Digital Commons Network^™

Teaching And Telling Difficult Stories: An Analysis Of Colombian Narratives Of Violence, Paula Liliana Mantilla Blanco

Master's Theses

Making sense of chaos takes a narrative form. It is for that reason that efforts to find and comprehend narratives commonly follow violent events. After all, violence leaves societies in a state of turmoil that demands some sort of order. Such order can only be reached through the act of telling and hearing difficult stories. However, in societies affected by conflict, stories are as diverse and biased as people’s experiences. Privileging a single story can have the unintended effect of aggravating violence by failing to recognize the validity of people’s interpretations of war. Echoing an array of stories is therefore …

Surveying Host Innate Immune Responses To Interferon Antagonist-Deficient Murine Coronaviruses, Aaron Brian Volk

Master's Theses

Two coronaviruses (CoVs)—severe acute respiratory syndrome (SARS) virus and Middle East respiratory syndrome (MERS) virus—have emerged in the 21st century from animal reservoirs into the human population, each causing an epidemic associated with significant disease and mortality. CoV epidemics are currently only controllable by rigorous public health measures; no targeted therapeutics or vaccines exist to treat or prevent any human CoV infection. One method of generating attenuated CoV strains to be studied as vaccine candidates involves specifically disrupting CoV-encoded interferon (IFN) antagonists, thereby rendering the virus vulnerable to host innate antiviral immunity. Deubiquitinating (DUB) activity encoded within CoV nonstructural protein …

Characterizing Immune Response To Hiv-1 Infection In Bicd2-Knockout Cells, Omar Abdel-Rahim

Master's Theses

An important part of the HIV-1 infection cycle is the attachment of the intracellular viral core to the host microtubule network, facilitated by attachment of the viral capsid to cargo adaptor proteins. One such cargo adaptor is Bicaudal D Homolog Protein 2 (BICD2). BICD2 can attach to both the HIV-1 capsid and the dynein/dynactin complex and facilitate the trafficking of the viral core towards the host nucleus. Removal of BICD2 can disrupt this viral translocation, resulting in an elevated immune response that impairs productive HIV-1 infection. In my research, we investigated what viral particles are detected in the absence of …

Investigating Autophagy, Extracellular Vesicles, And Glycobiology, Benjamin Cook

Master's Theses

Autophagy is a cellular process of degradation which degrades cellular materials in acidic organelles called lysosomes. Impairment of lysosomal degradation can lead to lysosomal storage disorders such as Parkinson's Disease. In Parkinson's Disease neurotoxic α-synuclein can spread from cell-to-cell via extracellular vesicles. We investigated the changes in extra vesicular glycans upon perturbation of autophagy using a class of glycan binding molecules termed lectins.

We found that upon induction of autophagy causes EV glycans to increase while others remained consistent. Additionally, we found that specific glycans are increased more than others. Conversely, when lysosomal degradation was impaired, we observed a decrease …

Induction Of Zika Virus-Specific Cd8+ T Cells By Means Of Dna Vaccine, Frank Gambino Jr.

Master's Theses

Zika virus (ZIKV) is a member of the virus family flaviviridae and is transmitted via Aedes aegypti mosquitos. Monoclonal antibodies against dengue virus have been found to cross-react with ZIKV but show no ability to neutralize it. Further studies have shown that Stat2-/- mice given plasma from dengue positive donors exhibit a heightened disease phenotype when challenged with ZIKV. Antibody dependent enhancement is theorized to cause such effect. The goal of this study was to design a plasmid which, when encoded, creates an antigen that will be used to stimulate exclusively CD8+ T cells. The gene sequence of NS3 was …

Cell Intrinsic Characteristics Of Cord Blood Naive Cd4 T Cells, Taylor Keller

Master's Theses

The neonatal immune system is functionally distinct from the adult immune system. Neonatal immune responses are less reactive than their adult counterparts, and as such, have an increased susceptibility to infection, resulting in increased duration and severity of disease. There is evidence that T-cells are partially responsible for the observed immunological differences between neonates and adults. Murine studies on neonatal immunity suggest that Th2 like responses predominate the neonatal immune system, an observation not found in the adult immune system. However, studies on human cord blood revealed that human neonates do not exhibit elevated Th2 like cytokines (with the exception …

Inhibition Of Mutant Egfr In Nsclc Promotes Endothelin-1-Mediated Nsclc Disease Progression, Stephen Ollosi

Master's Theses

Angiogenesis in NSCLC has been identified as important therapeutic target in combination with EGFR TKIs. However, only small incremental advancements have been made for the use of angiogenesis inhibitors in NSCLC and it remains elusive why the inhibition of VEGF-mediated neovascularization is not therapeutically efficacious. I present experimental evidence that a subpopulation of NSCLC cells with EGFR TKI-induced EMT contributes toward the attenuation of the response to EGFR TKI therapy. One of the hallmarks of cancer is heterogeneity and I have previously demonstrated that tumor heterogeneity within NSCLC cells lines harboring EGFR kinase domain mutations gives rise to divergent resistance …

The Power Of A Stereotype: American Depictions Of The Black Woman In Film Media, Brittany Terry

Master's Theses

How are black women depicted in popular films? The significance of this study is that it sheds new light on the ways in which black women are depicted in film, and exemplifies some means to deconstruct dehumanizing representations of ourselves. This work advances the goal of institutionalizing more accurate visual accounts of black femaleness thereby exposing the inaccuracies of the dominant gaze. This study also transparently marks my intersectional positionality as a black feminist spectator-- simultaneously privileged and marginalized. I identify as a heterosexual woman of color, raised in an upper-middle class American community. As such, I benefit from classism …

International Student Intersectionality In The Trump Era, Sarah Tolman

Master's Theses

This study examines the impact of the current U.S. presidential administration's policies and rhetoric on international student experiences and identities. The researcher approaches this question through the theoretical lens of intersectionality, with the goal of highlighting the complexity and diversity of international student identities in this unique historical moment. Through in-depth narratives collected from interviews with 8 diverse international students, it becomes clear that the 2016 presidential election and the administration's rhetoric and policies have influenced international student experiences and identities in significant ways. Students perceive the statements and actions of the current government to have shifted their perspectives and …

Desde La Caballería A La Cristiandad: La Transformación Espiritual De Don Quijote, Amanda Kathleen Verduin

Master's Theses

Este presente trabajo es un análisis literario, histórico y teológico del protagonista de la obra famosa de Miguel de Cervantes Saavedra, El Ingenioso Hidalgo Don Quijote de la Mancha. Esta tesina presenta el argumento que Alonso Quijano experimenta una transformación espiritual significativa, desde el momento en que pierde el juicio y se reinventa en el caballero andante, don Quijote, hasta el momento en que muere en su lecho, alabando a Dios por su misericordia. Específicamente, asevero que esta transformación parece a la transformación que Jesucristo describió como el vínculo que se establece entre Dios y la persona que vuelve …

The Characterization Of Rna Content And Biogenesis Pathways Of Extracellular Vesicles That Have Been Implicated In The Pathogenesis Of Hiv-1 Associated Neurocognitive Disorders, Virginia Elizabeth Zwikelmaier

Master's Theses

Patients infected with HIV-1 adhering to Anti-Retroviral Therapy (ART) still suffer from a variety of neurocognitive, behavioral, and motor dysfunctions, collectively referred to has HIV-1 Associated Neurocognitive Disorders (HAND). Current research suggests the manifestations of HAND might in part be due to the dissemination of toxic HIV-1 components throughout the brain via extracellular vesicles (EVs). Our goal is to characterize these pathogenic EVs to begin to gain a better understanding of this EV-mediated pathology.

We took the first steps in developing a technique to assess the microRNA content of individual EVs but it needs to be heavily optimized to eliminate …

Lidocaine Attenuates An Induced Inflammatory Response, Stephanie Zack

Master's Theses

Inflammation is common to the pathogenesis of a variety of diseases. Therapeutics which can regulate and reduce damaging inflammation are therefore valuable in the treatment of inflammation and inflammatory diseases.

One commonly used analgesic, recently identified as limiting inflammation, is lidocaine. Additionally, alternative, less toxic therapeutics like the snake venom peptides, Zep 3 and Zep 4, are thought to have anti-inflammatory effects. Yet a well-defined mechanism or cellular target for lidocaine or Zep peptides' anti-inflammatory effects has not been proposed.

We aimed to determine whether lidocaine and Zep peptides reduce the release of the proinflammatory cytokine, IL-1β, from activated human …

Everybody Else, Patricia Gaglia

Master's Theses

Everybody Else is a novel that follows the story of the Promise Scholars, a group of math whizzes thrust into the media spotlight after a tech billionaire launches an engineering program at their low-income, predominantly black, high school. The purpose of this novel is to explore contemporary racism in America, the complex relationship between philanthropy and poverty, and the role of technology in instigating social change. Each chapter is a complete story, representing a unique first person perspective as the students navigate the closure of their school, the dissolution of their benefactor’s interest, and their enrollment in an affluent neighboring …

Taking A Stand On One Knee: A Content Analysis Study Of The San Francisco 49ers' National Anthem Protests, Jack Hunter

Master's Theses

Previous communication studies have examined media bias in the coverage of social protest movements and issues of race in sports, but until now there has not been an opportunity to combine the two topics. This study examined media bias in coverage of the San Francisco 49ers’ national anthem protests, from August 2016 to February 2018. Utilizing articles from eight different publications, four from local San Francisco Bay Area outlets, and four from nationally syndicated outlets, a content analysis was conducted to determine whether coverage of the protests exhibited bias against the players and whether local sources were more supportive of …

Factors Associated With Violence Against Women In Rural India, Jennifer Lardner

Master's Theses

No abstract provided.

Human Dimensions Of Timber Rattlesnake (Crotalus Horridus) Management In Connecticut, Lindsay Keener-Eck

Master's Theses

No abstract provided.

Enhancing Icvd Modification Of Electrospun Membranes For Membrane Distillation Through A 3d Printed Scaffold, Nicole Beauregard

Master's Theses

In this work, initiated chemical vapor deposition, iCVD, is used as a modification technique for electrospun membranes. Electrospun membranes are often hydrophilic and cannot be used in membrane distillation which requires high hydrophobicity. In membrane distillation, a thermal driving force is supplied to create a vapor pressure difference across a membrane allowing vapor molecules to pass through while rejecting liquid and solids. iCVD can be used to conformally coat the individual nanofibers with a hydrophobic polymer to render the membrane viable for the MD process. The standard coating procedure uses natural convective diffusion as the method of transport of the …

Preparation And Characterization Of A (Viologen) Containing Main Chain Peg-Carbon Nanotubes Phase For Hybrid Supercapacitor Application, Kanishka Rana

Master's Theses

Supercapacitors (SCs) and batteries are recognized as the two most important electrical energy storage devices. SCs have some distinct advantages such as high-power density and long cycle life when compared to batteries. However, they have yet to match the energy densities of batteries. In an effort to improve the energy density of SCs, a hybrid supercapacitor was developed using a pair of single-walled carbon nanotube electrodes and two polyethylene glycol (PEG-400) gel-polymer electrolytes (GPEs) containing redox additives of viologen (V) and ferrocene dicarboxylic acid (Fc), respectively. The introduction of V and Fc, was expected to improve the energy performance of …

Small Arms: An Applied Approach To Children In Armed Conflict Prevention Initiatives In Africa, Tristan Burger

Master's Theses

For centuries, children have been used in times of war—serving as porters, cooks, spies, sex slaves, and soldiers. Unfortunately, this phenomenon is still pervasive today with an estimated 300,000 children involved in armed conflict as of 2015. This applied project examines a possible method for preventing the illegal practice of using children in combat by employing a new technology centered on community-based early warning theories. I seek to understand if implementing a text-based, mobile crowdsourcing platform in remote communities in Sub-Saharan Africa will be successful in predicting Lord’s Resistance Army raids, thereby reducing the number of children abducted and/or forcibly …

Urbanization, Land Rights And Development: A Case Study Of Waterfront Communities In Lagos, Nigeria., Gideon Olaniyi Omoniyi

Master's Theses

The aim of this study is to examine the root causes of forced evictions and displacement through the current urbanization process in Lagos, Nigeria. My particular attention is devoted to the legal complexities and how ethnolinguistic identities shape land laws, influence land tenure, and construct urban citizenship. Through this process, competing claims to land ownership provide fertile ground for forced evictions and displacement. Existing scholars suggest that poor urban residents lack rights to stay in their neighborhoods, while a powerful capitalist class has emerged and dispossessed the poor from their lands. Yet these existing approaches derived from the neoclassical and …

Gendered Impacts Of Community-Based Conservation Initiatives In Kimana/Tikondo Group Ranch Outside Of Amboseli National Park, Megan Clemens

Master's Theses

Community-based conservation has become a common solution to addressing local communities needs and concerns when it comes to conservation initiatives associated with, or outside the boundaries of national parks. Community-based initiatives associated with Amboseli National Park in southern Kenya mark one of the first attempts to include local communities in conservation initiatives and management as well as establish systems of benefit sharing between conservation and local communities. However, a critique of community-based conservation initiatives points out they often assume community homogeneity. Assumption of community homogeneity leads to inequities in benefits sharing, exclusion of subgroups (women, ethnic minorities) or even exacerbate …

Exploring Employment Equity: Diversity & Inclusion In Canada’S Legislation & Policy, Vanessa Toussaint Miller

Master's Theses

Multiculturalism is considered very much a part of Canada’s national heritage and identity, becoming the first nation to adopt multiculturalism as an official policy in 1971. Over the last 40 years, the Canadian population has undergone significant changes bringing in immigrants with different cultures, ideologies, religions and ways of life. Despite the various changes in society, the multiculturalism policies have remained the same. This thesis examines Canada’s Employment Equity-a policy intended to eliminate systemic discrimination in the workplace-and its effectivity at creating a diverse and inclusive workforce. The main research question is, in the past five years, has Employment Equity …

Falling Up: Building Language Use And Cultural Awareness Through The Implementation Of Humor In The Esl Classroom, Glen Kovar

Master's Theses

This study examined the importance of explicitly teaching humor to upper-intermediate and advanced adult English language learners (ELLs), and filled in the gap that exists in studies and literature by examining the use, and implementation of humor in English as a second language/foreign language (ESL/EFL) curricula. Humor is an important human behavior, playing a crucial role in communication, social interactions, and comprehension of a second language (L2) culture. High-level ELLs often lack the linguistic and cultural awareness necessary to effectively communicate. Language courses often accentuate test-taking and language strategies, and courses that explicitly engage with and teach humor to students …

How Patriotic Are Albanians? The Comparative Study Of Patriotic Attitudes In Albania And The Albanian Diaspora, Anxhela Spahiu

Master's Theses

In today’s post-modern digital world, patriotism may not be as prevalent as in the past. In this thesis, my principal aim is to investigate to what extent Albanians, a nationality to which I belong, identify with a patriotic attitude toward Albania. I chose to focus not only on Albanians who live in the diaspora, like myself, but also on Albanians who live in Albania. I believe that to understand national pride to its fullest, you must study the attitudes of those who live in the country of origin as well as of those who live in the diaspora. Many people …

Dadaab’S Hidden Ties: How Colonial Legacies And Informal Economies Contribute To Protracted Refugee Situations, Katherine Landberg

Master's Theses

Protracted Refugee Situations (PRS) persist despite the founding intentions of the international refugee regime. Explanations behind PRS typically focus on international law, human rights, and security concerns, while the conventional media narrative presents an oversimplification that erases complex contextual nuances. Using the case of the Dadaab refugee camp, I explore (1) historical colonial legacies of social control and domination in Kenya, and (2) Dadaab as an informal economic power center, as two ‘hidden ties’ that contribute to Dadaab’s persistence. By identifying and exploring hidden ties that contribute to PRS, policy-makers and power brokers gain a deeper understanding of the realities …

Undocumented Students’ Access To Higher Education In San Francisco, Bay Area, Sandra Miklosic

Master's Theses

This paper will explore the question: “in what ways does DACA status influence undocumented students’ ability to access higher education in San Francisco and Bay Area, California?” Even though DACA does not encompass any direct policies regarding access to education, there is a very strong correlation between having DACA status and accessing higher education for the undocumented students. In this research, I highlight the voices of undocumented students through the method of testimonio. Each participant reflects on their personal experiences with DACA while accessing postsecondary education. In this research, I explore how testimonio, as a methodology and a theoretical framework, …

Articulated Indigeneity And Tourism In HawaiʻI, Erika Nielsen

Master's Theses

The guiding research question for this thesis asks how Hawaiian indigeneity and self-determination are articulated within tourism spaces in Hawaiʻi. This thesis research works to uncover the nuanced ways that Hawaiian indigeneity is employed to manage and regulate tourism activities in Hawaiʻi. I seek to question the narrative that Hawaiians consent to, and prosper from, the largely unregulated mass tourism complex that has become a focal point of the post-colonial state. Native Hawaiians have actively resisted the erosion of their culture, lands, and nation through strategies that employ multiple understandings of indigeneity. We should not assume that the tourism industry …

Higher Education As A Development Tool: An Impact Assessment In Dzaleka Malawi, Emily Golike

Master's Theses

The purpose of this study is to determine the efficacy of accredited online diploma programs within refugee camps. When individuals are confined to camps and unable to work and travel in search of economic opportunity, does completing an accredited diploma program improve their quality of life and contribute to their human capital? Can higher education in refugee camps produce sustainable social service projects that benefit residents? There is a demonstrated value in a liberal arts education, but which aspects of this learning schema are most beneficial in the refugee camp context have yet to be explored.

The study conducted in …

Life Being An International Student In The United States: Acculturation, Culture Shock, And Identity Transformation, Lai Yan Vivyan Lam

Master's Theses

The population of international students at community colleges in the United States has increased significantly over the past decade. International students play a big role in building the cultural diversity on campus by bringing over different cultures and sharing their global perspective to the local community. However, they often face challenges adapting into American culture due to cultural differences in education system, language, lifestyle, etc. By looking into the acculturation process of international students to analyze the culture shock and cultural identity changes they experienced, this paper intends to seek ways to help this group of students to ease their …

Afro-Latinx Transnational Identities: Adults In The San Francisco Bay And Los Angeles Area, Koby Heramil

Master's Theses

This paper examines the identity construction of Afro-Latinas/os/x in the San Francisco Bay and Los Angeles Area. Marginalized communities predominately Black and Latina/ o/x concentrated are at the epicenter of disenfranchisement caused by the globalization of neoliberalism. Neoliberal reforms to education restrain the various nuances of pluralistic teaching, focusing only on the performance of standardized tests thus pressuring schools to center their interest in securing funding. This has greater implications for low-income communities of color where multicultural pedagogy is limited. More importantly, this association of neoliberalism reforms to education affects Afro-Latinx individuals, because they are maligned in the conversation about …