Digital Commons Network^™

Thrown To The Wolves: The Obstacles And Barriers Of International Student Athletes Prior To And During Enrollment In American Universities, Mary Elizabeth Boucher

Master's Theses

International student athletes (ISA’s) play an integral role among our nations university system. They diversify our colleges, provide our American students a chance to become familiar with other cultures, and they add intense value to our collegiate athletic programs. In order to maintain this diversity in our nation’s universities, we need to further understand the experiences of these student-athletes. It is inherent to provide international student-athletes with positive experiences as to fuel the globalization of sport.

This project is a small pilot study which focuses on male and female swimmers from Division I universities. It provides a closer look at …

The Effects Of Superordinate Identity Recategorization And Social Value Orientation On Ethical Decision-Making In A Business Dilemma, Thomas Steven Colville

Master's Theses

The purpose of the present study was to investigate potential solutions to the prevalence of unethical behavior in groups, specifically through the use of superordinate recategorization. Superordinate recategorization allows group members to feel an affinity with others not typically included in their in-group. This should promote ethical decision-making by enabling the inherent in-group favoring tendencies found in groups to be extended to a more inclusive category. In the context of the present study, the ethicality of participants' behavior in the Panalba scenario was determined by their choices on a 1 to 6 scale from least to most ethical. Additionally, participants’ …

Getting Students Employed: 21st Century Learning Competences And Career Competences, Kelly Cebold Sundberg

Master's Theses

This thesis explores the nexus between education and the economy in the 21st century knowledge-based economy to understand the relationship between the learning competences – as described in 21st century frameworks – and career competences – as recommended in the job descriptions of available employment opportunities. Theoretically, this study is grounded in human capital theory and it explores the indiscriminate nature of the data regarding a student’s required education level to achieve the prescribed learning competences. With the aid of a quantitative content analysis of selected employment opportunities, the research sought to explore: How are learning competences, as outlined by …

The Effects Of Parental Functioning And Socioeconomic Status On Initial Child Psychopathology Symptoms And Treatment Outcomes Following A Brief Trauma Focused Cognitive Behavioral Therapy Group, Anna Ros Ros

Master's Theses

The present study will investigate the impact of parental psychopathology and socioeconomic status on the severity of child PTSD and depression symptoms at baseline, in addition to the impact on treatment effectiveness. First, the study will examine how the presence of parental PTSD, depression and hostility act as proximal risk factors for the baseline severity of child PTSD and depression symptoms. Further, the study will investigate how these proximal parental factors affect symptom reduction following intervention for these children. Additionally, the current study will examine how low socioeconomic status affects baseline severity of child PTSD and depression symptoms as well …

Using Tcr Transgenic, Gp100 Reactive T Cells And Checkpoint Inhibition To Target Lymphangioleimyomatosis, Christian Ankney

Master's Theses

Lymphangioleiomyomatosis (LAM) is a low-grade neoplastic disease affecting primarily women. It is characterized by cystic lung disease as well as renal and retroperitoneal tumors called angiomyolipomas and lymphangiomas. Tumor cells have smooth muscle features as well as neuroendocrine cell surface markers, and the disease can be diagnosed by HMB45 staining of tumor cells. We questioned whether expression of melanocytic antigens, specifically gp100, creates an opportunity to treat LAM by adoptive T cell transfer. LAM lung lesions demonstrate poor immune surveillance, therefore adoptive T cell transfer could offer benefits in this disease.

A link was made between melanoma and depigmenting vitiligo …

Creating A Bret Assay To Monitor The Interaction Between Β-Arrestin-1 And Stam-1, James Buhrmaster

Master's Theses

CXCR4 is a chemokine receptor that is overexpressed in multiple disease states, including cancer. Understanding the mechanisms by which cells regulate CXCR4 expression is of high importance, as they can reveal downstream effectors that can potentially be targeted pharmacologically to more effectively treat diseases with fewer side effects.

CXCR4 is internalized in response to stimulation by its ligand CXCL12, and localizes to early endosomes as part of a homologous desensitization mechanism. From the endosome, CXCR4 can enter one of two pathways whereby it is either recycled back to the plasma membrane, where it can undergo another signaling event, or it …

The Unconventional Secretion Of Alpha-Synuclein By Autophagic Mechanisms And The Novel Characterization Of Pathological Alpha-Synuclein Associated Extracellular Vesicles, Kevin Burbidge

Master's Theses

Synucleinopathies are a group of neurodegenerative diseases associated with the intracellular accumulation of aggregated α-synuclein, a neurotoxic process resulting in cell death. Research indicates that pathology results from α-synuclein misfolding and self-propagation, as well as, cell-to-cell transmission. Furthermore, pathological α-synuclein transmission may occur through unconventional secretion.

In this thesis, we investigated how autophagy influences unconventional secretion of our novel α-synuclein dual-split protein model that we first verified by reproducing documented results from treatment of known autophagic regulators. Afterwards, we investigated how knocking out autophagic proteins ATG7 and Beclin-1 influenced α-synuclein secretion.

Additionally, we developed a methodology for analyzing extracellular vesicles …

Nutrient Removal And Vegetation Recovery Through Successive Harvesting Of The Invasive Hybrid Cattail (Typha X Glauca) In Great Lakes Coastal Wetlands, Kelsey Berke

Master's Theses

Excess nutrient levels have led to invasive hybrid cattail (Typha × glauca) dominance in many Laurentian Great Lakes coastal wetlands. Its ability to alter wetland structure and function has made T. × glauca a target invasive species with respect to Great Lakes coastal wetland

restoration. This study investigated the effect of harvesting invasive T. × glauca biomass on nutrient removal, specifically nitrogen and phosphorus, and plant diversity recovery in Great Lakes coastal wetland ecosystems. This study demonstrated that without considering external nutrient inputs and outputs, a single harvest at Cheboygan Marsh, MI could remove ~2% of the total N and …

The Impact Of Chronic Stress On Childhood Obesity And The Protective Effects Of Parental Warmth, Laura M. L. Distel

Master's Theses

Mexican American children have the highest rates of obesity in the U.S. Mexican American children may experience chronic stress, which has been linked to child obesity. Hair cortisol accumulation has been implicated as a mechanism for this association. Highly sensitive parenting may buffer the harmful effects of chronic stress and hair cortisol on obesity. Thus, the aims of this project were to 1) identify the direct and indirect effects of chronic stress and hair cortisol on children's zBMI and 2) examine the protective effects of parental warmth. This study examined hair cortisol levels, zBMI and chronic stress of children ages …

Coping With Exposure To Community Violence: Assessing The Role Of Avoidance In Reducing Delinquency And Aggression In Low-Income Urban Adolescents, Cara Marie Diclemente

Master's Theses

Exposure to community violence has disabling effects on the mental health of youth in the US, with high rates of exposure for African American adolescents from underserved, urban communities. Past literature suggests that avoidant coping, specifically behavioral avoidance, may be most useful for youth exposed to uncontrollable stress. The current study assessed the utility of coping strategies in reducing aggression and delinquency in 267 sixth through eighth grade African American youth. First, confirmatory factor analyses revealed a three-factor structure of coping: cognitive approach, behavioral approach, and avoidance. Next, moderated moderation findings showed that for boys, avoidance and approach strategies increased …

The Effects Of Treating Multispecies Biofilms With Bacteriophage, Alexandria Francis Cooper

Master's Theses

Biofilms can be found in any environment within proximity to water and are problematic in an assortment of industries. Numerous efforts have been employed to dislodge biofilms including bacteriophages (viruses that infect bacteria). Phage remediation is a promising solution for combatting biofilms that form on catheters in long term use patients. These biofilms often result in catheter-associated urinary tract infections (CAUTIs) and are the most common type of healthcare related infection reported. Additionally, they result in longer hospital stays and increased morbidity. To date, most of the research on the topic focuses on single species biofilms, despite their rarity in …

Phenotyping Temperature-Sensitive Coronaviruses, Amani Eddins

Master's Theses

Coronaviruses (CoVs) can cause a range of symptoms; from a mild common cold to life threatening acute respiratory distress syndrome (ARDS) upon infection. These emerging viruses have the ability to be highly pathogenic and detrimental to the human population. Two prime examples of CoV emergence, SARS-CoV (Severe Acute Respiratory Syndrome) and MERS-CoV, (Middle Eastern Respiratory Syndrome), which exhibits the pandemic potential of emerging CoVs that gain human tropism. Given the increasing potential of an emerging CoV outbreak there is a state of urgency to develop vaccines that will help protect the human population against current and future circulating strains. The …

Impact Of Visitation With Incarcerated Fathers On Behavioral Adjustment Among Children In The Foster Care System, Lauren Ashley Hindt

Master's Theses

This study sought to examine whether in-person visitation with incarcerated fathers related to less behavioral problems among children in foster care. The sample consisted of 282 youth (M = 10.18, SD = 2.36 years). Data were collected from the Illinois Department of Children and Family Services. Hierarchical Generalized Linear Modeling revealed paternal incarceration was associated with increased externalizing slope trajectories (ß1515 = .18, p = .025), but not internalizing. African American youth had lower externalizing slope trajectories compared to the remainder of the sample (ß20 = -.14, p = .032). The association between paternal incarceration and externalizing was attenuated …

Potential Efficacy Of Targeting Mll1 In Breast Cancer, Austin Gable Holmes

Master's Theses

In 2017, it is estimated that breast cancer will be the most prevalent newly diagnosed cancer in females, at 30% in the U.S. alone1. From the early 1990s to 2014 the death rate in females from breast cancer has dropped by 10% but still stands as the second highest cancer related death in females in the U.S.2. One of the biggest hurdles in breast cancer research is disease heterogeneity. New mechanisms of disease development and progression are encountered frequently. One mechanism studied in the past decades is epigenetics. It has been theorized that the cancer epigenome can maintain an abnormal …

The Novel Characterization Of Extracellular Vesicles Containing Proteins Which Have Been Implicated In The Pathogenesis Of Hiv Associated Neurocognitive Disorders, Grace Ispas

Master's Theses

Although Anti-Retroviral Therapy (ART) is practiced, HIV-1 positive individuals still experience HIV-Associated Neurocognitive Disorders (HAND), collectively described as the presentation of neurocognitive, behavioral and motor dysfunctions that decrease the quality of life, while increasing the mortality in ART suppressed HIV-1 positive patients.

Current literature suggests that extracellular vesicles are involved in the pathogenesis of HAND as they are believed to be transferring HIV-1 proteins to nearby neuronal cells. Although most studies assume homogeneity among populations, characterizing cellular proteins or RNA levels in bulk, we hypothesize that distinct populations of extracellular vesicles are released and that environmental conditions, including viral infections, …

Optimizing Clean Catch Urine Collection And Its Applications In Urinary Microbiome Studies, Danielle Johansen

Master's Theses

Clean catch was developed before the advancement of more sensitive assays for culturing urinary bacteria. I reassessed clean catch, endeavoring to optimize this method. Periurethral swabs and voided urines were routinely collected, while analyzing different aspects of the method. I determined that midstream urine contained the least amount of vulvo-vaginal contamination and that the time of collection did not impact the results. I also determined that the use of antiseptic wipes prior to void increased the level of vulvo-vaginal contamination. A small cohort of females collected daily urines over a 17-day period and kept a strict alcohol diary. Females who …

Fear Of Missing Out: A Moderated Mediation Approach To Social Media Use, Brynn M. Huguenel

Master's Theses

This study explores whether fear of missing out (FOMO) mediates the relation between social networking site (SNS) use and negative mental health outcomes, with moderators of Facebook activities and individual-level characteristics included. Short-term longitudinal data was collected from undergraduate students (N=296). Mediation analyses indicated that intensity of Facebook use did not predict anxiety or depression, as mediated by FOMO. Further, Facebook activities did not moderate the relation between intensity of Facebook use and FOMO, and social comparison and social connectedness did not moderate the relations between FOMO and negative mental health outcomes. Post-hoc analyses showed that social connectedness moderated the …

Perceived Partner Sexism And Stigma Consciousness: How 'Prince Charming' Undermines Relationship Satisfaction, Danielle Lauren Kellogg

Master's Theses

Perceived discrimination (outside of the relationship) relates to negative relationship outcomes, moderated by stigma consciousness (DeHart, 2017). Women who report higher (versus lower) levels of perceived partner benevolent sexism (i.e., perceptions of one's partner's endorsement of sexist attitudes) experience more negative relationship outcomes as well (Hammond & Overall, 2013; Hammond & Overall, 2014; Hammond & Overall, 2015). In addition, relationship partners adopt more traditional gender roles after becoming parents, which fosters benevolent sexism (Trillingsgaard, Baucom, & Heyman, 2014). In this study, married or cohabiting women with children were randomly assigned to either a sexism manipulation or control condition, prior to …

Functional Studies Of Novel Mosquito Stage-Specific Genes In The Malaria Parasite, Plasmodium Berghei., Kaitlyn Kiernan

Master's Theses

The development and survival of the malaria parasite Plasmodium within its mosquito vector is not very well understood. When the parasite is taken up by an Anopheles mosquito, it is exposed to digestive enzymes, reactive oxygen species, increasing pH, decreasing temperature, and a diverse microbial flora. Our lab is studying the adaptive mechanisms underlying parasite survival in this hostile environment, one of which is movement out of the midgut. In order to escape the midgut, the parasite develops into an elongated, motile form called the ookinete. I am investigating two genes, thioredoxin-like protein 1 (trxl-1) and subpellicular microtubule protein 1 …

Comparing The Risk Factors Of Recidivism For Offenders With And Without Mental Illness, Meghan J. Mahoney

Master's Theses

This study examined which risk factors were predictive of recidivism among inmates released from Illinois Department of Corrections (IDOC) who had no mental illness, a non-substance abusing mental illness (non-SUD MI), a substance use disorder (SUD), or a co-occurring mental illness and substance use disorder (COD). The predictors of being returned to prison or being rearrested for a violent, property, or drug crime were compared across these four groups. A secondary data analysis was conducted on data obtained by Olson, Stalans, and Escobar (2016) for a study examining the predictors of recidivism for inmates released from IDOC in 2007. Logistic …

Comparative Studies On Biochemical And Pharmacological Profiles Of Bovine, Ovine And Porcine Heparins, Ahmed Kouta

Master's Theses

Heparin, a highly sulfated glycosaminoglycan (GAG), is used extensively as an anticoagulant. It consists of repeating disaccharide units, containing iduronic acid (or glucuronic acid) and glucosamine, exhibiting variable degrees of sulfation. Heparin, and its analogues, are used during surgery and dialysis, and are often used to coat indwelling catheters and other devices where the vascular system is exposed. Administered parenterally, often continuously due to its short half-life, over 0.5 billion doses are required per year. Heparin is currently obtained from mucosal tissue of meat animals, mainly porcine intestine, and to a lesser extent bovine and ovine sources. The early stages …

Developmental Assets And Outcomes: An Analysis Of Male Serious Juvenile Offenders To Promote Evidence Based Approaches For Rehabilitation, Danielle Jordan Nesi

Master's Theses

Positive youth development is an approach that seeks to enhance and promote young people's developmental progress. Although there has been a shift toward asset building in rehabilitation of delinquent youth, research on positive youth development has historically focused on children at risk of adverse outcomes, rather than those who are already engaged in criminal behavior. Without knowledge about the distribution of assets among delinquent youth and the relations of these assets to outcomes later in life, it is unclear if interventions based on research of developmental assets among at-risk youth are appropriate for justice-involved youth. The 40 Developmental Assets (Search …

Domestic Violence Among Asian Indian Immigrant Women In The United States, Teuta Peja

Master's Theses

This study looks at how domestic violence is conceptualized by the research studies on

Asian Indian immigrant communities in the United States through different periods of time, and

how sociocultural factors are associated with domestic violence. Using the meta-synthesis

descriptive method, I analyzed and interpreted the findings of four research studies conducted

between 1995-2016 that included in-depth interviews with Asian Indian immigrant women who

experienced domestic violence. The analysis focuses on changes of the patterns of abuse, helping behavior, and leaving the abusive marriage as an option. The changes in U.S. domestic

violence legislation and policy regarding immigration and domestic …

Chronic Effects Of Lead Exposure On Atherinops Affinis (Topsmelt): Influence Of Salinity And Organism Age, Erik Joseph Reynolds

Master's Theses

Pb (lead) appears in the environment as a consequence of both natural and anthropogenic processes. Mining, smelting, coal burning, lead acid batteries, and cement manufacturing substantially release Pb into aquatic environments. The goal of this study was to determine the influence of salinity and organism age on chronic toxicity of Pb to Atherinops affinis (topsmelt) in support of development of a species sensitivity distribution (SSD). Species sensitivity distributions assist in ecological risk assessments and establishing quality criteria for contaminants. Three chronic exposure studies were conducted for 28 days in a water flow-through testing system. Survival, standard length, dry weight, and …

Children's Exposure To Violence Across Contexts: Profiles Of Family, School, And Community Witnessing And Victimization, Catherine Mary Rice

Master's Theses

Children residing in low-income, urban neighborhoods are at a disproportionately higher risk of exposure to violence (ETV) across multiple contexts compared to their peers, including witnessing violence and direct victimization. The many negative effects of ETV are compounded when youth experience ETV across multiple settings and when these experiences are chronic. Despite this, much of the research on ETV during childhood focuses on a single form of violence (e.g., family victimization or witnessing community violence). The current study examines patterns of frequency of ETV, including witnessing and victimization, across family, school, and community contexts, using person-centered methods to elucidate the …

Real-Time Fall Detection And Response On Mobile Phones Using Machine Learning, Ilona Shparii

Master's Theses

Falls are common and often dangerous for groups with impaired mobility, like the elderly or people with lower limb amputations. Finding ways of minimizing the frequency or impact of a fall can improve quality of life dramatically. When someone does fall, real-time detection of the fall and a long-lie can trigger fast medical assistance. Such a system can also collect reliable data on the nature of real-world falls that can be used to better understand the circumstances, to aid in prevention efforts. This work has been to develop a real-time fall tracking system specifically for subjects with lower limb amputations. …

Characterization Of Inhibitory Molecules Produced By Lactobacillus Crispatus, Giuseppe Anthony Pistone

Master's Theses

Lactobacillus species are widely accepted as beneficial bacteria of the human microbiota1-8. Lactobacilli spp. are well documented to inhibit pathogens by production and secretion of hydrogen peroxide (H2O2), organic acids, and/or proteinaceous bacteriocins into their environment. Most research attributes bactericidal activity of cell free supernatant (CFS) to H2O2 and/or lactic acid. Here, I demonstrate that CFS from a clinical isolate of Lactobacillus crispatus contains a molecule(s) that inhibits uropathogenic Escherichia coli (UPEC) colony formation independently of H2O2 and organic acids. Physiologic concentrations of H2O2 and organic acids produced by L. crispatus do not inhibit UPEC colony formation. Incubation of UPEC …

Grower Attitudes Towards Water Management Strategies While Mitigating Seawater Intrusion: A Case Study Of The Castroville Seawater Intrusion Project, Jason Ray Reed

Master's Theses

The Salinas River Valley Watershed has endured the effects of seawater intrusion for decades caused by overpumping groundwater from the Salinas River Groundwater Basin. The Castroville Seawater Intrusion Project began delivering recycled water in 1998 with other water sources due to wells becoming too saline. One-on-one, in-person interviews with eighteen growers, who own or lease farmland within the Project’s service area, were conducted during a severe, statewide drought. Interview questions explored grower attitudes and concerns regarding their water supply, and the impact of management strategies on the mitigation of seawater intrusion. Two research questions were posed, exploring factors that influence …

Green Vs. White: An Examination Of Of Media Portrayals Of Radical Environmentalists And White Supremacists, Laurence Pedroni

Master's Theses

The rise of the Trump presidency has highlighted not only the white supremacist history of the U.S., but also reflects danger to the survival of the species in the form of wholesale climate change denial. These ideologies are not unique to Trump or his cabinet, instead reflecting long standing U.S. policy. This research seeks to examine how the U.S. media supports and propagates propaganda to support these hegemonic goals. Relevant literature and research seem to suggest that because radical environmental movements often challenge the hegemony of capital accumulation, they might be portrayed as more violent and a greater terrorist threat …

Evaluation Of Oyster Shell Enhancement On Western Snowy Plover Breeding Success, Karine Tokatlian

Master's Theses

The Pacific Coast population of the western snowy plover (Charadrius nivosus nivosus; plover) is listed as a federally threatened species under the U.S. Endangered Species Act due to poor reproductive success from anthropogenic habitat loss, and high predation pressure. Plovers in the South San Francisco Bay use dry salt evaporation ponds, and wildlife-managed ponds, to breed and winter. However, the South Bay Salt Pond Restoration Project aims to restore up to 6,110 hectares of this habitat back to native tidal marsh, which will force plovers to breed in smaller areas and in higher densities. In order to recover plovers in …