Digital Commons Network^™

More Than Just Hyper: The Mislabeling And Overmedicating Of Adhd In Children Ages 5-10, Katlyn Waltz

Honors Theses

This thesis examines the frequency and consequences of the misdiagnosis and overmedicating of Attention Deficit Hyperactivity Disorder in elementary school aged children, ages 5-10. The information within this paper utilizes recent evidence-based psychological and medical research done surrounding ADHD in children. Specifically focusing on what a misdiagnosis looks like and how this can affect the child. Physically, if an alternative diagnosis is overlooked, the severity of the problem worsens. Emotionally children often feel misunderstood. Misdiagnosis often occurs due to symptoms being shared with other disorders such as thyroid disease, sleep disordered breathing, developmental delays or anxiety/depression.

For children who are …

The Role Of Suffering In The Development Of Character: A Philosophical, Psychological, And Theological Analysis, Taylor Moore

Honors Theses

Suffering is an inherent aspect of the human condition, often perceived as negative yet capable of fostering profound growth. This study explores the transformative potential of suffering through philosophical, psychological, and theological lenses. Specifically, it examines whether suffering is inherently evil or can instead serve as a catalyst for developing character traits essential to eudaimonia—the flourishing life described by Socrates and Aristotle. Drawing on theories of meaning-making and virtues-centered living, this research argues that suffering can create the conditions that can cultivate perseverance, resilience, hope, and relational intimacy, all of which are vital for human flourishing. Under certain conditions, suffering …

You Hit Your Head, What Comes Next? How Can Speech-Language Pathologists Assist In Traumatic Brain Injury Recovery?, Elayna R. Wollam

Honors Theses

Traumatic Brain Injuries are complex injuries caused by an impact or penetrating wound to the head that disrupts the typical functioning of the brain. TBIs are highly prevalent and complex injuries. They can present in different severities, have numerous causes, and result in a variety of different types of symptoms and impairments. These impairments can include articulation disorders, language disorders, fluency disorders, swallowing disorders, social communication disorders, cognitive communication disorders, and more. Every injury will be different, and every individual will experience different symptoms and have different priorities for their recovery. This means treatment should also be nuanced to reflect …

Me Or We In Criminal Behavior: A Cross-National Examination On The Impact Of Narcissism On Criminal Behavior, Adrian J. Zaragoza

Honors Theses

Crime is a worldwide issue that exists within any society. Many studies have not examined narcissism and its relation to crime in a cross-cultural perspective. The current study aimed to examine how culture can impact narcissism and criminal behavior. Hypothesis 1: Individual narcissism will be positively associated with criminal and antisocial responses to provocation scenarios in the United States. Hypothesis 2: Collective narcissism will be positively associated with criminal and antisocial responses to provocation scenarios in Kenya. Hypothesis 3: The association between individual narcissism and criminal/antisocial behavior will be stronger in the United States than in Kenya, …

Analyzing Antibody Immune Response In Α1,3galt-Ko Mice After Intranasal Vaccination Of Α-Gal Virus-Like Particle, Faith Brown

Honors Theses

In this study, we evaluated the immunogenicity of intranasal immunization with α-Gal-conjugated virus-like particles (VLPs) in an α1,3-galactosyltransferase-knockout (α1,3GalT-KO) mouse model that mimics the human immune response to the α-Gal epitope. The carbohydrate epitope galactose-α-1,3-galactose (α-Gal) is expressed on the cell surface of several pathogens, including Leishmania species. This molecule is absent in humans and has emerged as a promising immunogenic vaccine target. α1,3GalT-KO mice were intranasally immunized with 10 μg either Qβ-α-Gal or Qβ per nostril and boosted twice prior to sample collection. Blood and lung lavage samples were used to evaluate the antibody response. The Qβ-α-Gal group developed …

Effects Of “Zero Sugar” Energy Drinks On Microbial Proliferation In Relation To The Gastrointestinal Microbiome, Madison Hines

Honors Theses

Energy drinks have rapidly increased in popularity and availability in recent years. With the rise of high-caffeine beverages, complications due to caffeine consumption have become more common in younger populations. The aim of this study was to use controlled laboratory methods to determine the effect of energy drinks on a variety of organisms commonly found in the gastrointestinal (GI) tract. The diverse and dynamic nature of microbes in the gut makes conditions of the GI tract difficult to replicate in a laboratory setting. As an alternative, isolates of bacteria commonly found as normal flora in the GI tract were plated …

The Impact Of Pp1Β Cancer-Associated Polymorphisms On Pp1Β Protein Abundance And Cell Survival In Humanized Saccharomyces Cerevisiae, Kaylee Martinez

Honors Theses

PP1β is an understudied protein phosphatase that affects the cell’s ability to reproduce. It has been known to be an important part of the cell cycle. Mutations within PP1β have been found to affect that process and influence the development of cancer and disease. In this thesis, different PP1β cancer and disease associated polymorphisms are investigated through the use of humanized yeast. PP1β yeast variants are tested by using Live/Dead cell assay and western blot techniques. Live/Dead analysis was conducted on different strains grown at permissible temperature (room temperature) and non-permissible temperature (37°C) over the course of 6 or 48 …

Synthesis Of Piperidine Heterocycles With Specific Functional Groups Via Sn2 Reactions, Teyanna Monroe

Honors Theses

Piperidine is a heavily utilized nitrogen containing heterocycle found in numerous pharmaceutical agents, solidifying its importance as a building block in drug development. The focus of this research is to investigate different mechanisms of action for adding and replacing various functional groups utilizing readily available lab materials. These findings would lead to determining the overall influence of substitution patterns and functional groups have on stereochemistry, reactivity, and overall conformation of the piperidine ring. The synthetic approach involves the formation of 3-bromo-5-methoxy-tosylpiperidine intermediate through acid promoted cyclization, followed by nucleophilic substitution reactions to introduce various functional groups. Reaction progress and product …

Women Leading In Higher Education: Exploring The Experiences Of Women Leaders In Student Affairs, Amelia Lindsay

Honors Theses

Student affairs is a field within higher education that works to support students’ out-of-classroom needs and provide them with a college experience that promotes holistic growth. This study examines the experiences of women leaders in student affairs at a mid-sized university in the southeastern United States and the opportunities and barriers they encountered in their pathways to their careers. Through in-depth, qualitative interviews, clear themes emerged regarding both facilitators of and challenges to their progression to leadership. Data show that their early life characteristics, self-perceptions, collegiate involvement, and mentorship were the largest catalysts in their career trajectories while the challenge …

Developing A Range Prediction For The Imperiled Florida Harvester Ant (Pogonomyrmex Badius) Using Species Distribution Modeling, Noah Williamson

Honors Theses

The Florida Harvester Ant (Pogonomyrmex badius) was once widespread and commonplace throughout the sandhills of the Southeastern United States, providing key ecosystem services, such as seed dispersal and soil aeration. Over recent decades, however, Florida Harvester Ant populations have declined in some areas. Current literature postulates that Red Imported Fire Ants (RIFA), and the insecticides used to manage them, as well as further human encroachment onto their habitat, all likely contributed to Florida Harvester Ant population declines. Thus, to better protect these organisms, pursue data-driven conservation efforts, and guide management practices, more information about their nest site selection, as well …

Taphonomy And Fossil Record Of Eufistulana Mumia In The Owl Creek Formation Of The Mississippi Embayment, Riley Rilette

Honors Theses

This study examines the taphonomy and preservation of Eufistulana mumia, a boring bivalve, within the Owl Creek Formation of northeastern Mississippi. The formation was deposited in a shallow marine environment of Maastrichtian age within the Mississippi Embayment. A total of 66 specimens were collected from exposures within the formation and analyzed to evaluate morphometric variation and orientation patterns. Field measurements of trend and plunge of each specimen were recorded in situ using a geological compass, and specimens were later prepared and measured in the laboratory with digital calipers. Morphometric results show consistent tube morphology, with basal widths larger than distal …

The Spread Of Conspiracy Theories And Social Media Radicalization: “Stop The Steal” On Social Media, Zaynab Saleem

Honors Theses

This study examines how conspiracy-related content spread across social media platforms following the 2020 U.S. Presidential election, specifically the “Stop the Steal” (STS) movement. While conspiracy theories are often seen as influential on niche parts of the internet, less is known about how they compare to non-conspiracy content in terms of engagement, visibility, and how they change over time. To address this gap, this study uses a quantitative approach to compare STS and non-STS content across two distinct types of social media platforms: a text-based platform (Platform A) and a video-sharing platform (Platform B). Data was collected using keyword searches …

Synthesis And Photophysical Studies Of Coumarin-Quinoline Derivatives, Nishrenika Pokhrel

Honors Theses

A new family of oxime-functionalized coumarin-quinoline derivatives, 5a and 5b, has been synthesized through a five-step procedure in high yields (45-98%). Compound 5a is designed as the sensing probe, while 5b serves as a model system to support mechanistic understanding. The sensing approach is based on the reactivity of the oxime group, which can undergo phosphorylation in the presence of organophosphate nerve agents. Based on this behavior, it is hypothesized that 5a can react irreversibly with a nerve agent mimic. The structures were fully characterized by NMR, FTIR, and HRMS. Photophysical properties of 5a were studied in various solvents, …

An Insight Into The Venom Gland Proteome Of The Two-Spined Trap-Jaw Ant, Odontomachus Haematodus, Aaron Morgan

Honors Theses

Ants are ecologically important and highly abundant organisms, playing key roles in many ecosystems. One recently introduced species in the southeastern United States is Odontomachus haematodus (the two-spined trap-jaw ant), a South American native that has often been misidentified, contributing to limited research on its biology and venom composition. This study aimed to provide the first detailed characterization of the venom apparatus and proteome of O. haematodus. Specimens were collected and dissected, and venom-related proteins were extracted and analyzed using SDS-PAGE and tandem mass spectrometry (MS/MS-ESI). Confocal microscopy was also used to visualize the sting apparatus, including F-actin filaments and …

Who Then Can Be Saved? A Discussion Of Views Within The Christian Tradition Concerning The Salvation Of The Non-Christian, Logan A. Davis

Honors Theses

This thesis argues that, contrary to popular conception, the Christian Tradition is not strictly exclusivist in its understanding of salvation or in its assessment of the fate of the non-Christian but rather displays a rich diversity of views. Both the Christian Tradition and the Christian scriptures are characterized by a certain ambiguity on this issue; although a definitive answer may exist, it is not easily identifiable. Given this ambiguity, the study presents a representative spectrum of theological positions within the Christian Tradition and analyzes their respective treatments of the salvation of the non-Christian. In doing so, it seeks to provide …

Evaluating The Environmental Parameters Impacting Spawning Movement Of Gulf Sturgeon (Acipenser Desotoi) In The Bouie River System., Olivia St. Germain

Honors Theses

The anadromous Gulf Sturgeon (Acipenser desotoi) is federally listed as “threatened” and is natal to seven rivers from Louisiana to Florida. Only one spawning reach for Gulf Sturgeon natal to the Pascagoula River has been verified via the collection of eggs and larvae; a reach of the lower Bouie River. This reach is anthropogenically modified by four gravel mining formations, hereafter referred to as pits. The greater depths associated with this area have prompted previous researchers to suggest that Gulf Sturgeon may over-summer in pit formations instead of migrating to downstream holding areas in the Pascagoula River after spawning. The …

Bodies As Vessels: (Re)Production, Consumption, And Female Identity In The Handmaid’S Tale And Dawn, Shelby Clark

Honors Theses

This honors thesis examines how reproduction and food are used to signify power and impact female identity in Margaret Atwood’s The Handmaid's Tale and Octavia Butler’s Dawn. Both feminist dystopian novels portray societies that secure futurity through the commodification and management of women's domestic labor. The protagonist of each novel, Offred in The Handmaid's Tale and Lilith in Dawn, is responsible for ensuring the survival of humanity through forced reproduction and is additionally expected to produce or manage food. In this thesis, I argue that in both novels, female identity is reclaimed and affirmed as separate from a commodified state …

Evaluation Of Tick-Derived Peptides For Transmission-Blocking Vaccine Candidates, Madelyn Futral

Honors Theses

The lack of effective preventive measures for tick-borne diseases represents a major public health challenge. Transmission-blocking vaccines targeting tick molecules essential for feeding or reproduction could provide a sustainable and broad-spectrum solution. In this study, we evaluated two tick-derived proteins as potential vaccine antigens, subolesin, a key regulator of blood-feeding and cellular processes, and vitellogenin, a protein involved in egg development. Using bioinformatic tools, we identified immunogenic peptide sequences from each protein and chemically conjugated them to virus-like particles (VLPs) to enhance antigen presentation. C57BL/6 mice were immunized intradermally with VLP-peptide conjugates, followed by a booster dose. Blood and spleen …

Variable Hybridization Rates Between F2 Fundulus Notatus Females, Jordan Tanaka

Honors Theses

Hybridization between two related species has been widely observed and offers a lens into complex evolutionary processes. Endogenous and exogenous factors affect hybrid fitness and diversification, and pre-zygotic and post-zygotic barriers affect species’ ability to hybridize. Female mate choice is a pre-zygotic isolation mechanism which is known to be more significant than male mate choice in many species, a trend which is linked to females often investing more energy into offspring. Detailing the ways in which these mechanisms operate is integral to understanding hybridization on a larger scale. The species examined here, Fundulus notatus and Fundulus olivaceous, are closely …

Optimizing Barley Stripped Mosaic Virus Coat Protein Stability For Palladium Nanorod Biotemplating Via Terminal His-Tag Positioning, Emilie Hayes

Honors Theses

Viral biotemplating has become an exciting approach towards the production of nanomaterials with a controlled size and morphology. Rod-shaped plant viruses provide structurally consistent scaffolds that can guide the assembly of inorganic nanostructures, which can offer a biologically inspired platform to nanoscale material design. In the current study, computational modeling was used to examine the effect of palladium precursor chemistry on the reaction with viral protein templates. Molecular dynamics simulations were performed to test the stability of the viral scaffold, and the influence of N-terminal and C-terminal His-tag on protein flexibility. These simulations revealed that the viral coat protein is …

Carboxypeptidase O Expression In Ku812 Basophil Cells Decreases Upon Degranulation, Etien Balorda

Honors Theses

Basophils are leukocytes that mediate inflammatory responses through the exocytosis of granules containing enzymes and inflammatory mediators. Carboxypeptidase O (CPO) is a protease with Cterminal acidic amino acid specificity and is expressed in basophils. CPO expression and localization were assessed in KU812 basophil cells via Western blotting and immunocytochemistry. CPO expression decreased upon degranulation and is localized to cytosolic puncta. These data suggest that CPO may be localized in basophil granules and released upon degranulation.

The Ethical Limits Of Physician Autonomy In Reproductive Medicine, Isabel Martens

Honors Theses

In vitro fertilization is a relatively new medical practice that helps people who face infertility be able to reproduce. Reproductive medicine providers face ethical dilemmas often in their field, only some of which have standards of care. There are questions in the medical landscape pertaining to physician autonomy versus patient autonomy, which heavily apply to reproductive medicine providers. Patient autonomy is highly valued in medical ethics; however, physician autonomy should also be considered. When a physician decides who can and cannot reproduce, ethical considerations must be followed to maintain the practice of reproductive autonomy. Limited policies exist that manage reproductive …

The Effects Of Low-Frequency, Low-Intensity Ultrasound On Gene Expression In Macrophage-Endothelial Cell Co-Culture, Evelyn Hergenhan

Honors Theses

Introduction

Low-frequency, low-intensity ultrasound (LFLI US) has been shown to be a promising treatment for noninvasive accelerated chronic wound healing. However, the biological mechanisms of this ultrasound-assisted healing are not yet understood, limiting clinical adoption. The objective of this study is to characterize the effects of LFLI US on gene expression in a simulated chronic wound environment to gain a better understanding of the biological mechanisms underlying this therapeutic.

Methods

A simulated chronic wound environment consisting of endothelial cells and inflammatory M1 macrophages co-cultured in 3D was subject to LFLI US at 50, 100, or 150 mW/cm² Spatial-Peak, Temporal-Peak …

Leveraging Machine Learning Techniques To Identify Catastrophic Outliers In Photometric Redshift Estimates, Jason Yoo

Honors Theses

Leveraging the unprecedented data volumes from modern astronomical surveys, this work addresses the critical challenge of identifying catastrophic outliers (COs) in photometric redshift (photo-z) estimates. Reliable redshift estimation is essential for precision cosmology, yet COs (galaxies with severely erroneous photo-z) can introduce significant systematic bias. We develop and evaluate two machine learning approaches for robust CO identification: a multilayer perceptron (MLP) utilizing photo-z point estimates and probability distributions, and a convolutional neural network (CNN) leveraging raw 5-band photometric images. Using datasets emulating LSST conditions, we demonstrate that the MLP model achieves high accuracy and stability across redshift bins, correctly identifying …

Evaluating Quahog (Mercenaria Mercenaria) Nursery Methods And Production Costs To Support Diversification Of Maine’S Fisheries And Aquaculture Sector, Hannah G. Wolf

Honors Theses

Populations of wild and farmed quahogs in Maine are expanding, driven by warming waters, declining soft-shell clam populations, and the need to diversify fisheries. The Northern quahog (Mercenaria mercenaria) is a potential species to diversify Maine’s marine sector, as its geographical range is expanding, and they appear more resistant to green crab predation. Enhancing wild quahog stock provides economic and social advantages for both the aquaculture and wild harvest industries. However, there is limited understanding about the commercial viability of producing quahog seed on existing farms for wild shellfish enhancement in Maine. This research, part of a larger NOAA …

Climate Change And Species Interactions Jointly Shape Migration Timing And Growth At A Critical Ontogenetic Transition In Juvenile Sockeye Salmon, Margaret E. Veatch

Honors Theses

Climate change is shifting the timing of biological events globally, but the mechanisms linking environmental variation to phenological changes are poorly understood in many systems, particularly those where individuals undergo ontogenetic habitat shifts. Here, I examined the join influence of climate-driven environmental variability and species interactions migration timing and body size at migration in juvenile sockeye salmon (Oncorhynchus nerka) in Lake Aleknagik, Alaska, using a multi-decadal dataset (1967–2024). Migration timing varied widely among years and was best explained by a combination of ice-out phenology, epilimnetic temperature, and fish densities in littoral habitats. Juvenile sockeye salmon migrated earlier in …

"It's A Dance": Examining Midwives As Choreographers Of Reproduction In Maine, Annie Goldstein

Honors Theses

This thesis examines the contemporary work of community-based Maine midwives through the theoretical framework of choreography. In the context of this work, choreography can be understood as the well-thought-out, purposeful undertaking of a process during which negotiation, coordination, and improvisation are required to adapt to constantly changing circumstances. Using choreography, this thesis attempts to understand how Maine midwives navigate global market processes and practice under authoritative forms of biomedicine, ultimately linking them to other midwives across various global sites. Situated within Maine’s maternal health landscape that is characterized by the ongoing closure of labor and delivery units and rural hospitals, …

The Role Of Mscs In The Il23/17 Pathway And Their Response To Mechanical Stress, Norma Aileen Dominguez Jimenez

Honors Theses

Mechanical stress plays a central role in shaping cellular behavior within skeletal tissues. At the enthesis, where tendons and ligaments attach to bone, repeated mechanical loading is strongly associated with inflammation and the development of ankylosing spondylitis (AS). Although mesenchymal stem cells (MSCs) are known to contribute to tissue structure and repair at these sites, their potential role in inflammatory signaling, particularly within the I 23/IL 17 pathway, remains unclear. In this thesis I investigated whether MSCs are capable of expressing cytokines involved in this pathway and how mechanical stress and differentiation influence this expression. Using the mouse derived C3H/10T1/2 …

Ultra-Processed Or Ultra-Addictive? A Demand-Based Redefinition Of Ultra-Processed Foods, Braden Jondro

Honors Theses

Ultra-processed foods now comprise the majority of the U.S. food supply and have been directly associated with 32 chronic diseases including obesity, cardiovascular disease, cancer, and diabetes. Current classification systems such as NOVA provide a useful framework for identifying food processing, but rely on broad and subjective categorizations that may not capture the mechanisms most closely associated with promoting persistent overconsumption. In particular, existing classification systems remain limited in their ability to evaluate addiction-like behaviors associated with highly processed foods, including persistent purchasing patterns, reinforcement effects, and substitution responses. This paper introduces the Ultra-Processed Food Intensity (UPFI) index, an objective, …

Blood And Belonging: Remembering Massacres Of The American West In The Twentieth Century, Mountain Meadows And Sand Creek, Kenzie Burns

Honors Theses

The late nineteenth and early twentieth centuries marked a turning point in mainstream America’s sense of national identity. A wave of nostalgia for the American Frontier enshrined the region’s idealized nineteenth-century past as myth. A key part of the story is romanticized violence—often depicted through cultural imagery of cowboys, gunfights, and battles with American Indians. This project seeks to understand more about how violence is represented in the cultural memory of the American Western past. Within the past twenty years, scholars of the American West have begun to incorporate the study of memory into their scholarship, frequently with how cultural …