Digital Commons Network^™

Investigating The Role Of Endothelin-1 In Reactive Astrocytosis, Candace Betancourt-Szymanowska

Master's Theses

Glaucoma is a progressive optic neuropathy which results in blindness for many patients, even with treatment. Endothelin-1 (ET-1) is a vasoactive peptide known to be aberrantly upregulated in the eyes of individuals with glaucoma. Optic nerve head astrocytes (ONHA) are the resident glial cell of the optic nerve head and are among the first cell types to undergo changes to a reactive phenotype. In this thesis, we investigated the role of ET-1 overexpression and its putative role in eliciting a reactive phenotype in ONHA by inducing lentiviral-mediated over-expression of EDN1. ONHA transduced with EDN1 (ONHA ET-1) were verified to be …

Transcleral Chemotherapeutic Delivery By Fibrin Sealant In The Treatment Of Retinoblastoma, Christopher Himes

Master's Theses

Retinoblastoma is the most common intraocular cancer in children, accounting for roughly 9,000 new cases each year—claiming the lives of up to 70% of cases in certain regions of the world. While modern retinoblastoma treatments in developed countries have significantly reduced mortality rates, post-treatment consequences such as vision loss, off-site organ dysfunction, and secondary metastases remain unmet clinical needs. Past studies have confirmed transscleral delivery as an efficacious means to achieve high intraocular drug concentrations possibly superior to the standard systemic regimen of vincristine, etoposide, and carboplatin (VEC) for tumor suppression. This led to several studies exploring the use of …

The Influence Of Maternal Size/Age Effects On The Physiological Responses Of Adult Female Gopher Rockfish (Sebastes Carnatus) To Ocean Acidification And Hypoxia, Dylan H. Sarish

Master's Theses

Climate change is rapidly reshaping the chemistry of the ocean. Fishes living in California coastal waters are experiencing increased ocean acidification and hypoxia (OAH) due to more frequent and intense upwelling. Nearshore rockfish may be particularly threatened by these conditions due to their long generational times. However, it is unknown how OAH may impact maternal physiology and reproduction in these viviparous fish. To understand the physiological effects of OAH during gestation, adult female gopher rockfish, Sebastes carnatus, were exposed to a variety of combined OAH stress treatments during different gestational stages. Routine metabolic rate (RMR), maximum metabolic rate (MMR), blood …

Justice, Common Good, And Connectivity: A Thomistic Evaluation Of The Role Of Social Media In Shaping Global Integration, J S. Booth

Master's Theses

The growing influence of social media presents important implications for global integration and governance where platforms can rapidly be leveraged to promote cohesion, a sense of community or, sadly, as a powerful tool for societal fragmentation. The challenges and potential benefits of social media usage are examined in the context of a State’s integration responsibilities from a Thomistic ethical and moral perspective which emphasizes the need for justice and promotion of the common good. An assessment will be included on how social media platforms have been utilized to inform and mis-inform citizens under recent governmental integration campaigns and disintegration efforts …

Leveraging Data Science For Resilience: Improving Trauma-Informed Care Practice For Adverse Childhood Experience With Ai & Data Science Application, Mohmmad Arif Shaik

Master's Theses

Adverse Childhood Experiences (ACEs) have long-lasting effects on physical health, mental well-being, education, and socioeconomic outcomes. Resilient Georgia (RG), a statewide initiative, seeks to address ACEs through trauma-informed care and data-driven strategies. However, challenges in data collection, analysis, and tracking set back the effectiveness of these efforts. This study explores the role of data science and interactive visualization tools in improving outcomes for individuals and communities affected by ACEs. A key focus of this research is the development of a data science management application designed to enhance data collection and improve real-time decision-making. The application features interactive dashboards that allow …

Tricolored Bat (Perimyotis Subflavus) Population Genetic Structure In The Southeastern United States, Laura Henderson

Master's Theses

Tricolored bats (Perimyotis subflavus) have experienced substantial population losses from white-nose syndrome (WNS), a disease caused by the pathogenic fungus Pseudogymnoascus destructans (Pd) which infects hibernating bats. Determining population genetic structure helps assess genetic diversity and the impacts of wildlife threats to populations. Pre-WNS data shows weak-to-negligible structure and panmictic P. subflavus populations at core portions of their range. However, current genetic data from their southeastern U.S. range is lacking. I sought to determine whether recent genetic data help resolve genetic structure among southeastern populations and assess genetic differences at two stages of impact: post-WNS and …

Stream Response To A Dam Removal: Mill Creek, Davenport, Ca, Jessica J. Williamson

Master's Theses

Dams have many effects on stream morphology and ecology, including a loss of sediment supply downstream, reduced access to the entire stream for aquatic fauna, and a flooded area upstream of the dam. Dams are a hurdle for migrating organisms such as anadromous fish, which is a group of concern. An over 100-year-old dam on Mill Creek, a stream draining a coastal watershed in central California, was removed in the fall of 2021. The site is in the Santa Cruz Mountains, where endangered salmonids such as steelhead, Oncorhynchus mykiss, have historically lived. To study the change in the stream from …

Fault Box Modeling Of Dip Slip Faults: A Framework For Fault Box Design And Future Studies, Hailey Pressnell

Master's Theses

The behavior of soils during surface fault rupture is a serious concern in the planning and design of infrastructure that may be located within or near a fault zone. Challenges associated with developing mitigation measures for surface fault rupture include the uncertainty of fault rupture and the variability of fault behavior. Current analytical procedures define surface fault rupture according to the type of fault movement (strike slip, normal or reverse), the amount of displacement on the fault, and the mechanics of the material overlying the fault. The purpose of this thesis is to reconfirm analytical solutions and gain a better …

Genetic Influences On Individual Variability In Western Lowland Gorilla (Gorilla Gorilla Gorilla) Social Behavior, Hadley Mueller-Hill

Master's Theses

While primates are considered highly social animals, the evolutionary origins and mechanisms underlying their social behaviors remain unclear. Not only do they exhibit an extensive range of behaviors, but individuals within the same species can also vary widely in their social interactions. Genetics play a significant role in shaping these individual variations in behavior; multiple genetic variants have been associated with differences in social behavior in mammals. Examples of these include MAOA and OXTR genes, which influence the expression of behaviors associated with antisocial and prosocial temperaments. Genetic polymorphisms affect primate interactions, impacting an individual’s ability to maintain its status …

Separation And Surface Examination Of Spacecraft Cabin Particulates, Grace A. Belancik

Master's Theses

Particulate matter in the atmosphere is a known detriment to human health, but several factors affect any particulate’s particular toxicity including particle size, surface area, and chemical composition. Extensive studies have been conducted to examine particulate hazards on Earth, but in crewed spacecraft, like the International Space Station (ISS), the particulate environment is wholly unique due to both the controlled environment and lack of gravity. Atmospheric sampling studies are underway, but another convenient source of airborne particulates for analysis is the contents of the vacuum bags used by the astronauts to clean the air vents. However, no method currently exists …

Ml Model To Better Identify Instances Of Bullying Faced By Members Of The Lgbtq+ Community, Arslan Bisharat

Master's Theses

Cyberbullying poses a significant threat to online communities, with the LGBTQ+ community facing disproportionately higher rates of harassment. While existing cyberbullying detection systems have made progress in identifying general instances of online harassment, they often fail to capture the nuanced and context-dependent nature of LGBTQ+-targeted bullying. This thesis presents a novel approach to this challenge by developing SpectrumNet, an LGBTQ+-centric transformer-based model for cyberbullying detection. Our research was conducted in two phases. In Phase 1, we evaluated the effectiveness of pre-trained transformer models (RoBERTa, BERT, and GPT-2) in identifying LGBTQ+-related cyberbullying. Building on these findings, Phase 2 introduced SpectrumNet which …

Endocrine Responses To Two Distinct Foraging Contexts In The Bonobo (Pan Paniscus), Lauren Mitchell

Master's Theses

In gregarious animals, a social structure characterized by female dominance is relatively rare. However, bonobos (Pan paniscus), one of the two species most closely related to humans, are characterized by partial female dominance, with females forming close social bonds. In contrast, chimpanzees (Pan troglodytes), a close relative of the bonobo, are characterized by strong male-male bonding and social dominance with female chimpanzees lacking close social bonds. There is a lack of consensus concerning the reasons for these behavioral differences in Pan, specifically, the physiological processes responsible for female dominance in bonobos. The role of hormones …

The Radical Oxidation Of Hydroxyacetone: An Insight Into The Reaction Mechanism And Potential Tetraoxide Intermediates, Edward Buck

Master's Theses

This thesis presents the reaction of hydroxyacetone, a common volatile organic compound (VOC), with chlorine radicals in the presence of oxygen. Chapter one explores VOCs and their specific reactions and how tetraoxide intermediates could be formed from them. Chapter two analyses the experimental and computational methods used and the key theoretical concepts behind these methods. Experimental data was collected using multiplexed photoionization mass spectrometry at the Advanced Light Source Chemical Transformations Beamline, Lawrence Berkeley National laboratory. This data is combined with theoretical data using the CBS-QB3 composite method to determine the key reaction intermediates and mechanisms.

The main chapter of …

Indigenous Metal: Rage, Rejects, And The Reconstruction Of Culture, Louis W. Asbury

Master's Theses

Metal music’s latest frontier is Indigenous metal, combining explorations of Indigenous identity with the heavy and aggressive stylings of the music genre. To explore this new subgenre, this study asks to what extent can metal music be used as a political tool and what are some of the broader effects of metal bands working to better their communities. This thesis utilizes case studies of two notable Indigenous metal scenes, the Rez metal scene in the Navajo Nation and the Māori metal scene in Aotearoa. By collecting data from these scenes, including lyrics, videos, interviews, and audience interactions, this thesis thoroughly …

Closed Domain Question Answering With Language Models: Application Of Retrieval-Augmented Generation And Parameter Efficient Fine-Tuning In Healthcare, Aaron Cummings

Master's Theses

Dementia care presents significant challenges for informal caregivers, particularly in managing behavioral symptoms that affect over 90% of individuals with Alzheimer’s Disease and Related Dementias (ADRD) during the moderate-to-severe stages. These symptoms, including agitation, wandering, and repetitive activities, impose emotional and physical burdens on caregivers, often exacerbated by a lack of reliable, accessible, and personalized resources. Non-pharmacological interventions, while evidence-based, are underutilized due to knowledge gaps and the inefficiency of traditional training and information retrieval methods.

This research explores the adaptation of large language models (LLMs) to address these challenges by developing a framework for closed-domain Question Answering (QA) systems, …

Design, Synthesis, And Nmr-Guided Characterization Of A Targeted Covalent Inhibitor-Like Molecule Against Ivyp1 From P. Aeruginosa, Samuel Taylor Moore

Master's Theses

Multi-drug resistance poses a serious threat to future generations and historical antibiotic pipelines; consequently, the medical and economic burdens associated with treating multidrug-resistant bacteria are substantiated. In this context, P. aeruginosa (PA) emerges as one of the most significant healthcare challenges, being a leading cause of resistance-associated mortality worldwide. Despite modern efforts to combat these poor outcomes, drug-resistant cases continue to rise, and the need for novel antibiotic treatment is apparent. To this end, we investigated relevant resistance mechanisms and past antibiotic targets within PA, and in doing so, we identified relationships between peptidoglycan biology and a periplasmic protein, Inhibitor …

Measuring Gait Of Total Knee Arthroplasty Patients Pre-Op And Post-Op Using A Smartphone, Celeste A. Thai

Master's Theses

Motion capture technology is a tool often used in orthopedic applications, including measuring gait dysfunctions. However, gait analysis research focused on total knee arthroplasty (TKA) patients is limited, especially using motion capture systems. This may be due to a multitude of factors, such as inaccessibility to gait labs to the general public, difficulty of travel post-surgery, and overall costs of care and maintenance of motion lab equipment. New emerging novel methods use wearable devices such as smartphones and inertial measurement devices (IMUs) to perform gait assessment and are becoming favorable due to their increasingly ubiquitous nature. One such method using …

Host Response To Implantation Of A Poly N-Isopropylarylamide Injectable Cell Therapy Vehicle, Cole Matthew Burk

Master's Theses

There is a need to develop novel and effective therapies targeting end-stage peripheral arterial occlusive disease (PAOD). Inducing collateral arteriogenesis is a possible novel treatment that produces a natural bypass for blood flow, a promising solution to the long-term issues seen with current treatments. Regenerative therapies, and progenitor cells specifically, have demonstrated great promise in repair after injury and disease. While most progenitor or stem cells have poor efficacy in this context, muscle progenitor cells, or myoblasts, have encouraging results. Myoblasts enhance arteriogenesis and secrete cytokines or chemokines that recruit monocytes to injury sites. Implanting these adherent cells in a …

Design And Testing Of A Prototype Prosthesis For Pediatric Upper-Limb Transradial Amputees To Provide Adjustable Size And Modular Characteristics, Paul Heli

Master's Theses

This study was conducted to develop a financially accessible body-powered upper-limb prosthetic socket that can be adjusted to maintain fit and function for a growing child with a transradial amputation. The main objectives of the study were to design, manufacture, and test a device that was comfortable, functional, affordable, and adjustable. The socket was designed to be comfortable using global variables controlling the computer-aided design (CAD) model size with user-specific measurements. Comfort was also incorporated using shape-forming of the socket for specific residual limb features. The device was designed to perform the two main functions of suspension, or attachment to …

Quantifying The Mechanisms Behind Carbon Sequestration And Soil Health Following Compost Application In A Rangeland Chronosequence, Grace Damaschino

Master's Theses

Compost application to rangelands has the potential to sequester carbon (C) and add essential plant nutrients to the soil. The California Department of Food and Agriculture's (CDFA) Healthy Soils Project (HSP) provides financial support to farmers and landowners to implement innovative practices that promote soil health. The CDFA is currently recommending compost application rates of 6-10 tons per acre; however, previous research suggests that degraded soils may require a larger dose of compost to overcome limitations, therefore this recommendation might not meet soil health or soil carbon sequestration objectives. This study examines the compost rate effects on soil health, while …

Characteristics And Potential Sources Of Single-Use Plastics Debris In Two Aquatic Systems In New Haven, Connecticut, Ohene Boakye Adomako

Master's Theses

Plastic debris remains a major problem in aquatic ecosystems. This study provides an assessment of the proportion, potential sources, and geographic origin of plastics and other solid waste debris (PSWD) in both freshwater and marine systems in New Haven City, Connecticut. Data was collected through four (4) cleanup events within the Long Wharf Park (LWP) and West River Memorial Park (WRMP), working with community scientists in the New Haven area (CT) in May, September, and October, 2024. A total gross weight of 417 lb of PSWD was collected in approximately 1.4 km (0.9 mile) altogether in LWP and WRMP. The …

Cross-Training Effects: The Impact Of Ballet Instruction On Athletes' Physical Attributes And Performance, Erin Lane

Master's Theses

This thesis, titled "Cross-Training Effects: The Impact of Ballet Instruction on Athletes' Physical Attributes and Performance," investigates the influence of ballet training on the physical attributes and overall performance of athletes across various sports. Recognizing the historical use of ballet to enhance flexibility, strength, balance, and precision in its own training, this study focuses on the examination of the effects of ballet as a cross-training method. By employing a mixed-methods research design, the study involved 11 female participants from diverse athletic backgrounds who engaged in structured ballet instruction over six weeks. Quantitative assessments measured changes in flexibility, balance, speed, and …

Exploring The Impact Of Using Mirrors Versus Not Using Mirrors In An Intermediate High School Dance Class, Melanie Monnich

Master's Theses

The purpose of the study was to understand the use of mirrors vs. not using mirrors in the high school classroom. This thesis also expanded on research done in the last twenty years regarding students' relationship to the mirror and how educators could better use or not use the mirror in the classroom. The researcher asked five essential questions that guided this thesis:

Q1 How does using mirrors vs. not using mirrors affect a student's body image in a high school dance class?

Q2 Is it necessary to always use mirrors in the classroom as a learning tool for students? …

Fostering Creative Bravery: Exploring Innovation Among Future Female Pioneers In Dance Through Historical Composition Studies, Marlo Daron Harris

Master's Theses

The purpose of this study was to evaluate if learning from the innovative methods of past female choreographers could enhance the creative abilities of today’s young high school female dancers and dance-makers. This thesis aimed to teach young dancers about past dance pioneers and build confidence in young women when creating dances. Women have paved the way for dance choreography and innovative techniques throughout dance history. However, today’s generation of young choreographers rely on imitating movements they witness at dance competitions and on social media such as Instagram, YouTube, and TikTok instead of becoming originators.

This thesis aimed to answer …

Building Foundations For Success: A Study On Aligning Expectations And Realities In College Dance Programs, Ashley Walker Anderson

Master's Theses

The purpose of this research study was to take the information gathered from surveys and interviews with the participants and analyze the impact of the gaps between their expectations and realities, and the gap between the overall effectiveness and success of college dance programs in preparing students for their post-graduation goals. The goal of the researcher was to answer the following questions.

Q1 What factors determine where dancers attend college?

Q2 Are high schoolers making their college wish list based on prestige, faculty, performance opportunities, tuition cost, course requirements, career goals, or perhaps a combination of multiple factors?

Q3 Are …

Crafting Affective Engagement: The Impact Of Choreography And Design Choices On Audience's Emotional Experience In Dance Performances, Amy Morton

Master's Theses

This thesis explored how the engagement level of dance spectators influenced the lasting impressions they retain from a performance and whether these impressions can expand and sustain audience interest in dance. The purpose of the study was to identify the most engaging elements of an aerial dance concert. The study emphasized the significance of creating choreography that evokes emotional responses to advocate for dance education, community engagement, and the preservation of the art form. By examining a site-specific aerial dance concert, this research identified the elements that captivated audiences, particularly the contrast between aerial and ground-based performances.

The research addressed …

Induced Systemic Resistance Against Nematodes By Plant Growth-Promoting Microbes In Potatoes, Cole Grannan

Master's Theses

Biofertilizers consist of plant growth-promoting microorganisms that establish symbiotic relationships with plant roots and stems. These beneficial microbes play a crucial role in enhancing plant defenses against various threats including insects, nematodes, and microbial pathogens. The purpose of this study was to investigate the effectiveness of two fungal biofertilizers (an endophytic strain of Beauveria bassiana (BA) and a mixture of arbuscular mycorrhizal (AM) fungi), specifically their ability to induce systemic resistance against plant- parasitic nematodes (PPNs) in potatoes (Solanum tuberosum cv. Masquerade) under controlled greenhouse conditions. The study utilized soil collected from Colorado State University’s San Luis Valley (SLV) Research …

Social Justice In Dance: The Exploration Of Dance As A Tool For Promoting, Recognizing And Influencing Change, Michelle O'Konis Linnehan

Master's Theses

The purpose of this study was to prove that dance could be used as a platform for representation and to foster change within the community and beyond. This purpose aligned with the goal, which was to measure the impact of a structured choreographic curriculum on student engagement with social justice topics. The goal of this study was to answer the following research questions:

Q1 Can dance be a tool in promoting social justice?

Q2 How will students in the classroom respond to an integrated social justice theme through dance and production components?

Q3 How will these topics be interpreted to …

Ephemeral Legacy, Allison Hall

Master's Theses

Recently, my thoughts have centered on the problem of legacy. How do we forge bonds with other humans? What happens on an interpersonal level when these humans pass away, or when we pass, and they continue in life? How do queer spaces consistently offer deeper phenomena of interpersonal legacies; how does death operate as generational catalyst? I am particularly interested in putting these questions in the context of queer spaces. In queer culture, kinship is formed in ways that break from typical western notions of kinship. Despite being incoherent to western notions of family, queer bonds are extremely strong (Bradway …

Investigation Of Social Networks Upon Academic Performance And Mental Health, Rachel Izenson

Master's Theses

It has been shown that computing students have a statistically significantly lower overall sense of belongingness compared to other science students. A sense of community is important for many reasons. For example, there are studies that show that a student's sense of belonging correlates with improved academic performance. Our research aims to analyze the sense of belonging among computing students at Cal Poly San Luis Obispo through a network science lens. We surveyed for their sense of belonging, as well as their social network, to understand how friendships impact one's sense of belonging. When student responses were split by gender, …