research. Therefore, …

A Social Ecological Approach: Understanding The Factors Associated With Hiv Risk In Fishing Communities In Lake Victoria, Uganda., Paola Chanes-Mora

Master's Theses

Uganda has an estimated 1.4 million Human Immunodeficiency Virus (HIV) -positive adults (United Nations Program on HIV/AIDS [UNAIDS], 2011). The initial cases of acquired immune deficiency syndrome (AIDS) in Uganda were identified in fishing villages on the shores of Lake Victoria in 1985 (Serwadda et al., 1985). Fishing villages continue to remain at high risk of HIV transmission (United Nations Program on HIV/AIDS [UNAIDS], 2012). Evidence suggests that the HIV- prevalence rates among fishermen and commercial sex workers (CSWs) in the Wakiso District are more than 20 percent (Alex, Michael, & Nordin, 2011). The purpose of this study was to …

The Legacy Of Antonio Sant'elia: An Analysis Of Sant'elia's Posthumous Role In The Development Of Italian Futurism During The Fascist Era, Ashley Gardini

Master's Theses

This thesis is an examination of the posthumous legacy of Antonio Sant'Elia propagated by F.T. Marinetti during the 1920s and `30s in Fascist Italy. It is during the period of Second Futurism that the Manifesto of Futurist Architecture and the images from the La Città Nuova series came to define Sant'Elia's identity as the figurehead of Futurist architecture. This research contributes to the scholarly discussion of Second Futurism by giving context to specific actions taken by Marinetti during the Fascist era to control how Sant'Elia would be remembered.

This thesis analyzes the Fascist government's control over Italian society, religion, and …

Utilization Of Crowdsourced Maps In Catastrophic Disasters, Makiko Hong

Master's Theses

Crowdsourced data, the collective messages from citizens through social media like Twitter® or Facebook®, have been increasingly recognized as a vital information source in a catastrophic disaster. Because there is often insufficient emergency personnel to gather situational information during a big disaster, the crowdsourced data can offer a supplemental means for data collection or dissemination immediately after the disaster. In addition, crowdsourced maps can empower citizens with their involvement.

In the Haiti earthquake of 2010, crowdsourced data was first used to create a web map application to aid the humanitarian effort. With some success in Haiti, these crowdsourced maps have …

Experiences Of Immigration Among Women From Taiwan, Robert Johnston

Master's Theses

This thesis explores the transformative effects of immigration from the 1960s through the 2010s among women from Taiwan living in the County of Santa Clara. The study focused on three substantive areas: (1) early life experiences and factors leading to immigration; (2) shifts in social identities after leaving Taiwan (e.g., political, national, and ethnic self-concepts in various contexts); and (3) practices of child-rearing. Several methodological tools were employed during the data collection phase of the research process, including interviews, surveys, and participant observations. The findings of this study suggested a dynamic process of change in which informants adapted to, were …

Prediction Of Residual Stress And Distortion From Residual Stress In Heat Treated And Machined Aluminum Parts, Robert Michael Jones

Master's Theses

Parts machined from relatively large thickness cross sections can experience significant deformations from high residual stresses that develop in the part during the heat treatment used to form the aluminum alloy. Uphill quenching is a process that can create a part with low residual stress and stable dimensions when the process is controlled properly. The uphill quenching process involves a solution heat treat, quench, cool to liquid nitrogen, steam blast, and then age to final temper.

In this thesis two parts were modeled using ANSYS. The first part underwent the uphill quench process in the rough machined state. The second …

Development Of A Spatial Filtering Apparatus, Nicolle Wilson

Master's Theses

This thesis contains a discussion of the theoretical background for Fourier spatial filtering and a description of the design and construction of a portable in-class spatial filtering apparatus. A portable, in-class spatial filtering demonstration apparatus was designed and built. This apparatus uses liquid crystal display (LCD) panels from two projectors as the object and filter masks. The blue LCD panel from the first projector serves as the object mask, and the red panel from the second projector serves as the filter mask. The panels were extracted from their projectors and mounted onto aluminum blocks which are held in place by …

Radio:Reaching Young Adult Audiences, What Are The Challenges And Opportunities For Radio Programmers In Cultivating Young Adult Audiences In The Current Media Environment?, Joel David Abramson

Master's Theses

As young adults have adopted the use of digital new media technologies, previous scholarly research has predicted a lack of interest by young adults in traditional media, including radio. This waining interest in traditional media by young adults has also been reported in the popular press. An abandonment of radio by young adults could bring about an eventual decline in audience, resulting in adverse economic effects to the broadcast radio industry and related industries, including a decrease in radio revenues, the deflation in the value of radio properties, and potential job loss. This research examined the challenges radio programmers and …

Mapping The Monster: Locating The Other In The Labyrinth Of Hybridity, Jill Kristine Harper

Master's Theses

By the last two decades of the nineteenth century, Great Britain led the European contest for imperial dominion and successfully extended its influence throughout Africa, the Americas, South East Asia, and the Pacific. National pride in the world's leading empire, however, was laced with an increasing anxiety regarding the unbridled frontier and the hybridization of Englishness and the socio-ethnic and cultural Other. H. Rider Haggard's She, Bram Stoker's Dracula, and Richard Marsh's The Beetle, three Imperial Gothic novels, personify the monstrosity of hybridity in antagonists who embody multiple races and cultures. Moreover, as representatives of various ancient …

Commitment Types And Influence Of Daily Deals Among Boot Camp Participants, Linda Lund

Master's Theses

The sedentary lifestyle that many Americans exhibit reinforces the need for continued research into the factors associated with the adoption and maintenance of regular physical activity. Internet-based daily deal websites, such as Groupon® and LivingSocial®, feature deals and discounts on many products and services, including fitness programs. The purpose of this study was to determine the relationship between "daily deals" usage and the types of commitment exhibited by fitness program participants. The targeted program studied was a fitness boot camp. Boot camp participants (N=150), recruited from an indoor boot camp company, completed a questionnaire that included basic demographic information, membership …

Perspiration And Motivation: An Examination Of Body Image And Exercise, Melissa Luu

Master's Theses

The purpose of this study was to examine the relationship between body image and exercise. The study examined reasons for exercise and level of exercise as potential moderators of the relationship between body appreciation and exercise. Three hypotheses were tested: there will be sex differences in level of body appreciation, there will be a positive relationship between body appreciation and level of exercise, and the relationship will be moderated by reason for exercise - either health or appearance reason and exercise level. Two-hundred-eighty-nine participants selected from an introductory psychology course pool responded to four questionnaires: the Body Appreciation Scale (BAS), …

Professional Wushu Athletes: Potential Athletic/Personal Dissonance, Yang Zhang

Master's Theses

The success of Chinese professional athletes is attributable to the government-run elite sport system; it is seen as one of the most effective and successful systems at nurturing high-skilled athletes. However, within the Chinese professional sport system, tensions between athletes' athletic skills and overall personal development have been widely documented. Among all studies, very few have employed in-depth interviews with professional wushu athletes. In this study, the researcher utilized in-depth semi-structured interviews with professional wushu athletes from three of the 25 professional wushu teams in mainland China. The study was conducted in order to understand the potential conflicts between athletes' …

Countering The Dreamer Narrative: Storytelling, Immigration Reform, And The Work Of 67 Sueños, Drew Schmenner

Master's Theses

Research question: How has the practice of storytelling been used in the current U.S. conflicts over immigration?

Telling an effective story is an essential part of a complex strategy to bring about social change, but storytelling as a part of collective action has not been extensively studied. For activists in the United States fighting for immigrant rights, especially the passage of the DREAM Act, storytelling has been an important tactic, but the nature of the narrative that was constructed has its drawbacks because it excluded some members of the immigrant community. In 2010, the Bay Area-based group 67 Sueños (“67 …

Functional Characterization Of A Novel Thioredoxin Domain-Containing Protein Of The Malaria Parasite Plasmodium, Rachel Kooistra

Master's Theses

A novel thioredoxin domain-containing protein of the malaria parasite Plasmodium was identified and found to be conserved among eukaryotes. This protein belongs to the phosducin-like family of proteins (PhLPs), and was therefore assigned the name PhLP1, since it is the first phosducin-like protein to be identified in Plasmodium. PhLPs have been found to have various roles in G-protein signaling, cell cycle progression, and protein folding. However, the biochemical mechanism by which PhLPs perform their function is unknown. Here is described the cloning and biochemical characterization of both PhLP1 and its human homolog TXNDC9. Both purified PhLP1 and TXNDC9 showed enzymatic …

The Perceived Threat Of Secularism And Militancy Among Religious Fundamentalists, Chase Wilson

Master's Theses

Religious fundamentalism has been found to predict endorsement of aggressive counterterrorism techniques, such as the use of severe interrogations and pre-emptive military attacks (e.g. Barnes, Brown & Osterman, 2012). The present study tested whether a perceived increase in secularism constitutes a psychological threat to American religious fundamentalists, and thus increases endorsement of such counterterrorism tactics. Replicating previous research, religious fundamentalism was found to positively predict endorsement of aggressive counterterrorism techniques, even when controlling for ideology and party identification. Contrary to hypothesis, the secularism prime had no effect. An unpredicted finding of this study was that religious fundamentalism only related to …

High-Stakes Testing: The Student Voice, Julianna Marie Cechowski

Master's Theses

There has been an intense debate about standardized testing since they were first introduced into public schools in the nineteenth century. In this research, it is important to know why standardized tests were created and how they have been debated. Roy C. Owens said. "We cannot know where we're going if we don't know where we've come from." Past information is important in this research because it will show how far we have progressed since the start of the standardized testing movement.

What started out as standardized testing later changed into high-stakes testing. The high-stakes were created by tying student …

Life Histories, Diets, And Secondary Production Of Odonata Along A Temperature Gradient On The Copper River Delta, Alaska, Nicole Emilie Furlan

Master's Theses

Dragonflies (Odonata: Epiprocta) and damselflies (Odonata: Zygoptera) are a conspicuous aspect of the biota in ponds on southcentral Alaska's Copper River Delta (CRD). Odonate densities, secondary production, and diets were assessed in sixteen ponds classified by delta region (east vs. west) and landscape type (outwash plain (OP) vs uplifted marsh (UM)).

Enallagma boreale (Coenagrionidae) comprised 48.5% of collected odonates. Leucorrhinia hudsonica (Libellulidae) and Aeshna juncea (Aeshnidae) comprised 36.6% and 10.4% of collected odonates, respectively. L. hudsonica densities and secondary production were significantly higher (p<0.001) in west UM ponds than in other pond types. Ostracods (Ostracoda) and water boatmen (Corixidae) dominated west OP A. juncea diets. Midge larvae (Chironomidae) dominated A. juncea diets in remaining pond types, occurring in 68% of foreguts. 27% of A. juncea foreguts demonstrated intraguild predation, and 6% of foreguts demonstrated cannibalism. Foreguts containing threespine stickleback (Gasterosteus aculeatus) revealed A. juncea's apex predator role in CRD ponds.

Identifying Oncogenic Drivers In Nsclc Cells Harboring Egfr Kinase Domain Mutation With Resistance To Egfr Tki And Mesenchymal Phenotype, Yandi Gao

Master's Theses

EGFR kinase domain mutant NSCLC cells are exquisitely dependent on mutant EGFR for cell survival and proliferation. Patients with mutant EGFR respond well to the EGFR inhibitors. However, acquired drug resistance greatly limits the efficacy of the treatment. About 15% of the resistant tumors present an evidence of epithelial to mesenchymal transition (EMT). We hypothesize that the induction of mesenchymal promotes aberrant upregulation of other oncogenic drivers to replace the oncogenic mutant EGFR.

We observed overexpression of CXCR7 in NSCLC models of acquired resistance to EGFR TKI with mesenchymal phenotype. Additionally, our studies demonstrate that ectopically overexpressing CXCR7 in EGFR …

Characterizing The Mechanisms By Which Community Associated Methicillin-Resistant Staphylococcus Aureus Influences Keratinocyte Innate Immune Responses During Recurrent Infection, Ashley Lynn Larm

Master's Theses

Community associated–methicillin resistant Staphylococcus aureus (CA–MRSA) infection has become a major health concern. In human epidermal keratinocytes, S. aureus is mainly recognized through toll–like receptor 2 (TLR2) and its co–receptor, CD14. We hypothesize that CA–MRSA isolates cause recurrent infections by interrupting TLR2–mediated inflammation in keratinocytes. Recurrent CA–MRSA bacterial culture supernatant exposure to keratinocytes in vitro resulted in significant decreases in pro and anti–inflammatory cytokine and HMGB1 secretion from keratinocytes as assessed by ELISAs. Recurrent CA–MRSA live infection did not result in significant changes in cytokine or HMGB1 secretion, surface receptor expression, or NFκB activation post infection as assessed by ELISA …

Characterization Of The Female Urinary Microbiota And Their Association With The Female Bladder Uroepithelium, Evann Elizabeth Hilt

Master's Theses

The current clinical dogma assumes that urine is sterile in the absence of clinically relevant infection. However, recent evidence has demonstrated the existence of a female urinary microbiota in women with and without lower urinary tract symptoms. With the knowledge that the lower urinary tract possesses its own unique microbiota, I hypothesize that certain bacterial species of the female microbiota may be the cause or play a role in lower urinary tract syndromes such as overactive bladder syndrome (OAB). About 40-50% of OAB patients do not respond to conventional anti-muscarinic and beta-3 adrenergic agonist drug treatment. One possible explanation for …

An Investigation Of The Role Of Vibrio Vulnificus Rbda And Vibrio Parahaemolyticus Sypa In Biofilm Formation, Cecilia Thompson

Master's Theses

Vibrio vulnificus and Vibrio parahaemolyticus are both bacteria that cause human infection. V. vulnificus has a polysaccharide locus, rbd, responsible for bacterial aggregation, a form of biofilm. This locus is conserved in V. parahaemolyticus and in the non-pathogen V. fischeri.

In V. fischeri, the polysaccharide locus, syp, has been extensively characterized and shown to be important for biofilm formation. In V. fischeri, the first gene, sypA, is critical for biofilm formation. V. fischeri biofilm-proficient strains form wrinkled colonies. In contrast, sypA mutants form smooth colonies, indicating a lack of biofilm formation.

To understand the function of RbdA and SypAVP, proteins …

Teacher Attrition: The Job Choices Of Ex-Teachers, Becky Wock

Master's Theses

Teacher attrition is a phenomenon occurring in education systems throughout the world. As education policies alter and add to the demands of teachers, one solution for teachers is to leave the profession all together. While not all teachers have the option to find alternative employment and explore new careers, some regions boast plenty of employment opportunities. This research project focuses on the job choices of ex-teachers in the southeast region of Saskatchewan, Canada. The oil industry has made jobs plentiful throughout the province. This study seeks to further understand the factors impacting decisions to leave teaching and presents findings that …