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Synthesis, Cellular Studies, And Computational Analysis Of Porphyrin And Bodipy Conjugates With Affinity For Epidermal Growth Factor Receptor, Alecia Michelle Mccall
Synthesis, Cellular Studies, And Computational Analysis Of Porphyrin And Bodipy Conjugates With Affinity For Epidermal Growth Factor Receptor, Alecia Michelle Mccall
LSU Doctoral Dissertations
Chapter 1 is a description of the basic fundamental concepts of porphyrins and BODIPYs, (including synthetic methodologies), a general mechanism of the processes of EGFR, and computational concepts that are elaborated upon in future chapters. Chapter 2 is a discussion solely on the porphyrins that were synthesized to be used as fluorophores for EGFR-targeted conjugates, both peptidic and non-peptidic. The porphyrins were primarily synthesized via the Lindsey method as well as by O-alkylation of tetrahydroxy porphyrins. Synthesis of PEG linkages are discussed as well through three methodologies. Chapter 3 is a presentation of the synthesis, characterization, cellular studies, and computational …
Total Synthesis Of A Virotoxin And Analogs For Conformational Studies, Benson Jumba Edagwa
Total Synthesis Of A Virotoxin And Analogs For Conformational Studies, Benson Jumba Edagwa
LSU Doctoral Dissertations
This dissertation describes the first total synthesis of alloviroidin in trace amounts, along with that of three analogs containing L-proline (Pro), trans-3-hydroxyproline (3-Hyp) or cis-4-hydroxyproline (4-hyp) residue substituting for 2,3-trans-3,4-trans-dihydroxyproline in the natural product. We report herein an efficient strategy that provides a dipeptide containing a (2S,4S)-4,5-dihydroxyleucine (dihyLeu) residue, including a diastereoselective dihydroxylation. Nα-Carbobenzyloxy-(2S)-4,5-dehydroleucine was coupled with valine ethyl ester to give a dipeptide that was subjected to a Sharpless asymmetric dihydroxylation to introduce the diol. The relative configuration at C4 was assigned as S by X-ray crystallography after derivatization as an α-amino-γ-lactone hydrochloride salt. The preparation of the 2-(methylsulfonyl)tryptophan …
Single-Molecule Detection Of Molecular Beacons Generated From Ldr On Thermoplastic Microfluidic Device For Bioanalysis, Zhiyong Peng
Single-Molecule Detection Of Molecular Beacons Generated From Ldr On Thermoplastic Microfluidic Device For Bioanalysis, Zhiyong Peng
LSU Doctoral Dissertations
Current clinical techniques for nucleic acid detection and analysis often involve PCR, lacking adequate specificity or sensitivity to meet the stringent requirements in certain applications. This research aims to develop an innovative molecular assay and the associated hardware to rapidly signal the presence of certain targets using reporter sequence found in their genome without requiring PCR. This assay coupled the sensitivity of single-pair fluorescence resonance energy transfer (spFRET) with the specificity of ligase detection reaction (LDR) to provide near real-time readout of target biomarkers. Heightened concerns on potential bioterrorism threats, such as rapid dissemination of pathogenic bacteria or viruses into …
Preparation And Studies Of Ratiometric Fluorescent Chemosensors Based On The Attenuation Of Excitation Energy Transfer, Jiba Raj Acharya
Preparation And Studies Of Ratiometric Fluorescent Chemosensors Based On The Attenuation Of Excitation Energy Transfer, Jiba Raj Acharya
LSU Doctoral Dissertations
Molecular devices possessing pi-electron conjugated scaffold demonstrate unique capabilities as fluorescent chemosensors for the trace detection of analytes in a variety of environments. Important properties of these compounds such as charge transport and exciton migration, emission intensity etc. can be simply attenuated by external stimuli or analyte binding, leading to considerable changes in observable signals. The main goal of this Ph.D. dissertation was to study the possibility to control excitation energy migration in conjugated systems. Towards this goal, we designed surface-immobilized monodispersed oligo(p-phenylene ethynylene)s (OPEs) as a general basis for thin-film ratiometric fluorescent chemosensors. The sensor molecules have been functionalized …
Synthesis, Biological And Photophysical Studies Of Novel Compounds For Cancer Therapy, Edith Khavwajira Amuhaya
Synthesis, Biological And Photophysical Studies Of Novel Compounds For Cancer Therapy, Edith Khavwajira Amuhaya
LSU Doctoral Dissertations
Cancer remains the second most common cause of death in the United States. It is therefore imperative that a lot of effort be put into finding a cure for this dreadful disease that shows no discrimination, and virtually anybody is at risk of developing the disease. Chapter 1 introduces basic facts about cancer and the available treatments, including PDT and BNCT. Our focus will be on these two bimodal therapies, which form the basis of my research work, which involves the synthesis of potential sensitizers to be used either in PDT or BNCT or both. In Chapter 2, I discuss …
Formation And Stabilization Of Combustion-Generated Environmentally Persistent Free Radicals On Transition Metal Oxides Supported On Silica, Eric Warren Pimentel Vejerano
Formation And Stabilization Of Combustion-Generated Environmentally Persistent Free Radicals On Transition Metal Oxides Supported On Silica, Eric Warren Pimentel Vejerano
LSU Doctoral Dissertations
The formation of environmentally persistent free radicals in combustion system was investigated from chemisorptions of chlorine- and hydroxy-substituted benzenes on transition metal oxide surface under post-combustion conditions. This manuscript reports the formation of EPFRs on silica particles containing 5% Fe(III)2O3, Ni(II)O, and Zn(II)O. The EPFRs are formed by the chemisorption of substituted aromatic molecular adsorbates on the metal cation center followed by electron transfer from the adsorbate to the metal ion at temperatures from 150 to 400 oC. Depending on the nature of the adsorbate and the temperature, two organic EPFRs were formed: a phenoxyl-type radical, which has a lower …
Chemistry Of Rhenium(I) Tricarbonyl Complexes Of Biomedical Relevance, Theshini Perera
Chemistry Of Rhenium(I) Tricarbonyl Complexes Of Biomedical Relevance, Theshini Perera
LSU Doctoral Dissertations
fac-[ReI(CO)3L]n complexes serve as models for short-lived fac-[99mTcI(CO)3L] imaging tracers. Dangling groups on L, needed to achieve desirable biodistribution, complicate the NMR spectra, which are not readily understood. In fac-[ReI(CO)3L]+ with less complicated L, NH groups (exo-NH) projecting toward the L face sometimes showed an upfield shift attributable to steric shielding of the exo-NH group from the solvent by the chelate rings. To investigate whether exo-NH groups in six-membered rings exhibit the same effect and whether the …
Development And Application Of Dissociable Antibody Microarray (Dama) Staining Technique, Guanyuan Fu
Development And Application Of Dissociable Antibody Microarray (Dama) Staining Technique, Guanyuan Fu
LSU Doctoral Dissertations
Dissociable Antibody Microarray (DAMA) staining is a novel technique that integrates protein microarrays with conventional immunostaining techniques. It can simultaneously determine the expression and subcellular localizations (SCLs) of hundreds of proteins in cultured cells. I optimized this technology for protein expression and SCL profiling, and generated expression profile data analysis program DAMAPEP, molecular image database management program ChipView and automatic SCL assignment program DAMASCL. We demonstrated the application of this technique in the identification of potential biomarkers for breast cancer. We compared the expression profiles of 312 proteins among ten breast cell lines and identified 10 differentially expressed proteins. Among …
Bottom Boundary Layer Physics And Sediment Transport Along A Transgressive Sand Body, Ship Shoal, South-Central Louisiana: Implications For Fluvial Sediments And Winter Storms, Daijiro Kobashi
LSU Doctoral Dissertations
Ship Shoal, a shore-parallel sand body, was recently recognized as having a unique physical and biological environment and also as a potential sand resource for coastal restoration in coastal Louisiana. Little is known regarding such dynamics, in concert with fluvial sediments and winter storms, influenced in unique ecosystems, and likely in future potential sand mining. This dissertation addresses such the morphodynamics and sedimentary processes and their implications for the mining from the shoal using field measurements and numerical modeling studies. During the winter-spring season, fluvial sediment plumes shifted from the prevailing west to southeast during the post-frontal phases, resulted in …
Syntheses And Evaluation Of Phthalocyanine Derivatives For Applications In Photodynamic And Boron Neutron Capture Therapies For Cancer, Hairong Li
LSU Doctoral Dissertations
Chapter I introduced the background of phthalocyanines including its physical properties and various synthetic methods of free-base and metallo-phthalocyanines. The background of PDT and BNCT was introduced and the objective of ideal sensitizers was described. Chapter II described the synthesis and characterization of a series of pyridiloxy-substituted zinc phthalocyanines with different length of alkyl groups. Pyridiloxy-substituted silica phthalocyanines bearing different associated axial ligands, were alkylated with methyl or PEG chains. Biological study was performed on these cationic pyridiloxy-substituted zinc phthalocyanines. Chapter III introduced the synthesis and photophysical properties of A3B-type zinc phthalocyanines conjugated with one or two cobalta-carborane cages. They …
Synthesis And Properties Of Isoporphyrins And Related Derivatives For Application In Photodynamic Therapy, Sandra Celinah Mwakwari
Synthesis And Properties Of Isoporphyrins And Related Derivatives For Application In Photodynamic Therapy, Sandra Celinah Mwakwari
LSU Doctoral Dissertations
Isoporphyrins are tautomers of porphyrins with an interrupted macrocyclic conjugation owing to the presence of a sp3 hybridized meso-carbon. Due to their absorption at long wavelengths (~800nm), isoporphyrins are potential candidates as photosensitizers in photodynamic therapy (PDT), a ternary modality of cancer treatment. They are also of biological interest due to their unique redox properties among porphyrin derivatives and could be a new class of near-IR dyes. Isoporphyrins are known to be unstable with respect to transformation back to the fully conjugated porphyrin chromophore except when the meso-carbon is geminally substituted and for this reason a detailed study of this …
Floral Traits, Pollinator Behavior, And Plant Reproduction: Tests Of Natural And Sexual Selection In The Hummingbird-Pollinated Herb Chrysothemis Friedrichsthaliana, Jane Elizabeth Carlson
Floral Traits, Pollinator Behavior, And Plant Reproduction: Tests Of Natural And Sexual Selection In The Hummingbird-Pollinated Herb Chrysothemis Friedrichsthaliana, Jane Elizabeth Carlson
LSU Doctoral Dissertations
Pollinators may promote floral evolution by selectively visiting preferred floral phenotypes. Herbivores may also influence the evolution of floral traits, by reducing the fitness of poorly-defended plants, such as those without protective sepals. In this dissertation, I investigate the reproductive and evolutionary consequences of floral visitors for two floral traits of the Neotropical herb Chrysothemis friedrichsthaliana (Gesneriaceae). I focus on the trait male-biased nectar production, which results from coincident temporal shifts in nectar production rates and sexual function within flowers. First, I review theory relevant to male- and female-biased nectar production, and I generate hypotheses to explain its evolution in …
The Spectral And Photophysical Characterization Of Water Solubilizing Metal Phthalocyanines For Highly Sensitive Detection In Biological Studies, Vera Tamisha Verdree
The Spectral And Photophysical Characterization Of Water Solubilizing Metal Phthalocyanines For Highly Sensitive Detection In Biological Studies, Vera Tamisha Verdree
LSU Doctoral Dissertations
Efforts to improve the technology for DNA analyses stimulated the work presented here to develop a series of fluorescent probes that would aid in the increased multiplexing capabilities allowing the ability to detect multiple targets in a single measurement. Typically, spectral discrimination has been used to identify each DNA fragment in sequencing or diagnostic applications by means of unique emission properties from several labeling dyes. This has been accomplished with labels that fluoresce in the visible region. The limitations with these dyes is the broad emission profile making discrimination difficult, high intrinsic biological fluorescence and structural differences of the dyes …
Syntheseses [Sic] And Evaluation Of Porphyrin Derivatives For Applications In Medicine And In Material Science, Erhong Hao
LSU Doctoral Dissertations
Chapter 1 presents a concise introduction to porphyrins, especially on the synthesis of meso-tetraphenylporphyrins, which were synthesized during the course of my research and were used for further purposes in the following chapters. Chapter 2 describes the synthesis of a series of cobaltacarborane-porphyrin conjugates for the boron neutron capture therapy (BNCT) of tumors. Using an efficient and high yield ring-opening reaction, N-substituted porphyrins were also synthesized. The spectroscopic and structural properties of these compounds are presented. These high percentage boron and amphiphilic compounds are promising boron delivery agents for BNCT (prelimary cellular studies using some of these compounds have been …
Synthesis And Functionalizations Of Tetrapyrrole Derivatives, Lijuan Jiao
Synthesis And Functionalizations Of Tetrapyrrole Derivatives, Lijuan Jiao
LSU Doctoral Dissertations
Chapter 1 of this Dissertation presents a brief overview of the history of tetrapyrrole derivatives and of their fundamental properties. Overviews of porphyrins, benzoporphyrins, chlorins and porphycenes are presented. Work presented in Chapter 2 through Chapter 4 mainly focuses on the syntheses and functionalization of chromophore-extended porphyrin derivatives. Several new synthetic routes for the syntheses and functionalizations of extended porphyrins either at the β-position or at the meso-position of porphyrin are developed. From these improved synthetic routes, the regio-selective syntheses of porphyrin derivatives are described. Chapter 2 mainly focuses on the syntheses of β,β'-fused methylenepropanoporphyrins and related porphyrin dimers. Chapter …
Synthetic Development And Application Of Compounds With Biological Relevance, Jeffery Caleb Clark
Synthetic Development And Application Of Compounds With Biological Relevance, Jeffery Caleb Clark
LSU Doctoral Dissertations
Nature has provided a vast number of compounds that have medicinal application. The use of these compounds provided by nature however, is limited by the amount of a specific compound that nature provides. The synthesis of these molecules and their derivatives provides an even greater number of compounds for biological screening. Various pyrroles, the heterocyclic building blocks of porphyrins, can be prepared synthetically over several steps. The implementation of carboranes on pyrrole rings intrinsically provides substrates that can be converted into porphyrins bearing carborane substituents. The condensation of these carboranylpyrroles with carboranylaldehydes provides carboranylporphyrins bearing a higher order of carborane …
Seasonal Occurrence Of Phyllophaga Species And Biological Studies Of Phyllophage Ephilida (Say) On Sweet Potato, Ipomoea Batatas (L) Lam, In Louisiana, Aboubacar Diagne
Seasonal Occurrence Of Phyllophaga Species And Biological Studies Of Phyllophage Ephilida (Say) On Sweet Potato, Ipomoea Batatas (L) Lam, In Louisiana, Aboubacar Diagne
LSU Doctoral Dissertations
The biology of Phyllophaga ephilida (Say) was studied in Louisiana with both laboratory and field experiments from 1998 through 2003. The seasonal occurrence of common adult Phyllophaga species in sweet potato growing areas was surveyed with blacklight traps. P. ephilida and P. crinita (Burmeister) were the most common species at all locations. The attractiveness of seven methyl esters of L-isoleucine and L-valine blends to P. ephilida males was evaluated in sweet potato fields in 1999 and 2000. The 100% methyl ester of L-isoleucine was significantly more attractive than all other blend ratios that were tested. The life cycle of P. …
Evaluation Of Injury And Management Strategies For Stink Bugs (Heteroptera: Pentatomidae) On Cotton, Gossypium Hirsutum L., Melissa Marie Willrich
Evaluation Of Injury And Management Strategies For Stink Bugs (Heteroptera: Pentatomidae) On Cotton, Gossypium Hirsutum L., Melissa Marie Willrich
LSU Doctoral Dissertations
The effects of brown stink bug, Euschistus servus (Say), and southern green stink bug, Nezara viridula (L.), feeding on pre-flowering, flowering, and senescing cotton, Gossypium hirsutum L., plants were evaluated in field studies. Vegetative stage seedlings and flower buds (squares) were not significantly injured by adults or nymphs of either species in no-choice studies. Brown stink bug adults induced boll abscission, and reduced seedcotton yield and seed germination in bolls accumulating „T 350, „T 550, and 101 to „T 600 heat units beyond anthesis, respectively. In free-choice tests, boll preference was evaluated during each of the initial five weeks of …
Agronomic And Molecular Characterization Of Louisiana Native Spartina Alterniflora Accessions, Alicia Beatriz Ryan
Agronomic And Molecular Characterization Of Louisiana Native Spartina Alterniflora Accessions, Alicia Beatriz Ryan
LSU Doctoral Dissertations
Coastal erosion and wetland deterioration are serious and widespread problems affecting Louisiana’s coastal zone. The application of agronomic and molecular techniques for improving crop species is well documented. However, these have not been routinely applied to species of ecological and environmental value. Spartina alterniflora is used extensively for shoreline protection and tidal marsh restoration because of its aggressive spreading habit and tolerance to salinity. The progress of marsh revegetation projects is limited by the costs and labor associated with vegetative propagation of Spartina. Hence, a breeding program was initiated to develop improved smooth cordgrass accessions with superior seed producing ability …
Genome Analysis: Mutation Analysis Using Near Infrared Laser-Induced Fluorescence (Nir-Lif) And Single Molecule Detection In Microfluidic Devices, Musundi Ben Wabuyele
Genome Analysis: Mutation Analysis Using Near Infrared Laser-Induced Fluorescence (Nir-Lif) And Single Molecule Detection In Microfluidic Devices, Musundi Ben Wabuyele
LSU Doctoral Dissertations
A number of genotyping methods have been developed for mutation analysis, each of which has its own unique advantage. DNA amplification via polymerase chain reaction (PCR) provides an unlimited supply of material for subsequent genetic analysis even in case where only a single copy of the DNA molecule is present in the sample. Research presented in this dissertation first examines the efficiency of in vitro amplification of single copy DNA with subsequent sequencing analysis of PCR product. The PCR products (amplicons) were investigated for possible alteration, distortions or mutations due to the amplification process. The sequencing data for single copy …
Artificial Peptides Containing Ca,A- Disubstituted Amino Acids: Synthesis, Conformational Studies, And Application As Β-Strand Mimics, Yanwen Fu
LSU Doctoral Dissertations
Short peptides containing Cα,α-dipropylglycine (Dpg) at alternating sequence positions were synthesized and examined for conformational behavior. Peptide assembly was performed using Fmoc-solid-phase chemistry where the coupling with PyAOP could be significantly enhanced at elevated temperature. Circular dichroism (CD) and NMR conformational studies revealed that incorporation of Dpg residues induced folded structures into peptides. It was observed that Dpg residues adopted helical conformation in a helix-promoting sequence. The resulting helical structure was comprised of consecutive β-turns whose structure was stabilized by salt bridge in aqueous solution. In this study, the preparation of sterically and polyfunctional Cα,α-disubstituted amino …