Digital Commons Network^™

Higher Energy Gap Control Of Fluorescence In Conjugated Polymers, Chien-Hung Chiang

LSU Doctoral Dissertations

Chemo- and biosensors based on fluorescent conjugated polymer benefit from greater detection sensitivity due to amplification of the electronic perturbations produced by analyte binding. This amplification stems from the exciton-transporting properties of conjugated polymers. A conventional design paradigm relies on the analyte binding events which generate sites of lower energy relative to the polymer energy: either fluorescence quenching sites (turn-off sensors) or bathochromically shifted fluorophores (turn-on sensors). In both type sensors, the excitons migrate to the lower-energy site created by analyte binding.

This dissertation primarily focused the investigation of an alternative paradigm when analyte binding creates higher energy gap sites …

General Stochastic Integral And Itô Formula With Application To Stochastic Differential Equations And Mathematical Finance, Jiayu Zhai

LSU Doctoral Dissertations

A general stochastic integration theory for adapted and instantly independent stochastic processes arises when we consider anticipative stochastic differential equations. In Part I of this thesis, we conduct a deeper research on the general stochastic integral introduced by W. Ayed and H.-H. Kuo in 2008. We provide a rigorous mathematical framework for the integral in Chapter 2, and prove that the integral is well-defined. Then a general Itô formula is given. In Chapter 3, we present an intrinsic property, near-martingale property, of the general stochastic integral, and Doob-Meyer's decomposition for near-submartigales. We apply the new stochastic integration theory to several …

Synthesis, Characterization, And Assessment Of Cationic Polypeptoids Toward Gene Delivery And Development Of Air Stable N-Substituted N-Thiocarboxyanhydrides, Jessica Michelle Simpson

LSU Doctoral Dissertations

Peptoids are a class of peptidomimetic polymers, which have attracted much attention over the years. Due to their structural similarity to peptides, this group of polymers affords good biocompatibility making them of interest for biomedical applications. This dissertation is largely about the design, synthesis, and characterization of cationic polypeptoids for biological applications, particularly nonviral gene delivery. The dissertation will also cover the development, characterization, and polymerization behavior of a new, air stable N-thiocarboxyanhydride (NTA) monomer.

Introducing functionality, such as small biomolecules and organic compounds can provide distinctive properties to the polymers. Chapter 1 introduces gene therapy and concepts pertinent …

Numerical Experiment Of Sediment Dynamics Over A Dredged Pit On The Louisiana Shelf, Nazanin Chaichitehrani

LSU Doctoral Dissertations

Sediment transport over Sandy Point dredge pit in the northern Gulf of Mexico was examined using field measurements and a finely resolved numerical model. Delft3D model with well-vetted computational grid and input parameters was used. Numerical experiments were performed to examine the effect of wind-generated waves, wind-driven currents and their interaction on sediment dynamics in our study area during a cold front in November 2014 and fair-weather conditions between July and August of 2015. Sediment dispersal from the lower Mississippi River, sediment resuspension, transport and deposition with high spatial and temporal resolution were simulated. A reliable satellite-derived near-surface suspended particulate …

A Phenomenological Investigation Into The Impact Of The College Student Union On Student Engagement At A Historically Black University, Nathalie Nicole Godfrey

LSU Doctoral Dissertations

Known as the proverbial “living room of campus,” college student union facilities date back to the late 1800s. Unions were a place for congregation and fellowship, a place where student engagement was crucial. Today’s college union varies from campus to campus, with some focused on student development, some with a keen focus on generating revenue through providing services, and some that attempt to strike a balance between the two.

The concept of student engagement and the research surrounding engagement rarely has shed light on the role of the college student union facility in the engagement process. Entities traditionally found within …

Sediment And Plant Dynamics In A Degrading Coastal Louisiana Landscape, Glenn Michael. Suir

LSU Doctoral Dissertations

Alterations to Louisiana’s river systems and local hydrology have resulted in reduced freshwater, sediment, and nutrient inputs into wetland landscapes, causing significant negative impacts on marsh productivity and stability. To combat these losses many restoration projects have been constructed or planned throughout coastal Louisiana. Typical goals of wetland restoration efforts are to conserve, create, or enhance wetland form, and to achieve wetland function that approaches natural conditions. Failure to adequately maintain wetland elevation and hydrology can have serious implications on sedimentation and vegetation processes, which significantly reduces the likelihood of reaching structural and functional targets. Measures of wetland condition have …

Synthesis And Characterization Of Covalent Adaptable Networks Comprised Of Dynamic Imine And Aminal Covalent Bonds, Albert Chao

LSU Doctoral Dissertations

The dissertation is about the design, synthesis and characterization of materials comprised of covalent adaptable networks (CANs). There are three chapters within this dissertation.

Chapter 1 contains a short overview of conventional thermosets and thermoplastics. A new strategy of combining advantages from thermosets and thermoplastics is utilizing dynamic covalent chemistry (DCC) for material design. Dynamic covalent bonds are able to undergo dynamic exchange which allow the material to adapt to a new state when under stimuli such as stress or strain. Material comprised of such reversible networks is called covalent adaptable networks (CANs). These types of reversible covalent bonds followed …

5-Lipoxygenase (5-Lox)-5-Lipoxygenase Activating Protein (Flap)-Nanodisc Complex: A Model For The 5-Lox-Flap Interaction, Erin Elizabeth Schexnaydre

LSU Doctoral Dissertations

Leukotrienes (LT) are lipid mediators of the inflammatory response that play important roles in diseases such as asthma and atherosclerosis. Leukotriene A4 (LTA₄) is synthesized from arachidonic acid (AA) by 5-lipoxygenase (5-LOX) with the help of 5-lipoxygenase activating protein (FLAP), a trimeric nuclear transmembrane protein. Exactly how 5-LOX and FLAP interact is not well understood, however FLAP is essential for the production of leukotrienes in vivo. I used nanodiscs (NDs), engineered membrane systems, as a tool to study the 5-LOX-FLAP interaction. FLAP was incorporated into NDs with a phospholipid composition to mimic of the nuclear membrane. Structural features …

Signal Propagation, Provenance, And Climate Records In The Indus Submarine Canyon Since The Last Deglacial, Yuting Li

LSU Doctoral Dissertations

The Monsoon is one of the most powerful climatic phenomena on Earth and controls environments in South Asia. Erosion and weathering patterns are influenced by monsoon variations and can be reconstructed through marine sediment records. However, such reconstruction is based on the assumption that such sediments are representative of the onshore basins from which they are sourced. Debate continues regarding the degree to which storage and recycling homogenize short-term variations in sediment compositions. The Indus Submarine Canyon links the river mouth and the deep-water fan of the Indus drainage system. Determining how sediment fluxes through this canyon is important if …

Chemotherapeutic Applications Of Rhodamine Based Nanogumbos, Nimisha Bhattarai

LSU Doctoral Dissertations

The work presented in this dissertation employs nanomaterials derived from a group of uniform materials based on organic salts (GUMBOS) for selective chemotherapeutic applications. GUMBOS, similar to ionic liquids, are organic salts consisting of a bulky cationic and anionic moiety. In contrast to ionic liquids, these materials have melting points ranging from 25–250 °C, making them solid phase at room temperature. Similar to ionic liquids, GUMBOS display tunable properties, such as hydrophobicity and solubility, through counter ion variation. These tunable properties provide a variety of applications for these GUMBOS, including selective chemotherapeutics applications. The …

The Tensile Root Strength Of Emergent Coastal Macrophytes, Lauris Olivia Hollis

LSU Doctoral Dissertations

Spartina patens is a dominant emergent macrophyte in fresh, intermediate, and brackish marshes along the Atlantic and Gulf coasts of United States where its biomechanical properties are a key component of wetland health and resilience. Its root biomass and tensile root strength are essential for anchorage, erosion protection, and are important determinants of soil strength. Nutrients and the herbicide atrazine are suspected of negatively impacting this wetland plant and others. The objectives of this study were to: 1) ascertain the tensile root strength of five emergent coastal macrophytes in coastal estuaries, and 2) test the effects of nutrient addition, atrazine …

Microfluidic Technology And Application In Urinal Analysis, Jiwen Xiang

LSU Doctoral Dissertations

Microfluidic technology offers numerous advantages in minimizing and integrating the traditional assays. However, the lack of efficient control components of the microfluidic systems has been hindering the widely commercialization of the technology. The research work in this dissertation focused on the development of effective control components for microfluidic applications.

A linear peristaltic pump was firstly designed, fabricated, and tested for conventional microfluidics by synchronously compressing the microfluidic channel with a miniature cam-follower system in Chapter 2. The miniature cam-follower system and microfluidic chip was prototyped using three-dimensional (3D) printing technology and soft lithography technology. Results from experimental test showed that …

Natural And Anthropogenic Impacts On Sediment Dynamics And Preservation In Contrasting Mississippi Deltaic Coastal Environments, Jiaze Wang

LSU Doctoral Dissertations

Deltas worldwide share the same sinking problem in face of pressure from natural and anthropogenic activities. Many restoration strategies are being planned or have been implemented in the coasts around the world. However, many conventional hard structure constructions are energy-intensive. There are also associated uncertainties and limitations on the effectiveness and sustainability of these restoration plans. Soft or ecological engineering strategies normally take advantage of or mimic the coastal system self-response and feedbacks to natural and anthropogenic activities. The successful implementation of soft strategies relies on process-based studies on the change of complex coastal system. In addition, post-implementation monitoring work …

Innovative Monte Carlo Methods For Sampling Molecular Conformations, Aliasghar Sepehri

LSU Doctoral Dissertations

Sampling molecular conformations is an important step in evaluating physical, mechanical, hydrodynamic, and optical properties of flexible molecules especially polymers. One powerful method for this purpose is configurational-bias Monte Carlo in which one random segment of a molecule is chosen, all segments toward one random end are removed, and then regrown segment by segment to produce a new geometry to be accepted/rejected according to probability laws. The advantage of this method is the ability to generate acceptable conformations that are favorable for intra- and intermolecular energies to save computational costs. However, when there are several interdependent energetic terms, trial generation …

Extended Techniques For Intermediate Violin Students, Mariana Krewer

LSU Doctoral Dissertations

As we reach the end of the second decade of the 21st century, the performance of contemporary music is not a novelty in any concert hall. American orchestras frequently include contemporary works in their programs, and music schools offer specialized classes, ensembles, and even full degrees dedicated to contemporary music. However, for the violin, there are very few resources explaining extended techniques and other recent aesthetic innovations in a didactic manner. Most of the available material is directed at the advanced student or professional player. On the other hand, traditional instructional material often barely glosses over the 20th century repertoire, …

An Optimizing Java Translation Framework For Automated Checkpointing And Strong Mobility, Arvind Kumar Saini

LSU Doctoral Dissertations

Long-running programs, e.g., in high-performance computing, need to

write periodic checkpoints of their execution state to disk to allow

them to recover from node failure. Manually adding checkpointing code

to an application, however, is very tedious. The mechanisms needed

for writing the execution state of a program to disk and restoring it

are similar to those needed for migrating a running thread or a mobile

object. We have extended a source-to-source translation scheme that

allows the migration of mobile Java objects with running threads to

make it more general and allow it to be used for automated

checkpointing. Our translation …

A Case Study: The Attitudes Of A Teaching Assistant Of French Toward Instructional Technology, Farida Emelia Ngandu Tshiebue

LSU Doctoral Dissertations

Technology has shaped the personal experiences of Teaching Assistants (TAs) of French at the collegiate level in the United States (US), what they feel about the technology tools that are accessible in their work environment, and how they use these tools in their practice of teaching. Yet, there is limited research on the specific topic of the attitudes of TAs of French toward the instructional technologies that are available to them. This study sought to investigate the attitudes of a singular TA of French at a southern US university toward instructional technology (IT) by exploring the dynamics of IT use …

Image-Based Modeling Of Flow Through Porous Media: Development Of Multiscale Techniques For The Pore Level, Timothy Wayne Thibodeaux

LSU Doctoral Dissertations

Increasingly, imaging technology allows porous media problems to be modeled at microscopic and sub-microscopic levels with finer resolution. However, the physical domain size required to be representative of the media prohibits comprehensive micro-scale simulation. A hybrid or multiscale approach is necessary to overcome this challenge. In this work, a technique was developed for determining the characteristic scales of porous materials, and a multiscale modeling methodology was developed to better understand the interaction/dependence of phenomena occurring at different microscopic scales. The multiscale method couples microscopic simulations at the pore and sub-pore scales. Network modeling is a common pore-scale technique which employs …

System Nonlinear Performance Of Low-Rise Buildings Under Database-Assisted Hurricane Loads, Jing He

LSU Doctoral Dissertations

Light-frame wood buildings account for over 95% of all residential structures in the U.S, of which the majority are designed as low-rise buildings. These low-rise residential buildings in the U.S. have performed unsatisfactorily and are the largest source of the damage and fatality during the past extreme wind events. To deepen the understanding and reduce the vulnerability of the infrastructures, the accurate prediction of the hurricane loss has been an urgent need, and the hurricane catastrophe models are developed in response. However, the current hurricane catastrophe models are focused on the economy loss estimation rather than investigating the root causes …

Biomedical Applications Of Hydrogels And Gumbos, Kelsey Elizabeth Mcneel

LSU Doctoral Dissertations

Sodium deoxycholate (NaDC) is a small bile salt that was used in this dissertation to produce gelation of tris(hydroxymethyl)amino-methane (TRIS) solutions above, below, and near the pKa of NaDC. These solutions respectively yielded a neutral gelator, a charged gelator, and a mixture of each. Impacts of ionic interactions on gel formation were studied in detail and showed that pH can be used to modify many hydrogel properties including sol-gel temperature, crystallinity, and mechanical strength. It was also observed that pH modification of the hydrogels affected nanoparticle formation. Nanoparticles derived from a Group of Uniform Materials Based on Organic Salts (nanoGUMBOS), …

The Effects Of Accelerated Reader On 6th Grade At-Risk African American Males' Motivation As It Relates To Foucault's Power/Knowledge Theory, Theresa Williams

LSU Doctoral Dissertations

THE EFFECTS OF ACCELERATED READER ON 6TH GRADE AT-RISK AFRICAN AMERICAN MALES' MOTIVATION RELATED TO FOUCAULT'S POWER/KNOWLEDGE THEORY.

This interpretive qualitative study explored the effectiveness of the computerized reading management software, Accelerated Reader, on a select group of at-risk sixth grade African American male students' motivation to read as it relates to Michele Foucault's power/knowledge theory. The data was collected from 16 Black adolescent male students and their four English language arts teachers. The study was guided by one overreaching research question, and four sub questions probed students' self perception, motivations, teachers' perceptions, and power knowledge relations and practices. …

The Graphs And Matroids Whose Only Odd Circuits Are Small, Kristen Nicole Wetzler

LSU Doctoral Dissertations

This thesis is motivated by a graph-theoretical result of Maffray, which states that a 2-connected graph with no odd cycles exceeding length 3 is bipartite, is isomorphic to K_4, or is a collection of triangles glued together along a common edge. We first prove that a connected simple binary matroid M has no odd circuits other than triangles if and only if M is affine, M is M(K_4) or F_7, or M is the cycle matroid of a graph consisting of a collection of triangles glued together along a common edge. This result implies that a 2-connected loopless graph G …

Chaucer's Divided "I": Narrative Voice And Performance Dynamics In Late Fourteenth-Century English Literature, Isaac Mcduffie

LSU Doctoral Dissertations

Throughout the twentieth century, various Chaucer scholars have worked to achieve the now-consensus opinion that Chaucer wrote his works expecting them to be both listened to within a group setting and read privately in an individual setting. These scholars have either assumed or expressly stated that the experience of listening to and reading Chaucer’s works would have been the same. This dissertation argues otherwise. I show that in the late fourteenth century, English vernacular was only starting to be understood as a written language, and this peculiar circumstance created tensions between both listening and reading modes of reception. Such tensions …

Characterizations Of Some Classes Of Graphs That Are Nearly Series-Parallel, Victoria Fontaine

LSU Doctoral Dissertations

A series-parallel graph can be built from a single-edge graph by a sequence of series and parallel extensions. The class of such graphs coincides with the class of graphs that do not have the complete graph K₄ as a minor. This dissertation considers a class M₁ of graphs that are close to being series-parallel. In particular, every member of the class has the property that one can obtain a series-parallel graph by adding a new edge and contracting it out, or by splitting a vertex into two vertices whose neighbor sets partition the neighbor set of the original …

Nonlinear Model-Based Control For Neuromuscular Electrical Stimulation, Ruzhou Yang

LSU Doctoral Dissertations

Neuromuscular electrical stimulation (NMES) is a technology where skeletal muscles are externally stimulated by electrodes to help restore functionality to human limbs with motor neuron disorder. This dissertation is concerned with the model-based feedback control of the NMES quadriceps muscle group-knee joint dynamics. A class of nonlinear controllers is presented based on various levels of model structures and uncertainties. The two main control techniques used throughout this work are backstepping control and Lyapunov stability theory.

In the first control strategy, we design a model-based nonlinear control law for the system with the exactly known passive mechanical that ensures asymptotical tracking. …

Development Of Remote Hydroxylation Via Redox Catalysis And Mild Activation Of Thioglycosides For O-Glycosylation, Kristina Deveaux

LSU Doctoral Dissertations

The focus of this dissertation is the development of a C-H functionalization method using redox catalysis and the synthesis of saccharides using thioglycosides. Chapter 1 is a review of C-H functionalization and visible-light photoredox catalysis. Over the years there have been many significant contributions to the field of C-H functionalization. Select examples have been discussed and a foundation for the method developed in chapter 2 has been outlined. Chapter 2 discusses the development and optimization of a C-H functionalization method. This approach uses the Tz^o directing group and Ir(ppy)₃ to activate a remote C-H bond via 1,6- and …

Multimode Approach To Classical And Quantum Diffraction, Zhihao Xiao

LSU Doctoral Dissertations

I have investigated classical diffraction of optical beams with multimode approach, which is a significant improvement upon the traditional Huygens–Fresnel principle based diffraction theory. I have also investigated quantum diffraction with multimode approach, which describes the behavior of multimode quantum state. Multimode approach to classical and quantum diffraction provides a clear mathematical formalism and is verified by numerical simulations. In addition, I present the work on superconducting qubit and oscillator with time-dependent coupling coefficient, with first order correction with finite qubit energy and schemes based on and π pulses.

A Performer's Guide To Iosif Andriasov's "Concertino For Trumpet", Andrew K. Gerbitz

LSU Doctoral Dissertations

Iosif Andriasov’s Concertino for Trumpet is an excellent candidate for study and assimilation into the standard trumpet repertoire. A significant composer of Armenian descent from the former Soviet Union, Andriasov wrote his Concerto for Trumpet in 1960 and dedicated it to Yuri Usov. Timofei Dokshizer performed it on an album released in 1978 under the Melodya label. After immigrating to the United States in 1979, the composer revised the work and retitled it as Concertino for Trumpet in 1995. IMMA Publishing Company in New York made the revised work commercially available in 2001. This paper is presented to increase awareness …

Paleoenvironmental Reconstruction Using Coral Microatolls (Sp. Siderastrea Siderea) From The Gulf Of Gonâve, Haiti, Gilman Reno Ouellette Jr.

LSU Doctoral Dissertations

Natural and anthropogenic climate changes present unique and serious risks to society. In order to plan and implement adaptation and mitigation strategies successfully, regional manifestations of broad-scale climate changes must be understood robustly. The Caribbean region contains part of the Western Hemisphere Warm Pool (WHWP), a major sea surface temperature (SST) feature that plays a key role in North Atlantic climate. Climate variability in the Caribbean is captured poorly by climate models, due in part to a lack of continuous, multidecadal instrumental climate records from the region. I explored three research questions in this dissertation: Does non-systematic bias exist in …

Electromagnetic Resonant Scattering In Layered Media With Fabrication Errors, Emily Anne Mchenry

LSU Doctoral Dissertations

In certain layered electromagnetic media, one can construct a waveguide that supports a harmonic electromagnetic field at a frequency that is embedded in the continuous spectrum. When the structure is perturbed, this embedded eigenvalue moves into the complex plane and becomes a “complex resonance” frequency. The real and imaginary parts of this complex frequency have physical meaning. They lie behind anomalous scattering behaviors known collectively as “Fano resonance”, and people are interested in tuning them to specific values in optical devices. The mathematics involves spectral theory and analytic perturbation theory and is well understood [16], at least on a theoretical …