Digital Commons Network^™

A Validation Of The Claremont Purpose Scale (Cps) Within An Emerging Adult Population, Lillie Grace Veazey

Honors Theses

Having a strong sense of purpose in life leads individuals to have a better overall sense of well-being. Better physical, mental, and emotional outcomes are seen when purpose in life is acknowledged, sought after, and achieved. The Claremont Purpose Scale (CPS) was developed to measure three dimensions of purpose with adolescents. The aim of the present study was to examine the validity of the CPS for use with emerging adults, a population that has not been included in the previous study validating the CPS. It was hypothesized that (1) the CPS will have a three-factor structure, (2) all three factors …

Population Genetics Of A Recent Range Expansion By The Southern Pine Beetle, Dendroctonus Frontalis, Into The Northeastern United States, Megan Stubbs

Honors Theses

Population genetics as a field of study aims to determine the genetic variation among individuals in a population, and differences among populations. Certain population genetic analyses can provide such information and be used to better understand the biological aspects to a species’ expansion beyond its native range. The southern pine beetle (SPB), Dendroctonus frontalis, has become an invasive pest to pine forests in northeastern United States with its recent range expansion. Nine microsatellite loci were first developed and then used in analyses. To determine what the genetic variation is among individuals in SPB populations across its entire range, including …

Women Trailblazers In The Local Oxford Community: Real And Relevant Stories Of Six Unique Paths To Success, Karsyn S. King

Honors Theses

Women Trailblazers In The Local Oxford Community is a collection of six women’s stories in six different fields and their unique paths to success, all showcased through written and visual elements in a multi-modal website. The goal of the project was to have a diverse compilation of women from a variety of backgrounds, ages, careers, and experiences. The trailblazers represented include a woman in the STEM field (science, technology, engineering, math) who is the only female on the biomedical engineering staff, a first generation college student who now holds the second highest position in higher education academia, a local woman …

Characterization Of A Plasmid-Based Dna Vaccine For Simian Immunodeficiency Virus, Priya Sanipara

Honors Theses

Described as one of the world’s worst pandemics, HIV (Human Immunodeficiency Virus) infects millions of people each year and is the cause for AIDS (Acquired Immunodeficiency Syndrome). Despite the development of vaccines for numerous infectious diseases such as polio, small pox, and influenza, a vaccine for HIV remains elusive due to the virus’s high mutation rate and ability to evade the immune system. HIV causes depletion of CD4+ lymphocytes, resulting in a weakened immune system. However, the development of a plasmid-based DNA vaccine approach may help revolutionize vaccine development for HIV due to its ability to confer cellular and humoral …

Elucidating The Functional Location Of Platelet-Derived Growth Factor Receptor Alpha, Creation Of A Review Chapter On The Use Of Zebrafish In Studying Congenital Heart Defects, And Using 3d Printing To Create Laboratory Tools, Jaret Lieberth

Honors Theses

Congenital heart defects (CHDs) are currently the most prevalent form of birth defect in the United States. Their combined frequency and severity make necessary a deeper understanding of the molecular underpinnings guiding heart formation. The first major step in cardiac morphogenesis, cardiac fusion, involves the medial movement of bilateral populations of myocardial precursor cells to the embryonic midline, where they merge to form the primitive heart tube. Although crucial to subsequent organogenesis, the precise mechanisms governing cardiac fusion remain unknown. Previous studies have found that a mutation in platelet-derived growth factor receptor alpha (pdgfra), called refuse-to-fuse (ref), results …

A Raman Spectroscopic And Quantum Chemical Investigation Of Serotonin, It's Intramolecular Interactions, And The Solvent Effects Of Methanol, Ethanol, And Water, Mallory Loe

Honors Theses

Serotonin, or 5-hydroxytryptamine, is a neurotransmitter and metabolite vital to the normal function of the cardiovascular, gastrointestinal, and nervous systems. Although it might be colloquially known as the ‘happiness drug,’ malfunctions in serotoninergic pathways can result in mental health disorders, heart disease, irritable bowel syndrome, and even collateral death. Without a current method to directly measure, or even detect, serotonin in the human body, these diseases, along with many others, pose a threat of developing without proper warning. Raman spectroscopy presents a unique method to vibrationally characterize molecules based upon the inelastic scattering of light. Serotonin’s unique, amphipathic structure presents …

Foster A Better Future: A Comparative Analysis Of Foster Care Programs For Transition-Age Foster Youth And A Recommendation For The State Of Mississippi, Caroline Glaze

Honors Theses

The purpose of this study is to find and evaluate different programs aimed at

supporting older youth in foster care. This population of youth could be those in

high school and extends to youth who have aged out of the foster care system.

Through the evaluation of the selected programs based on a set of characteristics,

the study provides a policy recommendation for the state of Mississippi to begin to

better the lives of Mississippi foster youth. The methodology of this study is

qualitative and literature-based. Data was gathered from websites and other

published articles of the selected programs and …

Ensuring Brand Activism In Integrated Marketing Communications Campaigns Resonates With Millennial Consumers, Anna Hermann

Honors Theses

The purpose of this thesis is to determine how consumers, specifically in the millennial generation, perceive brand activism. Additionally, the study will give recommendations to marketing and public relations professionals creating activist-minded marketing campaigns. As brand activism can be incredibly divisive and controversial, this research is essential in order to understand how best to resonate with, instead of alienate, millennial consumers. The aim of the thesis is to answer the following research questions: (1) How do millennial consumers perceive brands that engage in brand activism and (2) How can marketing and public relations professionals ensure brand activism resonates with millennial …

"Monsters In Suburbia": Women's Bodies, Monstrosity, And Motherhood In The Mere Wife, Claire M. Bonvillain

Honors Theses

This thesis explores themes of monstrosity in Maria Dahvana Headley's novel The Mere Wife in connection with issues of women's bodies and feminism. It analyzes prominent female characters in the novel and the relationships of their bodies to patriarchal authority, showing how and why bodies are deemed monstrous. It discusses the role that motherhood plays in patriarchal society, as well as explores alternatives that the novel offers to this system.

Glucose Metabolism Of Breast Cancer Sub-Clones That Preferentially Metastasize To The Lungs And Bone, Anna G. Skubiz

Honors Theses

Malignant breast cancers exhibit preferential metastasis to bone and lung (1). While changes in gene expression in lung-specific (LM) and bone-specific metastasis (BoM) lines derived from the MDA-MB-231 breast cancer line have been identified, few metabolic genes are differentially expressed; thus it is unknown if tissue-specific metabolic reprogramming occurs. Two hallmarks of cancer cells are an altered metabolic phenotype characterized by enhanced conversion of glucose to lactate in spite of adequate oxygen availability for complete mitochondrial oxidation of this substrate (referred to as aerobic glycolysis or the Warburg effect) and a greater dependence on glutamine. These changes in primary tumor …

The Impact Of Age/Rage Signaling On Oxidative Stress Under Diabetic Conditions In Cardiac Fibroblasts, Christopher Dorroh

Honors Theses

Diabetes is a major health concern in the United States, with 1.5 million new cases diagnosed each year. Patients who suffer from diabetes have an increased risk of developing heart failure, a form of cardiovascular disease. Heart failure has been shown to result from increased left ventricular stiffness, which in turn is caused by increased remodeling of the extracellular matrix (ECM). This increase in ECM remodeling is a result of AGE/RAGE signaling, which occurs at a heightened level in the cardiac fibroblast cells of diabetics. Studies have shown that diabetics have elevated levels of AGEs (Advanced Glycation End-Products), which bind …

Receptive And Expressive Prosodic Abilities In Adults With Down Syndrome, Logan A. Kingry

Honors Theses

Individuals with Down syndrome, a population that often struggles with communication, present a unique linguistic profile of strengths and weaknesses. Almost no research has examined prosody in adults with DS, despite the important role it plays in effective communication. The present study investigated the prosodic profile of seven adults with Down syndrome (18;07-34;11 years) using the Profiling Elements of Prosody for Speech and Communication (PEPS-C), and compared the group’s expressive and receptive prosodic abilities to a group of seven adults with mixed-etiology intellectual and developmental disability (29;02-37;07 years) matched on nonverbal ability. Data analyses showed that the group with Down …

Fluorometric Characterization Of A Methylene Blue Derivative Sensitive To Reactive Oxygen Species (Ros), Matthew Weeks

Honors Theses

Methylene blue (MB) has many uses within both microbiology and pharmacology. MB can treat disorders such as methemoglobinemia, malaria, Alzheimer’s disease, and certain forms of cancer. MB is also useful for molecular imaging due to its off-on fluorescent capabilities. MB derivatives with a urea bond at the 10-N position have been cleavable by triggers such as light. However, I was interested in sensitivity to reactive oxygen species (ROS). In this study, I wanted to determine if the MB derivative MB-EA exhibited sensitivity to ROS. MB-EA was exposed to varying concentrations of hydrogen peroxide and MB release was measured. I concluded …

An Assessment Of Acne, Stress, And Psychological Symptoms In College Students: A Daily Diary Study, Sarah Berry

Honors Theses

Acne is one of the most common and burdensome skin diseases in the United States. Many factors, such as stress and psychological symptoms are believed to contribute to the development and exacerbation of this skin disease, and prior research suggests a cyclic relationship between these factors and acne. College students are known to experience heightened levels of stress and psychological morbidities; yet, most of the previous research on acne and these factors have been limited to adolescents. As such, the current study aimed to assess the relationships between acne, stress, depression, and anxiety in college students over a longitudinal period …

Comparison Of The Vibrational Modes Of Thiolated Gold Nanoparticles Undergoing Core-Conversions Via Raman Spectroscopy, William Gregory Cannella Jr.

Honors Theses

In this project, the vibrational characteristics/vibrational modes are explored via Raman Spectroscopy for thiolated-gold nanoparticles. This class of compounds is also known as gold nanoparticles (AuNPs). They remain of great interest in research areas such as catalysis, gold dependent nanoelectronics, drug delivery, and sensing, due to their unique size-dependent optical, chiroptical, and electronic properties. Vibrational spectroscopy of thiolated gold nanoparticles are oftentimes considered nontrivial as the compounds strongly absorb light in the visible region of the electromagnetic spectrum, are generally considered weak scatterers, and give off large amounts of fluorescence. This combined with their black appearance, susceptibility to localized heating, …

Examining The Possibilities Of Telehealth In Tallahatchie County, Taran Carrasco

Honors Theses

This thesis aims to analyze Tallahatchie County and determine the feasibility of establishing a telehealth program in the county. Telehealth is an evolving aspect in the medical field that incorporates technology with healthcare. This thesis used sociotechnical theory to explain how the feasibility of telehealth could be made more likely as the technology is used over time.Through interviewing UMMC telehealth directors, Tallahatchie Wellness center workers, and citizens of Charleston, this study aims to gauge professional and personal opinions on how feasible it would be to implement telehealth into the Charleston community, as well as how positively telehealth would be accepted …

The Effects Of Alpha-Tocopherol And Ascorbic Acid On Metastatic Breast Cancer Cells, Scout Treadwell

Honors Theses

Breast cancer is a multifaceted, complex disease that affects hundreds of thousands of patients every year. Although there has a been a decline in the mortality rate of this disease, it is still vital to investigate and discover new possible treatments. One area of research involves the generation of reactive oxygen species (ROS) in cancer cells and the possibility of ROS-induced apoptosis. Antioxidants such as Vitamin C and Vitamin E have been shown to serve as pro-oxidants. Instead of detoxifying the cell from damaging ROS, these compounds can stimulate ROS production, triggering an apoptotic cascade in the cell. In this …

Behavioral Ecology Of Territorial Aggression In Uca Pugilator And Uca Pugnax, Abbey N. Thomas

Honors Theses

The nature of animal aggression has long been a research interest in many different scientific fields. Resources, including food, shelter, and mates are all common assets for which animals compete. Two species of fiddler crabs, the Atlantic Sand Fiddler Crab (Uca pugilator) and the Atlantic Marsh Fiddler Crab (U. pugnax) were studied in regards to their aggression shown when competing for shelter. One crab was placed in a contained shelter for two days, and then a second of the same species was introduced. Aggressive interactions were scored and compared with claw and carapace size to ascertain …

Glucose Oxidase And Prussian Blue Nanoparticles Encapsulated Within A Xerogel For Electrochemical Detection Of Glucose, Daniel Baker

Honors Theses

Recent literature reports examples of electrochemical biosensor systems based on the encapsulation of enzymes and metal nanoparticles into a xerogel for the detection of biologically important compounds, such as glucose. While these systems are very successful with acceptable detection limits and linear ranges. However, Prussian Blue modified electrodes have been shown to be better than metal electrodes for the detection of hydrogen peroxide. Here, a biosensor system where a xerogel in formed with both glucose oxidase and Prussian Blue nanoparticles.

Comorbidity Of Childhood Sexual Abuse And Infertility, Brenna Payne

Honors Theses

This paper investigates the association between sexual abuse during childhood and female adult infertility. The initial purpose of this study is to determine if the two experiences share a correlational or causational relationship. Raw data on the incidence of childhood sexual abuse (CSA) is drawn from sources such as the World Health Organization and the Centers for Disease Control and Prevention (CDC). A number of peer-reviewed scientific articles provide information on subjects including the following: female infertility, genital abnormalities resulting from CSA, and techniques used in the clinical examination of victims of sexual abuse. A few case studies of survivors …

Is Anyone Home? Year Round Site Fidelity Vs. Temporal Territories In Estuarine Blennies, Nicholas Govostes

Honors Theses

Temperate oyster reef blennies use articulated oyster shells as nest sites in warmer months during breeding season but little is known about their site fidelity during non-breeding season. Unlike coral reef blennies that occupy territories year-round, rocky intertidal temperate blenny species display temporal territories and seasonally migrate into breeding shelters. Striped blenny (Chasmodes bosquianus) shelter use was described from November 2019 through March 2020 at Oyster Landing, North Inlet estuary, SC to quantify the proportion of daylight hours when fish were in residence and describe potential relationships between shelter occupancy and neighboring fishes. Replicate PVC shelters were monitored …

Test Using Sedimentary Records To Quantify Extreme Paleo-Flood: A Case Study Of An Oxbow Lake In South Carolina, Molly Aeschliman

Honors Theses

Extreme flooding has become an increasing issue along the coasts for people’s health and infrastructure stability. As the effect of climate change continues to persist, the need to prepare for such events becomes imperative. To improve the understanding of climatic forecasting with regards to extreme flooding, there is merit in searching flooding history beyond the instrumental records. There has been some work done in the past to correlate extreme flooding and its sedimentary traces preserved in floodplain depressions, such as oxbow lakes, based on the assumption that the coarser grain sediments in the sediment layers correspond with higher peak discharges …

Physiological And Perceptual Responses To Various Types Of Exercise, Jenna Thompson

Honors Theses

Previously, we found that variable-intensity exercise (VIIE) was more enjoyable than high-intensity interval exercise (HIIT), but the physiological stress was reduced. This study will examine exercise intensity, energy expenditure (EE), and perceptual responses during and after moderate-intensity exercise (MIE), HIIT, and VIIE. On separate days, the three work-matched bouts of exercise (MIE, HIIT, & VIIE) were randomized and performed. Oxygen consumption, heart rate (HR), and muscle oxygenation were collected over the entire bout for all conditions. OMNI ratings of perceived exertion (RPE) and affect, via Feelings Scale, were measured in-exercise and enjoyment was measured post-exercise using the physical activity enjoyment …

Development Of Methods To Track Oyster Movement Under Field Conditions In North Inlet Estuary, South Carolina, Alyssa M. Leclaire

Honors Theses

Eastern oyster (Crassostrea virginica) reefs provide important habitat structure and ecosystem services in saltmarsh tidal creek estuaries. Reef persistence depends on growth of resident individuals and regular recruitment to maintain suitable shell substrate. Boat wakes potentially physically displace oyster clumps. The objective of this research was to develop methods to track oyster clump position and biomass on two natural fringing oyster reefs in North Inlet estuary, South Carolina. Boat traffic (number of boats making wakes per day), oyster clump displacement (cm/d) over time, oyster biomass (g dry tissue), and condition index (biomass/g dry shell weight) were quantified from …

The Effects Of Acute Exercise And Psychological Stress On Episodic Memory, Lauren Koehler

Honors Theses

Research has suggested that exercise has an effect on memory function. Studies have also shown that exercise mitigates the effects of stress. The relationship between exercise and stress in regard to memory function is noteworthy. There has been little research on this relationship in young adults. This thesis discusses the effects of acute exercise on the episodic memory of young adults when they are exposed to a psychosocial stressor. The results of the research study show that acute aerobic exercise before memory encoding or consolidation was not associated with memory function after exposure to a stressor. Future research in this …

Multi-Generational Effects Of ∆9-Tetrahydrocannabinol Exposure On Gene Expression In Liver Tissue, Kayla Lovitt

Honors Theses

Cannabis is the most commonly used, cultivated, and trafficked illicit drug worldwide. Increased availability and acceptance of cannabis and cannabinoid-containing products provide the necessity for understanding how these substances influence aging. In this study, zebrafish (Danio rerio) were exposed to concentrations of Δ⁹-tetrahydrocannabinol (THC) (0.08, 0.4, 2 µM) during embryonic-larval development, the effects on aging were measured 30 months later and in the offspring of the exposed fish (F1 generation. We observed results indicating a biphasic and hormetic effect. Treatment with the lowest concentration of THC significantly increased egg production, while higher concentrations resulted in impaired …

Feminism And Low Breastfeeding Rates In France, Megan Wadsworth

Honors Theses

Breastfeeding rates in France are among the lowest in high-income countries, indicating that French mothers do not breastfeed for nearly as long as is recommended by healthcare professionals and international health organizations. French government, society and conflicting feminist perspectives all influence the likelihood that mothers will breastfeed. The French government has regulations in place to protect women’s right to breastfeed in public and in the workplace, but it is unclear if these are truly beneficial for French women. French society is a seemingly inhospitable environment in which mothers do not feel safe and secure to breastfeed publicly. Motherhood and feminism …

Vital Signs: Exploring Medical American Sign Language Interpreting Services In Mississippi, Morgan Pfleger

Honors Theses

This research involves the regulation, education and training, and availability of medical sign language interpreters in Mississippi, a topic that is seldom studied. The research consisted of a review of past literature on topics related to interpretation and Deaf and hard-of-hearing population, systematic policy review, and interviews with 9 individuals from 7 different medical facilities and one interview with 4 participants together in Mississippi including primary care providers, hospitals, and community health centers. These data were used to explore the interpreting services being provided for those using sign language in Mississippi. Both national and state policies require that alternative methods …

The Effects Of Largazole, A Histone Deacetylase Inhibitor, On Breast Cancer Cell Viability And Metastasis, Hannah Mccowan

Honors Theses

Histone deacetylase enzymes modify epigenetic characteristics of a genome by removing acetyl groups from histone proteins in chromatin. Histone deacetylase inhibitors work by stopping this activity which can have various results in a cell including apoptosis, cell cycle arrest, differentiation, and migration. The purpose of these experiments was to see how largazole, a histone deacetylase inhibitor, affected cell viability for breast cancer and associated metastatic cell lines in both normoxic and hypoxic conditions. The experiment was completed by setting up two 96-well plates with varying concentrations of largazole and conducting a sulforhodamine viability assay. The specific cell lines used in …

Effects Of Invasion By Plants And Beetles On Roots And Mycorrhizal Fungi Of Plantation Scots Pines In Poland, Meghan M. Van

Honors Theses

Biological invasions can cause significant changes to the environment in which they occur. One of the main changes that is caused is how invasive species can disrupt mutualisms between native species in ecosystems. The mutualism between mycorrhizal fungi and plants is one of the most important mutualisms that a plant forms. This mutualism is very important because it is the source of many nutrients that the plant needs. This study took place in a Scots pine (Pinus sylvestris) plantation in northeastern Poland, and aimed to determine the effects of plant and beetle invaders on ectomycorrhizal (ECM) fungi and …