Digital Commons Network^™

La Pma Pour Toutes : Comment L'Histoire Et La Société Façonnent La Médecine Et La Bioéthique En France, Lauren A. Ruddy

Honors Theses

La diversification des configurations familiales continue à susciter de vifs débats en France, où il existe encore une sorte d’intolérance à l’égard de ceux qui sortent du modèle « traditionnel » de la famille. Ces dernières années, le développement des techniques de procréation médicalement assistée (PMA) est devenu le sujet d’une forte controverse. Plus spécifiquement, la question de l’accès à la PMA pour des mères « non-normatives » telles que des femmes lesbiennes, célibataires et âgées est d’un intérêt particulier. Jusqu’à maintenant, la discussion sur le droit d’accéder à ces procédures se concentre principalement sur les barrières biologiques, éthiques et …

Identifying Metabolites As Markers Of Fatigue In Athletes, Christopher D. George

Honors Theses

Fatigue in athletes caused by inadequate rest and other stressors can be severely detrimental to their health, and yet there is no reliable way to measure and track fatigue. Many classical measures of fatigue like body mass and resting heart rate are not reliable ways to track the physical fatigue of an athlete because they can change with many factors. In addition, it is not known how academic stress on top of physical stress affects fatigue. Metabolomics is a relatively new area of study and tracking metabolites offers the possibility to produce biomarkers to assess fatigue. This study collected saliva …

The Impact Of Climate Change On The Migration Phenology Of New England’S Anadromous River Herring And American Shad, Charles K. Cobb

Honors Theses

Anadromous fish play important roles in food webs and nutrient cycling in both aquatic and marine ecosystems. As a result of climate change however, anadromous fish’s migration timing has begun to change, with potentially deleterious consequences to both anadromous fish, and the species that depend on them. Western coastal US studies have linked earlier anadromous fish returns to warming marine temperatures and changes in river flow regimes, but the exact temperatures thresholds that anadromous fish respond to, and the relative importance of temperatures and river flows, remain somewhat unknown. Additionally, there has been relatively little research on anadromous fish phenology …

Measuring Differential Forest Growth In The Sheepscot River Headwaters With Bitemporal Lidar, Soren Denlinger

Honors Theses

In recent years, lidar has proven itself as a forestry tool capable of accurate, large- scale inventories. Lidar has even shown utility in multitemporal analysis and growth assessment, given high-resolution or small-scale point clouds. However, lidar’s efficacy as a multitemporal tool with relatively low-resolution, large-scale datasets is comparatively unknown. In this study, I compared forest in Midcoast Maine bitemporally, with publicly available datasets from the years 2007 and 2012. Specifically, I compared differences in growth characteristics of riparian, wetland, and upland forests. Although the 2007 dataset (created for geomorphological research) and the 2012 dataset (statewide, general-purpose) possess varying point densities …

Projecting Regions Of North Atlantic Right Whale, Eubalaena Glacialis, Habitat Suitability In The Gulf Of Maine In 2050, Camille Ross

Honors Theses

North Atlantic right whales (Eubalaena glacialis) are endangered. Understanding the role environmental conditions play in habitat suitability is key to determining the regions in need of protection for conservation of the species, particularly as climate change shifts suitable habitat. This thesis uses three species distribution modeling algorithms, together with historical data on whale abundance(1993 to 2009) and environmental covariates to build monthly ensemble models of past E. glacialis habitat suitability in the Gulf of Maine. Then, the models are projected onto the year 2050 for a range of climate scenarios. Specifically, the distribution of the species was modeled …

The “Humanitarian Mystique:” Tracing The Rhetoric And Politics Of Aid In Southeast Asia From The Age Of The Civilizing Mission To The Present, Elizabeth M. Holland

Honors Theses

In contemporary Western popular culture, humanitarian action often serves as the ultimate expression of altruism, compassion, and moral obligation. This research historicizes humanitarianism to understand the assumptions that underlie its affective appeal. Oversimplified narratives of aid work frequently fail to acknowledge the historical and geopolitical context in which this work occurs. I argue that humanitarianism, as both a discursive tool and code of practice, makes visible some legacies of the ‘civilizing mission’ – the ideology used to justify colonialism in the late nineteenth and early twentieth centuries. An exercise in comparative history, this research consists of three spatially and temporally …

Development And Validation Of Gene Delivery Methods For ​Crassostrea Virginica, Adrienne N. Tracy

Honors Theses

The Eastern oyster (Crassostrea virginica) is an important part of the East Coastal USA economy because aquaculture creates jobs. Sadly, the oysters are under constant threat due to increasing pollution, red tides, and diseases. Bivalves, and oysters in particular, are also becoming potential model organisms in medical research. With the sequencing of the oyster genome, scientists are focusing on deciphering the function of the predicted genes. However, the limited number of molecular and cellular tools available makes functional annotation of the genome challenging. A consistent, replicable gene delivery system needs to be developed to assess gene function and understand the …

"They Shall Be A Kosmos:" Alexander Von Humboldt And The Ecopoetics Of Walt Whitman, Benjamin Theyerl

Honors Theses

Places the naturalist Alexander Von Humboldt's proto-ecological ideas in conversation with Walt Whitman's poetry to show how the poet developed an ecopoetics in conversation with the natural sciences of his time, with specific attention to Von Humboldt's theory of the "kosmos" - by which Whitman's poetic persona self-identified. These recognitions are combined with how Whitman's idealized version of the American poet as a “kosmos” creates a political ecology in Whitman’s work, placing his ecopoetics into environmental discourses that resonate from their origin in the nineteenth century to our present ecological moment today.

How Race, Socioeconomic Status, And Gender Shape Feelings Of Competition Within The Pre-Med Department At A Small Liberal Arts College, Amanda B. Deming

Honors Theses

This study aims to understand how students of color navigate feelings of competition in the pre-medical (“pre-med”) track at a small liberal arts college. I argue that there are differences in navigational strategies by race, socioeconomic status (SES), and gender. Respondents in my sample (9 women and 6 men) were interviewed for 30 to 60 minutes about their relationships with fellow pre-med students, mentors, alumni, advisors, and professors. The primary findings of this project were that students who are more competitive dominate the culture among pre-med students; less competitive individuals persist through the pre-med track by forming study groups with …

Assessing A Two-Hit Model Of Schizophrenia: Prenatal Choline Deficiency And Induced Hypofunction Of Nmda Receptors In Male And Female Long Evans Rats, Samuel Gray, Samuel W. Gray

Honors Theses

Choline is an essential dietary nutrient essential to the development and function of the central nervous system. Prenatal choline deficiency alters hippocampal development as well as acetylcholine metabolism, leading to cognitive impairments and attentional and sensory processing deficits into adulthood. MK-801 is an NMDA receptor antagonist frequently used in rodent models of neuropsychiatric conditions, particularly schizophrenia. Acutely and sub- chronically, it causes hyperlocomotion and social withdrawal. One primary goal of the present study were to investigate prenatal choline deficiency induces a biological vulnerability to the motor deficits, anhedonia, and social impairment precipitated by low-dose sub-chronic MK-801 administration in adulthood. Another …

Executive Function Deficit As A Precursor To Memory Impairments In Hapoe4 Transgenic Rats, Kaitlin Mcmanus

Honors Theses

The hApoE4 allele is one of the strongest genetic risk factors for Alzheimer’s disease (AD). It underlies amyloid-bdeposits and neurofibrillary tangles, the two hallmarks associated with AD pathology, and is subsequently associated with AD symptomology. Despite its importance, no rat animal studies to date use hApoE4 knock-ins. In addition to this deficit in the field of AD literature, the vast majority of AD studies focus on memory, even though executive function deficits may precede memory impairments in AD, and may be a predictor of AD development. Thus, the present study addressed these gaps in AD research by investigating the behavioral …

Nanoparticles As Alternative Ceramic Glaze Colorants, Nathan Dinh

Honors Theses

Metallic nanoparticles, including gold and silver, have been used in wide-ranging applications due to their versatile characteristics. These include catalysis, biosensing, imaging, cancer treatments, and art. Due to the phenomenon called surface plasmon resonance, metallic particles change optical properties when sized in the nanoscale based on their composition, shape, diameters, or aspect ratios. In study, these robust nanoparticle systems are applied as an alternative to traditional bulk metal colorants in ceramic glazes.

In this study, the research goals are two-fold: to understand firing mechanism on the gold nanoparticle size and to develop these processes for wider use by regular artisans. …

The Long Arm Of Medicine: Creation Of The Turkish Medical Infrastructure, Legitimacy, Governmentality, And The Rockefeller Foundation, Eric Bossert

Honors Theses

During the early Turkish Republic, a goal of the new government was to set up systems that would help develop the country. One of these systems was their medical infrastructure which included medical education, public health, and hospitals. Ever suspicious of foreign investment since the events leading to the decline of the Ottoman Empire, the Turkish government decided to employ the help of the American aid organization, the Rockefeller Foundation because of their seeming lack of imperialistic goals. Turkish government and the Rockefeller Foundation sought to further their aims through cooperation. The Turkish government sought to gain legitimacy for its …

Identification Of Odorant Receptor Genes In The Antennal Transcriptome Of The Common Eastern Fireflies, Photinus Pyralis, Hanh Tran

Honors Theses

The insect odorant receptor, OR, gene family has been hypothesized to play a critical role in reproduction. Odorant receptor proteins, located on the olfactory sensory neuronal dendrites, detect odorant chemicals such as pheromones and then mediate key behaviors such as mate choice. Although olfaction is known to play a predominant role in sexual communication, there are still large numbers of olfactory genes that have not been studied in many insect species including fireflies. In this study, I investigated the sequencing data of one of the common eastern fireflies, Photinus pyralis (Coleoptera: Lampyridae). This firefly species is well known for their …

On The Question Of Thinking: A Study Of Heidegger's Later Philosophy, Shishir Budha

Honors Theses

This thesis explores the writings of the 20th-century German philosopher Martin Heidegger to understand what “thinking” is and how thinking needs to be undertaken. I examine Heidegger’s commitments to phenomenology in his early writings, his revaluation of the meaning of truth in traditional Western metaphysics, his criticism of calculative thinking and scientific rationality, his diagnosis of the human alienation and homelessness, and his evocation of the redemptive power of art and poetry through which we can find our place in the world. By questioning through all these themes, I attempt to trace Heidegger’s path towards a deeper and more original …

To Be Human, Layla S. Gordon

Honors Theses

I write in an attempt to convey the way I perceive the world and my place in it. I am not separate from the natural world but, as a human, deeply part of it. I want my readers to feel how, as much as any other species, our history and existence are part of the Earth. Sometimes in the built environment, especially large cities, I lose my connection to my roots and to my own person. In writing, I reclaim that connection and hope to restore it for my audience. Every human behavior is either conditioned or evolutionary. Either we …

Crystalline Architecture And Stratigraphy Of Coral Skeletal Density Banding: A Geobiological Record Of Changing Coral Reef Ecology, Kyle Fouke

Honors Theses

Coral skeletal density banding (CSDB), composed of alternating high density band (HDB) and low density band (LDB) layers that comprise the CaCO₃ (aragonite) skeleton of scleractinian corals, are used as chronometers for global paleoclimatic reconstructions of sea surface temperature (SST). Scleractinian coral skeletons have been intensively studied for centuries with detail analysis of the macro- and microscale skeletal structure to establish taxonomic and evolutionary relationships of coral species, mechanisms of biomineralization, and seafloor physical, chemical and biological alteration (diagenesis) of the skeleton. This study is the first to determine the crystalline architecture of HDBs and CSDB stratigraphic …

The Theology Of John Donne's Body Politic, Carolyn P. Marino

Honors Theses

This thesis investigates John Donne’s body/soul dialectic, and discusses how this relationship extends towards both the individuated and communal body. The first chapter grounds Donne’s “Songs and Sonnets” in theology through his facilitation of the Platonic Ladder and the Great Chain of Being. It also gestures towards a shift in Donne’s poetry from subjectivity to intersubjectivity. Finally, it discusses Donne’s commissioned elegies, interrogating Renaissance ideas about the gendered soul, and expounding upon the impact of one person’s death on the communal body. The second chapter historically contextualizes ideas of martyrdom, suicide, and Donne’s term “self-homicide.” It discusses the content of …

Evaluating A Culprit: A Review Of The Biochemical Mechanisms Of Non-Celiac Gluten Intolerance, Callie Cinque

Honors Theses

Non-Celiac Gluten Intolerance (NCGI) has evaded biological and chemical mechanisms since it was first reported in 1978. Celiac Disease, a multi-system immune mediated disorder has long served as the most similar counterpart to NCGI. Less cases of celiac disease are going undiagnosed reflecting an improvement on sensitive and decisive diagnostic tools. However, NCGI has been significantly growing as a diagnosis over the past decade with little match or similarity to the markers found in celiac disease patients. Critical evaluation of NCGI theories, experimentation, and existing hypotheses is necessary. This review seeks to synthesize multiple disciplines of gluten research and enhance …

The Influence Of Flooding On Macroinvertebrate Diversity Of The James River Rock Pools, Meghan Leber

Honors Theses

Biodiversity within an ecosystem can be greatly influenced by environmental disturbances, such as fires, flooding, or other extreme events. Studying the effects of these disturbances on species diversity can be complicated though, due to difficulties tracking species-level responses and isolating the effects of disturbances. Model systems in community ecology, such as rock pools, are a beneficial way to scale down the study of disturbances in discrete communities without losing the ability to analyze important influences or interactions. In this study, macroinvertebrates within the James River rock pools were surveyed to investigate seasonal and annual differences in species richness and diversity, …

Storytelling For Fundraising: Assessing The Impact Of Personal Stories On Donation Behavior, Kate A. Mccarthy

Honors Theses

In fundraising, some nonprofits have sought to channel the power of personal stories by including them in appeal letters. Are stories an effective tool in soliciting donations? In this study, participants read one of three appeals from an unnamed abortion fund. Two conditions contained a personal story, either an “unapologetic” or a “uncontroversial” narrative, about a woman who underwent an abortion; one condition did not include a story. Participants were then asked questions regarding the appeal and the organization before being given a “bonus” dollar, and offered the option of donating a portion of that to an abortion fund. Results …

Design Of New Ruthenium Complexes For Photoactivated Chemotherapy, Lindsey Paul

Honors Theses

Photoactivated chemotherapy (PACT) offers a targeted approach to cancer treatment through selective drug activation. Substitutionally labile ruthenium-based prodrugs undergo ligand-loss when irradiated, producing an unbound ligand and a Ru-aqua complex. We report the synthesis and cytotoxicity of several new ruthenium-centered complexes and their irradiation products for use in PACT. A series of complexes were synthesized in order to study the effects of structural differences on cell viability. Cell viability was tested on T47D human breast cancer cells in the presence of compound to determine cytotoxicity and dose-response. While neither the Rucomplexes nor their ligands demonstrated cytotoxicity, their Ru-aqua dissociation complexes …

“Put Your Phone Down, And Say Hi!” Cultivating Positivity Resonance At Ur, Natalie Szumel

Honors Theses

The goal of this study is to advance our understanding of outcomes related to experiencing positivity resonance and additionally to examine the role of technology as a potential barrier to experiencing positivity resonance (PR). I expect to see positivity resonance associated with physical, psychological, and social well-being, while phone use will predict lower levels of positivity resonance.

This study is unique because it focuses on a college campus population and analyses how their well-being is affected by their social behaviors. This study is especially important for a campus like UR given how segregated and exclusive the student population has become, …

Application Of Β-Chloroenals: One-Pot Syntheses To Create Highly Variable, Functional, And Biologically Interesting Molecules, Julia Powell Siewert

Honors Theses

Pyrroles and pyrazoles are privileged structures which provide a molecular framework found in many different classes of bioactive compounds, thus rendering their syntheses useful in pharmaceutical drug development. Additionally, being able to selectively create these molecules with interesting substituents allows for different pharmacological and biological activities, such as antitumor and antibiotic effects. Our group has used β-chloroenals in the application of many different unique synthetic strategies in the past, and here I show that chloroenals can be used to synthesize novel 1,2,5 trisubstituted pyrroles as well as 1,5 di- and 1,4,5 trisubstituted pyrazoles in fewer steps and with milder conditions …

Biasing Medial Axis Rapidly-Exploring Random Trees With Safe Hyperspheres, David Qin

Honors Theses

Motion planning is a challenging and widely researched problem in robotics. Motion planning algorithms aim to not only nd unobstructed paths, but also to construct paths with certain qualities, such as maximally avoiding obstacles to improve path safety. One such solution is a Rapidly-Exploring Random Tree (RRT) variant called Medial Axis RRT that generates the safest possible paths, but does so slowly. This paper introduces a RRT variant called Medial Axis Ball RRT (MABallRRT) that uses the concept of clearance -- a robot's distance from its nearest obstacle -- to efficiently construct a roadmap with safe paths. The safety of …

The Effects Of Signaling Molecules To Agrobacterium Tumefaciens Tumorigenesis At Plant Wound Sites, Nicole Walker

Honors Theses

Agrobacterium tumefaciens can live independently within soil before infecting its host (McCullen and Binns, 2006). The bacterium infects the plant through the rhizosphere, an area of soil along the plant root surface which contains microorganisms, making up the “external metabolome” (Bais et al. 2006). As these bacteria live in the rhizosphere, they are exposed to a multitude of chemical signals. These chemical signals include several conditions that must be met before the virulence machinery is expressed. These conditions include signaling from phenols and sugars as well as low PO4 levels and low pH. Upon wounding, sugars and phenols are released …

Variability In Antibacterial Activity In The Caribbean Sponge Amphimedon Compressa, Mackenzie Reilly

Honors Theses

Coral reefs are essential ecosystems that provide an abundance of natural resources. Sponges, common reef inhabitants, produce a diversity of secondary metabolites that are known to serve as chemical defenses. Secondary metabolites often have ecological functions, such as antipredator and antibacterial activities. I studied the common Caribbean sponge species, Amphimedon compressa, which is known to be chemically defended. Samples were collected from three sites in Belize, two sites in Grand Cayman, and three sites in St. Croix, U.S. Virgin Islands. To determine whether antibacterial activity varied across broad or local geographic scales, sponge extracts were tested against four bacterial strains …

Microfiber Concentrations In Sand From Nesting Sea Turtle Beaches In Costa Rica, South Carolina, And Florida., Kaylin Leroy, George Boneillo

Honors Theses

Microplastics are an increasing threat to marine environments and the organisms that inhabit them. Since plastic pollution in the ocean is prominent throughout the globe, microplastic is washing ashore, affecting important sea turtle nesting sites. This study quantified microfibers in the sand of various sea turtle nesting sites around the world. Sand samples were collected in Myrtle Beach (South Carolina), Destin (Florida) and the Pacuare Reserve (Costa Rica). The microfibers were retrieved using a super saline solution and then filtered under a hood. Filters were then counted using microscopy. Microfibers were found at every sampling site, with the lowest surface …

Predation Effects On Mid-Marsh Ribbed Mussel Mortality, Cluster Size, And Facilitation Of Cordgrass Growth, Colten Winter, Keith Walters

Honors Theses

Reciprocal facilitation between Geukensia demissa, ribbed mussels, and Sporobolus alterniflorus, cordgrass, has a positive effect on salt marsh ecosystems. Mussel clusters enhance cordgrass growth and drought resistance and cordgrass provides attachment and shade for mussel aggregations. Along with benefits for both mussels and cordgrass, the mutualism facilitates increased biodiversity and shoreline stabilization and enhances marsh ecosystem functions. Aspects of mussel patch configuration including cluster size, perimeter and connectivity modulate the reciprocal facilitation effects of cordgrass and mussels on marsh ecosystems. In a northern South Carolina marsh system, mussel patch configuration positively influenced cordgrass biomass. Predation affected mussel patch …

Personal Identity, Psychological Continuity, And Survival, James D. Martin, Dennis Earl

Honors Theses

In this paper, I consider the question of personal identity, namely: in virtue of what is one person the same person at two different points in time? I first raise objections to theories which argue it is in virtue of physical continuity or continuity soul, then argue that an account of psychological continuity is most successful. One might object to psychological continuity on the grounds of reduplication and fusion problems. I argue that strict numerical identity is a bar set too high and rather that survival (construed as the continuation of a first-person perspective) is what matters for personal identity. …