Digital Commons Network^™

The Effect Of Cannabinoids And Terpenes On The Activation Of Hmc3 Microglial Cells, Mohamed Marzouk

Honors Theses

Life expectancies of people living with HIV have significantly lengthened due to the availability of antiretroviral therapies. Despite their ability to increase survival, these treatments do not “cure” HIV, nor do the stop the onset of neurological symptoms associated with infection, termed neuroHIV. NeuroHIV describes a myriad of neurological impairments including mood disorders (depression and anxiety), cognitive impairment, neuropathic pain, and motor disinhibition that reduce quality of life for people living with HIV. Mechanistically, the neurological impairments may involve actions of neurotoxic proteins directly produced by the virus. One of these proteins that has been well-characterized is the HIV trans …

All The Rage: Assessing The Age/Rage Signaling Pathway’S Effects On Healthspan And The Physiological Processes Of Aging, Brandon Ashmore

Honors Theses

Advanced glycation end products (AGEs) are protein, lipid, or nucleotide molecules that have been combined with sugars through nonenzymatic, irreversible glycation and oxidation reactions. Their accumulation in the body has been associated with the natural aging process and a wide range of pathologies, including chronic inflammation, sustained oxidative stress, diabetes, neurodegenerative diseases, atherosclerosis, and cancer. Their interaction with the receptor for advanced glycation end products (RAGE) has been linked to several proinflammatory signaling pathways associated with neurotoxicity and vascular lesions. While some research has been done on the possible health benefits of RAGE inhibition to extend lifespan, our study hopes …

Meet Them Where They Are: Investigating The Feasibility And Acceptability Of Artificial Intelligence-Avatar-Delivered Community-Based Psychological First Aid Programming In A University Setting, Sarah Ryann M. Fortner, Joshua Semko, Stefan E. Schulenberg

Honors Theses

The purpose of the current study was to evaluate the acceptability and feasibility of implementing an Artificial Intelligence (AI) avatar to deliver Community-Based Psychological First Aid training (CBPFA) to undergraduate students in a university setting. College students report high stress levels, and chronic stress is associated with negative physical, mental, and academic outcomes. CBPFA may be an effective way for colleges and universities to provide students with psychosocial support; however, traditional models utilize in-person training, which may not be accessible on a large scale. The present study developed a web-based AI-avatar-delivered CBPFA training to provide an alternative training modality. The …

Trauma Informed Teaching Practices For Indigenous Children, Raegan Gourley

Honors Theses

This thesis aims to introduce educators to trauma-informed teaching practices for Indigenous children. Due to generational trauma, adultification, and other issues Indigenous children face, it is imperative to find strategies that educators can use to combat trauma-based behaviors that take place in the classroom. While there is a lot of research on the generational trauma that Indigenous children face, there is no connection to having it manifest in the classroom. Through a review of interviews, literature, and research, it was found that practices like restorative justice, Applied Behavioral Analysis, and activities like the Blanket Exercise by Kairos are all trauma-informed …

"Beowulf": Interpretation And Supplementation, Abigail Martin

Honors Theses

This thesis investigates the various ways in which Beowulf has been interpreted across time, explaining how factors, called paratexts, have played a large part in shaping these interpretations and how, especially in reading the Beowulf manuscript, we inherit the sum of these influences. In order to demonstrate this, I present a variety of arguments and perspectives on the text that have been developed by scholars over the years based on different types of paratexts (physical, intangible, and translational) in the absence of a known author. At each stage of Beowulf’s life, there have been opportunities for individuals with authority …

The Greek Advantage: Implications Of Greek Affiliation On Student Government At The University Of Mississippi, Lila Osman

Honors Theses

Greek life is a prominent group at the University of Mississippi, especially when it comes to membership in the Associated Student Body (ASB). ASB is the student governing body at the University so it is important to analyze its membership to understand how reflective it is of the entire university campus it represents. This research answers the question: “How and to what extent does Greek affiliation affect candidates for student government at the University of Mississippi?” Through two mixed methods surveys, one sent to members elected to ASB in the spring 2022 election cycle and the other to the general …

Examining The Relationship Between Misophonia And Depression, Mary Bishop

Honors Theses

Because research on misophonia is in its early stages, few studies have examined correlations with other disorders. Misophonia has been shown to co-occur with a variety of anxiety-related and mood disorders. Understanding the link between depression and misophonia is important because both disorders contribute to significant impairment in daily work, social, and role functioning. This study aims to examine the relation between misophonia and depression in a community sample, which would expand knowledge demonstrated by previous studies using clinical and college samples. We hypothesized that misophonia and depression would have a positive correlation and that women would experience higher levels …

De Novo Design Of Artificial Cu Peptide For Substrate Oxidation And An Electrochemical Approach To Determine Reorganization Energy, Morgan Murphy

Honors Theses

Copper enzymes are found in nature. Their mechanisms and properties are unknown, as spectroscopy is limited. By creating artificially designed copper peptides through de novo design, the behavior, characteristics, and spectroscopy of copper enzymes can be studied to enhance understanding of the mechanisms involved with enzyme catalysis. Design, synthesis, purification, and characterization are completed to create a quality peptide mutant that can be studied to learn about natural enzymes. This plays an important role in pharmaceutical research, renewable energy sourcing, and studies of biological processes in the body. In this study, 3SCC de novo peptide is mutated at different positions, …

Determining The Effect Of Cuff Deflation On Post-Exercise Arterial Occlusion Pressure, John Benton

Honors Theses

While it is recommended that blood flow restriction be applied relative to pre-exercise arterial occlusion pressure (AOP), no guidelines exist for an initial rest period prior to the measurement. Remeasuring AOP post-exercise can be used to estimate the cardiovascular response. When measuring post-exercise (pre-) AOP, different methods could be used. Some increase the cuff pressure from blood flow restriction exercise pressure (without deflation), or deflate the cuff prior to post-exercise (post-) AOP measurement. It is unknown if pre-AOP is affected by initial rest period, or if post- AOP is affected by cuff deflation. Thus, the purpose of this study was …

Influences Of Post-Fledging Protein Supplementation On Growth And Reactive Stress Response In Zebra Finches (Taeniopygia Castanotis), Gabrielle Morris, Mary Lindley Tharp

Honors Theses

Protein needs of non-poultry birds, like Zebra Finches (ZF) are understudied. ZFs consume proteinaceous half-ripe seeds during breeding and chicken eggs are recommended supplements for captive ZFs; but developmental needs are unclear. Eggs contain essential amino acids that impact the “stress” hormone, corticosterone (CORT). Diet and corticosterone influence avian growth and stress management. Juvenile egg-fed ZFs outgrow seed-fed birds. Juvenile egg-supplementation boosts adult male attractiveness due to cheek patch augmentation compared to seed-only birds. Across studies, timing of diet (nestling Vs. fledgling) varies, both sexes have not been included, and simultaneous measures of growth and corticosterone are lacking. We are …

Prescription Drug Misuse Among Graduate Students: Prevalence And Links To Mental Health And Academic Burnout, Madison De Gruiter

Honors Theses

The aims of this study are to examine the prevalence of prescription drug misuse (PDM) among doctoral students and assess associations between PDM and anxiety and burnout in this population. Additional analyses analyzed differential associations by doctoral degree type (i.e., research versus professional programs). A sample of doctoral students (n=131) affiliated with the University of Mississippi participated in an anonymous survey to assess research aims.

The Design Estimate Of A Warehouse Refrigeration System, Jackson Dear

Honors Theses

The intention of this project was to provide a design and cost estimate for the refrigeration systems within an industrial cold storage distribution center for Magnolia Country Frozen Foods, Inc. in East Rutherford, NJ. The facility includes eighteen 300,000 ft3 units (200 ft x 100 ft x 15 ft). These units require 200 tons of refrigeration at a maintained temperature of 0oF. This project's scope included choosing an optimal refrigeration system, selecting a refrigerant for use within the system, and providing a cost estimate for the purchase of the refrigeration system equipment and for the yearly cost associated with running …

Examining The Influence Of Training On An Event-Based Prospective Memory Task In 3-Year-Olds, Emeri Rose Nosal

Honors Theses

Given the significance of prospective memory (PM) throughout an individual’s lifespan, PM has gained great momentum as a topic of research. Surprisingly, less studies have examined PM in children than adults despite the fact that cognitive abilities are developing during this time. Performance in event-based PM tasks has been shown to be poor in preschoolers and particularly weak in 3-year-olds. Previous studies of event-based PM tasks have included manipulations such as cues and incentives to aid in performance. In this study, I examined another potential manipulation to aid in PM performance not previously examined in literature: training. To assess whether …

The Effects Of Acute Exercise On Memory: Considerations Of The Testing Effect, Philip Christian

Honors Theses

This study had three main objectives. The first objective was to determine whether or not there was evidence of a testing effect being present when a short-term memory assessment is included along with a long-term memory assessment. The second objective was to determine whether acute exercise can improve long-term memory recall over a control condition. The third objective was to determine if the potential effects of acute exercise on long-term memory are confounded by the inclusion of a short-term memory assessment. Participants were 54 undergraduate students at the University of Mississippi, with an age range of 18-22 years old. Participants …

Identification Of Signal Transducers In Plant Shoot Gravitropism Using Genetic Screens, Lilla Reed

Honors Theses

Gravitropism is an essential response for plant growth and architecture. The signal transduction pathway that links gravity sensing to gravity response remains unclear because the key signal transducers involved in this pathway are unknown. In this project, we applied an artificial microRNA(amiRNA)-assisted genetic screen in isolating mutants displaying altered gravitropic phenotype in the darkness. Two amiRNA lines showed a significantly decreased gravitropic phenotype in the hypocotyl, and amiRNAs in these lines were identified to target a hypothetical transmembrane protein and a receptor kinase, respectively. Further experiments need to be done to confirm their phenotypes and establish them as signal transducers …

What Happens When A Company's Marketing Strategy No Longer Mirrors The Shopping Trends Of The American Consumer: A Case Study Of Sears, Roebuck And Company, Savannah Burnett

Honors Theses

Once America’s largest mass merchandiser, Sears is a name that remains recognizable for many people. Throughout our country’s history, the U.S. retail industry has often shifted alongside its country’s major historical events. However, one major corporation who once mirrored the ebbs and flows of the United States economy slowly faded out of the minds of the American consumer. This thesis seeks to answer if Sears’ fall from grace was a direct reflection of American consumer trends.

Secondary data was gathered through books accessed from the university library, newspaper articles, scholarly journals, and online news sources, as well as the company’s …

Synthesis Of Salvimadol Analogues For The Studies Of Pain, Anxiety, And Depression, Seth Mccaughan

Honors Theses

From 2001 to 2013, worldwide prescriptions of opioids more than doubled from around 3 billion daily opioid doses per year to 7 billion due to major shifts in pain management culture and attitude.¹ This surge in opioid prescriptions brought quick pain relief to patients, but it also brought new challenges, such as nonmedical opioid use, opioid use disorders, and overdose deaths.² In 2015, 33,091 of the 52,404 drug overdose deaths were contributed to opioids, and in 2013, the cost of opioid overdose and addiction was estimated to be $78 billion in economic burden.^3,4 The social and economic …

Functional And Location Context Effects On Reading Sentences In Healthy Young Adults: Evidence From Eye Tracking Methods, Elizabeth Baird

Honors Theses

Spreading activation theory proves the way our brains are semantically wired to accept outside information and understand it. Previous studies have demonstrated the effects of spreading activation theory in different settings and activities. These effects are important to understand because they can be used in therapy and assessment for communication disorders. This study explores how the context of sentences affects reading time on noun targets in healthy young adults using an eye tracking method. Specifically, we compared functional and location context types and manipulated the context to be incongruent or congruent to the targets. Our research questions were (1) whether …

The Auditory Radiations And Migraines: A Diffusion Tensor Imaging Study, Eva Kiparizoska

Honors Theses

Previous literature shows that there is a known correlation between the presence of migraines and hearing loss. The purpose of the current study was to better understand how a history of migraines can affect the integrity of the auditory radiations and the increased risk of hearing loss in individuals with migraine history. We used Diffusion Tensor Imaging (DTI) in order to examine the effect of a history of migraines on the auditory radiation systems in the brain. The DTI neuroimaging data was collected from the Nathan Kline Institute-Rockland Sample, and participants’ demographics closely paralleled the United States demographic distributions. Our …

Kindness Without Barriers: An Investigation Of The Benefits Of Social Organizations For Students With Disabilities, Abby Newton

Honors Theses

While legislation such as the Americans with Disabilities Act of 1990 and the reauthorized Individuals with Disabilities Education Act of 2004 (IDEA) has made monumental progress in education for individuals with disabilities, there is still an evident need for increased accessibility and equity of opportunity within the K-12 environment. IDEA guarantees students with disabilities will receive a Free Appropriate Public Education, but this law does not include discussion on the evolving barriers to social participation students with disabilities often face, and sequentially, the impact this has on one’s learning environment. This report will examine the benefits of extracurricular activities for …

The Association Between Sleep And Relationship Quality Among Undergraduate Students, Catherine Smith

Honors Theses

This study sought out to examine the association between sleep and relationship quality in undergraduate student populations. Attending university is a novel experience for emerging adults but is subsequently associated with increased sleep difficulties and increased exposure to various social relationships. Indeed, the literature suggests social relationships can influence sleep in all populations, but few have explored relationship quality in the context of conflict and support in undergraduates. The quality of different social relationships (romantic, family, and friend), the severity of insomnia symptoms, and length of sleep duration were investigated. The current study collected data from a sample of ten …

Ms. Eep's Compass: A Hope-Filled Story Inspired By A Trauma-Informed Teaching Framework, Sadie Stocks

Honors Theses

This thesis examines the literature on childhood trauma, its manifestations in the classroom, and effective trauma-informed teaching practices. The literature indicates the widespread prevalence of Adverse Childhood Experiences (ACEs) and the consequences these experiences have on both the developing brains of children and future health risks. While drawing the correlation of this widespread trauma to its common manifestations in the classroom, Maslow’s Hierarchy of Needs further justifies the indispensable link of safety preceding learning. Trauma-Informed teaching practices include environmental considerations like safety, the value of relationship building, a strengths-based guided classroom, models of self-regulation, developmentally appropriate practice, and an emphasis …

Effects Of Group Ii Metal Binding On The Stability Of Dna I-Motif Structures, Charlotte Powers

Honors Theses

B-form DNA can adopt alternative structures while in superhelical duress. Alternative DNA structures are favored when there is an asymmetric distribution on complementary DNA strands. Cytosine rich strands may utilize cytosine-cytosine base pairing to form a four-stranded structure known as the i-motif (iM). The stability of iMs is affected by several factors such as DNA sequence, temperature, pH, ionic strength of the solution, and crowded conditions. While the effects of temperature, pH, and crowding conditions on iM stability have been well documented, the effects of ion presence in a solution has been less studied. Hence, those studies are the basis …

Anticoagulant And Anti-Sars-Cov-2 Effects Of Botryocladia Occidentalis Sulfated Glycans, Reena Thara

Honors Theses

Marine algal species are composed of various macromolecules endowed with potential biological actions, such as carbohydrates. Sugars are complex in nature with a multitude of monosaccharides constructed into polymers. We call complex carbohydrate polysaccharides those of great structural variation. The sulfation pattern adds to their complexity, creating scientific interest in the aquatic organisms from which these molecules can be extracted. Sulfated polysaccharides are now increasingly studied for their potential biological properties as anticoagulants and as antivirals. Heparin is a naturally occurring sugar in the human body that is necessary for proper anticoagulation. Many people today suffer from a dysfunctional coagulation …

The Great Transition: A Qualitative Examination Of The Transition From Pharmacy Student To Pharmacist, Jessica Marlee Wilson

Honors Theses

Background: Over the years, community pharmacy practice has expanded and increased the number of responsibilities pharmacists must manage. Tasks such as managing the pharmacy, counseling patients, and administering vaccines are among the duties that pharmacists must carry out. The recent Covid-19 pandemic placed a significant strain on the retail pharmacy work environment and acted as an obstacle to the jobs of community pharmacists. Recent pharmacy graduates are often thrown into this variable work environment, and it seems that there is limited literature regarding the preparedness that they feel in this area of pharmacy work.

Objectives: To uncover the level of …

The New Teacher Of Ideas: A Study On Social Media, Political Influencers, And Generation Z, Brenley Rinaudo

Honors Theses

The current study focuses on members of Generation Z and where they learn about politics and receive political news. Different than previous generations, Generation Z receives news on social media more than on traditional media platforms (Murmuration, 2023). Politicians must quickly begin to understand how to engage and connect with the next generation of voters on these social media platforms. For these reasons, this study surveyed members of Generation Z at The University of Mississippi. Current University of Mississippi students are members of Generation Z and reflect common trends among this Generation, such as constant usage of social media. This …

Southern Sustainability: An Examination Of Waste Management Mechanisms Within The University Of Mississippi Community, Haley Clift

Honors Theses

The purpose of this thesis is to analyze and study local mechanisms surrounding waste management at The University of Mississippi. The research study gathers quantitative and qualitative research to make conclusions about sustainability and recycling practices on The University of Mississippi's campus. The thesis discusses whether those practices are effective for those in The University of Mississippi's community based on the data collected and research conducted. The researcher also offers proposals for the University of Mississippi community based on the research conducted.

The gap that exists in the waste management processes at The University of Mississippi was addressed by blending …

Tourism's Power To Promote Peacebuilding In Post-Conflict Societies - A Northern Ireland Case Study, Margaret Walker

Honors Theses

This thesis explores the capacity of tourism to promote peacebuilding in post-conflict societies, specifically focusing on Northern Ireland. This study assesses the current state of conflict tourism in Northern Ireland by analyzing two tourist sites and considering variables that may impact peacebuilding in the greater Northern Ireland community. It measures the success of the Northern Ireland approach by comparing the effects of tourism in other post-conflict and conflict societies. This study culminates with the presentation of certain strategies that Northern Ireland should implement to positively impact peacebuilding through tourism. Curators must portray history in a balanced, sensitive manner that avoids …

The Adventures Of A Right-Handed Debitor, James Aubrey Christian

Honors Theses

The Accounting Capstone is designed to force accounting students to think through problems in the accounting industry. This will be accomplished by working through a series of case studies dealing with several areas of financial reporting. After selecting the group’s focus area, my group and I presented a case study regarding tax recommendations for Goldman Sachs.

Links Between Mental Health And Employment Outcomes Among Adults With Autism Spectrum Disorder, Emma Atkinson

Honors Theses

Problem: Mental health outcomes related to Autism Spectrum Disorder (ASD) have been extensively researched, although most research in the area is on children with ASD. Studies on adults with ASD are scarcer. More specifically, studies that analyze the association between mental health and work-life balance (WLB) as well as mental health and job satisfaction (JS) among employed adults with ASD is limited. The purpose of this study was to analyze the association between mental health and WLB among adults with ASD, the association between mental health and perceived JS among adults with ASD, and whether or not ASD severity moderates …