Digital Commons Network^™

Acoustic Intensity Measurement System: Application In Localized Drug Delivery, Natalie Phipps

Master's Theses

Ultrasound is used for many applications in diagnostics and therapy. New developments are being made specifically for the use of therapeutic ultrasound for enhancement of localized drug delivery. The long term goal of this study is to find ultrasound pulsing sequences that will allow for controlled mass diffusion from hydrogel drug reservoirs. Developing this new method requires the calibration and characterization of therapy transducers using power and acoustic intensity measurements. Mechanical index, spatial peak pulse average intensity, and spatial temporal pulse average intensity calculations were made using hydrophone measurements set-up in a tank measurement system. These were compared to safety …

Ethnic Identity As A Moderator Of Ingroup Bias, Katherine Stokes-Guinan

Master's Theses

This thesis replicated and extended work by Perdue, Dovidio, Gurtman, and Tyler (1990) by priming 132 Asian, Hispanic, and White participants with ingroup and outgroup designators outside of conscious awareness before asking them to make judgments about positive and negative trait words. While bias patterns were similar for participants from all three ethnic groups, they were different among individuals with high and low scores on a measure of ethnic identity (the Multigroup Ethnic Identity Measure by Phinney, 1992). Specifically, participants with high ethnic identity scores demonstrated ingroup bias along ethnic lines, while participants with low ethnic identity scores did not. …

Automation In Cs1 With The Factoring Problem Generator, Joshua B. Parker

Master's Theses

As the field of computer science continues to grow, the number of students enrolled in related programs will grow as well. Though one-on-one tutoring is one of the more effective means of teaching, computer science instructors will have less and less time to devote to individual students. To address this growing concern, many tools that automate parts of an instructor’s job have been proposed. These tools can assist instructors in presenting concepts and grading student work, and they can help students learn to program more effectively. A growing group of intelligent tutoring systems attempts to tie all of this functionality …

Galvanic Vestibular Stimulation Applied To Flight Training, Joel D. Hanson

Master's Theses

Between 1994 and 2003 spatial disorientation resulted in at least 202 aircraft

accidents, 184 of them resulting in fatalities. Galvanic Vestibular Stimulation (GVS)

provides a cost effective and safe way to simulate spatial disorientation and

potentially test pilot’s vestibular system prior to aircraft operation. This experiment

investigates the use of GVS as an indicator of motion sensitivity and explores the

effects of GVS on flight simulation performance. Bilateral bipolar rectangular pulse

electrical stimulations were given to subjects via skin-mounted electrodes placed over

each mastoid process to stimulate the vestibular system with roll and yaw sensations.

Two studies were conducted in …

Measurement And Modeling Of Blocking Contacts For Cadmium Telluride Gamma Ray Detectors, Patrick R. Beck

Master's Theses

Gamma ray detectors are important in national security applications, medicine, and astronomy. Semiconductor materials with high density and atomic number, such as Cadmium Telluride (CdTe), offer a small device footprint, but their performance is limited by noise at room temperature; however, improved device design can decrease detector noise by reducing leakage current.

This thesis characterizes and models two unique Schottky devices: one with an argon ion sputter etch before Schottky contact deposition and one without. Analysis of current versus voltage characteristics shows that thermionic emission alone does not describe these devices. This analysis points to reverse bias generation current or …

Two-Phase Boost Converter, Tadeus Gunawan

Master's Theses

A boost converter is one of the most efficient techniques to step up DC input voltage to a higher needed DC output voltage. The boost converter has many possible applications, such as in a photovoltaic system, hybrid car and battery charger. The proposed prototype in this report is a proof of concept that a Two-Phase Boost Converter is a possible improvement topology to offer higher efficiency without compromising any advantages readily offered by a basic boost. The prototype is designed to be able to handle up to 200 watts of output power with an input of 36 volts and an …

Single Cell Impedance Measurements Using Microfabricated Electrodes And Labview Graphical Programming, Stephanie Sophia Hernandez

Master's Theses

This Master’s Thesis project consists of the research, design, and fabrication of a system that could perform broadband impedance measurements (1kHz-20Mhz) of single cells using National Instruments Labview data acquisition and programming in coordination with a single cell capture device. Presented first is the background information on cells and their electrical properties, along with background in micro-total-analysis systems as well as impedance spectroscopy. Experimental Methods are then discussed for the electrode design, cellular modeling in COMSOL, fabrication methods, and Labview 8.0 Set-up and programming. Measurements were performed using the single-cell capture device on saline, yeast cells, and a polysterene bead. …

Evaluating Head Gestures For Panning 2-D Spatial Information, Matthew O. Derry

Master's Theses

New, often free, spatial information applications such as mapping tools, topological imaging, and geographic information systems are becoming increasingly available to the average computer user. These systems, which were once available only to government, scholastic, and corporate institutions with highly skilled operators, are driving a need for new and innovative ways for the average user to navigate and control spatial information intuitively, accurately, and efficiently. Gestures provide a method of control that is well suited to navigating the large datasets often associated with spatial information applications. Several different types of gestures and different applications that navigate spatial data are examined. …

Development Of An Air-Cycle Environmental Control System For Automotive Applications, Christopher James Forster

Master's Theses

An air‐cycle air conditioning system, using a typical automotive turbocharger as the core of the system, was designed and tested. Effects on engine performance were kept to a minimum while providing the maximum amount of cooling possible and minimizing weight and space requirements. A test stand utilizing shop compressed air was developed to measure component performance. An unmodified automotive turbocharger was tested initially as a baseline in a Reversed‐Brayton Cycle air cooling system. Once the baseline was established, another aircycle machine, assembled from commercial turbocharger components chosen individually to optimize their performance for cooling purposes, was tested to improve the …

Laser Scanning Confocal Microscopy (Lscm): An Application For The Detection Of Morphological Alterations In Skin Structure, Shea C. Smith

Master's Theses

Laser scanning confocal microscopy (LSCM) is an optical imaging technique that provides improved resolution and sensitivity over conventional methods of optical microscopy. However, the cost of most commercial LSCM systems exceeds the financial limitations of many smaller laboratories. The design of a custom LSCM created at a fraction of the cost of a commercial model is discussed in this paper.

The increase in the incidence rate of skin cancer in the world today is alarming, as such, it is essential to provide an early, rapid and effective method for in vivo diagnostics of human skin tissue. LSCM is capable of …

The Electrical Properties Of Human Tissue For The Diagnosis And Treatment Of Melanoma Skin Cancer, Glenn Cameron Stante

Master's Theses

This thesis discusses the research, experimental methods, and data gathered for the investigation of a novel method for the diagnosis of melanoma skin cancer. First, a background about human skin tissue is presented. Then, a detailed description of melanoma along with current diagnosis techniques and treatment options are presented. In the experimental methods, the electrical properties of several types of tissue were analyzed, the purpose of which was to discover if a tissue type can be distinguished by its electrical properties alone. This would allow for the diagnosis of melanoma to be done by examining the electrical properties of the …

A Computational Model Of Apoptotic Osteocyte Correlation To Cortical Bone Remodeling Parameters, Michael Stephen Alexander

Master's Theses

The onset of osteoporosis caused by aging, disease states, and post-menopausal conditions significantly impacts patient quality of life, required healthcare funding, personal autonomy losses from increased fracture risk and the subsequent corrective surgery. Research has indicated that osteocyte apoptosis may be a key parameter in bone remodeling, raising the possibility of remodeling rate modulation for the mitigation of bone mass resorption. By developing therapies that target osteocyte apoptosis, it may be possible to prevent undesired bone remodeling activity while maintaining a healthy balance between damage formation in the form of microcracks induced by the strain environment and the removal of …

An Assessment Of Indoor Infiltration Parameters For Black Carbon From Residential Wood Combustion And The Spectral Dependence Of Light Absorption For Organic Carbon, Christopher John Malejan

Master's Theses

Black carbon, a proxy for woodsmoke was measured indoors and outdoors for an occupied residence in Cambria, CA during the winter months of 2009. The purpose was to investigate the infiltration parameters: air exchange rate, deposition rate, and penetration factor. The second part of this study investigated the light absorption properties of organic carbon from residential wood combustion, the dominant fraction of woodsmoke.

To assess woodsmoke variation, a study conducted parallel to the one presented in this thesis (Ward, 2009), a grid array of personal emission monitors (PEMS) and aethalometers were placed in a small area, approximately one square kilometer, …

Changing Portrayals Of Captain James Cook In Hawaiian Education, Christopher Aaron Straub

Master's Theses

This paper covers the portrayals of Captain James Cook within Hawaiian education. It begins by providing a backdrop to early European portrayals of Captain Cook and then proceeds to investigate how these portrayals changed as they were incorporated into Hawaiian textbooks. The paper then continues to illustrate the changes made in Cook’s portrayal within Hawaiian textbooks and how these changes coincide with the prevailing interests of the eras in which the authors wrote them.

A Neural Network Approach To Border Gateway Protocol Peer Failure Detection And Prediction, Cory B. White

Master's Theses

The size and speed of computer networks continue to expand at a rapid pace, as do the corresponding errors, failures, and faults inherent within such extensive networks. This thesis introduces a novel approach to interface Border Gateway Protocol (BGP) computer networks with neural networks to learn the precursor connectivity patterns that emerge prior to a node failure. Details of the design and construction of a framework that utilizes neural networks to learn and monitor BGP connection states as a means of detecting and predicting BGP peer node failure are presented. Moreover, this framework is used to monitor a BGP network …

But Not In Vain: The Civil Rights Movement In San Luis Obispo, California 1947–1969, Joshua M. Harmon

Master's Theses

Civil rights have long been an important focus of historical scholarship. As the United States continues to grapple with issues of racism and the complicated legacy of the Civil Rights Movement, it is imperative that a variety of perspectives are incorporated into scholarship on the subject. Traditional scholarship on the subject has focused on the large organizations, individuals, marches, and activities that have come to characterize the Civil Rights movement. This study seeks to integrate the perspectives of a case study population, African Americans in San Luis Obispo, California, to assess the ways in which African Americans away from large …

Enhancing Dynamics Courses With Model Eliciting Activities, Lawrence H. Fong

Master's Theses

Model eliciting activities are assignments which require students to develop models to describe realistic situations. Every MEA follows six principles: model-construction, reality, self-assessment, model documentation, generalizability, and effective prototype. The six principles provide a solid guideline in which instructors can develop more MEAs, which can then be shared and used among several participating universities. Under NSF CCLI Grant #0717595, Cal Poly is currently developing Model Eliciting Activities for the subject of Mechanical Engineering.

This report documents the undertakings to implement and enhance two Model Eliciting Activities (MEAs) into the Cal Poly curriculum. Specifically, the development of the Vehicle Accident Reconstruction …

No-Till Tomato Production, Bradley L. Booker

Master's Theses

Tillage increases erosion rates and diminishes the quality of soils but has traditionally been a way to manage weeds and prepare a seedbed. No-till vegetable production can ameliorate the ill-effects of tillage in an economically effective way but has not been studied much in California. The objective of this thesis was to determine the viability of no-till vegetable cropping on the Central Coast of California. Tomatoes were grown in no-till and conventionally tilled treatments. Total yield, fruit weight, weed emergence, soil bulk density, soil aggregate stability, and soil organic carbon content were measured and compared. Yields and soil tests in …

Aerodynamic Performance Enhancement Of A Naca 66–206 Airfoil Using Supersonic Channel Airfoil Design, David Michael Giles

Master's Theses

Supersonic channel airfoil design techniques have been shown to significantly reduce drag in high-speed flows over diamond shaped airfoils by Ruffin and colleagues. The effect of applying these techniques to a NACA 66-206 airfoil is presented. The design domain entails channel heights of 8-16.6% thickness-to-chord and speeds from Mach 1.5-3.0. Numerical simulations show an increase in the lift-to-drag ratio for airfoils at Mach 2.5 at a 35,000-ft altitude with a 12% channel height geometry showing a benefit of 17.2% at 6-deg angle of attack and a sharp channel leading edge. Wave drag is significantly reduced while viscous forces are slightly …

Sensor Integration For Low-Cost Crash Avoidance, Stephane M. Roussel

Master's Theses

This report is a summary of the development of sensor integration for low-cost crash avoidance for over-land commercial trucks. The goal of the project was to build and test a system composed of low-cost commercially available sensors arranged on a truck trailer to monitor the environment around the truck. The system combines the data from each sensor to increase the reliability of the sensor using a probabilistic data fusion approach. A combination of ultrasonic and magnetoresistive sensors was used in this study. In addition, Radar and digital imaging were investigated as reference signals and possible candidates for additional sensor integration. …

Traffic Signal Control With Ant Colony Optimization, David T. Renfrew

Master's Theses

Traffic signal control is an effective way to improve the efficiency of traffic networks and reduce users’ delays. Ant Colony Optimization (ACO) is a metaheuristic based on the behavior of ant colonies searching for food. ACO has successfully been used to solve many NP-hard combinatorial optimization problems and its stochastic and decentralized nature fits well with traffic flow networks. This thesis investigates the application of ACO to minimize user delay at traffic intersections. Computer simulation results show that this new approach outperforms conventional fully actuated control under the condition of high traffic demand.

The Next Generation Router System Cooling Design, Garrett A. Glover

Master's Theses

Advancements in the networking and routing industry have created higher power electronic systems which dissipate large amounts of heat while cooling technology for these electronic systems has remained relatively unchanged. This report illustrates the development and testing of a hybrid liquid-air cooling system prototype implemented on Cisco’s 7609s router. Water was the working fluid through cold plates removing heat from line card components. The water was cooled by a compact liquid-air heat exchanger and circulated by two pumps. The testing results show that junction temperatures were maintained well below the 105°C limit for ambient conditions around 30°C at sea level. …

A Rapid Prototyping Method For Constructing A Complex Three-Dimensional Substrate, Kathryn Jacoba Hart

Master's Theses

Cell culturing on three-dimensional structures has increased the possibilities in tissue engineering and bioreactor research. These structures enable cells to differentiate, proliferate, mobilize, and function in a conformation that more accurately mimics in vivo conditions. Computer generated models aid in development and rapid alteration of three-dimensional cell substrates, defining their internal structure as well as their external morphology. The rapid transition from substrate design to a viable culture is imperative to quickly advance research in biomedical and tissue engineering applications.

The aim of this thesis is to investigate the feasibility of a rapid prototyping process by selectively cross-linking and assembling …

The Effect Of All-Trans Retinoic Acid And Fatty Acids On Mcf-7 Breast Cancer Cell Progression, David A. Brown

Master's Theses

Vitamin A metabolites and retinoids may slow the progression of breast cancer and elicit anti-neoplastic properties similar to those of omega-3 fatty acids. Studies using animal models show a decrease in the incidence, growth and metastisis of mammary tumors in the presence of specific fatty acids. This effect is also seen with use of retinoids, specifically all-trans retinoic acid (AtRA). Thus, fatty acids may also alter retinoid homeostasis in mammary carcinoma cells (MCF-7s). The potential for inter/co dependency among fatty acids and retinoids is considerable, and here it has been hypothesized that a decrease in cancer progression will occur in …

Impact Of Dietary Arginine On Immunity In Broiler Chicks, Jennifer Lynn D'Amato

Master's Theses

Arginine (ARG) is an immunologic modulator due in part to its role as a substrate for leukocytes. Therefore, the objective of these studies was to evaluate the impact of dietary ARG on ARG utilization in peripheral blood mononuclear cells (PBMC) and thymocytes in broiler chicks as they provide a model that is not confounded by de novo ARG synthesis. Several experiments were performed to measure: 1) ARG transporters as markers of ARG utilization by leukocytes; 2) thymocyte proliferation; 3) PBMC phenotype, and 4) ARG’s impact on the acute phase response (APR). In experiment 1, chicks were fed diets containing 1.20% …

Composite Manufacturing Of Small Wind Turbine Blades- Utility Scale Methods Applied To Small Wind, Bryan Kyle Edwards

Master's Theses

Cal Poly, San Luis Obispo’s first wind turbine explores the methods and processes that are employed to manufacture utility scale wind turbines, and applies them to small scale wind turbines. The primary objective is to promote the development of small scale wind turbine blades in ways that resemble, as closely as possible, the construction and methods of utility scale turbine blade manufacturing. Vacuum infusion is employed to create a hollow, multi piece, lightweight design using carbon fiber and fiberglass with an epoxy based resin. A “rapid prototyping” method is developed using high density foam molds that allows short cycle time …

Orbital Propagators For Horizon Simulation Framework, Mitra Farahmand

Master's Theses

This thesis describes the models of four common orbital propagators and outlines the process of integrating them into the Horizon Simulation Framework (HSF). The results of the Two-Body, J2, and J4 propagators from the HSF are then compared against the outcomes of these propagators in MATLAB and Satellite Toolkit (STK). The MATLAB algorithms verify the functionality of the propagators and determine the accuracy of the HSF implementation. The compassion against STK validates the formulation of the HSF propagators. In order to equip the HSF with a more precise means of orbit determination, adding the Simplified General Perturbations 4 (SGP4) propagator …

Rayleigh Flow Of Two-Phase Nitrous Oxide As A Hybrid Rocket Nozzle Coolant, Lauren May Nelson

Master's Theses

The Mechanical Engineering Department at California Polytechnic State University in San Luis Obispo currently maintains a lab-scale hybrid rocket motor for which nitrous oxide is utilized as the oxidizer in the combustion system. Because of its availability, the same two-phase (gas and liquid) nitrous oxide that is used in the combustion system is also routed around the throat of the hybrid rocket’s converging-diverging nozzle as a coolant. While this coolant system has proven effective empirically in previous tests, the physics behind the flow of the two-phase mixture is largely unexplained. This thesis provides a method for predicting some of its …

The Interaction Between Throttling And Thrust Vectoring Of An Annular Aerospike Nozzle, David Michael Imbaratto

Master's Theses

Applied research and testing has been conducted at the Cal Poly San Luis Obispo High-pressure Blow-Down facility to study the affects of throttling in a thrust-vectored aerospike nozzle. This study supports the ongoing research at Cal Poly to effectively thrust vector a hybrid rocket motor. Such thrust vectoring is achieved by small secondary ports in the nozzle body that are perpendicular to the main nozzle. The testing conducted included characterizing and comparing the performance of a straight aerospike nozzle to that of a thrust-vectored aerospike nozzle. Throttling effects on the aerospike nozzle in an unvectored and in a vectored configuration …

Hole-Type Aerospike Compound Nozzle Thrust Vectoring, Stanley Ikuo Beebe

Master's Theses

Compound aerospike nozzles were designed and tested as part of an ongoing

experimental study to determine the feasibility of thrust vectoring an aerospike

nozzle with the addition of a secondary port. Earlier phases of the study have

indicated that a compound aerospike nozzle could provide sufficient thrust

vectoring. The addition of a hole-type secondary port was found to provide

effective thrust vectoring.

Experiments were carried out to determine the effects of secondary port size,

secondary port inlet geometry and compound aerospike nozzle chamber

pressure. Results show good predictability, axisymmetric flow, and emphasize

the importance of a radius on secondary port …